{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:52:40Z","timestamp":1785937960296,"version":"3.56.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012239","name":"Hubei Technological Innovation Special Fund","doi-asserted-by":"publisher","award":["2019ACA140"],"award-info":[{"award-number":["2019ACA140"]}],"id":[{"id":"10.13039\/501100012239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012239","name":"Hubei Technological Innovation Special Fund","doi-asserted-by":"publisher","award":["2020BCA071"],"award-info":[{"award-number":["2020BCA071"]}],"id":[{"id":"10.13039\/501100012239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013338","name":"Major Technology Innovation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701463"],"award-info":[{"award-number":["81701463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030111"],"award-info":[{"award-number":["82030111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0803900"],"award-info":[{"award-number":["2020YFA0803900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["TFJC2018001"],"award-info":[{"award-number":["TFJC2018001"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.scitotenv.2021.148440","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T11:25:33Z","timestamp":1623410733000},"page":"148440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["H19\/let-7 axis mediates caffeine exposure during pregnancy induced adrenal dysfunction and its multi-generation inheritance"],"prefix":"10.1016","volume":"792","author":[{"given":"Zheng","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2021.148440_bb0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1089\/met.2006.4.129","article-title":"Perinatal programming of central obesity and the metabolic syndrome: role of glucocorticoids","volume":"4","author":"Achard","year":"2006","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0010","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/bmj.301.6761.1111","article-title":"The fetal and infant origins of adult disease","volume":"301","author":"Barker","year":"1990","journal-title":"Br. Med. J."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ntt.2013.11.002","article-title":"A multi-generational study on low-dose BPA exposure in Wistar rats: effects on maternal behavior, flavor intake and development","volume":"41","author":"Boudalia","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0020","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/bdrb.20288","article-title":"Evaluation of the reproductive and developmental risks of caffeine","volume":"92","author":"Brent","year":"2011","journal-title":"Birth Defects Res. Part B - Dev. Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.ctdb.2016.12.004","article-title":"Mechanisms of glucocorticoid action during development","volume":"125","author":"Busada","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0030","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.beem.2015.04.007","article-title":"Specificity and sensitivity of glucocorticoid signaling in health and disease","volume":"29","author":"Cain","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0035","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.yfrne.2008.03.003","article-title":"Epigenetic mechanisms and the transgenerational effects of maternal care","volume":"29","author":"Champagne","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.taap.2018.01.008","article-title":"IGF1\/MAPK\/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats","volume":"341","author":"Chen","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152308","article-title":"Prenatal glucocorticoids exposure and fetal adrenal developmental programming","volume":"428","author":"Chen","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0050","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2337\/db11-1314","article-title":"Transgenerational glucose intolerance with Igf2\/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia","volume":"61","author":"Ding","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.tem.2009.11.006","article-title":"Intergenerational transmission of programmed effects: public health consequences","volume":"21","author":"Drake","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0060","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ygcen.2017.11.012","article-title":"Glucocorticoids and CBG during pregnancy in mammals: diversity, pattern, and function","volume":"259","author":"Edwards","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0065","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1093\/hmg\/ddl237","article-title":"CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19\/Igf2 locus","volume":"15","author":"Engel","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0070","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1203\/00006450-200110000-00009","article-title":"Body mass index, body composition, and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction","volume":"50","author":"Engelbregt","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104374","article-title":"Trans-generational stress regulation: mother-infant cortisol and maternal mental health across the perinatal period","volume":"109","author":"Galbally","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0080","doi-asserted-by":"crossref","first-page":"13799","DOI":"10.1093\/nar\/gku1160","article-title":"The H19\/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells","volume":"42","author":"Gao","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0085","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1017\/S2040174420000112","article-title":"A heretical view: rather than a solely placental protective function, placental 11\u00df hydroxysteroid dehydrogenase 2 also provides substrate for fetal peripheral cortisol synthesis in obese pregnant ewes","volume":"12","author":"Ghnenis","year":"2021","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0090","doi-asserted-by":"crossref","first-page":"625.e1","DOI":"10.1016\/j.ajog.2016.01.194","article-title":"Alterations in expression of imprinted genes from the H19\/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR)","volume":"214","author":"Gonzalez-Rodriguez","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0095","first-page":"230","article-title":"The world health report 2002 - reducing risks, promoting healthy life [2]","volume":"16","author":"Guilbert","year":"2003","journal-title":"Educ. Health"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0100","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/35013106","article-title":"CTCF mediates methylation-sensitive enhancer-blocking activity at the H19\/Igf2 locus","volume":"405","author":"Hark","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0105","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.yhbeh.2010.06.007","article-title":"Glucocorticoids, prenatal stress and the programming of disease","volume":"59","author":"Harris","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0110","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1039\/C5TX00265F","article-title":"Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms","volume":"5","author":"He","year":"2016","journal-title":"Toxicol. Res. (Camb)"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14881-0","article-title":"High-fat diet and chronic stress aggravate adrenal function abnormality induced by prenatal caffeine exposure in male offspring rats","volume":"7","author":"He","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0120","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.arcmed.2017.11.013","article-title":"Insulin-like growth factor 1 mediates adrenal development dysfunction in offspring rats induced by prenatal food restriction","volume":"48","author":"He","year":"2017","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxlet.2018.12.001","article-title":"Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure","volume":"302","author":"He","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1042\/bse0480187","article-title":"Genomic imprinting and human disease","volume":"48","author":"Hirasawa","year":"2010","journal-title":"Essays Biochem."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0135","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2015.07.005","article-title":"Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms","volume":"288","author":"Huang","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molcel.2013.08.027","article-title":"The imprinted H19 LncRNA antagonizes Let-7 microRNAs","volume":"52","author":"Kallen","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0145","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/infa.12216","article-title":"Mother\u2013toddler cortisol synchrony moderates risk of early internalizing symptoms","volume":"23","author":"Kalomiris","year":"2018","journal-title":"Infancy"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0150","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.fct.2004.05.002","article-title":"Beverage caffeine intake in US consumers and subpopulations of interest: estimates from the Share of Intake Panel survey","volume":"42","author":"Knight","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0155","first-page":"1334","article-title":"Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study","volume":"337","author":"Konje","year":"2008","journal-title":"Bmj"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0160","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3727\/096504018X15202945197589","article-title":"H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7","volume":"27","author":"Kou","year":"2019","journal-title":"Oncol. Res."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0165","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.annfar.2009.04.011","article-title":"Caffeine in pregnancy: a cause for concern?","volume":"28","author":"Kuczkowski","year":"2009","journal-title":"Ann. Fr. Anesth. Reanim."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0170","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.taap.2013.11.020","article-title":"Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation rats","volume":"274","author":"Luo","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0175","doi-asserted-by":"crossref","first-page":"750","DOI":"10.2174\/138920111795470868","article-title":"Glucocorticoids in pregnancy","volume":"12","author":"Marciniak","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006497","article-title":"Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants","volume":"16","author":"McCarthy","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1210\/en.2016-1340","article-title":"The steroidogenic acute regulatory protein (StAR) is regulated by the H19\/let-7 axis","volume":"158","author":"Men","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0190","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.cell.2013.02.029","article-title":"CTCF and cohesin: linking gene regulatory elements with their targets","volume":"152","author":"Merkenschlager","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0195","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biocel.2015.04.014","article-title":"Germline-derived DNA methylation and early embryo epigenetic reprogramming: the selected survival of imprints","volume":"67","author":"Monk","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169225","article-title":"The glucocorticoid receptor regulates the ANGPTL4 gene in a CTCF-mediated chromatin context in human hepatic cells","volume":"12","author":"Nakamoto","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0300","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000084092","article-title":"Adrenal function of low-birthweight children","volume":"8","author":"Ong","year":"2005","journal-title":"Endocr. Dev."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0205","doi-asserted-by":"crossref","first-page":"M17","DOI":"10.1530\/JOE-18-0684","article-title":"The GC-IGF1 axis-mediated testicular dysplasia caused by prenatal caffeine exposure","volume":"242","author":"Pei","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0210","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cbi.2011.11.001","article-title":"Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells","volume":"195","author":"Ping","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-015-0458-2","article-title":"The H19 long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory","volume":"14","author":"Raveh","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0220","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0225","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.lfs.2009.04.005","article-title":"Impairment in protein expression profile of testicular steroid receptor coregulators in male rat offspring perinatally exposed to Bisphenol A","volume":"85","author":"Salian","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0230","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1741-7015-11-42","article-title":"Maternal Caffeine intake during pregnancy is associated with birth but not with gestational length","volume":"11","author":"Sengpiel","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0235","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1016\/j.ajpath.2018.08.008","article-title":"Intrauterine programming of glucocorticoid\u2013insulin-like growth Factor-1 Axis\u2013mediated developmental origin of osteoporosis susceptibility in female offspring rats with prenatal caffeine exposure","volume":"188","author":"Shangguan","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0240","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.reprotox.2010.10.012","article-title":"Epigenetic transgenerational actions of endocrine disruptors","volume":"31","author":"Skinner","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/7683bb48-85db-4c7e-87c0-304a7d53a587","article-title":"Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line","volume":"8","author":"Skinner","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0250","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.yfrne.2011.07.003","article-title":"The adrenal peripheral clock: glucocorticoid and the circadian timing system","volume":"32","author":"Son","year":"2011","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0255","first-page":"354","article-title":"Caffeine fatalities\u2014do sales restrictions prevent","volume":"48","author":"Thelander","year":"2010","journal-title":"Clin. Toxicol. Off. J. Am. Acad. Clin. Toxicol. Eur. Assoc. Poisons Centres Clin. Toxicol"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0260","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng0495-407","article-title":"A paternal\u2013specific methylation imprint marks the alleles of the mouse H19 gene","volume":"9","author":"Tremblay","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0265","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1101\/gr.136101.111","article-title":"Widespread plasticity in CTCF occupancy linked to DNA methylation","volume":"22","author":"Wang","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0270","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.toxlet.2013.11.006","article-title":"Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring","volume":"224","author":"Wang","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0275","article-title":"Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"issue":"80","key":"10.1016\/j.scitotenv.2021.148440_bb0305","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1126\/science.aam5339","article-title":"Germ line\u2013inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition","volume":"357","author":"Zenk","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0280","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2014.08.015","article-title":"Prenatal xenobiotic exposure and intrauterine hypothalamus-pituitary-adrenal axis programming alteration","volume":"325","author":"Zhang","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.148440_bb0285","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10221","article-title":"H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase","volume":"6","author":"Zhou","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0290","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.lfs.2006.03.021","article-title":"High-fat emulsion-induced rat model of nonalcoholic steatohepatitis","volume":"79","author":"Zou","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2021.148440_bb0295","doi-asserted-by":"crossref","first-page":"38398","DOI":"10.18632\/oncotarget.9534","article-title":"H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating T\u03b2R3 in placentae with fetal growth restriction","volume":"7","author":"Zuckerwise","year":"2016","journal-title":"Oncotarget"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721035129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721035129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:35:21Z","timestamp":1785936921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721035129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":61,"alternative-id":["S0048969721035129"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.148440","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H19\/let-7 axis mediates caffeine exposure during pregnancy induced adrenal dysfunction and its multi-generation inheritance","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.148440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"148440"}}