{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:46:32Z","timestamp":1785941192401,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41401583"],"award-info":[{"award-number":["41401583"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41771527"],"award-info":[{"award-number":["41771527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673177"],"award-info":[{"award-number":["81673177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071715"],"award-info":[{"award-number":["82071715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1005200"],"award-info":[{"award-number":["2019YFC1005200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1005203"],"award-info":[{"award-number":["2019YFC1005203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.scitotenv.2021.148405","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T03:50:56Z","timestamp":1623297056000},"page":"148405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Serum zinc concentration and risk of adverse outcomes to in vitro fertilization and embryo transfer: A prospective cohort study in northern China"],"prefix":"10.1016","volume":"792","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigen","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 2","key":"10.1016\/j.scitotenv.2021.148405_bb0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000371618","article-title":"The epidemiology of global micronutrient deficiencies","volume":"66","author":"Bailey","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0010","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.reprotox.2010.09.013","article-title":"Associations between blood metals and fecundity among women residing in New York State","volume":"31","author":"Bloom","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111733","article-title":"Variability of essential and non-essential trace elements in the follicular fluid of women undergoing in vitro fertilization (IVF)","volume":"209","author":"Butts","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0020","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0025","first-page":"1","article-title":"Maternal serum zinc concentration and neural tube defects in offspring: a meta-analysis","volume":"20","author":"Cheng","year":"2020","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0030","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/BF02041521","article-title":"Studies of trace element involvement in human disease by in vitro activation analysis","volume":"203","author":"Ehmann","year":"1996","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mam.2005.07.013","article-title":"Relevance, essentiality and toxicity of trace elements in human health","volume":"26","author":"Fraga","year":"2005","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0040","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.rbmo.2019.09.005","article-title":"Endometrial thickness and IVF cycle outcomes: a meta-analysis","volume":"40","author":"Gao","year":"2020","journal-title":"Reprod. BioMed. Online"},{"key":"10.1016\/j.scitotenv.2021.148405_bb0045","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3390\/biom10081176","article-title":"The role of Fe, Zn, and Cu in pregnancy","volume":"10","author":"Grzeszczak","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.scitotenv.2021.148405_bb0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10815-016-0853-7","article-title":"Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study","volume":"34","author":"Ingle","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3382\/ps.0710161","article-title":"Zinc-induced molt: evidence for a direct inhibitory effect on granulosa cell steroidogenesis","volume":"71","author":"Johnson","year":"1992","journal-title":"Poult. Sci."},{"issue":"Suppl","key":"10.1016\/j.scitotenv.2021.148405_bb0060","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.4103\/ijmr.IJMR_1864_17","article-title":"Role of environmental factors & oxidative stress with respect to in vitro fertilization outcome","volume":"148","author":"Kumar","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143106","article-title":"Association between exposure of light rare earth elements and outcomes of in vitro fertilization-embryo transfer in north China","volume":"762","author":"Li","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0070","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.chemosphere.2018.11.115","article-title":"Trace element profiles in pregnant women\u2019s sera and umbilical cord sera and influencing factors: repeated measurements","volume":"218","author":"Liang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.148405_bb0075","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/nu9030309","article-title":"Reference values of 14 serum trace elements for pregnant Chinese women: a cross-sectional study in the China nutrition and health survey 2010\u20132012","volume":"9","author":"Liu","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.scitotenv.2021.148405_bb0080","first-page":"129","article-title":"Human follicular fluid levels of calcium, copper and zinc","volume":"23","author":"Ng","year":"1987","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3181\/00379727-198-43289","article-title":"Influence of short-term maternal zinc deficiency on the in vitro development of preimplantation mouse embryos","volume":"198","author":"Peters","year":"1991","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0090","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.reprotox.2019.07.005","article-title":"Associations between ambient air pollution and pregnancy rate in women who underwent in vitro fertilization in Shenyang, China","volume":"89","author":"Qiu","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/002367774780943913","article-title":"Zinc deficiency in female rabbits","volume":"8","author":"Shaw","year":"1974","journal-title":"Lab. Anim."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/jn\/110.3.575","article-title":"Zinc deficiency in rhesus and bonnet monkeys including effects on reproduction","volume":"110","author":"Swenerton","year":"1980","journal-title":"J. Nutr."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/rmb2.12305","article-title":"Clinical outcomes of MII oocytes with refractile bodies in patients undergoing ICSI and single frozen embryo transfer","volume":"19","author":"Takahashi","year":"2020","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0110","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1210\/en.2011-1599","article-title":"Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice","volume":"153","author":"Tian","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2021.148405_bb0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ydbio.2013.01.015","article-title":"Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development","volume":"376","author":"Tian","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0120","first-page":"1","article-title":"Preconception zinc deficiency disrupts postimplantation fetal and placental development in mice","volume":"83","author":"Tian","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejogrb.2016.01.001","article-title":"Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome","volume":"198","author":"Tolunay","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0130","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1479-828X.2010.01276.x","article-title":"Adenomyosis is a potential cause of recurrent implantation failure during IVF treatment","volume":"51","author":"Tremellen","year":"2011","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0135","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s12011-018-1421-z","article-title":"Toxic metal and trace element concentrations in blood and outcome of in vitro fertilization in women","volume":"188","author":"Tuli\u0107","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0140","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/humrep\/des157","article-title":"The preconception diet is associated with the chance of ongoing pregnancy in women undergoing IVF\/ICSI treatment","volume":"27","author":"Twigt","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0145","doi-asserted-by":"crossref","first-page":"213","DOI":"10.26444\/aaem\/75422","article-title":"Evaluation of trace metals in follicular fluid in ICSI-treated patients","volume":"25","author":"Wdowiak","year":"2018","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.scitotenv.2021.148405_bb0150","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/14647273.2018.1543898","article-title":"Potential effect of inflammation on the failure risk of in vitro fertilization and embryo transfer among infertile women","volume":"23","author":"Xie","year":"2020","journal-title":"Hum. Fertil. (Camb)"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721034768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721034768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:49:23Z","timestamp":1785937763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721034768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":30,"alternative-id":["S0048969721034768"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.148405","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum zinc concentration and risk of adverse outcomes to in vitro fertilization and embryo transfer: A prospective cohort study in northern China","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.148405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"148405"}}