{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:47:55Z","timestamp":1792802875806,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["300727"],"award-info":[{"award-number":["300727"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.scitotenv.2021.150541","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T02:33:47Z","timestamp":1632710027000},"page":"150541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"P2","title":["Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications"],"prefix":"10.1016","volume":"806","author":[{"given":"Jonathan Ricardo","family":"Rosas-Ram\u00edrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Orozco-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Axel","family":"Elizalde-Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrio","family":"Rald\u00faa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariz","family":"Islas-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leobardo Manuel","family":"G\u00f3mez-Oliv\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2021.150541_bb0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.chemosphere.2014.06.062","article-title":"Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta, Vietnam","volume":"119","author":"Andrieu","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0020","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4067\/S0716-10182019000300253","article-title":"Changes in prescriptions and antibiotic consumption after the implementation of recommendations for use: experience in a university hospital","volume":"36","author":"\u00c1vila","year":"2019","journal-title":"Rev. Chil. Infectol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0025","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.scitotenv.2013.10.004","article-title":"Synthesis and characterization of combined cross-linked laccase and tyrosinase aggregates transforming acetaminophen as a model phenolic compound in wastewaters","volume":"487","author":"Ba","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0030","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0006-291X(02)02331-8","article-title":"Oxidative stress induced by ciprofloxacin in Staphylococcus aureus","volume":"297","author":"Becerra","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0035","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.scitotenv.2021.150541_bb5070","first-page":"2517","article-title":"Over-the-counter medications in pregnancy - American Family Physician","volume":"67","author":"Black","year":"2003","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0045","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.scitotenv.2018.06.088","article-title":"An investigation into the occurrence and removal of pharmaceuticals in colombian wastewater","volume":"642","author":"Botero-Coy","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2014.07.046","article-title":"Nox family NADPH oxidases: molecular mechanisms of activation","volume":"76","author":"Brandes","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2021.150541_bb5075","series-title":"Drugs in Pregnancy and Lactation\u202f: A Reference Guide to Fetal and Neonatal Risk","author":"Briggs","year":"2011"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150541_bb5035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jphysparis.2003.10.009","article-title":"Steps during the development of the zebrafish locomotor network","volume":"97","author":"Brustein","year":"2003","journal-title":"J. Physiol.-Paris"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"[30] microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"issue":"10","key":"10.1016\/j.scitotenv.2021.150541_bb0070","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1007\/s11356-014-3929-x","article-title":"A 3-year study on occurrence of emerging contaminants in an urban stream of S\u00e3o Paulo State of Southeast Brazil","volume":"22","author":"Campanha","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113816","article-title":"Acetaminophen affects the survivor, pigmentation and development of craniofacial structures in zebrafish (Danio rerio) embryos","volume":"174","author":"Cedron","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.scitotenv.2021.150541_bb5105","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0165-6147(87)90110-6","article-title":"A textbook of modern toxicology","volume":"8","author":"Chambers","year":"1987","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.aquatox.2018.02.007","article-title":"The effects of chronic acetaminophen exposure on the kidney, gill and liver in rainbow trout (Oncorhynchus mykiss)","volume":"198","author":"Choi","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.150541_bb5060","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3565(25)09682-X","article-title":"Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells","volume":"273","author":"Dai","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0085","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/jat.1446","article-title":"Effects of acetaminophen (paracetamol) in the embryonic development of zebrafish, Danio rerio","volume":"29","author":"David","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb5100","series-title":"The toxicology of fishes","author":"Di Giulio","year":"2008"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131213","article-title":"Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism","volume":"285","author":"Elizalde-Vel\u00e1zquez","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149432","article-title":"Oxidative stress as a potential mechanism by which guanylurea disrupts the embryogenesis of Danio rerio","volume":"799","author":"Elizalde-Vel\u00e1zquez","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.scitotenv.2021.150541_bb5040","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.celrep.2016.01.016","article-title":"Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid","volume":"14","author":"Fraher","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.scitotenv.2021.150541_bb5020","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jhazmat.2017.01.005","article-title":"Ciprofloxacin induces oxidative stress in duckweed (Lemna minor L.): implications for energy metabolism and antibiotic-uptake ability","volume":"328","author":"Gomes","year":"2017","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.scitotenv.2021.150541_bb5000","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.chemosphere.2006.07.051","article-title":"Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast","volume":"66","author":"G\u00f3mez","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0145","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1007\/s11270-012-1261-y","article-title":"Assessing the oxidative stress induced by paracetamol spiked in artificial sediment on hyalella azteca","volume":"223","author":"G\u00f3mez-Oliv\u00e1n","year":"2012","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0150","doi-asserted-by":"crossref","DOI":"10.1061\/(ASCE)HZ.2153-5515.0000346","article-title":"Occurrence of high levels of fluoroquinolones in aquatic environment due to effluent discharges from bulk drug manufacturers","volume":"21","author":"Gothwal","year":"2017","journal-title":"J. Hazard. Toxic Radioact. Waste"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0155","doi-asserted-by":"crossref","DOI":"10.1007\/s10787-013-0172-x","article-title":"The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings","author":"Graham","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.scitotenv.2021.150541_bb5095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.etap.2017.05.005","article-title":"Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure","volume":"53","author":"Guiloski","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0170","series-title":"Handbook Methods for Oxygen Radical Research","first-page":"285","article-title":"Glutathione peroxidase","author":"G\u00fcnzler","year":"1985"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0175","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0891-5849(01)00508-1","article-title":"Microsomal metabolism of ciprofloxacin generates free radicals","volume":"30","author":"G\u00fcrbay","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144585","article-title":"Survival and malformations rates, oxidative status in early life stages of Cyprinus carpio due to exposure to environmentally realistic concentrations of paracetamol","volume":"768","author":"Guti\u00e9rrez-Noya","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0185","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/es60130a004","article-title":"Trimmed spearman-karber method for estimating median lethal concentrations in toxicity bioassays","volume":"11","author":"Hamilton","year":"1977","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.150541_bb0195","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/bdrc.20085","article-title":"Oxidative stress as a mechanism of teratogenesis","volume":"78","author":"Hansen","year":"2006","journal-title":"Birth Defects Res. C Embryo Today Rev."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0200","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cotox.2017.11.003","article-title":"Oxidative stress during development: chemical-induced teratogenesis","volume":"7","author":"Hansen","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150541_bb5050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vascn.2012.10.003","article-title":"A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity","volume":"67","author":"He","year":"2013","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0205","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jpba.2014.11.020","article-title":"Detection of a wide variety of human and veterinary fluoroquinolone antibiotics in municipal wastewater and wastewater-impacted surface water","volume":"106","author":"He","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0210","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tiv.2011.01.005","article-title":"Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies","volume":"25","author":"Hermsen","year":"2011","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0220","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/S0140-6736(00)03409-7","article-title":"Methadone, ciprofloxacin, and adverse drug reactions","volume":"356","author":"Herrlin","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0240","series-title":"Pharmaceuticals Market, Consumption Trends and Disease Incidence Are Not Driving the Pharmaceutical Research on Water and Wastewater","author":"Israel","year":"2021"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0245","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00044011-200626040-00007","article-title":"Oral ciprofloxacin affects the pharmacokinetics of paracetamol in saliva","volume":"26","author":"Issa","year":"2006","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0250","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2165\/00044011-200727070-00003","article-title":"Effects of paracetamol on the pharmacokinetics of ciprofloxacin in plasma using a microbiological assay","volume":"27","author":"Issa","year":"2007","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0255","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0003-2697(92)90122-N","article-title":"Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein","volume":"202","author":"Jiang","year":"1992","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150541_bb0260","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.watres.2008.10.047","article-title":"The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters","volume":"43","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2021.150541_bb5080","series-title":"Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings","first-page":"5061","article-title":"Mechanical property characterization of the zebra!sh embryo chorion","author":"Kim","year":"2004"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0265","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0275","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010860","article-title":"Consumer concerns about paracetamol: a retrospective analysis of a medicines call centre","volume":"6","author":"Lau","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0280","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","article-title":"[37] carbonyl assays for determination of oxidatively modified proteins","volume":"233","author":"Levine","year":"1994","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150541_bb5015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.colsurfb.2011.07.011","article-title":"A mechanistic study of ciprofloxacin removal by kaolinite","volume":"88","author":"Li","year":"2011","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0290","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aquatox.2019.03.014","article-title":"Assessment of oxidative stress of paracetamol to Daphnia magna via determination of Nrf1 and genes related to antioxidant system","volume":"211","author":"Liu","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0300","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.scitotenv.2021.150541_bb5045","first-page":"915","article-title":"Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism","volume":"7","author":"Miyares","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0305","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/archdischild-2014-307287","article-title":"Paracetamol: pharmacology, prescribing and controversies","volume":"101","author":"Moriarty","year":"2016","journal-title":"Arch. Dis. Child. Educ. Pract. Ed."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0310","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.32873","article-title":"Metabolism of AM404 from acetaminophen at human therapeutic dosages in the rat brain","volume":"6","author":"Muramatsu","year":"2016","journal-title":"Anesthesiol. Pain Med."},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2021.150541_bb5055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/03602539509029821","article-title":"Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury","volume":"27","author":"Nelson","year":"1995","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0315","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/tox.22819","article-title":"Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs","volume":"34","author":"Nogueira","year":"2019","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb5085","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ecoenv.2014.05.027","article-title":"Toxic potential of paracetamol to freshwater organisms: a headache to environmental regulators?","volume":"107","author":"Nunes","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150541_bb0320","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2166\/wst.2008.822","article-title":"Removal efficiency of 66 pharmaceuticals during wastewater treatment process in Japan","volume":"57","author":"Okuda","year":"2008","journal-title":"Water Sci. Technol."},{"issue":"7","key":"10.1016\/j.scitotenv.2021.150541_bb5065","first-page":"640","article-title":"Combination of Antibiotics with Analgesic and Antipyretic Substances. Zentralblatt F\u00fcr Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene","volume":"134","author":"Pas\u0103re","year":"1979","journal-title":"Zweite Naturwissenschaftliche Abteilung: Mikrobiologie Der Landwirtschaft, Der Technologie Und Des Umweltschutzes"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0355","doi-asserted-by":"crossref","first-page":"22028","DOI":"10.1016\/S0021-9258(18)54740-2","article-title":"Detection of catalase in rat heart mitochondria","volume":"266","author":"Radi","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.150541_bb5090","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.etap.2014.04.005","article-title":"Effect of acetaminophen exposure in Oncorhynchus mykiss gills and liver: detoxification mechanisms, oxidative defence system and peroxidative damage","volume":"37","author":"Ramos","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0365","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.etap.2017.03.002","article-title":"Industrial release of fluoroquinolones (FQs) in the waste water bodies with their associated ecological risk in Pakistan","volume":"52","author":"Riaz","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0370","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s11356-012-1359-1","article-title":"A novel \u201cintegrated biomarker response\u201d calculation based on reference deviation concept","volume":"20","author":"Sanchez","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2015.05.088","article-title":"NSAID-manufacturing plant effluent induces geno-and cytotoxicity in common carp (Cyprinus carpio)","volume":"530","author":"SanJuan-Reyes","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0380","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.scitotenv.2013.04.077","article-title":"Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals","volume":"461","author":"Santos","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.150541_bb0390","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chemosphere.2010.10.026","article-title":"Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures","volume":"82","author":"Sim","year":"2011","journal-title":"Chemosphere"},{"issue":"20","key":"10.1016\/j.scitotenv.2021.150541_bb0400","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1016\/j.watres.2011.10.004","article-title":"Reconnaissance of selected PPCP compounds in Costa Rican surface waters","volume":"45","author":"Spongberg","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0405","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1037\/1040-3590.12.1.77","article-title":"Development and validation of the Stephenson Multigroup Acculturation Scale (SMAS)","volume":"12","author":"Stephenson","year":"2000","journal-title":"Psychol. Assess."},{"issue":"10","key":"10.1016\/j.scitotenv.2021.150541_bb5005","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/etc.4532","article-title":"Occurrence, distribution, and ecological risk of fluoroquinolones in rivers and wastewaters","volume":"38","author":"Teglia","year":"2019","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0420","series-title":"Seminars in Cell & Developmental Biology","first-page":"17","article-title":"Redox stress and signaling during vertebrate embryonic development: regulation and responses","volume":"vol. 80","author":"Timme-Laragy","year":"2018"},{"key":"10.1016\/j.scitotenv.2021.150541_bb5030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/B978-0-12-374814-0.00024-0","article-title":"Aquaculture and husbandry at the zebrafish international resource center","volume":"104","author":"Varga","year":"2011","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0445","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.scitotenv.2012.04.055","article-title":"Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment","volume":"430","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0450","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/BF02035128","article-title":"Possible direct role of reactive oxygens in the cause of cutaneous phototoxicity induced by five quinolones in mice","volume":"66","author":"Wagai","year":"1992","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.scitotenv.2021.150541_bb0455","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2134\/jeq2012.0014","article-title":"Occurrence of ciprofloxacin, enrofloxacin, and florfenicol in animal wastewater and water resources","volume":"41","author":"Wei","year":"2012","journal-title":"J. Environ. Qual."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0460","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tox.2011.01.004","article-title":"Zebrafish (Danio rerio) embryos as a model for testing proteratogens","volume":"281","author":"Weigt","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2021.150541_bb5025","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish Danio (\u201cBrachydanio Rerio\u201d)","author":"Westerfield","year":"2007"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.150541_bb0465","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2134\/jeq2007.0365","article-title":"Removal of organic wastewater contaminants in septic systems using advanced treatment technologies","volume":"38","author":"Wilcox","year":"2009","journal-title":"J. Environ. Qual."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.150541_bb0470","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00253-012-4414-4","article-title":"Paracetamol in the environment and its degradation by microorganisms","volume":"96","author":"Wu","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0475","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.chemosphere.2017.05.054","article-title":"Effects of ibuprofen, diclofenac and paracetamol on hatch and motor behavior in developing zebrafish (Danio rerio)","volume":"182","author":"Xia","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.150541_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.febslet.2008.01.063","article-title":"Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology","author":"Xu","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.scitotenv.2021.150541_bb5010","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.scitotenv.2017.06.215","article-title":"Effect of ciprofloxacin on biological nitrogen and phosphorus removal from wastewater","volume":"605","author":"Yi","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.150541_bb0490","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/etc.3317","article-title":"The effects of ciprofloxacin on early life stages of common carp (Cyprinus carpio)","volume":"35","author":"Zivna","year":"2016","journal-title":"Environ. Toxicol. Chem."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721056187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721056187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:20:37Z","timestamp":1790011237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721056187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":81,"alternative-id":["S0048969721056187"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150541","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.150541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"150541"}}