{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:16:36Z","timestamp":1790727396091,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","award":["2019QNRC001"],"award-info":[{"award-number":["2019QNRC001"]}],"id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["4187070430"],"award-info":[{"award-number":["4187070430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42007370"],"award-info":[{"award-number":["42007370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42171073"],"award-info":[{"award-number":["42171073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.scitotenv.2022.154116","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T17:58:09Z","timestamp":1645725489000},"page":"154116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Estimating antibiotics use in major cities in China through wastewater-based epidemiology"],"prefix":"10.1016","volume":"826","author":[{"given":"Sheng","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.154116_bb0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1257\/aer.99.2.184","article-title":"Winter heating or clean air? Unintended impacts of China's Huai River policy","volume":"99","author":"Almond","year":"2009","journal-title":"Am. Econ. Rev."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0010","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.mex.2019.04.016","article-title":"Simultaneous determination of 24 opioids, stimulants and new psychoactive substances in wastewater","volume":"6","author":"Bade","year":"2019","journal-title":"MethodsX"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1126\/science.aar3777","article-title":"Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens","volume":"360","author":"Baker","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138376","article-title":"Monitoring psychoactive substance use at six european festivals through wastewater and pooled urine analysis","volume":"725","author":"Bijlsma","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0025","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.chemosphere.2015.10.010","article-title":"Estimating the use of antibiotics for humans across China","volume":"144","author":"Bu","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0030","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1021\/es302722f","article-title":"Evaluation of uncertainties associated with the determination of community drug use through the measurement of sewage drug biomarkers","volume":"47","author":"Castiglioni","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115653","article-title":"Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in european wastewaters","volume":"175","author":"Castrignan\u00f2","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.envint.2018.08.009","article-title":"Population histamine burden assessed using wastewater-based epidemiology: the association of 1,4-methylimidazole acetic acid and fexofenadine","volume":"120","author":"Choi","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0055","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.trac.2018.06.004","article-title":"Wastewater-based epidemiology biomarkers: past, present and future","volume":"105","author":"Choi","year":"2018","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0060","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrmicro.2017.28","article-title":"Next-generation approaches to understand and combat the antibiotic resistome","volume":"15","author":"Crofts","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.watres.2015.07.025","article-title":"Methamphetamine and ketamine use in major chinese cities, a nationwide reconnaissance through sewage-based epidemiology","volume":"84","author":"Du","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105645","article-title":"A revised excretion factor for estimating ketamine consumption by wastewater-based epidemiology \u2013 utilising wastewater and seizure data","volume":"138","author":"Du","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148838","article-title":"Analysing wastewater to estimate fentanyl and tramadol use in major chinese cities","volume":"795","author":"Du","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.envint.2016.12.016","article-title":"Measuring biomarkers in wastewater as a new source of epidemiological information: current state and future perspectives","volume":"99","author":"Gracia-Lor","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0090","doi-asserted-by":"crossref","first-page":"10640","DOI":"10.3390\/ijerph182010640","article-title":"Simultaneous determination of seven antibiotics and five of their metabolites in municipal wastewater and evaluation of their stability under laboratory conditions","volume":"18","author":"Han","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139696","article-title":"Estimating the prevalence of hepatitis B by wastewater-based epidemiology in 19 cities in China","volume":"740","author":"Hou","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146961","article-title":"Occurrence of areca alkaloids in wastewater of major chinese cities","volume":"783","author":"Huang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0105","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.envpol.2009.03.017","article-title":"Illicit drugs and pharmaceuticals in the environment \u2013 forensic applications of environmental data. Part 1: estimation of the usage of drugs in local communities","volume":"157","author":"Kasprzyk-Hordern","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0110","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/add.12006","article-title":"Profiles of illicit drug use during annual key holiday and control periods in Australia: wastewater analysis in an urban, a semi-rural and a vacation area","volume":"108","author":"Lai","year":"2013","journal-title":"Addiction"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0115","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g1083","article-title":"China's misuse of antibiotics should be curbed","volume":"348","author":"Li","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0120","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1377\/hlthaff.2010.0965","article-title":"Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids","volume":"31","author":"Li","year":"2012","journal-title":"Health Aff. (Millwood)"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics9050212","article-title":"Cleaning up China\u2019s medical cabinet\u2014an antibiotic take-back programme to reduce household antibiotic storage for unsupervised use in rural China: a mixed-methods feasibility study","volume":"9","author":"Lin","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0130","doi-asserted-by":"crossref","first-page":"7220","DOI":"10.1021\/es100233w","article-title":"Trends in antibiotic resistance genes occurrence in the Haihe River, China","volume":"44","author":"Luo","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0135","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.watres.2015.10.040","article-title":"Critical review on the stability of illicit drugs in sewers and wastewater samples","volume":"88","author":"McCall","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0040","series-title":"Chinese Medicine Statistics Year Book of 2017","author":"MIITC","year":"2018"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.envpol.2008.07.020","article-title":"Cocaine and metabolites in waste and surface water across Belgium","volume":"157","author":"van Nuijs","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0045","series-title":"China Statistical Year Book of 2017","author":"NBSC","year":"2018"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0145","series-title":"Report of Antimicrobial Drug Management and Bacterial Resistance, 2017","author":"NHCC","year":"2018"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.healthpol.2008.09.002","article-title":"Factors influencing antibiotic prescribing in China: an exploratory analysis","volume":"90","author":"Reynolds","year":"2009","journal-title":"Health Policy"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jchromb.2014.08.008","article-title":"Simultaneous determination of most prescribed antibiotics in multiple urban wastewater by SPE-LC-MS\/MS","volume":"969C","author":"Rossmann","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0160","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.emcon.2019.08.001","article-title":"Antibiotics in two municipal sewage treatment plants in Sri Lanka: occurrence, consumption and removal efficiency","volume":"5","author":"Samaraweera","year":"2019","journal-title":"Emerg. Contam."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111623","article-title":"Spatial analysis of metformin use compared with nicotine and caffeine consumption through wastewater-based epidemiology in China","volume":"208","author":"Shao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0170","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.watres.2013.10.019","article-title":"Effects of sewer conditions on the degradation of selected illicit drug residues in wastewater","volume":"48","author":"Thai","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0175","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.scitotenv.2015.02.020","article-title":"What have we learned from worldwide experiences on the management and treatment of hospital effluent? \u2014 An overview and a discussion on perspectives","volume":"514","author":"Verlicchi","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0180","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ijantimicag.2017.04.009","article-title":"Massive misuse of antibiotics by university students in all regions of China: implications for national policy","volume":"50","author":"Wang","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.scitotenv.2022.154116_bb0185","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.scitotenv.2018.07.415","article-title":"The occurrence, distribution and degradation of antibiotics by ionizing radiation: an overview","volume":"646","author":"Wang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0190","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11270-020-04565-3","article-title":"Occurrence of stimulant drugs of abuse in a San Diego, CA, stream and their consumption rates in the neighboring community","volume":"231","author":"Watanabe","year":"2020","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0195","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1021\/es506081z","article-title":"Relationships between antibiotics and antibiotic resistance gene levels in municipal solid waste leachates in Shanghai, China","volume":"49","author":"Wu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0200","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.scitotenv.2019.06.117","article-title":"Assessing the trend of diabetes mellitus by analyzing metformin as a biomarker in wastewater","volume":"688","author":"Xiao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0205","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.envpol.2017.03.018","article-title":"Fate and mass balance of bisphenol analogues in wastewater treatment plants in Xiamen City, China","volume":"225","author":"Yan","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0210","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2166\/wst.2015.526","article-title":"Levels of six antibiotics used in China estimated by means of wastewater-based epidemiology","volume":"73","author":"Yuan","year":"2016","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0215","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0220","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.envint.2019.01.061","article-title":"Wastewater-based epidemiology in Beijing, China: prevalence of antibiotic use in flu season and association of pharmaceuticals and personal care products with socioeconomic characteristics","volume":"125","author":"Zhang","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0225","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11783-016-0868-4","article-title":"Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China","volume":"10","author":"Zhao","year":"2016","journal-title":"Front. Environ. Sci. Eng."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0230","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.scitotenv.2012.11.087","article-title":"Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China","volume":"444","author":"Zhou","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0235","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.1222743110","article-title":"Diverse and abundant antibiotic resistance genes in chinese swine farms","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.scitotenv.2022.154116_bb0240","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1289\/ehp.11022","article-title":"Estimating community drug abuse by wastewater analysis","volume":"116","author":"Zuccato","year":"2008","journal-title":"Environ. Health Perspect."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722012086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722012086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T17:55:23Z","timestamp":1731866123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722012086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":47,"alternative-id":["S0048969722012086"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154116","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estimating antibiotics use in major cities in China through wastewater-based epidemiology","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154116"}}