{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:07:05Z","timestamp":1778850425509,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21677019"],"award-info":[{"award-number":["21677019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2018-1-3012"],"award-info":[{"award-number":["2018-1-3012"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.scitotenv.2021.150028","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T05:58:56Z","timestamp":1630475936000},"page":"150028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Formation and occurrence of disinfection byproducts of benzodiazepine drug estazolam in drinking water of Beijing"],"prefix":"10.1016","volume":"804","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.scitotenv.2021.150028_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103232","article-title":"Diazepam and fluoxetine decrease the stress response in zebrafish","volume":"9","author":"Abreu","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.scitotenv.2021.150028_bb0010","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.phrs.2007.08.006","article-title":"Genotoxicity and carcinogenicity studies of benzodiazepines","volume":"56","author":"Brambilla","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0015","series-title":"Drugs in Pregnancy and Lactation","author":"Briggs","year":"2005"},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150028_bb0020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/poc.861","article-title":"Kinetic and mechanistic studies on the hydrolysis and photodegradation of diazepam and alprazolam","volume":"18","author":"Cabrera","year":"2005","journal-title":"J. Phys. Org. Chem."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0025","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.watres.2017.04.063","article-title":"Reaction of diazepam and related benzodiazepines with chlorine. kinetics, transformation products and in-silico toxicological assessment","volume":"120","author":"Carpinteiro","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0030","series-title":"Standard Methods for the Examination of Water and Wastewater","first-page":"461","author":"Clesceri","year":"1998"},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150028_bb0035","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s10393-007-0105-5","article-title":"Pharmaceutical contaminants in potable water: potential concerns for pregnant women and children","volume":"4","author":"Collier","year":"2007","journal-title":"EcoHealth"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0040","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.gaceta.2012.01.018","article-title":"Psychoactive pharmaceutical residues in the watersheds of Galicia (Spain)","volume":"26","author":"Esteban","year":"2012","journal-title":"Gac. Sanit."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150028_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40545-017-0128-4","article-title":"Analysis of changes in trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs","volume":"11","author":"Garc\u00eda","year":"2018","journal-title":"J. Pharm. Policy Pract."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0050","series-title":"Applications of Time-of-flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis","first-page":"283","article-title":"High-resolution mass spectrometry identification of micropollutants transformation products produced during drinking water disinfection with chlorine and related chemicals","author":"Gonz\u00e1lez-Mari\u00f1o","year":"2016"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0055","doi-asserted-by":"crossref","first-page":"13460","DOI":"10.1038\/ncomms13460","article-title":"GABAergic anxiolytic drug in water increases migration behaviour in salmon","volume":"7","author":"Hellstrom","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0060","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Human","volume":"vol. 1-88","year":"2006"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0065","series-title":"Psychotropic Substances 2015 - Statistics for 2014","year":"2016"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0070","series-title":"Psychotropic Substances 2019 - Statistics for 2018","year":"2020"},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2021.150028_bb0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhydrol.2007.09.054","article-title":"Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study","volume":"348","author":"Johnson","year":"2008","journal-title":"J. Hydrol."},{"issue":"5","key":"10.1016\/j.scitotenv.2021.150028_bb0080","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0272-0590(84)90105-2","article-title":"Carcinogenic evaluation of estazolam via diet in CD strain Sprague-Dawley rats and B6C3F1 mice for 2 years","volume":"4","author":"Kimura","year":"1984","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0085","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.scitotenv.2019.05.488","article-title":"Less anxious salmon smolt become easy prey during downstream migration","volume":"687","author":"Klaminder","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150028_bb0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.watres.2011.10.056","article-title":"Environmental occurrence, fate and transformation of benzodiazepines in water treatment","volume":"46","author":"Kosjek","year":"2012","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150028_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00498258609043501","article-title":"Metabolism of 14C-estazolam in dogs and humans","volume":"16","author":"Machinist","year":"1986","journal-title":"Xenobiotica"},{"issue":"16","key":"10.1016\/j.scitotenv.2021.150028_bb0100","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1039\/C6GC00720A","article-title":"Assessment of predictive models for estimating the acute aquatic toxicity of organic chemicals","volume":"18","author":"Melnikov","year":"2016","journal-title":"Green Chem."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/164_2018_154","article-title":"Designer benzodiazepines: another class of new psychoactive substances","volume":"252","author":"Moosmann","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150028_bb0110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/toxsci\/kfm291","article-title":"Effects and interactions in an environmentally relevant mixture of pharmaceuticals","volume":"102","author":"Pomati","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0115","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.scitotenv.2018.11.228","article-title":"Behavioural effects of psychoactive pharmaceutical exposure on european perch (Perca fluviatilis) in a multi-stressor environment","volume":"655","author":"Saaristo","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"14","key":"10.1016\/j.scitotenv.2021.150028_bb0120","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.1007\/s11356-014-2786-y","article-title":"Oxidation of artificial sweetener sucralose by advanced oxidation processes: a review","volume":"21","author":"Sharma","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2021.150028_bb0125","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tox.2006.04.032","article-title":"Use of computer-assisted prediction of toxic effects of chemical substances","volume":"224","author":"Simon-Hettich","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0130","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.scitotenv.2019.02.049","article-title":"Behavioural alterations induced by the anxiolytic pollutant oxazepam are reversible after depuration in a freshwater fish","volume":"665","author":"Sundin","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"34","key":"10.1016\/j.scitotenv.2021.150028_bb0135","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.2174\/138161207782794257","article-title":"Predictive QSAR modeling workflow, model applicability domains, and virtual screening","volume":"13","author":"Tropsha","year":"2007","journal-title":"Curr. Pharm. Des."},{"issue":"18","key":"10.1016\/j.scitotenv.2021.150028_bb0140","doi-asserted-by":"crossref","first-page":"15379","DOI":"10.1007\/s11356-017-8922-8","article-title":"Occurrence of diazepam and its metabolites in wastewater and surface waters in Beijing","volume":"24","author":"Wang","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0145","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.2147\/CIA.S218849","article-title":"Relationship between potentially inappropriate medications and the risk of hospital readmission and death in hospitalized older patients","volume":"14","author":"Wang","year":"2019","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0150","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.chemosphere.2015.07.002","article-title":"Occurrence and fate of psychiatric pharmaceuticals in the urban water system of Shanghai, China","volume":"138","author":"Wu","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ecoenv.2017.12.049","article-title":"The fate and risk assessment of psychiatric pharmaceuticals from psychiatric hospital effluent","volume":"150","author":"Xiang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.150028_bb0160","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cej.2018.08.082","article-title":"Aqueous chlorination of benzodiazepines diazepam and oxazepam: kinetics, transformation products and reaction pathways","volume":"354","author":"Yang","year":"2018","journal-title":"Chem. Eng. J."},{"issue":"60","key":"10.1016\/j.scitotenv.2021.150028_bb0165","doi-asserted-by":"crossref","first-page":"102381","DOI":"10.18632\/oncotarget.22057","article-title":"Benzodiazepine drug use and cancer risk: a dose-response meta analysis of prospective cohort studies","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chemosphere.2018.11.076","article-title":"Determination of emerging chlorinated byproducts of diazepam in drinking water","volume":"218","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150028_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8815349","article-title":"Diazepam and its disinfection byproduct promote the early development of nervous system in zebrafish embryos","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxidative Med. Cell. Longev."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721051032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721051032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T17:49:05Z","timestamp":1732643345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721051032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":35,"alternative-id":["S0048969721051032"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150028","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formation and occurrence of disinfection byproducts of benzodiazepine drug estazolam in drinking water of Beijing","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"150028"}}