{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:55:18Z","timestamp":1792270518271,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["678396"],"award-info":[{"award-number":["678396"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["CIDEGENT\/2020\/043"],"award-info":[{"award-number":["CIDEGENT\/2020\/043"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009599","name":"Ministerio de Agricultura y Pesca, Alimentaci\u00f3n y Medio Ambiente","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022107","name":"Universit\u00e9 de Limoges","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.scitotenv.2021.151190","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T16:14:55Z","timestamp":1635178495000},"page":"151190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"P2","title":["Effects of aquaculture waste feeds and antibiotics on marine benthic ecosystems in the Mediterranean Sea"],"prefix":"10.1016","volume":"806","author":[{"given":"Bel\u00e9n","family":"Gonz\u00e1lez-Gaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Garc\u00eda-Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Buelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Rico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.scitotenv.2021.151190_bb0005","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1080\/10643389.2019.1692611","article-title":"Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: current knowledge and questions to be answered","volume":"50","author":"Amarasiri","year":"2020","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"issue":"12","key":"10.1016\/j.scitotenv.2021.151190_bb0010","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1111\/j.1462-2920.2009.01972.x","article-title":"The role of antibiotics and antibiotic resistance in nature","volume":"11","author":"Aminov","year":"2009","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0015","series-title":"For PRIMER: Guide to Software and Statistical Methods","author":"Anderson","year":"2008"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/a06-005","article-title":"A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms","volume":"14","author":"Arnot","year":"2006","journal-title":"Environ. Rev."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0025","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/jac\/dkq167","article-title":"Quantitative multiplex real-time PCR for detecting class 1, 2 and 3 integrons","volume":"65","author":"Barraud","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0030","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0044-8486(90)90324-G","article-title":"Residues of oxytetracycline in wild fish and sediments from fish farms","volume":"86","author":"Bj\u00f6rklund","year":"1990","journal-title":"Aquaculture"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.aquaculture.2009.04.037","article-title":"Assessing the suitability of a range of benthic indices in the evaluation of environmental impact of fin and shellfish aquaculture located in sites across Europe","volume":"293","author":"Borja","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s40168-017-0309-z","article-title":"Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects","volume":"5","author":"Buelow","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0045","first-page":"94","article-title":"Limited influence of hospital wastewater on the microbiome and resistome of wastewater in a community sewerage system","author":"Buelow","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0050","article-title":"Hospital discharges in urban sanitation systems: long-term monitoring of wastewater resistome and microbiota in relationship to their eco-exposome","volume":"7","author":"Buelow","year":"2020","journal-title":"Water Res. X"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aquaculture.2010.05.020","article-title":"Chemical use in salmon aquaculture: a review of current practices and possible environmental effects","volume":"306","author":"Burridge","year":"2010","journal-title":"Aquaculture"},{"issue":"7","key":"10.1016\/j.scitotenv.2021.151190_bb0060","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/1462-2920.12134","article-title":"Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health","volume":"15","author":"Cabello","year":"2013","journal-title":"Environ. Microb."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.151190_bb0065","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/raq.12208","article-title":"Attraction and repulsion of mobile wild organisms to finfish and shellfish aquaculture: a review","volume":"10","author":"Callier","year":"2018","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0044-8486(96)01330-0","article-title":"Antibacterial residues in marine sediments and invertebrates following chemotherapy in aquaculture","volume":"145","author":"Capone","year":"1996","journal-title":"Aquaculture"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.watres.2018.02.003","article-title":"Complex pollution of antibiotic resistance genes due to beta-lactam and aminoglycoside use in aquaculture farming","volume":"134","author":"Chen","year":"2018","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.151190_bb0080","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3354\/aei00034","article-title":"MERAMOD-predicting the deposition and benthic impact of aquaculture in the eastern Mediterranean","volume":"2","author":"Cromey","year":"2012","journal-title":"Aquac. Environ. Interact."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2021.151190_bb0085","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.scitotenv.2003.09.018","article-title":"The bryophyte Fontinalis antipyretica hedw. Bioaccumulates oxytetracycline, flumequine and oxolinic acid in the freshwater environment","volume":"322","author":"Del\u00e9p\u00e9e","year":"2004","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0095","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.watres.2012.02.004","article-title":"Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment","volume":"46","author":"Gao","year":"2012","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.151190_bb0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4056\/aigs.1443528","article-title":"The earth microbiome project: meeting report of the \u201c1 st EMP meeting on sample selection and acquisition\u201d at Argonne National Laboratory October 6th 2010","volume":"3","author":"Gilbert","year":"2010","journal-title":"Stand. Genomic Sci."},{"issue":"6","key":"10.1016\/j.scitotenv.2021.151190_bb0105","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/ismej.2014.226","article-title":"Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution","volume":"9","author":"Gillings","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0110","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.scitotenv.2018.06.079","article-title":"An optimized sample treatment method for the determination of antibiotics in seawater, marine sediments and biological samples using LC-TOF\/MS","volume":"643","author":"Gonz\u00e1lez-Gaya","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0115","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/aem.56.6.1890-1896.1990","article-title":"Insertion elements on lactococcal proteinase plasmids","volume":"56","author":"Haandrikman","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0120","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1139\/m92-215","article-title":"Effects of oxytetracycline, oxolinic acid, and flumequine on bacteria in an artificial marine fish farm sediment","volume":"38","author":"Hansen","year":"1992","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0044-8486(94)00310-K","article-title":"Persistence of antibacterial agents in marine sediments","volume":"133","author":"Hektoen","year":"1995","journal-title":"Aquaculture"},{"issue":"9","key":"10.1016\/j.scitotenv.2021.151190_bb0130","doi-asserted-by":"crossref","first-page":"0203641","DOI":"10.1371\/journal.pone.0203641","article-title":"Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes","volume":"13","author":"Higuera-Llant\u00e9n","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0135","series-title":"Environmental Effects of Marine Finfish Aquaculture, Handbook of Environmental Chemistry","first-page":"181","article-title":"Organic enrichment from marine Finfish aquaculture and effects on sediment biogeochemical processes","author":"Holmer","year":"2005"},{"issue":"6","key":"10.1016\/j.scitotenv.2021.151190_bb0140","first-page":"748","article-title":"The effect of environmental factors on the degradation of florfenicol in marine sediment","volume":"27","author":"Hu","year":"2007","journal-title":"China Environ. Sci."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3354\/meps295091","article-title":"Organic carbon content of sediments as an indicator of stress in the marine benthos","volume":"295","author":"Hyland","year":"2005","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0150","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1093\/jac\/dks250","article-title":"Prevalence and characteristics of \u03b2-lactamase and plasmid-mediated quinolone resistance genes in Escherichia coli isolated from farmed fish in China","volume":"67","author":"Jiang","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0155","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.marpolbul.2005.09.034","article-title":"Benthic impacts of fish farming: meta-analysis of community and geochemical data","volume":"52","author":"Kalantzi","year":"2006","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142843","article-title":"Fish farming, metals and antibiotics in the eastern Mediterranean Sea: is there a threat to sediment wildlife?","volume":"764","author":"Kalantzi","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2021.151190_bb0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquaculture.2008.10.003","article-title":"Comparison of bacterial communities in fish farm sediments along an organic enrichment gradient","volume":"287","author":"Kawahara","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0170","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.chemosphere.2008.12.060","article-title":"Degradation of oxolinic acid and flumequine in aquaculture pond waters and sediments","volume":"75","author":"Lai","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0175","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.marpolbul.2003.08.018","article-title":"Experimental study on the bioaccumulation of oxytetracycline and oxolinic acid by the blue mussel (Mytilus edulis). An evaluation of its ability to bio-monitor antibiotics in the marine environment","volume":"48","author":"Le Bris","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0180","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/raq.12286","article-title":"Oxytetracycline in intensive aquaculture: water quality during and after its administration, environmental fate, toxicity and bacterial resistance","volume":"11","author":"Leal","year":"2019","journal-title":"Rev. Aquac."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.151190_bb0185","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1021\/acs.est.6b04556","article-title":"Antibiotic pollution in marine food webs in Laizhou Bay, North China: trophodynamics and human exposure implication","volume":"51","author":"Liu","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0190","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/raq.12344","article-title":"Antibiotic use in aquaculture, policies and regulation, health and environmental risks: a review of the top 15 major producers","volume":"12","author":"Lulijwa","year":"2020","journal-title":"Rev. Aquac."},{"issue":"21","key":"10.1016\/j.scitotenv.2021.151190_bb0195","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0200","first-page":"133","article-title":"Effect of sediment grain size and bioturbation on decomposition of organic matter from aquaculture","volume":"125","author":"Martinez-Garcia","year":"2015"},{"issue":"5","key":"10.1016\/j.scitotenv.2021.151190_bb0205","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10499-006-9051-4","article-title":"Effect of feed and feeding in the culture of salmonids on the marine aquatic environment: a synthesis for European aquaculture","volume":"14","author":"Mente","year":"2006","journal-title":"Aquac. Int."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0210","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fmicb.2013.00233","article-title":"Mechanisms of antimicrobial resistance in finfish aquaculture environments","volume":"4","author":"Miranda","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0215","first-page":"9","article-title":"Current status of the use of antibiotics and the antimicrobial resistance in the Chilean Salmon farms","author":"Miranda","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0220","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0269-7491(01)00140-3","article-title":"Nematode community response to fish-farm impact in the western Mediterranean","volume":"116","author":"Mirto","year":"2002","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0225","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2754\/avb200877030461","article-title":"Oxytetracycline assay in pond sediment","volume":"77","author":"Nepejchalov\u00e1","year":"2008","journal-title":"Acta Vet. Brno"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0022-0981(02)00529-4","article-title":"Bioturbation, sediment fluxes and benthic community structure around a salmon cage farm in Loch Creran, Scotland","volume":"285\u2013286","author":"Nickell","year":"2003","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0235","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.marpolbul.2013.05.027","article-title":"Development and validation of a method for the simultaneous extraction and separate measurement of oxytetracycline, florfenicol, oxolinic acid and flumequine from marine sediments","volume":"73","author":"Norambuena","year":"2013","journal-title":"Mar. Pollut. Bull."},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151190_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-015-2153-5","article-title":"Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential","volume":"16","author":"Pal","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0245","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2109.2011.02801.x","article-title":"Influence of fish food and faecal pellets on short-term oxygen uptake, ammonium flux and acid volatile sulphide accumulation in sediments impacted by fish farming and non-impacted sediments","volume":"43","author":"Piedecausa","year":"2012","journal-title":"Aquac. Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2021.151190_bb0250","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1128\/AAC.44.4.967-971.2000","article-title":"Macrolide resistance genes in enterococcus spp","volume":"44","author":"Portillo","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0255","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fmars.2020.00524","article-title":"Temporal changes in microbial communities beneath fish farm sediments are related to organic enrichment and fish biomass over a production cycle","volume":"7","author":"Quero","year":"2020","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0260","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/raq.12274","article-title":"Use of models for the environmental risk assessment of veterinary medicines in european aquaculture: current situation and future perspectives","volume":"11","author":"Rico","year":"2019","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0265","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.marenvres.2006.05.006","article-title":"Benthic recovery during open sea fish farming abatement in Western Mediterranean, Spain","volume":"62","author":"Sanz-L\u00e1zaro","year":"2006","journal-title":"Mar. Environ. Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2021.151190_bb2005","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.envpol.2010.10.035","article-title":"Biofilm responses to marine fish farm wastes","volume":"159","author":"Sanz-L\u00e1zaro","year":"2011","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0270","series-title":"An Environmental Assessment of the Proposed Use of Oxytetracycline-Medicated Feed in Freshwater Aquaculture","first-page":"98","author":"Schmidt","year":"2007"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151190_bb0275","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2672.2008.03960.x","article-title":"A conjugative macrolide resistance gene, mef (A), in environmental Clostridium perfringens carrying multiple macrolide and\/or tetracycline resistance genes","volume":"106","author":"Soge","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0285","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s11356-011-0475-7","article-title":"Antibiotic contaminants in coastal wetlands from vietnamese shrimp farming","volume":"18","author":"Thuy","year":"2011","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0290","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.aquaculture.2015.07.019","article-title":"Benthic community response to sediment organic enrichment by Mediterranean fish farms: case studies","volume":"450","author":"Tomassetti","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0295","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/1758-2229.12327","article-title":"Antimicrobial resistance genes in marine bacteria and human uropathogenic Escherichia coli from a region of intensive aquaculture","volume":"7","author":"Tomova","year":"2015","journal-title":"Environ. Microbiol. Rep."},{"issue":"2","key":"10.1016\/j.scitotenv.2021.151190_bb0300","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","article-title":"Fish bioaccumulation and biomarkers in environmental risk assessment: a review","volume":"13","author":"Van der Oost","year":"2003","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008388","article-title":"High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water","volume":"4","author":"Verner-Jeffreys","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0310","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3354\/aei00044","article-title":"Discharge of nutrient wastes from salmon farms: environmental effects, and potential for integrated multi-trophic aquaculture","volume":"2","author":"Wang","year":"2012","journal-title":"Aquac. Environ. Interact."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0315","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.marpolbul.2016.09.032","article-title":"Assessing benthic ecological impacts of bottom aquaculture using macrofaunal assemblages","volume":"114","author":"Wang","year":"2017","journal-title":"Mar. Pollut. Bull."},{"issue":"7","key":"10.1016\/j.scitotenv.2021.151190_bb2010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068313","article-title":"Changes in benthos associated with mussel (Mytilus edulis L.) farms on the west-coast of Scotland","volume":"8","author":"Wilding","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0320","author":"WHO"},{"key":"10.1016\/j.scitotenv.2021.151190_bb0325","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.envpol.2016.12.026","article-title":"Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater lake","volume":"222","author":"Xie","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136557","article-title":"Bioaccumulation, trophic transfer, and human health risk of quinolones antibiotics in the benthic food web from a macrophyte-dominated shallow lake, North China","volume":"712","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0335","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.1222743110","article-title":"Diverse and abundant antibiotic resistance genes in chinese swine farms","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2021.151190_bb0340","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00128-009-9923-1","article-title":"Research on florfenicol residue in coastal area of Dalian (Northern China) and analysis of functional diversity of the microbial Community in Marine Sediment","volume":"84","author":"Zong","year":"2010","journal-title":"Bull. Environ. Contam. Toxicol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721062689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721062689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:15:12Z","timestamp":1790010912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721062689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":68,"alternative-id":["S0048969721062689"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.151190","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of aquaculture waste feeds and antibiotics on marine benthic ecosystems in the Mediterranean Sea","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.151190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151190"}}