{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:42:26Z","timestamp":1792320146253,"version":"4.4.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.scitotenv.2021.150328","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:48:33Z","timestamp":1631702913000},"page":"150328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":294,"special_numbering":"P1","title":["Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids"],"prefix":"10.1016","volume":"806","author":[{"given":"Wei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.scitotenv.2021.150328_bb0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/BJ20060659","article-title":"Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase","volume":"399","author":"Adamson","year":"2006","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.150328_bb0010","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.yexmp.2015.11.008","article-title":"Induction of CYP2E1 in non-alcoholic fatty liver diseases","volume":"99","author":"Aljomah","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0015","doi-asserted-by":"crossref","first-page":"121992","DOI":"10.1016\/j.jhazmat.2019.121992","article-title":"Hepatotoxicity of pristine polyethylene microplastics in neotropical physalaemus cuvieri tadpoles (Fitzinger, 1826)","volume":"386","author":"Araujo","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0020","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.actbio.2019.07.047","article-title":"3-D culture and endothelial cells improve maturity of human pluripotent stem cell-derived hepatocytes","volume":"95","author":"Ardalani","year":"2019","journal-title":"Acta Biomater."},{"issue":"24","key":"10.1016\/j.scitotenv.2021.150328_bb0025","doi-asserted-by":"crossref","first-page":"14392","DOI":"10.1021\/acs.est.8b04848","article-title":"Rainbow trout maintain intestinal transport and barrier functions following exposure to polystyrene microplastics","volume":"52","author":"Asmonaite","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.scitotenv.2021.150328_bb0030","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.clinre.2011.04.015","article-title":"Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role","volume":"35","author":"Aubert","year":"2011","journal-title":"Clin. Res. Hepatol. Gas."},{"issue":"8","key":"10.1016\/j.scitotenv.2021.150328_bb0035","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1074\/jbc.M510484200","article-title":"Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione","volume":"281","author":"Bai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142518","article-title":"Micro- and nanoplastic induced cellular toxicity in mammals: a review","volume":"755","author":"Banerjee","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.scitotenv.2021.150328_bb0045","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","author":"Champion","year":"2008","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150328_bb0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2018.05.027","article-title":"Generation of hepatic stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis","volume":"23","author":"Coll","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0055","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jhazmat.2018.06.017","article-title":"Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (Mus musculus)","volume":"357","author":"Deng","year":"2018","journal-title":"J. Hazard. Mater."},{"issue":"41","key":"10.1016\/j.scitotenv.2021.150328_bb0060","doi-asserted-by":"crossref","first-page":"37973","DOI":"10.1074\/jbc.C200420200","article-title":"Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand","volume":"277","author":"Dhe-Paganon","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2018.03.001","article-title":"Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis niloticus)","volume":"238","author":"Ding","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0070","doi-asserted-by":"crossref","first-page":"121575","DOI":"10.1016\/j.jhazmat.2019.121575","article-title":"Polystyrene microplastic particles: in vitro pulmonary toxicity assessment","volume":"385","author":"Dong","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.scitotenv.2021.150328_bb0075","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1124\/dmd.118.081398","article-title":"Regulation of cytosolic sulfotransferases in models of human hepatocyte development","volume":"46","author":"Dubaisi","year":"2018","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.150328_bb0080","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/acs.chemrestox.0c00486","article-title":"Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes","volume":"34","author":"Goodman","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12861-019-0183-y","article-title":"Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms","volume":"19","author":"Goto-Silva","year":"2019","journal-title":"BMC Dev. Biol."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.150328_bb0090","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1124\/dmd.112.048439","article-title":"Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease","volume":"41","author":"Hardwick","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0095","doi-asserted-by":"crossref","first-page":"112012","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/Caspase-1 signaling pathway in rats","volume":"212","author":"Hou","year":"2021","journal-title":"Ecotox. Environ. Safe"},{"issue":"6","key":"10.1016\/j.scitotenv.2021.150328_bb0100","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","article-title":"Long-term expansion of functional mouse and human hepatocytes as 3D organoids","volume":"175","author":"Hu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0105","doi-asserted-by":"crossref","first-page":"124399","DOI":"10.1016\/j.jhazmat.2020.124399","article-title":"Microplastics and nanoplastics in the environment: macroscopic transport and effects on creatures","volume":"407","author":"Huang","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150328_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-64464-9","article-title":"Potential toxicity of polystyrene microplastic particles","volume":"10","author":"Hwang","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.scitotenv.2021.150328_bb0115","doi-asserted-by":"crossref","first-page":"13090222","DOI":"10.3390\/ph13090222","article-title":"Nonalcoholic fatty liver disease (NAFLD) and hepatic cytochrome P450 (CYP) enzymes","volume":"13","author":"Jamwal","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chemosphere.2019.05.003","article-title":"Adverse outcome pathways potentially related to hazard identification of microplastics based on toxicity mechanisms","volume":"231","author":"Jeong","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0125","doi-asserted-by":"crossref","first-page":"121725","DOI":"10.1016\/j.jhazmat.2019.121725","article-title":"Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: caenorhabditis elegans transcription factor RNAi screening and zebrafish study","volume":"388","author":"Kim","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0130","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.9968","article-title":"Generation of human liver organoids from pluripotent stem cell-derived hepatic endoderms","volume":"8","author":"Kulkeaw","year":"2020","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150328_bb0135","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12272-021-01306-w","article-title":"Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes","volume":"44","author":"Kwon","year":"2021","journal-title":"Arch. Pharm. Res."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150328_bb0140","doi-asserted-by":"crossref","first-page":"20190041","DOI":"10.1098\/rsfs.2019.0041","article-title":"Multiscale modelling of drug transport and metabolism in liver spheroids","volume":"10","author":"Leedale","year":"2020","journal-title":"Interface Focus"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2017.11.103","article-title":"Microplastic particles cause intestinal damage and other adverse effects in zebrafish Danio rerio and nematode Caenorhabditis elegans","volume":"619","author":"Lei","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.scitotenv.2021.150328_bb0150","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1007\/s00204-017-2045-3","article-title":"Adverse outcome pathways: opportunities, limitations and open questions","volume":"91","author":"Leist","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.026","article-title":"Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro","volume":"78","author":"Leite","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0160","doi-asserted-by":"crossref","first-page":"125492","DOI":"10.1016\/j.chemosphere.2019.125492","article-title":"Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice","volume":"244","author":"Li","year":"2020","journal-title":"Chemosphere"},{"issue":"Pt A","key":"10.1016\/j.scitotenv.2021.150328_bb0165","doi-asserted-by":"crossref","first-page":"115025","DOI":"10.1016\/j.envpol.2020.115025","article-title":"Polystyrene microplastics cause cardiac fibrosis by activating Wnt\/beta-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats","volume":"265","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0170","doi-asserted-by":"crossref","first-page":"123933","DOI":"10.1016\/j.jhazmat.2020.123933","article-title":"Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects","volume":"402","author":"Li","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0175","doi-asserted-by":"crossref","first-page":"126329","DOI":"10.1016\/j.jhazmat.2021.126329","article-title":"Biodegradable plastics in the air and soil environment: low degradation rate and high microplastics formation","volume":"418","author":"Liao","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0180","doi-asserted-by":"crossref","first-page":"128330","DOI":"10.1016\/j.chemosphere.2020.128330","article-title":"Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412","volume":"262","author":"Lim","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0185","doi-asserted-by":"crossref","first-page":"122346","DOI":"10.1016\/j.jhazmat.2020.122346","article-title":"Desorption of pharmaceuticals from pristine and aged polystyrene microplastics under simulated gastrointestinal conditions","volume":"392","author":"Liu","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0190","doi-asserted-by":"crossref","first-page":"127204","DOI":"10.1016\/j.chemosphere.2020.127204","article-title":"Influence of the digestive process on intestinal toxicity of polystyrene microplastics as determined by in vitro Caco-2 models","volume":"256","author":"Liu","year":"2020","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.scitotenv.2021.150328_bb0195","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1021\/acs.est.6b00183","article-title":"Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver","volume":"50","author":"Lu","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0200","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice","volume":"631-632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0205","doi-asserted-by":"crossref","first-page":"113122","DOI":"10.1016\/j.envpol.2019.113122","article-title":"Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring","volume":"255","author":"Luo","year":"2019","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150328_bb0210","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J. Hepatol."},{"issue":"23","key":"10.1016\/j.scitotenv.2021.150328_bb0215","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1016\/j.febslet.2013.09.043","article-title":"Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4alpha","volume":"587","author":"McIntosh","year":"2013","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.scitotenv.2021.150328_bb0220","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jhep.2019.06.030","article-title":"Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids","volume":"71","author":"Mun","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0225","doi-asserted-by":"crossref","first-page":"114790","DOI":"10.1016\/j.taap.2019.114790","article-title":"Development of organoid-based drug metabolism model","volume":"385","author":"Park","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0230","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.toxlet.2020.01.008","article-title":"Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation","volume":"324","author":"Park","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.aquatox.2017.11.017","article-title":"Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)","volume":"194","author":"Pitt","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0240","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envpol.2017.11.043","article-title":"Airborne microplastics: consequences to human health?","volume":"234","author":"Prata","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0245","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.scitotenv.2019.01.245","article-title":"Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish","volume":"662","author":"Qiao","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"50","key":"10.1016\/j.scitotenv.2021.150328_bb0250","doi-asserted-by":"crossref","first-page":"abd1211","DOI":"10.1126\/sciadv.abd1211","article-title":"Environmental exposure enhances the internalization of microplastic particles into cells","volume":"6","author":"Ramsperger","year":"2020","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150328_bb0255","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10937404.2019.1700598","article-title":"Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models","volume":"23","author":"Rubio","year":"2020","journal-title":"J. Toxicol. Env. Heal. B."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0260","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.envres.2017.08.043","article-title":"Cytotoxic effects of commonly used nanomaterials and microplastics on cerebral and epithelial human cells","volume":"159","author":"Schirinzi","year":"2017","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150328_bb0265","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hep.31037","article-title":"Large-scale production of LGR5-positive bipotential human liver stem cells","volume":"72","author":"Schneeberger","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0270","doi-asserted-by":"crossref","first-page":"115769","DOI":"10.1016\/j.envpol.2020.115769","article-title":"Size matters: zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism","volume":"268","author":"Sendra","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0275","doi-asserted-by":"crossref","first-page":"111700","DOI":"10.1016\/j.marpolbul.2020.111700","article-title":"Chemical composition and abundance of microplastics in the muscle of commercial shrimp Pleoticus muelleri at an impacted coastal environment (Southwestern Atlantic)","volume":"161","author":"Severini","year":"2020","journal-title":"Mar. Pollut. Bull."},{"issue":"20","key":"10.1016\/j.scitotenv.2021.150328_bb0280","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1089\/scd.2017.0023","article-title":"A scalable approach for the generation of human pluripotent stem cell-derived hepatic organoids with sensitive hepatotoxicity features","volume":"26","author":"Sgodda","year":"2017","journal-title":"Stem Cells Dev."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.150328_bb0285","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/j.gastro.2020.10.002","article-title":"High-fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids","volume":"160","author":"Shinozawa","year":"2021","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.scitotenv.2021.150328_bb0290","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cmet.2017.08.006","article-title":"Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis","volume":"26","author":"Simcox","year":"2017","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.scitotenv.2021.150328_bb0295","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s00204-019-02478-7","article-title":"Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo","volume":"93","author":"Stock","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150328_bb0300","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.devcel.2018.11.030","article-title":"Drosophila HNF4 directs a switch in lipid metabolism that supports the transition to adulthood","volume":"48","author":"Storelli","year":"2019","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.scitotenv.2021.150328_bb0305","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00216-020-03066-w","article-title":"The potential of fluorescent dyes-comparative study of Nile red and three derivatives for the detection of microplastics","volume":"413","author":"Sturm","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0310","doi-asserted-by":"crossref","first-page":"116169","DOI":"10.1016\/j.envpol.2020.116169","article-title":"Toxic effects of exposure to microplastics with environmentally relevant shapes and concentrations: accumulation, energy metabolism and tissue damage in oyster Crassostrea gigas","volume":"269","author":"Teng","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0315","doi-asserted-by":"crossref","first-page":"154705","DOI":"10.1016\/j.metabol.2021.154705","article-title":"PPARalpha\/RXRalpha downregulates amino acid catabolism in the liver via interaction with HNF4alpha promoting its proteasomal degradation","volume":"116","author":"Tobon-Cornejo","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0320","doi-asserted-by":"crossref","first-page":"117352","DOI":"10.1016\/j.envpol.2021.117352","article-title":"Microplastics and microfibers in urban runoff from a suburban catchment of Greater Paris","volume":"287","author":"Treilles","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0325","doi-asserted-by":"crossref","first-page":"110066","DOI":"10.1016\/j.ecoenv.2019.110066","article-title":"Microplastics and seafood: lower trophic organisms at highest risk of contamination","volume":"190","author":"Walkinshaw","year":"2020","journal-title":"Ecotox. Environ. Safe."},{"issue":"11","key":"10.1016\/j.scitotenv.2021.150328_bb0330","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1021\/bm5011382","article-title":"Effect of surface modification and macrophage phenotype on particle internalization","volume":"15","author":"Wang","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0335","doi-asserted-by":"crossref","first-page":"113024","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0340","doi-asserted-by":"crossref","first-page":"124357","DOI":"10.1016\/j.jhazmat.2020.124357","article-title":"Environmental source, fate, and toxicity of microplastics","volume":"407","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0345","doi-asserted-by":"crossref","first-page":"142099","DOI":"10.1016\/j.scitotenv.2020.142099","article-title":"Microplastic accumulation via trophic transfer: can a predatory crab counter the adverse effects of microplastics by body defence?","volume":"754","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0350","doi-asserted-by":"crossref","first-page":"117604","DOI":"10.1016\/j.envpol.2021.117604","article-title":"Microplastic pollution in sophisticated urban river systems: combined influence of land-use types and physicochemical characteristics","volume":"287","author":"Wang","year":"2021","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150328_bb0355","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/taap.1998.8547","article-title":"Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression","volume":"153","author":"Wong","year":"1998","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0360","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.chemosphere.2019.01.056","article-title":"Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells","volume":"221","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0365","doi-asserted-by":"crossref","first-page":"109612","DOI":"10.1016\/j.ecoenv.2019.109612","article-title":"Environmental occurrences, fate, and impacts of microplastics","volume":"184","author":"Wu","year":"2019","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0370","doi-asserted-by":"crossref","first-page":"136479","DOI":"10.1016\/j.scitotenv.2019.136479","article-title":"Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var. larvae","volume":"716","author":"Xia","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0375","doi-asserted-by":"crossref","first-page":"110133","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.scitotenv.2021.150328_bb0380","doi-asserted-by":"crossref","first-page":"133794","DOI":"10.1016\/j.scitotenv.2019.133794","article-title":"Internalization and toxicity: a preliminary study of effects of nanoplastic particles on human lung epithelial cell","volume":"694","author":"Xu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0385","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jhazmat.2018.12.048","article-title":"Toxicity-based toxicokinetic\/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice","volume":"366","author":"Yang","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.150328_bb9050","doi-asserted-by":"crossref","first-page":"138679","DOI":"10.1016\/j.scitotenv.2020.138679","article-title":"Polystyrene microplastics (PS-MPs) toxicity induced oxidative stress and intestinal injury in nematode Caenorhabditis elegans","volume":"726","author":"Yu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0390","doi-asserted-by":"crossref","first-page":"144010","DOI":"10.1016\/j.scitotenv.2020.144010","article-title":"A review of data for quantifying human exposures to micro and nanoplastics and potential health risks","volume":"756","author":"Zarus","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0395","doi-asserted-by":"crossref","first-page":"136279","DOI":"10.1016\/j.scitotenv.2019.136279","article-title":"Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish","volume":"710","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150328_bb0400","doi-asserted-by":"crossref","first-page":"143085","DOI":"10.1016\/j.scitotenv.2020.143085","article-title":"Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis","volume":"750","author":"Zheng","year":"2021","journal-title":"Sci. Total Environ."}],"updated-by":[{"DOI":"10.1016\/j.scitotenv.2022.158139","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000}}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972105405X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972105405X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T01:05:35Z","timestamp":1672621535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896972105405X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":81,"alternative-id":["S004896972105405X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150328","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150328","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"150328"}}