{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:15:56Z","timestamp":1778012156094,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52100201"],"award-info":[{"award-number":["52100201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.scitotenv.2022.154436","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T17:50:47Z","timestamp":1646761847000},"page":"154436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Transcriptomics unveiled metabolic perturbations in Desmodesmus quadricauda by sulfacetamide: Key functional genes involved in the tolerance and biodegradation process"],"prefix":"10.1016","volume":"826","author":[{"given":"Jiu-Qiang","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.154436_bb0005","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41592-019-0492-x","article-title":"Gene expression atlas of a developing tissue by single cell expression correlation analysis","volume":"16","author":"Bageritz","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scitotenv.2022.154436_bb6000","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.watres.2017.09.019","article-title":"Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries","volume":"126","author":"Bielen","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114554","article-title":"Ecotoxicological effects of sulfonamides and fluoroquinolones and their removal by a green alga (Chlorella vulgaris) and a cyanobacterium (Chrysosporum ovalisporum)","volume":"263","author":"Chen","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.131436","article-title":"CO2 mitigation and phycoremediation of industrial flue gas and wastewater via microalgae-bacteria consortium: possibilities and challenges","volume":"425","author":"Chia","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117533","article-title":"Spatiotemporal profiling of antibiotics and resistance genes in a river catchment: human population as the main driver of antibiotic and antibiotic resistance gene presence in the environment","volume":"203","author":"Elder","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115483","article-title":"Gene expression response of the alga fucus virsoides (Fucales, Ochrophyta) to glyphosate solution exposure","volume":"267","author":"Gerdol","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0030","article-title":"A review on the enzymes and metabolites identified by mass spectrometry from bacteria and microalgae involved in the degradation of high molecular weight PAHs","volume":"797","author":"Garc\u00eda","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116762","article-title":"Fate of antibiotics and antibiotic resistance genes in home water purification systems","volume":"190","author":"Gu","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11120-009-9512-5","article-title":"Enzymatic properties of the ferredoxin-dependent nitrite reductase from Chlamydomonas reinhardtii. Evidence for hydroxylamine as a late intermediate in ammonia production","volume":"103","author":"Hirasawa","year":"2009","journal-title":"Photosynth. Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0045","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.cell.2019.08.010","article-title":"Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans","volume":"178","author":"Hagan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0050","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jclepro.2018.12.255","article-title":"Acclimation of consortium of micro-algae help removal of organic pollutants from meat processing wastewater","volume":"214","author":"Hu","year":"2019","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2020.102163","article-title":"Microalgae acclimatization in industrial wastewater and its effect on growth and primary metabolite composition","volume":"53","author":"Japar","year":"2021","journal-title":"Algal Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0065","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biortech.2017.09.195","article-title":"Growth improvement and metabolic profiling of native and commercial Chlorella sorokiniana strains acclimatized in recycled agricultural wastewater","volume":"247","author":"Khalid","year":"2018","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0070","doi-asserted-by":"crossref","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","article-title":"Global increase and geographic convergence in antibiotic consumption between 2000 and 2015","volume":"115","author":"Klein","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0075","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.envpol.2016.03.024","article-title":"Uptake of caprolactam and its influence on growth and oxygen production of desmodesmus quadricauda algae","volume":"213","author":"Kalinov\u00e1","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phytochem.2013.12.003","article-title":"Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and ascophyllum nodosum","volume":"98","author":"Kim","year":"2014","journal-title":"Phytochemistry"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature01213","article-title":"Chloroplast avoidance movement reduces photodamage in plants","volume":"420","author":"Kasahara","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107754","article-title":"Algae biostimulants: a critical look at microalgal biostimulants for sustainable agricultural practices","volume":"49","author":"Kapoore","year":"2021","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126818","article-title":"Effects of various antibiotics on aerobic nitrogen removal and antibiotic degradation performance: mechanism, degradation pathways, and microbial community evolution","volume":"422","author":"Liang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105964","article-title":"Tylosin toxicity in the alga raphidocelis subcapitata revealed by integrated analyses of transcriptome and metabolome: photosynthesis and DNA replication-coupled repair","volume":"239","author":"Li","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122149","article-title":"Toxicity of benzophenone-3 and its biodegradation in a freshwater microalga Scenedesmus obliquus","volume":"389","author":"Lee","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124014","article-title":"Physiological and molecular responses in halotolerant Dunaliella Salina exposed to molybdenum disulfide nanoparticles","volume":"404","author":"Luo","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112753","article-title":"Proteomic mechanisms for the regulation of growth, photosynthetic activity and nitrogen fixation in nostoc sp. PCC 7120 exposed to three antibiotic contaminants","volume":"225","author":"Liu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.envpol.2017.11.081","article-title":"Evaluation of the toxic response induced by azoxystrobin in the non-target green alga Chlorella pyrenoidosa","volume":"234","author":"Lu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0125","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/ppl.13404","article-title":"Regulatory electron transport pathways of photosynthesis in cyanobacteria and microalgae: recent advances and biotechnological prospects","volume":"173","author":"Nikkanen","year":"2021","journal-title":"Physiol. Plant."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116446","article-title":"A review of the biotransformations of priority pharmaceuticals in biological wastewater treatment processes","volume":"188","author":"Nguyen","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116476","article-title":"A critical review of interactions between microplastics, microalgae and aquatic ecosystem function","volume":"188","author":"Nava","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0140","series-title":"Organization for Economic Co-operation and Development (OECD) Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems Test No. 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test OECD","author":"OECD TG 201","year":"2011"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115965","article-title":"Transcriptomic responses to silver nanoparticles in the freshwater unicellular eukaryote Tetrahymena thermophila","volume":"269","author":"Piersanti","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2022.102278","article-title":"Ecotoxicological effects of sulfacetamide on a green microalga, desmodesmus quadricauda: cell viability, antioxidant system, and biotransformation","volume":"26","author":"Qi","year":"2022","journal-title":"Environ. Technol. Innov."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0155","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3389\/fpls.2015.00899","article-title":"Understanding nitrate assimilation and its regulation in microalgae","volume":"6","author":"Sanz-Luque","year":"2015","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0160","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1105\/tpc.110.073858","article-title":"Arachidonic acid: an evolutionarily conserved signaling molecule modulates plant stress signaling networks","volume":"22","author":"Savchenko","year":"2010","journal-title":"Plant Cell"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jare.2018.03.004","article-title":"A review on algae and plants as potential source of arachidonic acid","volume":"11","author":"Shanab","year":"2018","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2020.102181","article-title":"Biomolecule composition and draft genome of a novel, high-lipid producing Scenedesmaceae microalga","volume":"54","author":"Soos","year":"2021","journal-title":"Algal Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0175","article-title":"Potential of phytohormones as a strategy to improve microalgae productivity for biotechnological applications","volume":"44","author":"Strick","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0180","article-title":"A dysfunctional tricarboxylic acid cycle enhances fitness of Staphylococcus epidermidis during \u03b2-lactam stress","volume":"4","author":"Thomas","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124518","article-title":"Effects of moxifloxacin and gatifloxacin stress on growth, photosynthesis, antioxidant responses, and microcystin release in Microcystis aeruginosa","volume":"409","author":"Wan","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0190","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.cej.2016.11.017","article-title":"Biodegradation of levofloxacin by an acclimated freshwater microalga, Chlorella vulgaris","volume":"313","author":"Xiong","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.biortech.2016.01.038","article-title":"Biodegradation of carbamazepine using freshwater microalgae Chlamydomonas mexicana and Scenedesmus obliquus and the determination of its metabolic fate","volume":"205","author":"Xiong","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0200","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.chemosphere.2018.11.146","article-title":"Toxicity of sulfamethazine and sulfamethoxazole and their removal by a green microalga, Scenedesmus obliquus","volume":"218","author":"Xiong","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0205","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jclepro.2018.12.255","article-title":"Acclimation of consortium of micro-algae help removal of organic pollutants from meat processing wastewater","volume":"214","author":"Xu","year":"2019","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.123452","article-title":"Insights into the effect of cerium oxide nanoparticle on microalgal degradation of sulfonamides","volume":"309","author":"Xiong","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117819","article-title":"Antibiotics adaptation costs alter carbon sequestration strategies of microorganisms in karst river","volume":"288","author":"Xiang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117413","article-title":"Multiple metabolic pathways of enrofloxacin by Lolium perenne L.: ecotoxicity, biodegradation, and key driven genes","volume":"202","author":"Zhao","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115735","article-title":"Transcriptome aberration in marine microalgae Phaeodactylum tricornutum induced by commercial naphthenic acids","volume":"268","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.154436_bb0230","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1186\/s12864-019-6191-2","article-title":"Transcriptome analysis reveals a positive effect of brassinosteroids on the photosynthetic capacity of wucai under low temperature","volume":"20","author":"Zhao","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.scitotenv.2022.154436_bb0235","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722015297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722015297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T17:58:00Z","timestamp":1731866280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722015297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":48,"alternative-id":["S0048969722015297"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154436","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomics unveiled metabolic perturbations in Desmodesmus quadricauda by sulfacetamide: Key functional genes involved in the tolerance and biodegradation process","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154436"}}