{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:19:30Z","timestamp":1784715570473,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["130090\/2019-0"],"award-info":[{"award-number":["130090\/2019-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/19573-7"],"award-info":[{"award-number":["2019\/19573-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08216-2"],"award-info":[{"award-number":["2013\/08216-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/26998-9"],"award-info":[{"award-number":["2017\/26998-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.scitotenv.2021.151097","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T08:20:33Z","timestamp":1635150033000},"page":"151097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis"],"prefix":"10.1016","volume":"809","author":[{"given":"Cintia Scucuglia","family":"Heluany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Scharf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayda Henriques","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Barbim","family":"Donate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"dos Reis Pedreira Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Franco","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Queiroz","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Helena Poliselli","family":"Farsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.scitotenv.2021.151097_bb0005","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1084\/jem.20122759","article-title":"IL-2 coordinates IL-2\u2013producing and regulatory T cell interplay","volume":"210","author":"Amado","year":"2013","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.scitotenv.2021.151097_bb0010","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/jamainternmed.2017.1419","article-title":"Heat-not-burn tobacco cigarettes","volume":"177","author":"Auer","year":"2017","journal-title":"JAMA Int. Med."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.151097_bb0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1164\/rccm.200908-1220OC","article-title":"Cigarette smoke\u2013induced oxidative stress","volume":"182","author":"Barreiro","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.scitotenv.2021.151097_bb0020","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/thoraxjnl-2016-208932","article-title":"Rheumatoid arthritis-associated autoantibodies and subclinical interstitial lung disease: the multi-ethnic study of atherosclerosis","volume":"71","author":"Bernstein","year":"2016","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.scitotenv.2021.151097_bb0025","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/art.27405","article-title":"Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study","volume":"62","author":"Bongartz","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.151097_bb0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrrheum.2017.205","article-title":"Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis","volume":"14","author":"Bouta","year":"2018","journal-title":"Nat. Rev. Rheum."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0035","first-page":"114","article-title":"Rodent models of rheumatoid arthritis","volume":"55","author":"Brand","year":"2005","journal-title":"Comp. Med."},{"issue":"Suppl. 2","key":"10.1016\/j.scitotenv.2021.151097_bb0040","article-title":"Electronic cigarettes: human health effects","volume":"23","author":"Callahan-Lyon","year":"2014","journal-title":"Tob. Control."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017120118","article-title":"Cigarette smoke induces miR-132in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis","volume":"118","author":"Donate","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0050","article-title":"Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells","volume":"401","author":"Dusautoir","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113554","article-title":"Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl\/6 mice","volume":"257","author":"Fabris","year":"2020","journal-title":"Environ. Pollut."},{"issue":"6937","key":"10.1016\/j.scitotenv.2021.151097_bb0060","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.scitotenv.2021.151097_bb0065","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/ni1540","article-title":"Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27\u2013stimulated T cells","volume":"8","author":"Fitzgerald","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0070","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yrtph.2017.10.006","article-title":"Assessment of novel tobacco heating product THP1.0. Part 3: comprehensive chemical characterisation of harmful and potentially harmful aerosol emissions","volume":"93","author":"Forster","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"18","key":"10.1016\/j.scitotenv.2021.151097_bb0075","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1073\/pnas.1722124115","article-title":"Shared epitope\u2013aryl hydrocarbon receptor crosstalk underlies the mechanism of gene\u2013environment interaction in autoimmune arthritis","volume":"115","author":"Fu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01085","article-title":"Expression and function of the cholinergic system in immune cells","volume":"8","author":"Fujii","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.151097_bb0090","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/ar4498","article-title":"Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis","volume":"16","author":"Giuseppe","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117037","article-title":"Synergistic benefits of nicotine and thymol in alleviating experimental rheumatoid arthritis","volume":"239","author":"Golbahari","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phrs.2017.10.005","article-title":"Nicotine and autoimmunity: the lotus\u2019 flower in tobacco","volume":"128","author":"Gomes","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.151097_bb0105","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jadohealth.2015.04.015","article-title":"Prospective predictors of novel tobacco and nicotine product use in emerging adulthood","volume":"57","author":"Hampson","year":"2015","journal-title":"J. Adolesc. Health"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cbi.2018.06.016","article-title":"Hydroquinone exposure worsens the symptomatology of rheumatoid arthritis","volume":"291","author":"Heluany","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2018.06.010","article-title":"In vivo exposure to hydroquinone during the early phase of collagen-induced arthritis aggravates the disease","volume":"408","author":"Heluany","year":"2018","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.scitotenv.2021.151097_bb0120","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3390\/antiox10060929","article-title":"Hydroquinone exposure worsens rheumatoid arthritis through the activation of the aryl hydrocarbon receptor and Interleukin-17 pathways","volume":"10","author":"Heluany","year":"2021","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.scitotenv.2021.151097_bb0130","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/rheumatology\/kel065","article-title":"Synovial fibroblasts: key players in rheumatoid arthritis","volume":"45","author":"Huber","year":"2006","journal-title":"Rheumatology"},{"issue":"11","key":"10.1016\/j.scitotenv.2021.151097_bb0135","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1136\/annrheumdis-2019-215463","article-title":"Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor","volume":"78","author":"Ishikawa","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5828056","article-title":"Metallothionein in brain disorders","volume":"2017","author":"Ju\u00e1rez-Rebollar","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0145","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0022-3565(24)39216-X","article-title":"Effects of cigarette smoke on immune response: chronic exposure to cigarette smoke impairs antigen-mediated signaling in T cells and depletes IP3-sensitive Ca(2+) stores","volume":"293","author":"Kalra","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2019.03.033","article-title":"Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review","volume":"702","author":"Karami","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0155","article-title":"Aryl hydrocarbon receptor antagonism and its role in rheumatoid arthritis","volume":"29","author":"Kishimoto","year":"2015","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0160","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA\u2013DR (shared epitope)\u2013restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.scitotenv.2021.151097_bb0165","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/rheumatology\/ken259","article-title":"A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis","volume":"47","author":"Kobayashi","year":"2008","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0960327119874439","article-title":"Cellular pathologies and genotoxic effects arising secondary to heavy metal exposure: a review","volume":"39","author":"Kocadal","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0175","first-page":"644","article-title":"Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis","volume":"56","author":"Lee","year":"2017","journal-title":"Rheumatology"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0180","article-title":"SOCS3 participates in cholinergic pathway regulation of synovitis in rheumatoid arthritis","volume":"1\u20138","author":"Li","year":"2017","journal-title":"Connect. Tissue Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.151097_bb0185","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1186\/ar2728","article-title":"Smoking and nicotine exposure delay development of collagen-induced arthritis in mice","volume":"11","author":"Lindblad","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2019.00287","article-title":"Heated tobacco products: a review of current knowledge and initial assessments","volume":"7","author":"Mallock","year":"2019","journal-title":"Front. Public Health"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autneu.2013.12.007","article-title":"The cholinergic anti-inflammatory pathway: a critical review","volume":"182","author":"Martelli","year":"2014","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01102","article-title":"Distinct roles of \u03b17 nAChRs in antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation","volume":"10","author":"Mashimo","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.scitotenv.2021.151097_bb0205","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.151097_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152925","article-title":"Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis","volume":"11","author":"Mateen","year":"2016","journal-title":"PLoS ONE"},{"issue":"23","key":"10.1016\/j.scitotenv.2021.151097_bb0215","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.151097_bb0220","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.yfrne.2014.04.004","article-title":"Gender differences in autoimmune disease","volume":"35","author":"Ngo","year":"2014","journal-title":"Front. Neuroendrocinol."},{"issue":"6","key":"10.1016\/j.scitotenv.2021.151097_bb0225","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00281-013-0392-6","article-title":"Aryl hydrocarbon receptor and experimental autoimmune arthritis","volume":"35","author":"Nguyen","year":"2013","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0230","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/1547691X.2017.1377323","article-title":"Expression of aryl hydrocarbon receptor, inflammatory cytokines, and incidence of rheumatoid arthritis in vietnamese dioxin-exposed people","volume":"14","author":"Nguyen","year":"2017","journal-title":"J. Immunotoxicol."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.151097_bb0235","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/rccm.201004-0622OC","article-title":"Rheumatoid arthritis-interstitial lung Disease\u2013associated mortality","volume":"183","author":"Olson","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0245","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","article-title":"Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis","volume":"281","author":"Phull","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.151097_bb0250","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/gene.2010.72","article-title":"Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of na\u00efve CD4 T cells toward the Th1, Th2 and Th17 lineages","volume":"12","author":"Qian","year":"2011","journal-title":"Genes Immun."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0255","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0725-1","article-title":"Immunomodulatory effects of nicotine on interleukin 1\u03b2 activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism","volume":"13","author":"Revathikumar","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0265","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.3390\/ijms14036044","article-title":"The role of metallothionein in oxidative stress","volume":"14","author":"Ruttkay-Nedecky","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0270","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.yrtph.2016.10.001","article-title":"Evaluation of the tobacco heating system 2.2. Part 2: chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol","volume":"81","author":"Schaller","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115863","article-title":"Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on jurkat T cell functions","volume":"268","author":"Scharf","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0280","article-title":"Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation","author":"Schneider","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00455","article-title":"Induction of Interleukin-10 producing dendritic cells as a tool to suppress allergen-specific T helper 2 responses","volume":"9","author":"Sch\u00fclke","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0290","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jbspin.2018.03.001","article-title":"Air pollution as a determinant of rheumatoid arthritis","volume":"86","author":"Sigaux","year":"2019","journal-title":"Joint Bone Spine"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0295","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/taap.2000.8897","article-title":"Acute and chronic nicotine exposures modulate the immune system through different pathways","volume":"164","author":"Singh","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"21","key":"10.1016\/j.scitotenv.2021.151097_bb0300","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1080\/15287390701457654","article-title":"Concentration of oxygenated polycyclic aromatic hydrocarbons and oxygen free radical formation from urban particulate matter","volume":"70","author":"Sklorz","year":"2007","journal-title":"J. Toxic. Environ. Health A"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0305","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1136\/ard.2005.050377","article-title":"Patterns of cardiovascular risk in rheumatoid arthritis","volume":"65","author":"Solomon","year":"2006","journal-title":"Ann. Rheum. Dis."},{"issue":"Suppl. 1","key":"10.1016\/j.scitotenv.2021.151097_bb0310","doi-asserted-by":"crossref","first-page":"s30","DOI":"10.1136\/tobaccocontrol-2018-054321","article-title":"IQOS: examination of Philip Morris International\u2019s claim of reduced exposure","volume":"27","author":"St. Helen","year":"2018","journal-title":"Tob. Control."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0315","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.tiv.2017.04.003","article-title":"Studies on the contributions of smoke constituents, individually and in mixtures, in a range of in vitro bioactivity assays","volume":"42","author":"Stabbert","year":"2017","journal-title":"Toxicol. In Vitro"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0320","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-018-1609-9","article-title":"Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells","volume":"20","author":"Talbot","year":"2018","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.scitotenv.2021.151097_bb0325","doi-asserted-by":"crossref","first-page":"A288","DOI":"10.1016\/j.autrev.2009.11.019","article-title":"The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis","volume":"9","author":"Tobon","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0330","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-59745-402-5_18","article-title":"Murine antigen-induced arthritis","volume":"136","author":"van den Berg","year":"2007","journal-title":"Arthritis Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0335","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/art.24177","article-title":"Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice","volume":"60","author":"van Maanen","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.scitotenv.2021.151097_bb0340","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.1800907","article-title":"IL-2\/CD25: a long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2 receptor on regulatory T cells","volume":"201","author":"Ward","year":"2018","journal-title":"J. Immunol."},{"issue":"6921","key":"10.1016\/j.scitotenv.2021.151097_bb0345","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor \u03b17 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2021.151097_bb0350","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaut.2016.12.009","article-title":"Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis","volume":"78","author":"Was\u00e9n","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0355","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejphar.2014.04.019","article-title":"Attenuation of collagen induced arthritis via suppression on Th17 response by activating cholinergic anti-inflammatory pathway with nicotine","volume":"735","author":"Wu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0360","first-page":"831","article-title":"Regulatory effect of nicotine on the differentiation of Th1, Th2 and Th17 lymphocyte subsets in patients with rheumatoid arthritis","author":"Wu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.scitotenv.2021.151097_bb0365","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3109\/14397595.2013.862352","article-title":"Regulatory effect of nicotine on collagen-induced arthritis and on the induction and function of in vitro-cultured Th17 cells","volume":"24","author":"Yang","year":"2013","journal-title":"Mod. Rheumatol."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0370","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2249.2006.03169.x","article-title":"Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7","volume":"146","author":"Yoshikawa","year":"2006","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.151097_bb0375","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/art.30219","article-title":"Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin-17 and anti-cyclic citrullinated peptide antibodies","volume":"63","author":"Yu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.scitotenv.2021.151097_bb0380","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jhazmat.2017.10.057","article-title":"Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches","volume":"344","author":"Zhao","year":"2018","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151097_bb0385","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00296-010-1549-4","article-title":"Nicotine inhibits tumor necrosis factor-\u03b1 induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"32","author":"Zhou","year":"2010","journal-title":"Rheumatol. Int."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721061751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721061751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:21:52Z","timestamp":1777396912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721061751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":73,"alternative-id":["S0048969721061751"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.151097","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.151097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151097"}}