{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:33:18Z","timestamp":1791909198083,"version":"4.3.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009018","name":"Shanghai Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.scitotenv.2021.146958","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T01:28:25Z","timestamp":1617845305000},"page":"146958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis"],"prefix":"10.1016","volume":"783","author":[{"given":"Yajie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2021.146958_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246315","article-title":"Cadmium and lead decrease cell-cell aggregation and increase migration and invasion in Renca mouse renal cell carcinoma cells","volume":"20","author":"Akin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0010","first-page":"1","article-title":"Statement on tolerable weekly intake for cadmium 1 EFSA Panel on Contaminants in the Food Chain (CONTAM)","volume":"9","author":"Alexander","year":"2011","journal-title":"EFSA J."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0015","doi-asserted-by":"crossref","unstructured":"Asgharpour, A., Cazanave, S.C., Pacana, T., Seneshaw, M., Vincent, R., Banini, B.A., Kumar, D.P., Daita, K., Min, H.K., Mirshahi, F., et al. (2016). A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J. Hepatol. 65, 579\u2013588. doi:https:\/\/doi.org\/10.1016\/j.jhep.2016.05.005.","DOI":"10.1016\/j.jhep.2016.05.005"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0020","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1289\/EHP360","article-title":"Sex-dependent effects of cadmium exposure in early life on gut microbiota and fat accumulation in mice","volume":"125","author":"Ba","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0025","doi-asserted-by":"crossref","unstructured":"Bansal, M.B., Kovalovich, K., Gupta, R., Li, W., Agarwal, A., Radbill, B., Alvarez, C.E., Safadi, R., Fiel, M.I., Friedman, S.L., et al. (2005). Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J. Hepatol. 42, 548\u2013556. doi:https:\/\/doi.org\/10.1016\/j.jhep.2004.11.043.","DOI":"10.1016\/j.jhep.2004.11.043"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102507","article-title":"Epigenetic mechanisms in hepatic stellate cell activation during liver fibrosis and carcinogenesis","volume":"20","author":"Barcena-Varela","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/pros.20479","article-title":"Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells","volume":"67","author":"Benbrahim-Tallaa","year":"2007","journal-title":"Prostate"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0040","doi-asserted-by":"crossref","unstructured":"Benhammou, J.N., Lin, J., Hussain, S.K., and El-Kabany, M. (2020). Emerging risk factors for nonalcoholic fatty liver disease associated hepatocellular carcinoma. Hepatoma Research 6. doi:10.20517\/2394-5079.2020.16.","DOI":"10.20517\/2394-5079.2020.16"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0045","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hep.20746","article-title":"Hepatic targeting of transplanted liver sinusoidal endothelial cells in intact mice","volume":"42","author":"Benten","year":"2005","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/hep.30696","article-title":"Pharmacologic inhibition of epidermal growth factor receptor suppresses nonalcoholic fatty liver disease in a murine fast-food diet model","author":"Bhushan","year":"2019","journal-title":"Hepatology (Baltimore, Md) 70, 1546\u20131563."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1515\/znc-2001-1-218","article-title":"Pathogenesis of carbon tetrachloride-induced hepatocyte injury bioactivation of CCI4 by cytochrome P450 and effects on lipid homeostasis","volume":"56","author":"Boll","year":"2001","journal-title":"Zeitschrift fur Naturforschung C, Journal of Biosciences"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0060","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.24127","article-title":"Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings","volume":"53","author":"Brunt","year":"2011","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0065","doi-asserted-by":"crossref","unstructured":"Cao, H. (2014). Adipocytokines in obesity and metabolic disease. J. Endocrinol. 220, T47\u201359. doi:https:\/\/doi.org\/10.1530\/joe-13-0339.","DOI":"10.1530\/JOE-13-0339"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12072-010-9192-4","article-title":"Angiogenesis: multiple masks in hepatocellular carcinoma and liver regeneration","volume":"4","author":"Chen","year":"2010","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0075","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-4781(85)90056-9","article-title":"Protein synthesis by hepatic mitochondria isolated from carbon tetrachloride-exposed rats","volume":"824","author":"De Wit","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125113","article-title":"Health risk assessment of heavy metals and pesticides: a case study in the main drinking water source in Dalian, China","volume":"242","author":"Dong","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0090","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4254\/wjh.v7.i3.377","article-title":"Angiogenesis and liver fibrosis","volume":"7","author":"Elpek","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0095","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1289\/ehp.1306587","article-title":"Cadmium exposure and cancer mortality in a prospective cohort: the strong heart study","volume":"122","author":"Garcia-Esquinas","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0100","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00535-016-1190-4","article-title":"Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights","volume":"51","author":"Greuter","year":"2016","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13063-016-1248-x","article-title":"Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial","volume":"17","author":"Hackshaw-McGeagh","year":"2016","journal-title":"Trials"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0110","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1021\/acs.est.9b05131","article-title":"Inhibition of mitochondrial fatty acid oxidation contributes to development of nonalcoholic fatty liver disease induced by environmental cadmium exposure","volume":"53","author":"He","year":"2019","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxlet.2019.10.018","article-title":"Metalloestrogenic effects of cadmium are absent in long-term estrogen-deprived MCF-7 cells: evidence for the involvement of constitutively activated estrogen receptor \u03b1 and very low expression of G protein-coupled estrogen receptor 1","volume":"319","author":"Hirao-Suzuki","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0120","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1365-2036.2011.04695.x","article-title":"Validation of the non-alcoholic fatty liver disease activity score","volume":"34","author":"Hjelkrem","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114677","article-title":"Cadmium uptake from soil and transport by leafy vegetables: a meta-analysis","volume":"264","author":"Huang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0130","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.envpol.2019.05.039","article-title":"The association between prenatal cadmium exposure and birth weight: a systematic review and meta-analysis of available evidence","volume":"251","author":"Huang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0135","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s11605-013-2210-9","article-title":"Cadmium exposure and liver disease among US adults","volume":"17","author":"Hyder","year":"2013","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133314","article-title":"Glucagon receptor signaling and glucagon resistance","volume":"20","author":"Janah","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0150","doi-asserted-by":"crossref","unstructured":"Li, X., Li, H., Cai, D., Li, P., Jin, J., Jiang, X., Li, Z., Tian, L., Chen, G., Sun, J., et al. (2020). Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice. Food Chem. Toxicol.: an international journal published for the British Industrial Biological Research Association 148, 111944. doi:https:\/\/doi.org\/10.1016\/j.fct.2020.111944.","DOI":"10.1016\/j.fct.2020.111944"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152925","article-title":"NOD-like receptor signaling in inflammation-associated cancers: from functions to targeted therapies","volume":"64","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0160","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s11434-011-4708-4","article-title":"Effects of cadmium, 17 beta-estradiol and their interaction in the male Chinese loach (Misgurnus anguillicaudatus)","volume":"57","author":"Lu","year":"2012","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0165","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/exmp.2001.2399","article-title":"Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats","volume":"71","author":"Luckey","year":"2001","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0170","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/0006-2952(90)90368-U","article-title":"Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats","volume":"40","author":"Masuda","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0175","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1158\/1078-0432.CCR-18-1254","article-title":"The role of angiogenesis in hepatocellular carcinoma","volume":"25","author":"Morse","year":"2019","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0180","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.fct.2017.03.027","article-title":"Arsenic, cadmium, mercury, sodium, and potassium concentrations in common foods and estimated daily intake of the population in Valdivia (Chile) using a total diet study","volume":"109","author":"Munoz","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0190","first-page":"413","article-title":"Loss of calcium sequestration capacity in endoplasmic reticulum of isolated hepatocytes treated with carbon tetrachloride","volume":"36","author":"Pencil","year":"1982","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0195","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/mc.22170","article-title":"Acute and chronic cadmium exposure promotes E-cadherin degradation in MCF7 breast cancer cells","volume":"54","author":"Ponce","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0200","doi-asserted-by":"crossref","unstructured":"Ren, C., Ren, L., Yan, J., Bai, Z., Zhang, L., Zhang, H., Xie, Y., and Li, X. (2020). Cadmium causes hepatopathy by changing the status of DNA methylation in the metabolic pathway. Toxicology Letters. doi:https:\/\/doi.org\/10.1016\/j.toxlet.2020.12.009.","DOI":"10.1016\/j.toxlet.2020.12.009"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0205","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.etp.2016.06.001","article-title":"Effect of cadmium on bone tissue in growing animals","volume":"68","author":"Rodriguez","year":"2016","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0210","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10534-010-9351-z","article-title":"Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs","volume":"23","author":"Saboli\u0107","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s15010-019-01345-y","article-title":"Epidemiological and etiological variations in hepatocellular carcinoma","volume":"48","author":"Sagnelli","year":"2020","journal-title":"Infection"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0220","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/138920012799320446","article-title":"Long-term exposure to cadmium in food and cigarette smoke, liver effects and hepatocellular carcinoma","volume":"13","author":"Satarug","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111480","article-title":"Cadmium induces epithelial\u2013mesenchymal transition and migration of renal cancer cells by increasing PGE2 through a cAMP\/PKA-COX2 dependent mechanism","volume":"207","author":"Shi","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126785","article-title":"Cadmium down-regulates 11beta-HSD2 expression and elevates active glucocorticoid level via PERK\/p-eIF2alpha pathway in placental trophoblasts","volume":"254","author":"Shi","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13010088","article-title":"Cadmium chloride induces DNA damage and apoptosis of human liver carcinoma cells via oxidative stress","volume":"13","author":"Skipper","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0240","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.taap.2015.05.010","article-title":"Requirement of ER\u03b1 and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK\/ERK pathway in human breast cancer MCF-7 cells","volume":"287","author":"Song","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0245","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tox.2004.01.006","article-title":"Acute cadmium exposure enhances AP-1 DNA binding and induces cytokines expression and heat shock protein 70 in HepG2 cells","volume":"197","author":"Souza","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0250","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2010.08.011","article-title":"The protective role of hydrogen-rich saline in experimental liver injury in mice","volume":"54","author":"Sun","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0255","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI24930","article-title":"Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease","volume":"115","author":"Tamura","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0260","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.envint.2013.06.008","article-title":"Dietary cadmium exposure and kidney stone incidence: a population-based prospective cohort study of men & women","volume":"59","author":"Thomas","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0265","doi-asserted-by":"crossref","unstructured":"Tinkov, A.A., Filippini, T., Ajsuvakova, O.P., Aaseth, J., Gluhcheva, Y.G., Ivanova, J.M., Bjorklund, G., Skalnaya, M.G., Gatiatulina, E.R., Popova, E.V., et al. (2017). The role of cadmium in obesity and diabetes. Sci. Total Environ. 601\u2013602, 741\u2013755. doi:https:\/\/doi.org\/10.1016\/j.scitotenv.2017.05.224.","DOI":"10.1016\/j.scitotenv.2017.05.224"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2015.10.003","article-title":"Dietary exposure to cadmium and risk of breast cancer in postmenopausal women: a systematic review and meta-analysis","volume":"86","author":"Van Maele-Fabry","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0275","first-page":"180","article-title":"Gomphrena claussenii, the first South-American metallophyte species with indicator-like Zn and Cd accumulation and extreme metal tolerance","volume":"4","author":"Villafort Carvalho","year":"2013","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0280","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0285","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0300-483X(03)00305-6","article-title":"Molecular and cellular mechanisms of cadmium carcinogenesis","volume":"192","author":"Waisberg","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0290","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0295","doi-asserted-by":"crossref","unstructured":"White, D.L., Kanwal, F., and El-Serag, H.B. (2012). Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clinical Gastroenterology and Hepatology 10, 1342\u20131359.e1342. doi:https:\/\/doi.org\/10.1016\/j.cgh.2012.10.001.","DOI":"10.1016\/j.cgh.2012.10.001"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0300","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.toxlet.2014.07.003","article-title":"SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation","volume":"229","author":"Wu","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0305","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jtemb.2017.07.003","article-title":"Health risk assessment of Chinese consumers to cadmium via dietary intake","volume":"44","author":"Yu","year":"2017","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0310","unstructured":"Yuan, G., Dai, S., Yin, Z., Lu, H., Jia, R., Xu, J., Song, X., Li, L., Shu, Y., Zhao, X., et al. (2014). Sub-chronic lead and cadmium co-induce apoptosis protein expression in liver and kidney of rats. Int. J. Clin. Exp. Pathol. 7, 2905\u20132914."},{"key":"10.1016\/j.scitotenv.2021.146958_bb0315","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jat.3742","article-title":"Chronic cadmium exposure induced hepatic cellular stress and inflammation in aged female mice","volume":"39","author":"Zhang","year":"2019","journal-title":"Journal of Applied Toxicology: JAT"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0320","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1080\/15548627.2018.1503146","article-title":"Activation of ferritinophagy is required for the RNA-binding protein ELAVL1\/HuR to regulate ferroptosis in hepatic stellate cells","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.scitotenv.2021.146958_bb0325","doi-asserted-by":"crossref","unstructured":"Zhao, X., Fu, J., Xu, A., Yu, L., Zhu, J., Dai, R., Su, B., Luo, T., Li, N., Qin, W., et al. (2015). Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1\/JNK pathway. Cell Death Dis. 6, e1751-e1751. doi:https:\/\/doi.org\/10.1038\/cddis.2015.120.","DOI":"10.1038\/cddis.2015.120"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721020283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721020283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T16:57:08Z","timestamp":1733245028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721020283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":65,"alternative-id":["S0048969721020283"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146958","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.146958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"146958"}}