{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:40:28Z","timestamp":1781826028592,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.scitotenv.2021.151211","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T06:57:33Z","timestamp":1635317853000},"page":"151211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"P3","title":["Combined toxicity of zinc oxide nanoparticles and cadmium inducing root damage in Phytolacca americana L."],"prefix":"10.1016","volume":"806","author":[{"given":"Yunmu","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimoor Hassan","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wende","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2021.151211_bb0005","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1080\/01904167.2016.1262399","article-title":"Comparison of the effects of nano-iron fertilizer with ironchelate on growth parameters and some biochemical properties of Catharanthus roseus","volume":"40","author":"Askary","year":"2017","journal-title":"J. Plant Nutr."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0010","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0015","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ecoenv.2017.07.074","article-title":"Cell cycle arrest mediated by cd-induced DNA damage in arabidopsis root tips","volume":"145","author":"Cui","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fenvs.2014.00053","article-title":"Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants","volume":"2","author":"Das","year":"2014","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735568","article-title":"Effects of including triticale on growth performance, digestive enzyme activity, and growth-related genes of Nile tilapia (Oreochromis Nilo- ticus)","volume":"528","author":"Dawood","year":"2020","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.scitotenv.2021.151211_bb0030","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41467-017-02588-9","article-title":"Nanoparticle elasticity directs tumor uptake","volume":"9","author":"Guo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0035","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijbiomac.2021.03.025","article-title":"Exogenous melatonin positively regulates lignin biosynthesis in Camellia sinensis","volume":"179","author":"Han","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1126\/science.aau8299","article-title":"Natural, incidental, and engineered nanomaterials and their impacts on the earth system","volume":"363","author":"Hochella","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2021.151211_bb0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.envpol.2012.08.011","article-title":"Ecotoxicity of manufactured ZnO nanoparticles \u2013 a review","volume":"172","author":"Ma","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121599","article-title":"MOF derived ZnO\/C nanocomposite with enhanced adsorption capacity and photocatalytic performance under sunlight","volume":"385","author":"Hu","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0055","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.envpol.2018.08.036","article-title":"Zinc oxide nanoparticles alter the wheat physiological response and reduce the cadmium uptake by plants","volume":"242","author":"Hussain","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0060","series-title":"Modern Environmental Analysis Techniques for Pollutants","first-page":"1","article-title":"Chapter 1 - environmental pollution and environmental analysis","author":"Hussain","year":"2020"},{"issue":"2","key":"10.1016\/j.scitotenv.2021.151211_bb0065","article-title":"The cd: zn ratio in a soil affects cd toxicity in spinach spinacea oleracea L","volume":"53","author":"Hussain","year":"2016","journal-title":"Pak. J. Agric. Sci."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0070","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1021\/acs.est.6b05200","article-title":"Susceptibility of over-weight mice to liver injury as a result of the ZnO nanoparticle-enhanced liver deposition of Pb2+","volume":"51","author":"Jia","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0075","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41586-019-1449-z","article-title":"Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx","volume":"572","author":"Jiang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2021.151211_bb0080","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1021\/ez400106t","article-title":"Predicted releases of engineered nanomaterials: from global to regional to local","volume":"1","author":"Keller","year":"2014","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124168","article-title":"2D Sb2C3 monolayer: a promising material for the recyclable gas sensor for environmentally toxic nitrogen-containing gases (NCGs)","volume":"405","author":"Kumar","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"21","key":"10.1016\/j.scitotenv.2021.151211_bb0090","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.8b01060","article-title":"Hyperaccumulator plants from China: a synthesis of the current state of knowledge","volume":"52","author":"Li","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110641","article-title":"Stability of Nano-ZnO in simulated landfill leachate containing heavy metal ions","volume":"198","author":"Li","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.128419","article-title":"Carbon doped hexagonal boron nitride nanoribbon as efficient metal-free electrochemical nitrogen reduction catalyst","volume":"410","author":"Li","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"15","key":"10.1016\/j.scitotenv.2021.151211_bb0105","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1021\/es800422x","article-title":"Root uptake and phytotoxicity of ZnO nanoparticles","volume":"42","author":"Lin","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124014","article-title":"Physiological and molecular responses in halotolerant Dunaliella Salina exposed to molybdenum disulfide nanoparticles","volume":"404","author":"Luo","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0115","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jallcom.2019.05.044","article-title":"Effect of mn in ZnO using DFT calculations: magnetic and electronic changes","volume":"795","author":"Gallegos","year":"2019","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ecoenv.2017.06.074","article-title":"Bioavailability of coated and uncoated ZnO nanoparticles to cucumber in soil with or without organic matter","volume":"144","author":"Moghaddasi","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136662","article-title":"Bioavailability and translo-cation of metal oxide nanoparticles in the soil-rice plant system","volume":"713","author":"Peng","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0130","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jechem.2016.12.007","article-title":"Enhanced hydrogen produ- ction activity over BiOX-TiO2 under solar irradiation: improved charge transfer through bismuth oxide clusters","volume":"26","author":"Reddy","year":"2017","journal-title":"J. Energy. Chem."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0135","series-title":"Advances in Agronomy","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-407247-3.00001-9","article-title":"Chapter one - use of synchrotron-based techniques to elucidate metal uptake and metabolism in plants","author":"Sarret","year":"2013"},{"key":"10.1016\/j.scitotenv.2021.151211_bb0140","doi-asserted-by":"crossref","first-page":"16401","DOI":"10.1021\/acssuschemeng.9b03531","article-title":"Zinc oxide nanoparticles alleviated the bioavailability of cadmium and lead and changed the uptake of iron in hydroponically grown lettuce (Lactuca sativa L. Var. Longifolia)","volume":"7","author":"Sharifan","year":"2019","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110177","article-title":"Zinc oxide (ZnO) nanoparticles elevated iron and copper con-tents and mitigated the bioavailability of lead and cadmium in different leafy greens","volume":"191","author":"Sharifan","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.151211_bb2005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2136\/sssaj1988.03615995005200010032x","article-title":"A unifying quantitative analysis of soil texture: improvement of precision and extension of scale","volume":"52","author":"Shirazi","year":"1988","journal-title":"Soil Sci. Soc. Am. J."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jhazmat.2018.01.040","article-title":"Zinc, zinc nanoparticles and plants","volume":"349","author":"Sturikova","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molp.2020.10.011","article-title":"Protein quality control in plant organelles: current progress and future perspectives","volume":"14","author":"Sun","year":"2021","journal-title":"Mol. Plant"},{"key":"10.1016\/j.scitotenv.2021.151211_bb0160","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.scitotenv.2019.01.275","article-title":"Effects of ZnO nanoparti-cles on the toxicity of cadmium to duckweed Lemna minor","volume":"662","author":"Sun","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0165","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cej.2019.02.168","article-title":"Core-shell materials, lipid particles and nanoemul-sions, for delivery of active anti-oxidants in cosmetics applications: challenges and development strategies","volume":"368","author":"Tran","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139558","article-title":"In vivo phytotoxicity, uptake, and transloca- tion of PbS nanoparticles in maize (Zea mays L.) plants","volume":"737","author":"Ullah","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"06","key":"10.1016\/j.scitotenv.2021.151211_bb0175","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1872-2067(20)63710-X","article-title":"Atomic structures and electronic properties of cr-doped ZnO (100) surfaces","volume":"42","author":"Huang","year":"2021","journal-title":"Chin. J. Catal."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0180","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.chemosphere.2018.06.099","article-title":"Combined effects of ZnO NPs and cd on sweet sorghum as influenced by an arbuscular mycorrhizal fungus","volume":"209","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2021.151211_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141054","article-title":"Phosphate removal by ZIF-8@MWCNT hybrids in presence of effluent organic matter: adsorbent structure, wastewater quality, and DFT analysis","volume":"745","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0190","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1007\/s11356-014-3892-6","article-title":"Assessment of cadmium (Cd) concentration in arable soil in China","volume":"22","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0195","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1039\/C7EN00953D","article-title":"Hydroxyapatite nanoparticles in root cells: reduc-ing the mobility and toxicity of pb in rice","volume":"5","author":"Ye","year":"2018","journal-title":"Environ. Sci-Nano"},{"key":"10.1016\/j.scitotenv.2021.151211_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123473","article-title":"Catalytic mechanism and pathways of 1, 2-dichloropropane oxidation over LaMnO3 perovskite: an experimental and DFT study","volume":"402","author":"Zhang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110728","article-title":"Effects of iron oxide nanoparticles on fe and heavy metal accumulation in castor (Ricinus communis L.) plants and the soil aggregate","volume":"200","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0210","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cej.2017.09.072","article-title":"Toxic effects of CuO, ZnO and TiO2 nanoparticles in environmental concentration on the nitrogen removal, microbial activity and community of anammox process","volume":"332","author":"Zhang","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139636","article-title":"Phosphate sequestration by magnetic La-impregnated bentonite granules: a combined experimental and DFT study","volume":"738","author":"Zhong","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2021.151211_bb0220","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1039\/C8TC01529E","article-title":"Crystal-phase control of GaAs-GaAsSb core-shell\/axial nanowire heterostructures by a two-step growth method","volume":"6","author":"Zhou","year":"2018","journal-title":"J. Mater. Chem. C"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721062896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969721062896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:21:30Z","timestamp":1758720090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969721062896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":45,"alternative-id":["S0048969721062896"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.151211","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined toxicity of zinc oxide nanoparticles and cadmium inducing root damage in Phytolacca americana L.","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2021.151211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151211"}}