{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:02:49Z","timestamp":1790186569802,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["IMAP ANR-16-CE34-0006-01"],"award-info":[{"award-number":["IMAP ANR-16-CE34-0006-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005388","name":"Instituto Tecnol\u00f3gico de Costa Rica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.scitotenv.2021.146387","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T23:41:41Z","timestamp":1615506101000},"page":"146387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Elucidating venlafaxine metabolism in the Mediterranean mussel (Mytilus galloprovincialis) through combined targeted and non-targeted approaches"],"prefix":"10.1016","volume":"779","author":[{"given":"N.","family":"Ariza-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Courant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Dumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2021.146387_bb0005","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.talanta.2014.12.035","article-title":"Multi-residue method for the analysis of pharmaceuticals and some of their metabolites in bivalves","volume":"136","author":"Alvarez-Mu\u00f1oz","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.scitotenv.2021.146387_bb0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envres.2015.09.018","article-title":"Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe","volume":"143","author":"Alvarez-Mu\u00f1oz","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0015","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.aquatox.2014.06.014","article-title":"Environmental levels of the antidepressant venlafaxine impact the metabolic capacity of rainbow trout","volume":"155","author":"Best","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.scitotenv.2017.01.063","article-title":"Metabolic profiling identification of metabolites formed in Mediterranean mussels (Mytilus galloprovincialis) after diclofenac exposure","volume":"583","author":"Bonnefille","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0025","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jchromb.2016.07.016","article-title":"Development of a multi-residue method for scrutinizing psychotropic compounds in natural waters","volume":"1047","author":"Brieudes","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0030","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.scitotenv.2018.10.290","article-title":"Pharmaceuticals as chemical markers of wastewater contamination in the vulnerable area of the Ebro Delta (Spain)","volume":"652","author":"\u010celi\u0107","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0035","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1002\/pmic.201400255","article-title":"Basics of mass spectrometry based metabolomics","volume":"14","author":"Courant","year":"2014","journal-title":"Proteomics"},{"key":"10.1016\/j.scitotenv.2021.146387_bb0040","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s11356-012-0964-3","article-title":"Bioconcentration of pharmaceuticals (benzodiazepines) and two personal care products (UV filters) in marine mussels (Mytilus galloprovincialis) under controlled laboratory conditions","volume":"19","author":"Gomez","year":"2012","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0045","unstructured":"Gomez, E., Boillot, C., Martinez Bueno, MJ., Munaron, D., Mathieu, O., Courant, F., Fenet, H., n.d. In Vivo Exposure of Marine Mussel to Venlafaxine: Bioconcentration and Metabolization. Sumitted."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0050","doi-asserted-by":"crossref","unstructured":"Ings, J.S., George, N., Peter, M.C.S., Servos, M.R., Vijayan, M.M. 2012. Venlafaxine and atenolol disrupt epinephrine-stimulated glucose production in rainbow trout hepatocytes. Aquat. Toxicol. 106\u2013107, 48\u201355.","DOI":"10.1016\/j.aquatox.2011.10.006"},{"key":"10.1016\/j.scitotenv.2021.146387_bb0055","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1021\/tx300457f","article-title":"Biotransformation pathways of biocides and pharmaceuticals in freshwater crustaceans based on structure elucidation of metabolites using high resolution mass spectrometry","volume":"26","author":"Jeon","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jat\/33.7.345","article-title":"Determination of heroin and its main metabolites in small sample volumes of whole blood and brain tissue by reversed-phase liquid chromatography-tandem mass spectrometry","volume":"33","author":"Karinen","year":"2009","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0065","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/138920010792927343","article-title":"Direct analysis of glucuronides with liquid chromatography-mass spectrometric techniques and methods","volume":"11","author":"Ketola","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0070","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00216-013-7477-x","article-title":"Occurrence of venlafaxine residues and its metabolites in marine mussels at trace levels: development of analytical method and a monitoring program","volume":"406","author":"Mart\u00ednez Bueno","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0075","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.scitotenv.2018.04.015","article-title":"Differential behavioural responses to venlafaxine exposure route, warming and acidification in juvenile fish (Argyrosomus regius)","volume":"634","author":"Maulvault","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0080","doi-asserted-by":"crossref","first-page":"9509","DOI":"10.1007\/s00216-013-7371-6","article-title":"The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography-tandem mass spectrometry","volume":"405","author":"McEneff","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0085","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1021\/cr020443g","article-title":"Mechanism of oxidation reactions catalyzed by cytochrome P450 enzymes","volume":"104","author":"Meunier","year":"2004","journal-title":"Chem. Rev."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0090","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00217619","article-title":"In vivo metabolism of benzo (a) pyrene in the mussel Mytilus galloprovincialis","volume":"28","author":"Michel","year":"1995","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0095","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.envres.2016.01.001","article-title":"Do pharmaceuticals bioaccumulate in marine molluscs and fish from a coastal lagoon?","volume":"146","author":"Moreno-Gonz\u00e1lez","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.scitotenv.2016.08.089","article-title":"Presence of pharmaceuticals in the Lis river (Portugal): sources, fate and seasonal variation","volume":"573","author":"Pa\u00edga","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0105","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.scitotenv.2018.08.129","article-title":"Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS\/MS: hourly variation","volume":"648","author":"Pa\u00edga","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0110","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.envpol.2017.06.009","article-title":"Assessing the effects of the antidepressant venlafaxine to fathead minnows exposed to environmentally relevant concentrations over a full life cycle","volume":"229","author":"Parrott","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/FPC.0000000000000003","article-title":"PharmaGKB summary: venlafaxine pathway","volume":"24","author":"Sangkuhl","year":"2014","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.scitotenv.2021.146387_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.chroma.2016.01.079","article-title":"Development of a modified acetonitrile-based extraction procedure followed by ultra-high performance liquid chromatography\u2013tandem mass spectrometry for the analysis of psychiatric drugs in sediments","volume":"1437","author":"Santos","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2021.146387_bb0125","doi-asserted-by":"crossref","first-page":"140226","DOI":"10.1016\/j.scitotenv.2020.140226","article-title":"Insights on the metabolization of the antidepressant venlafazine by meagre (Argyrosomus regius) using a combined target and suspect screening approach","volume":"737","author":"Santos","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.aquatox.2011.03.011","article-title":"Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows","volume":"104","author":"Schultz","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0135","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0140","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.envpol.2018.02.018","article-title":"Effects of water warming and acidification on bioconcentration, metabolization and depuration of pharmaceuticals and endocrine disrupting compounds in marine mussels (Mytilus galloprovincialis)","volume":"236","author":"Serra-Compte","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0145","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.envpol.2016.02.022","article-title":"Uptake, accumulation and metabolization of the antidepressant fluoxetine by Mytilus galloprovincialis","volume":"213","author":"Silva","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0150","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0166-445X(00)00085-0","article-title":"Cytochrome P450 enzymes in aquatic invertebrates: recent advances and future directions","volume":"48","author":"Snyder","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146387_bb0155","doi-asserted-by":"crossref","unstructured":"\u015awiacka, K., Szaniawska, A., Caban, M., 2019. Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study. Mar. Pollut. Bull.141, 249\u2013255.","DOI":"10.1016\/j.marpolbul.2019.02.050"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721014558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721014558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:22:23Z","timestamp":1790184143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721014558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"alternative-id":["S0048969721014558"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146387","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating venlafaxine metabolism in the Mediterranean mussel (Mytilus galloprovincialis) through combined targeted and non-targeted approaches","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146387"}}