{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:26:33Z","timestamp":1791555993296,"version":"4.3.4"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.scitotenv.2022.154744","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T19:07:17Z","timestamp":1648148837000},"page":"154744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Transformation products of sulfonamides in aquatic systems: Lessons learned from available environmental fate and behaviour data"],"prefix":"10.1016","volume":"830","author":[{"given":"Neele","family":"Puhlmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"K\u00fcmmerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.scitotenv.2022.154744_bb0005","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.2166\/wst.2008.539","article-title":"Detection and identification of degradation products of sulfamethoxazole by means of LC\/MS and -MSn after ozone treatment","volume":"58","author":"Abell\u00e1n","year":"2008","journal-title":"Water Sci. Technol. J. Int. Assoc. Water Pollut. Res."},{"issue":"11","key":"10.1016\/j.scitotenv.2022.154744_bb0010","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1021\/acs.est.7b06716","article-title":"Biotransformation of sulfonamide antibiotics in activated sludge: the formation of Pterin-conjugates leads to sustained risk","volume":"52","author":"Achermann","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0015","series-title":"Green Chemistry: Theory and Practice","year":"1998"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0020","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.scitotenv.2016.10.129","article-title":"Antibiotic pollution in the Katari subcatchment of the Titicaca Lake: major transformation products and occurrence of resistance genes","volume":"576","author":"Archundia","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhazmat.2011.08.082","article-title":"Effects of the presence of sulfonamides in the environment and their influence on human health","volume":"196","author":"Baran","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0030","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.chemosphere.2017.01.035","article-title":"Mixture toxicity of six sulfonamides and their two transformation products to green algae Scenedesmus vacuolatus and duckweed Lemna minor","volume":"173","author":"Bia\u0142k-Bieli\u0144ska","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133824","article-title":"Fate and behaviour of veterinary sulphonamides under denitrifying conditions","volume":"695","author":"B\u00edlkov\u00e1","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"13","key":"10.1016\/j.scitotenv.2022.154744_bb0040","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1021\/es303777k","article-title":"Direct photolysis of human metabolites of the antibiotic sulfamethoxazole: evidence for abiotic back-transformation","volume":"47","author":"Bonvin","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"14","key":"10.1016\/j.scitotenv.2022.154744_bb0045","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1021\/es0353053","article-title":"Photochemical fate of sulfa drugs in the aquatic environment: sulfa drugs containing five-membered heterocyclic groups","volume":"38","author":"Boreen","year":"2004","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.scitotenv.2022.154744_bb0050","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1021\/es048331p","article-title":"Triplet-sensitized photodegradation of sulfa drugs containing six-membered heterocyclic groups: identification of an SO2 extrusion photoproduct","volume":"39","author":"Boreen","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jhazmat.2017.04.015","article-title":"4-Nitroso-sulfamethoxazole generation in soil under denitrifying conditions: field observations versus laboratory results","volume":"334","author":"Brienza","year":"2017","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jhazmat.2018.08.075","article-title":"Veterinary pharmaceutical residues from natural water to tap water: sales, occurrence and fate","volume":"361","author":"Charuaud","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0065","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.scitotenv.2018.06.016","article-title":"Overview of sulfonamide biodegradation and the relevant pathways and microorganisms","volume":"640-641","author":"Chen","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.154744_bb0070","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/acs.estlett.6b00455","article-title":"Integrated framework for identifying toxic transformation products in complex environmental mixtures","volume":"4","author":"Chibwe","year":"2017","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0075","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.envint.2018.03.003","article-title":"Can the pharmaceutically active compounds released in agroecosystems be considered as emerging plant stressors?","volume":"114","author":"Christou","year":"2018","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.154744_bb0080","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1039\/C8EM00515J","article-title":"Why is high persistence alone a major cause of concern?","volume":"21","author":"Cousins","year":"2019","journal-title":"Environ Sci Process Impacts"},{"issue":"12","key":"10.1016\/j.scitotenv.2022.154744_bb0085","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nrd4128","article-title":"Chemical predictive modelling to improve compound quality","volume":"12","author":"Cumming","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0090","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fmicb.2019.00338","article-title":"Antibiotics in the soil environment-degradation and their impact on microbial activity and diversity","volume":"10","author":"Cyco\u0144","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0095","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.scitotenv.2017.05.271","article-title":"Suspect screening of micropollutants and their transformation products in advanced wastewater treatment","volume":"601-602","author":"Deeb","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.154744_bb0100","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1021\/es204621q","article-title":"Electrochemical treatment of the antibiotic sulfachloropyridazine: kinetics, reaction pathways, and toxicity evolution","volume":"46","author":"Dirany","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0105","author":"ECHA"},{"issue":"11","key":"10.1016\/j.scitotenv.2022.154744_bb0110","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.chemosphere.2004.07.017","article-title":"Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae","volume":"57","author":"Eguchi","year":"2004","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jelechem.2012.11.013","article-title":"Degradation of sulfanilamide in acidic medium by anodic oxidation with a boron-doped diamond anode","volume":"689","author":"El-Ghenymy","year":"2013","journal-title":"J. Electroanal. Chem."},{"issue":"9","key":"10.1016\/j.scitotenv.2022.154744_bb0120","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1021\/es1030799","article-title":"Recent advances in environmental risk assessment of transformation products","volume":"45","author":"Escher","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0125","author":"Escher"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0130","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0135","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0140","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0145","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0150","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0155","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0160","author":"European Medicines Agency"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0165","author":"European Medicines Agency"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0170","series-title":"EU Regulation (EC) No 1107\/2009 of the European Parliament and of the Council of 21 October 2009 Concerning the Placing of Plant Protection Products on the Market and Repealing Council Directives 79\/117\/EEC and 91\/414\/EEC, 2009","author":"European Union","year":"2009"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0175","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jhazmat.2018.07.092","article-title":"Human and veterinary antibiotics during composting of sludge or manure: global perspectives on persistence, degradation, and resistance genes","volume":"359","author":"Ezzariai","year":"2018","journal-title":"J. Hazard. Mater."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.154744_bb0180","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1039\/c8pp00311d","article-title":"Photocatalytic abatement of emerging pollutants in pure water and wastewater effluent by TiO2 and Ce-ZnO: degradation kinetics and assessment of transformation products","volume":"18","author":"Fabbri","year":"2019","journal-title":"Photochem. Photobiol. Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00216-010-4300-9","article-title":"Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research","volume":"399","author":"Fatta-Kassinos","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.154744_bb0190","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.chemosphere.2011.06.082","article-title":"Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes - degradation, elucidation of byproducts and assessment of their biological potency","volume":"85","author":"Fatta-Kassinos","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172813","article-title":"Antimicrobial pharmaceuticals in the aquatic environment - occurrence and environmental implications","volume":"866","author":"Felis","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0200","author":"Fenner"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jenvman.2015.04.002","article-title":"Photocatalytic decomposition behavior and reaction pathway of sulfamethazine antibiotic using TiO2","volume":"157","author":"Fukahori","year":"2015","journal-title":"J. Environ. Manag."},{"issue":"6","key":"10.1016\/j.scitotenv.2022.154744_bb0210","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.ultsonch.2013.04.007","article-title":"Factors affecting sonolytic degradation of sulfamethazine in water","volume":"20","author":"Gao","year":"2013","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0215","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jhazmat.2014.04.024","article-title":"Oxidation of sulfamethoxazole (SMX) by chlorine, ozone and permanganate\u2014a comparative study","volume":"274","author":"Gao","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0220","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.talanta.2016.05.061","article-title":"Multiresidue trace analysis of pharmaceuticals, their human metabolites and transformation products by fully automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry","volume":"158","author":"Garc\u00eda-Gal\u00e1n","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0225","series-title":"Recommendation List for the Monitoring of Metabolites of Plant Protection Agents in German Groundwater: German Federal Environmental Agency","author":"German Federal Environmental Agency","year":"2019"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0230","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.scitotenv.2015.08.014","article-title":"Phototransformation of sulfamethoxazole under simulated sunlight: transformation products and their antibacterial activity toward Vibrio fischeri","volume":"538","author":"Gmurek","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0235","first-page":"18","article-title":"Chemical and toxicological evolution of the antibiotic sulfamethoxazole under ozone treatment in water solution","volume":"192","author":"G\u00f3mez-Ramos","year":"2011","journal-title":"J. Hazard. Mater."},{"issue":"21","key":"10.1016\/j.scitotenv.2022.154744_bb0240","doi-asserted-by":"crossref","first-page":"26103","DOI":"10.1007\/s11356-020-08881-3","article-title":"Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms","volume":"27","author":"Grabarczyk","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"7524","key":"10.1016\/j.scitotenv.2022.154744_bb0245","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/bmj.38636.593461.68","article-title":"Effectiveness and efficiency of search methods in systematic reviews of complex evidence: audit of primary sources","volume":"331","author":"Greenhalgh","year":"2005","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.122147","article-title":"Nonradical transformation of sulfamethoxazole by carbon nanotube activated peroxydisulfate: kinetics, mechanism and product toxicity","volume":"378","author":"Guan","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.scitotenv.2022.154744_bb0255","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1039\/c3cy20811g","article-title":"Photodegradation of sulfamethazine in an aqueous solution by a bismuth molybdate photocatalyst","volume":"3","author":"Guo","year":"2013","journal-title":"Catal. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0260","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.watres.2014.12.042","volume":"72","author":"Haddad","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105533","article-title":"A strategy for an initial assessment of the ecotoxicological effects of transformation products of pesticides in aquatic systems following a tiered approach","volume":"137","author":"Hensen","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0270","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.trac.2014.08.003","article-title":"Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry","volume":"63","author":"Hernandez","year":"2014","journal-title":"TRAC-Trends Analyt. Chem."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127351","article-title":"UV-Fenton degradation of diclofenac, sulpiride, sulfamethoxazole and sulfisomidine: degradation mechanisms, transformation products, toxicity evolution and effect of real water matrix","volume":"258","author":"Hong","year":"2020","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.scitotenv.2022.154744_bb0280","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1016\/j.watres.2007.02.026","article-title":"Oxidation of sulfamethoxazole and related antimicrobial agents by TiO2 photocatalysis","volume":"41","author":"Hu","year":"2007","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126541","article-title":"Rational construct CQDs\/BiOCOOH\/uCN photocatalyst with excellent photocatalytic performance for degradation of sulfathiazole","volume":"404","author":"Hu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127661","article-title":"Comparison of chemical and biological degradation of sulfonamides: solving the mystery of sulfonamide transformation","volume":"424","author":"Hu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0295","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cej.2016.06.012","article-title":"Solar photocatalytic degradation of sulfamethoxazole over tungsten \u2013 modified TiO2","volume":"318","author":"Ioannidou","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0300","doi-asserted-by":"crossref","first-page":"115480","DOI":"10.1016\/j.envpol.2020.115480","article-title":"Fate and risk assessment of sulfonamides and metabolites in urban groundwater","volume":"267","author":"Jurado","year":"2020","journal-title":"Environ. Pollut. (Barking, Essex : 1987)"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0305","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.watres.2016.02.022","article-title":"Enhanced sulfamethoxazole degradation through ammonia oxidizing bacteria co-metabolism and fate of transformation products","volume":"94","author":"Kassotaki","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0310","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cej.2015.04.139","article-title":"Ferrate promoted oxidative cleavage of sulfonamides: kinetics and product formation under acidic conditions","volume":"279","author":"Kim","year":"2015","journal-title":"Chem. Eng. J."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.154744_bb0315","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.envint.2008.07.009","article-title":"Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes","volume":"35","author":"Klavarioti","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0320","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.watres.2016.04.069","article-title":"Elimination of micropollutants and transformation products from a wastewater treatment plant effluent through pilot scale ozonation followed by various activated carbon and biological filters","volume":"100","author":"Knopp","year":"2016","journal-title":"Water Res."},{"issue":"8","key":"10.1016\/j.scitotenv.2022.154744_bb0325","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1039\/b618298b","article-title":"Sustainable from the very beginning: rational design of molecules by life cycle engineering as an important approach for green pharmacy and green chemistry","volume":"9","author":"K\u00fcmmerer","year":"2007","journal-title":"Green Chem."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0330","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-environ-052809-161223","article-title":"Pharmaceuticals in the Environment","volume":"35","author":"K\u00fcmmerer","year":"2010","journal-title":"Annu. Rev. Environ. Resour."},{"issue":"6399","key":"10.1016\/j.scitotenv.2022.154744_bb0335","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.aau2405","article-title":"A path to clean water","volume":"361","author":"K\u00fcmmerer","year":"2018","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0340","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.scitotenv.2018.10.219","article-title":"Reducing aquatic micropollutants - increasing the focus on input prevention and integrated emission management","volume":"652","author":"K\u00fcmmerer","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117463","article-title":"Abiotic transformation and ecotoxicity change of sulfonamide antibiotics in environmental and water treatment processes: a critical review","volume":"202","author":"Li","year":"2021","journal-title":"Water Res."},{"issue":"10","key":"10.1016\/j.scitotenv.2022.154744_bb0350","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nrd1523","article-title":"The role of the medicinal chemist in drug discovery\u2014then and now","volume":"3","author":"Lombardino","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0355","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.envpol.2012.11.022","article-title":"Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain","volume":"174","author":"L\u00f3pez-Serna","year":"2013","journal-title":"Environ. Pollut. (Barking, Essex : 1987)"},{"issue":"37","key":"10.1016\/j.scitotenv.2022.154744_bb0360","doi-asserted-by":"crossref","first-page":"12461","DOI":"10.1021\/acssuschemeng.1c03070","article-title":"Toward application and implementation of in silico tools and workflows within benign by design approaches","volume":"9","author":"Lorenz","year":"2021","journal-title":"ACS Sustain. Chem. Eng."},{"issue":"10","key":"10.1016\/j.scitotenv.2022.154744_bb0365","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1021\/tx500267x","article-title":"Antibacterial activity of sulfamethoxazole transformation products (TPs): general relevance for sulfonamide TPs modified at the para position","volume":"27","author":"Majewsky","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0370","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1007\/s00216-015-8748-5","article-title":"Systematic suspect screening and identification of sulfonamide antibiotic transformation products in the aquatic environment","author":"Majewsky","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0375","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cej.2017.08.050","article-title":"Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation","volume":"331","author":"Mamo","year":"2018","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0380","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ibiod.2013.11.016","article-title":"Improvement of the activated sludge treatment by its combination with electro Fenton for the mineralization of sulfamethazine","volume":"88","author":"Mansour","year":"2014","journal-title":"Int. Biodeterior. Biodegradation"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0385","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.envint.2016.11.003","article-title":"Transformation products in the water cycle and the unsolved problem of their proactive assessment: a combined in vitro\/in silico approach","volume":"98","author":"Menz","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0390","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chemosphere.2018.04.102","article-title":"Hierarchical magnetic petal-like Fe3O4-ZnO@g-C3N4 for removal of sulfamethoxazole, suppression of photocorrosion, by-products identification and toxicity assessment","volume":"205","author":"Mirzaei","year":"2018","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.scitotenv.2022.154744_bb0395","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.watres.2012.01.028","article-title":"Evidence for the microbially mediated abiotic formation of reversible and non-reversible sulfamethoxazole transformation products during denitrification","volume":"46","author":"N\u00f6dler","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0400","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jhazmat.2016.02.013","article-title":"Investigating the formation and toxicity of nitrogen transformation products of diclofenac and sulfamethoxazole in wastewater treatment plants","volume":"309","author":"Osorio","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0405","author":"PathPred"},{"issue":"12","key":"10.1016\/j.scitotenv.2022.154744_bb0410","doi-asserted-by":"crossref","first-page":"8934","DOI":"10.1007\/s11356-013-1836-1","article-title":"Photodegradation of sulfonamides and their N 4-acetylated metabolites in water by simulated sunlight irradiation: kinetics and identification of photoproducts","volume":"20","author":"Peri\u0161a","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"14","key":"10.1016\/j.scitotenv.2022.154744_bb0415","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1039\/D1GC01048D","article-title":"Towards the design of active pharmaceutical ingredients mineralizing readily in the environment","volume":"23","author":"Puhlmann","year":"2021","journal-title":"Green Chem."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0420","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cej.2014.03.086","article-title":"Degradation of sulfamethoxazole by microwave-activated persulfate: kinetics, mechanism and acute toxicity","volume":"249","author":"Qi","year":"2014","journal-title":"Chem. Eng. J."},{"issue":"9","key":"10.1016\/j.scitotenv.2022.154744_bb0425","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1021\/es900300u","article-title":"Fate of the antibiotic sulfamethoxazole and its two major human metabolites in a water sediment test","volume":"43","author":"Radke","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0430","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.chemosphere.2014.03.119","article-title":"Designing green derivatives of \u03b2-blocker Metoprolol: a tiered approach for green and sustainable pharmacy and chemistry","volume":"111","author":"Rastogi","year":"2014","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0435","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1039\/C4RA10294K","article-title":"A sustainable chemistry solution to the presence of pharmaceuticals and chemicals in the aquatic environment \u2013 the example of re-designing \u03b2-blocker Atenolol","volume":"5","author":"Rastogi","year":"2015","journal-title":"RSC Adv."},{"issue":"19","key":"10.1016\/j.scitotenv.2022.154744_bb0440","doi-asserted-by":"crossref","first-page":"11756","DOI":"10.1021\/acs.est.5b03051","article-title":"Re-designing of existing pharmaceuticals for environmental biodegradability: a tiered approach with \u03b2-blocker propranolol as an example","volume":"49","author":"Rastogi","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0445","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1128\/AEM.00911-13","article-title":"Ipso-hydroxylation and subsequent fragmentation: a novel microbial strategy to eliminate sulfonamide antibiotics","author":"Ricken","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0450","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.nbt.2015.03.005","article-title":"Degradation of sulfonamide antibiotics by Microbacterium sp. strain BR1 - elucidating the downstream pathway","author":"Ricken","year":"2015","journal-title":"New Biotechnol."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0455","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12302-019-0286-x","article-title":"Persistent, mobile and toxic substances in the environment: a spotlight on current research and regulatory activities","volume":"32","author":"R\u00fcdel","year":"2020","journal-title":"Environ. Sci. Eur."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0460","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12302-019-0203-3","article-title":"Future pesticide risk assessment: narrowing the gap between intention and reality","volume":"31","author":"Sch\u00e4fer","year":"2019","journal-title":"Environ. Sci. Eur."},{"issue":"11","key":"10.1016\/j.scitotenv.2022.154744_bb0465","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1021\/acs.est.9b01386","article-title":"The role of reactive nitrogen species in sensitized photolysis of wastewater-derived trace organic contaminants","volume":"53","author":"Scholes","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0470","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12302-021-00503-0","article-title":"Environmental fate and effects assessment of human pharmaceuticals: lessons learnt from regulatory data","volume":"33","author":"Schwarz","year":"2021","journal-title":"Environ. Sci. Eur."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.154744_bb0475","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0480","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0045-6535(01)00007-8","article-title":"META V. A model of photodegradation for the prediction of photoproducts of chemicals under natural-like conditions","volume":"45","author":"Sedykh","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0485","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.scp.2018.06.004","article-title":"Occurrence and fate of antibiotics in manure during manure treatments: a short review","volume":"9","author":"Spielmeyer","year":"2018","journal-title":"Sustain. Chem. Pharm."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0490","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.chemosphere.2016.01.049","article-title":"Biodegradation of sulfamethoxazole photo-transformation products in a water\/sediment test","volume":"148","author":"Su","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0495","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cej.2019.04.121","article-title":"Removal of sulfachloropyridazine by ferrate(VI): kinetics, reaction pathways, biodegradation, and toxicity evaluation","volume":"372","author":"Sun","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.123423","article-title":"Recent progress in sustainable technologies for adsorptive and reactive removal of sulfonamides","volume":"389","author":"Tian","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2014.02.001","article-title":"Environmental risk assessment of anti-cancer drugs and their transformation products: a focus on their genotoxicity characterization-state of knowledge and short comings","author":"Toolaram","year":"2014","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"issue":"16","key":"10.1016\/j.scitotenv.2022.154744_bb0510","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1016\/j.watres.2009.04.006","article-title":"Degradation of sulfamethoxazole in water by solar photo-Fenton. Chemical and toxicological evaluation","volume":"43","author":"Trov\u00f3","year":"2009","journal-title":"Water Res."},{"issue":"10","key":"10.1016\/j.scitotenv.2022.154744_bb0515","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.chemosphere.2009.09.065","article-title":"Photodegradation of sulfamethoxazole in various aqueous media: persistence, toxicity and photoproducts assessment","volume":"77","author":"Trov\u00f3","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0520","series-title":"The United Nations World Water Development Report 2017","article-title":"Wastewater. The untapped resource report 2017","author":"UN Water","year":"2017"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0525","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jhazmat.2014.06.069","article-title":"Environmental side effects of pharmaceutical cocktails: what we know and what we should know","volume":"279","author":"Vasquez","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0530","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.watres.2016.06.042","article-title":"A non-target approach to identify disinfection byproducts of structurally similar sulfonamide antibiotics","volume":"102","author":"Wang","year":"2016","journal-title":"Water Res."},{"issue":"8","key":"10.1016\/j.scitotenv.2022.154744_bb0535","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1007\/s00253-018-8845-4","article-title":"Microbial degradation of sulfamethoxazole in the environment","volume":"102","author":"Wang","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0540","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jenvman.2018.03.096","article-title":"Biodegradation of typical pharmaceutical compounds by a novel strain Acinetobacter sp","volume":"217","author":"Wang","year":"2018","journal-title":"J. Environ. Manag."},{"issue":"8","key":"10.1016\/j.scitotenv.2022.154744_bb0545","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world\u2019s rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.154744_bb0550","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12302-016-0091-8","article-title":"Occurrence and transformation of veterinary pharmaceuticals and biocides in manure: a literature review","volume":"28","author":"Wohde","year":"2016","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0555","series-title":"WHO Report on Surveillance of Antibiotic Consumption: 2016\u20132018 Early Implementation. Licence: CC BY-NC-SA 3.0 IGO","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.scitotenv.2022.154744_bb0560","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.watres.2017.03.054","article-title":"Degradation of sulfamethoxazole by UV, UV\/H2O2 and UV\/persulfate (PDS): formation of oxidation products and effect of bicarbonate","volume":"118","author":"Yang","year":"2017","journal-title":"Water Res."},{"issue":"65","key":"10.1016\/j.scitotenv.2022.154744_bb0565","doi-asserted-by":"crossref","first-page":"40905","DOI":"10.1039\/C7RA06852B","article-title":"Occurrence and attenuation of pharmaceuticals and their transformation products in rivers impacted by sewage treatment plants","volume":"7","author":"Zha","year":"2017","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.154744_bb0570","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1021\/acs.est.5b05604","article-title":"UV\/H2O2 and UV\/PDS treatment of trimethoprim and sulfamethoxazole in synthetic human urine: transformation products and toxicity","volume":"50","author":"Zhang","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.122354","article-title":"Degradation of sulfamethoxazole by UV\/persulfate in different water samples: influential factors, transformation products and toxicity","volume":"379","author":"Zhang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.154744_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123950","article-title":"Enhanced electro-Fenton degradation of sulfonamides using the N, S co-doped cathode: mechanism for H2O2 formation and pollutants decay","volume":"403","author":"Zhu","year":"2021","journal-title":"J. Hazard. Mater."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972201837X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972201837X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:10:51Z","timestamp":1758723051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896972201837X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":116,"alternative-id":["S004896972201837X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154744","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transformation products of sulfonamides in aquatic systems: Lessons learned from available environmental fate and behaviour data","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"154744"}}