{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:09:19Z","timestamp":1790186959098,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"am","delay-in-days":261,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.scitotenv.2021.146358","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T23:41:36Z","timestamp":1615506096000},"page":"146358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Route of exposure influences pesticide body burden and the hepatic metabolome in post-metamorphic leopard frogs"],"prefix":"10.1016","volume":"779","author":[{"given":"Donna A.","family":"Glinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Van Meter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Thomas","family":"Purucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Matthew","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2021.146358_bb0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12302-016-0085-6","article-title":"Amphibians and plant-protection products: what research and action is needed?","volume":"28","author":"Aldrich","year":"2016","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0010","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1242\/jeb.01623","article-title":"Body wiping behaviors associated with cutaneous lipids in hylid tree frogs of Florida","volume":"208","author":"Barbeau","year":"2005","journal-title":"J. Exp. Biol."},{"issue":"9","key":"10.1016\/j.scitotenv.2021.146358_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2166\/wst.2002.0213","article-title":"Potential toxicity of pesticides measured in midwestern streams to aquatic organisms","volume":"45","author":"Battaglin","year":"2002","journal-title":"Water Sci. Technol."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.146358_bb5005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1752-1688.2005.tb03738.x","article-title":"Glyphosate, other herbicides, and transformation products in midwestern streams, 20021","volume":"41","author":"Battaglin","year":"2005","journal-title":"J Am Water Resour Assoc"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11270-010-0643-2","article-title":"Occurrence of azoxystrobin, propiconazole, and selected other fungicides in US streams, 2005\u20132006","volume":"218","author":"Battaglin","year":"2011","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.scitotenv.2016.05.062","article-title":"Potential interactions among disease, pesticides, water quality and adjacent land cover in amphibian habitats in the United States","volume":"566","author":"Battaglin","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0030","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1007\/s10646-012-0897-0","article-title":"A metabolomics based test of independent action and concentration addition using the earthworm Lumbricus rubellus","volume":"21","author":"Baylay","year":"2012","journal-title":"Ecotoxicology"},{"issue":"9","key":"10.1016\/j.scitotenv.2021.146358_bb0035","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1897\/04-357R.1","article-title":"Vegetated agricultural drainage ditches for the mitigation of pyrethroid-associated runoff","volume":"24","author":"Bennett","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0040","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/ajplegacy.1972.223.2.361","article-title":"Zonal differences in permeability of the skin of some anuran Amphibia","volume":"223","author":"Bentley","year":"1972","journal-title":"American Journal of Physiology-Legacy Content"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0045","series-title":"Amphibienschutz in kleingew\u00e4sserreichen Ackerbaugebieten (Conservation of Amphibians in Agricultural Landscapes Rich in Small Water Bodies)","volume":"vol. 384","author":"Berger","year":"2011"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1005988611661","article-title":"Anuran development, density and diversity in relation to agricultural activity in the Holland River watershed, Ontario, Canada (1990\u20131992)","volume":"57","author":"Bishop","year":"1999","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2427.2011.02695.x","article-title":"The effects of multiple stressors on wetland communities: pesticides, pathogens and competing amphibians","volume":"57","author":"Buck","year":"2012","journal-title":"Freshw. Biol."},{"issue":"6","key":"10.1016\/j.scitotenv.2021.146358_bb0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10661-016-5215-5","article-title":"Storm-event-transport of urban-use pesticides to streams likely impairs invertebrate assemblages","volume":"188","author":"Carpenter","year":"2016","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0065","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/etc.5620220522","article-title":"Effects of agricultural pesticides on the immune system of Rana pipiens and its resistance to parasitic infection","volume":"22","author":"Christin","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0048-3575(82)90104-3","article-title":"Two different types of inhibitory effects of pyrethroids on nerve Ca-and Ca+ Mg-ATPase activity in the squid, Loligo pealei","volume":"18","author":"Clark","year":"1982","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0075","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/MCO.0000000000000189","article-title":"Galactose metabolism and health","volume":"18","author":"Coelho","year":"2015","journal-title":"Current Opinion in Clinical Nutrition & Metabolic Care"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0080","series-title":"Breeding Habits and Habitats of the Amphibians of the Edwin S","author":"Collins","year":"1979"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1939-1676.1994.tb03201.x","article-title":"Ammonia metabolism and the urea cycle: function and clinical implications","volume":"8","author":"Dimski","year":"1994","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0090","doi-asserted-by":"crossref","unstructured":"EFSA. Conclusion on the peer review of the pesticide risk assessment of the active substance bifenthrin. EFSA Journal 9.5; 2011; 2159.","DOI":"10.2903\/j.efsa.2011.2159"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0095","doi-asserted-by":"crossref","unstructured":"EFSA, Panel on Plant Protection Products and their Residues (PPR), Ockleford C, Adriaanse P, Berny P, Brock T, et al. Scientific Opinion on the state of the science on pesticide risk assessment for amphibians and reptiles. EFSA J. 2018; 16: e05125.","DOI":"10.2903\/j.efsa.2018.5125"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0100","doi-asserted-by":"crossref","unstructured":"Fernandez-Cornejo J, Nehring RF, Osteen C, Wechsler S, Martin A, Vialou A. Pesticide Use in US Agriculture: 21 Selected Crops, 1960\u20132008. EIB-124, U.S. Department of Agriculture, Economic Research Service 2014.","DOI":"10.2139\/ssrn.2502986"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0105","doi-asserted-by":"crossref","unstructured":"Fryday S, Thompson H. Toxicity of pesticides to aquatic and terrestrial life stages of amphibians and occurrence, habitat use and exposure of amphibian species in agricultural environments. Food and Environment Research Agency Supporting Publications EN-343 2012.","DOI":"10.2903\/sp.efsa.2012.EN-343"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0110","doi-asserted-by":"crossref","unstructured":"Gilliom RJ, Barbash JE, Crawford CG, Hamilton PA, Martin JD, Nakagaki N, et al. Pesticides in the nation's streams and ground water, 1992\u20132001. Geological Survey (US), 2006.","DOI":"10.3133\/cir1291"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0115","doi-asserted-by":"crossref","first-page":"16192","DOI":"10.1007\/s11356-018-1830-8","article-title":"Effect of hydration status on pesticide uptake in anurans following exposure to contaminated soils","volume":"25","author":"Glinski","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2018.02.016","article-title":"Using in vitro derived enzymatic reaction rates of metabolism to inform pesticide body burdens in amphibians","volume":"288","author":"Glinski","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.chemosphere.2018.06.116","article-title":"Analysis of pesticides in surface water, stemflow, and throughfall in an agricultural area in South Georgia, USA","volume":"209","author":"Glinski","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1071\/EN18163","article-title":"Endogenous and exogenous biomarker analysis in terrestrial phase amphibians (Lithobates sphenocephala) following dermal exposure to pesticide mixtures","volume":"16","author":"Glinski","year":"2019","journal-title":"Environ. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0135","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.envpol.2016.11.010","article-title":"Assessment of chlorpyrifos toxic effects in zebrafish (Danio rerio) metabolism","volume":"220","author":"G\u00f3mez-Canela","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0140","series-title":"Ecological and Environmental Physiology of Amphibians","author":"Hillman","year":"2009"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0145","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1139\/f03-095","article-title":"The effects of adjacent land use on wetland amphibian species richness and community composition","volume":"60","author":"Houlahan","year":"2003","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-21534-3","article-title":"The genes of the sulphoquinovose catabolism in Escherichia coli are also associated with a previously unknown pathway of lactose degradation","volume":"8","author":"Kaznadzey","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/tox.21903","article-title":"Effects of chlorpyrifos on the metabolome of the freshwater carp, Cyprinus carpio","volume":"30","author":"Kokushi","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0160","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.baae.2014.10.005","article-title":"Temporal coincidence of amphibian migration and pesticide applications on arable fields in spring","volume":"16","author":"Lenhardt","year":"2015","journal-title":"Basic and Applied Ecology"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.aquatox.2013.10.024","article-title":"NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus)","volume":"146","author":"Li","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0170","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1039\/C6TX00011H","article-title":"Multi-tissue metabolic responses of goldfish (Carassius auratus) exposed to glyphosate-based herbicide","volume":"5","author":"Li","year":"2016","journal-title":"Toxicology Research"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.aquatox.2017.05.004","article-title":"Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure","volume":"188","author":"Li","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0180","doi-asserted-by":"crossref","first-page":"120995","DOI":"10.1016\/j.jhazmat.2019.120995","article-title":"Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: adverse effects on the nervous system during metamorphic development of Xenopus laevis","volume":"381","author":"Li","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0185","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.chemosphere.2015.07.030","article-title":"1H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus)","volume":"138","author":"Liu","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0190","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1021\/ac900036d","article-title":"MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing","volume":"81","author":"Lommen","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-014-0031-4","article-title":"Hypothesizing if responses to climate change affect herbicide exposure risk for amphibians","volume":"26","author":"L\u00f6tters","year":"2014","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0200","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.envpol.2009.05.015","article-title":"Amphibians and agricultural chemicals: review of the risks in a complex environment","volume":"157","author":"Mann","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0205","doi-asserted-by":"crossref","first-page":"39328","DOI":"10.1038\/srep39328","article-title":"Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of roundup herbicide","volume":"7","author":"Mesnage","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0210","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pestbp.2017.08.002","article-title":"Comparison of subacute effects of two types of pyrethroid insecticides using metabolomics methods","volume":"143","author":"Miao","year":"2017","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.chemosphere.2016.06.012","article-title":"Occurrence of current-use fungicides and bifenthrin in Rainwater Basin wetlands","volume":"159","author":"Mimbs","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.aquatox.2015.11.023","article-title":"Metabolomics reveals energetic impairments in Daphnia magna exposed to diazinon, malathion and bisphenol-A","volume":"170","author":"Nagato","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0225","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.chroma.2014.11.005","article-title":"Comparative evaluation of eight software programs for alignment of gas chromatography\u2013mass spectrometry chromatograms in metabolomics experiments","volume":"1374","author":"Niu","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119250","article-title":"Modifying effects of vitamin E on chlorpyrifos toxicity in Atlantic salmon","volume":"10","author":"Olsvik","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0235","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2016.09.009","article-title":"A new view into the regulation of purine metabolism: the purinosome","volume":"42","author":"Pedley","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0240","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0168-9525(97)01379-6","article-title":"The fundamental importance of human galactose metabolism: lessons from genetics and biochemistry","volume":"14","author":"Petry","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0245","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.scitotenv.2013.08.070","article-title":"Endosulfan wet deposition in Southern Florida (USA)","volume":"468-469","author":"Potter","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0250","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11306-008-0140-4","article-title":"NMR-based metabolomics using earthworms as potential indicators for soil health","volume":"5","author":"Rochfort","year":"2009","journal-title":"Metabolomics"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0255","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/etc.680","article-title":"Multiple stressors and complex life cycles: insights from a population-level assessment of breeding site contamination and terrestrial habitat loss in an amphibian","volume":"30","author":"Salice","year":"2011","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb5000","series-title":"US Geological Survey Data Series","first-page":"36","article-title":"Occurrence of pesticides in water and sediment collected from amphibian habitats located throughout the United States, 2009\u20132010","volume":"707","author":"Smalling","year":"2012"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0260","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.scitotenv.2014.08.114","article-title":"Pesticide concentrations in frog tissue and wetland habitats in a landscape dominated by agriculture","volume":"502","author":"Smalling","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0265","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.envpol.2007.06.009","article-title":"Contaminant exposure in terrestrial vertebrates","volume":"150","author":"Smith","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0270","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.aquatox.2016.11.018","article-title":"Biomarker analysis of American toad (Anaxyrus americanus) and grey tree frog (Hyla versicolor) tadpoles following exposure to atrazine","volume":"182","author":"Snyder","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0275","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tox.2016.11.005","article-title":"Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats","volume":"377","author":"de Souza","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0280","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/etc.5620200725","article-title":"Pesticides and amphibian population declines in California, USA","volume":"20","author":"Sparling","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0285","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.aam9305","article-title":"Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass","volume":"358","author":"Spinelli","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0290","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.341.6147.730","article-title":"Infographic: pesticide planet","volume":"341","author":"Stokstad","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0295","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1126\/science.1103538","article-title":"Status and trends of amphibian declines and extinctions worldwide","volume":"306","author":"Stuart","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0300","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cbpa.2006.12.021","article-title":"Amphibian aquaporins and adaptation to terrestrial environments: a review","volume":"148","author":"Suzuki","year":"2007","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0305","unstructured":"U.S. EPA. Estimation Programs Interface Suite\u2122 for Microsoft\u00ae Windows, v 4.11, United States Environmental Protection Agency, Washington, DC, USA, 2012."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0310","unstructured":"US Geological Survey. USGS NAWQA: The Pesticide National Synthesis Project. Estimated annual agricultural pesticide use. 2016. https:\/\/water.usgs.gov\/nawqa\/pnsp\/usage\/maps\/county-level\/. Accessed 3 Mar 2021."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0315","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.envpol.2014.07.003","article-title":"Estimating terrestrial amphibian pesticide body burden through dermal exposure","volume":"193","author":"Van Meter","year":"2014","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0320","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00244-015-0183-2","article-title":"Pesticide uptake across the amphibian dermis through soil and overspray exposures","volume":"69","author":"Van Meter","year":"2015","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0325","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1002\/etc.3439","article-title":"Soil organic matter content effects on dermal pesticide bioconcentration in American toads (Bufo americanus)","volume":"35","author":"Van Meter","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0330","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.scitotenv.2017.12.175","article-title":"Influence of exposure to pesticide mixtures on the metabolomic profile in post-metamorphic green frogs (Lithobates clamitans)","volume":"624","author":"Van Meter","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0335","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/etc.4375","article-title":"Agrochemical mixtures and amphibians: the combined effects of pesticides and fertilizer on stress, acetylcholinesterase activity and bioaccumulation in a terrestrial environment","volume":"38","author":"Van Meter","year":"2019","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0340","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/1354700031000120116","article-title":"Biomarkers of effect in toads and frogs","volume":"8","author":"Venturino","year":"2003","journal-title":"Biomarkers"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0345","series-title":"Metabolomics: Methods and Protocols","first-page":"229","article-title":"Revealing the metabolome of animal tissues using 1H nuclear magnetic resonance spectroscopy","author":"Viant","year":"2007"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0350","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/0003-3472(77)90118-X","article-title":"The social behaviour of anuran amphibians","volume":"25","author":"Wells","year":"1977","journal-title":"Anim. Behav."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0355","doi-asserted-by":"crossref","first-page":"8352","DOI":"10.1073\/pnas.0611256104","article-title":"Amphibian and reptile declines over 35\u00a0years at La Selva, Costa Rica","volume":"104","author":"Whitfield","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0360","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2307\/1563068","article-title":"Courtship, reproductive rates, and mating system in three Australian Pseudophryne (Amphibia, Anura, Leptodactylidae)","author":"Woodruff","year":"1976","journal-title":"J. Herpetol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0365","doi-asserted-by":"crossref","unstructured":"Xia J, Wishart DS. Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis. Current Protocols in Bioinformatics 2016: 14.10. 1\u201314.10. 91.","DOI":"10.1002\/cpbi.11"},{"key":"10.1016\/j.scitotenv.2021.146358_bb0370","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aquatox.2014.11.020","article-title":"1H NMR based metabolomics approach to study the toxic effects of herbicide butachlor on goldfish (Carassius auratus)","volume":"159","author":"Xu","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0375","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/acs.chemrestox.5b00054","article-title":"Metabolomics analysis and biomarker identification for brains of rats exposed subchronically to the mixtures of low-dose cadmium and chlorpyrifos","volume":"28","author":"Xu","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0380","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.aquatox.2011.04.022","article-title":"Exposure to atrazine affects the expression of key genes in metabolic pathways integral to energy homeostasis in Xenopus laevis tadpoles","volume":"104","author":"Zaya","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146358_bb0390","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.chemosphere.2016.03.055","article-title":"Effects of chlorpyrifos on the gut microbiome and urine metabolome in mouse (Mus musculus)","volume":"153","author":"Zhao","year":"2016","journal-title":"Chemosphere"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721014261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721014261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:44:25Z","timestamp":1790185465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721014261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":79,"alternative-id":["S0048969721014261"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146358","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Route of exposure influences pesticide body burden and the hepatic metabolome in post-metamorphic leopard frogs","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146358"}}