{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:03:03Z","timestamp":1792609383592,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.scitotenv.2022.155058","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T20:25:21Z","timestamp":1649103921000},"page":"155058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects"],"prefix":"10.1016","volume":"832","author":[{"given":"Jonne","family":"Rietdijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Georgieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maris","family":"Lapins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Carreras-Puigvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Spjuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.155058_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103373","article-title":"Bisphenol A-induced metabolic disorders: from exposure to mechanism of action","volume":"77","author":"Akash","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.155058_bb0010","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/ijerph17030746","article-title":"Toxic effects of the mixture of phthalates and bisphenol A\u2014subacute oral toxicity study in wistar rats","volume":"17","author":"Barali\u0107","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7391","key":"10.1016\/j.scitotenv.2022.155058_bb0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.scitotenv.2022.155058_bb0020","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1038\/nprot.2016.105","article-title":"Cell painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes","volume":"11","author":"Bray","year":"2016","journal-title":"Nat. Protoc."},{"issue":"12","key":"10.1016\/j.scitotenv.2022.155058_bb0025","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giw014","article-title":"A dataset of images and morphological profiles of 30 000 small-molecule treatments using the cell painting assay","volume":"6","author":"Bray","year":"2017","journal-title":"GigaScience"},{"key":"10.1016\/j.scitotenv.2022.155058_bb0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.copbio.2016.04.003","article-title":"Applications in image-based profiling of perturbations","volume":"39","author":"Caicedo","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"issue":"41","key":"10.1016\/j.scitotenv.2022.155058_bb0035","doi-asserted-by":"crossref","first-page":"14715","DOI":"10.1002\/anie.201907853","article-title":"Design, synthesis, and phenotypic profiling of pyrano-furo-pyridone pseudo natural products","volume":"58","author":"Christoforow","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105267","article-title":"Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment","volume":"134","author":"Drakvik","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay6636","article-title":"Tracking complex mixtures of chemicals in our changing environment","author":"Escher","year":"2020","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.scitotenv.2022.155058_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080999","article-title":"Multiplex cytological profiling assay to measure diverse cellular states","volume":"8","author":"Gustafsdottir","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.scitotenv.2022.155058_bb0055","article-title":"New approaches to risk assessment of chemical mixtures","volume":"3","author":"Hayes","year":"2019","journal-title":"Toxicol. Res. Appl."},{"issue":"53","key":"10.1016\/j.scitotenv.2022.155058_bb0060","doi-asserted-by":"crossref","first-page":"47844","DOI":"10.1039\/C6RA05406D","article-title":"Risk assessment of environmental mixture effects","volume":"6","author":"Heys","year":"2016","journal-title":"RSC Adv."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.155058_bb0065","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1177\/2472555220917115","article-title":"High-content phenotypic profiling in esophageal adenocarcinoma identifies selectively active pharmacological classes of drugs for repurposing and chemical starting points for novel drug discovery","volume":"25","author":"Hughes","year":"2020","journal-title":"SLAS Discov. Adv. Sci. Drug Discov."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.colsurfb.2013.10.021","article-title":"Cationic surfactants in the form of nanoparticles and micelles elicit different human neutrophil responses: a toxicological study","volume":"114","author":"Hwang","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"3","key":"10.1016\/j.scitotenv.2022.155058_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.201900799","article-title":"Effects of cetyltrimethylammonium bromide on the toxicity of gold nanorods both in vitro and in vivo: molecular origin of cytotoxicity and inflammation","volume":"4","author":"Jia","year":"2020","journal-title":"Small Methods"},{"issue":"28","key":"10.1016\/j.scitotenv.2022.155058_bb0080","first-page":"2213","article-title":"A plastic stabilizer dibutyltin dilaurate induces subchronic neurotoxicity in rats","volume":"7","author":"Jin","year":"2012","journal-title":"Neural Regen. Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.155058_bb0085","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/2472555218818756","article-title":"Transfer learning with deep convolutional neural networks for classifying cellular morphological changes","volume":"24","author":"Kensert","year":"2019","journal-title":"SLAS Discov. Adv. Life Sci. R D"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0090","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.foodhyd.2007.01.024","article-title":"Behavior of cationic surfactants micellar solution solubilizing an endocrine disruptor bisphenol a","volume":"22","author":"Kosaka","year":"2008","journal-title":"Food Hydrocoll."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1476-069X-14-13","article-title":"Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment","volume":"14","author":"Lagarde","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.scitotenv.2022.155058_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fct.2017.03.054","article-title":"Effects of individual and combined toxicity of bisphenol a, dibutyl phthalate and cadmium on oxidative stress and genotoxicity in HepG 2 cells","volume":"105","author":"Li","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.155058_bb0105","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s41591-019-0404-8","article-title":"The landscape of cancer cell line metabolism","volume":"25","author":"Li","year":"2019","journal-title":"Nat. Med."},{"issue":"37","key":"10.1016\/j.scitotenv.2022.155058_bb0110","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1021\/jacs.8b07319","article-title":"Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds","volume":"140","author":"Melillo","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0115","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3389\/fphar.2017.00507","article-title":"Dibutyltin compounds effects on PPAR\u03b3\/RXR\u03b1 activity, adipogenesis, and inflammation in mammalians cells","volume":"08","author":"Milton","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142941","article-title":"Effects of bisphenol a on cardiovascular disease: an epidemiological study using National Health and nutrition examination survey 2003\u20132016 and meta-analysis","volume":"763","author":"Moon","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0125","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.watres.2017.07.016","article-title":"Development of a bioanalytical test battery for water quality monitoring: fingerprinting identified micropollutants and their contribution to effects in surface water","volume":"123","author":"Neale","year":"2017","journal-title":"Water Res."},{"issue":"9","key":"10.1016\/j.scitotenv.2022.155058_bb0130","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1007\/s11356-019-04228-9","article-title":"A mini review of bisphenol a (BPA) effects on cancer-related cellular signaling pathways","volume":"26","author":"Nomiri","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.155058_bb0135","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","article-title":"Quantitative proteomics of the cancer cell line encyclopedia","volume":"180","author":"Nusinow","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2022.155058_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114876","article-title":"Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling","volume":"389","author":"Nyffeler","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.155058_bb0145","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3390\/molecules23071654","article-title":"Effect of dibutyltin dilaurate on triglyceride metabolism through the inhibition of the MTOR pathway in human HL7702 liver cells","volume":"23","author":"Qiao","year":"2018","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0150","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12915-021-01086-1","article-title":"A phenomics approach for antiviral drug discovery","volume":"19","author":"Rietdijk","year":"2021","journal-title":"BMC Biol."},{"issue":"22","key":"10.1016\/j.scitotenv.2022.155058_bb0155","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1002\/cbic.202000381","article-title":"Morphological profiling identifies a common mode of action for small molecules with different targets","volume":"21","author":"Schneidewind","year":"2020","journal-title":"ChemBioChem"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/etc.5242","article-title":"The eco-exposome concept: supporting an integrated assessment of mixtures of environmental chemicals","volume":"41","author":"Scholz","year":"2022","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.155058_bb0165","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/acs.chemrestox.0c00303","article-title":"Comparison of cellular morphological descriptors and molecular fingerprints for the prediction of cytotoxicity- and proliferation-related assays","volume":"34","author":"Seal","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0170","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.gene.2018.01.016","article-title":"The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer","volume":"647","author":"Shafei","year":"2018","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.scitotenv.2022.155058_bb0175","doi-asserted-by":"crossref","first-page":"067006","DOI":"10.1289\/EHP8610","article-title":"Mining of consumer product ingredient and purchasing data to identify potential chemical coexposures","volume":"129","author":"Stanfield","year":"2021","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0180","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"Cell profiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0185","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scitotenv.2022.155058_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110819","article-title":"Incorporating new approach methodologies in toxicity testing and exposure assessment for tiered risk assessment using the RISK21 approach: case studies on food contact chemicals","volume":"134","author":"Turley","year":"2019","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0195","doi-asserted-by":"crossref","first-page":"11398","DOI":"10.1038\/srep11398","article-title":"Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo","volume":"5","author":"Wan","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.155058_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115209","article-title":"High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways","volume":"28","author":"Warchal","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.scitotenv.2022.155058_bb0205","doi-asserted-by":"crossref","DOI":"10.1091\/mbc.E20-12-0784","article-title":"Predicting cell health phenotypes using image-based morphology profiling","author":"Way","year":"2021","journal-title":"Mol. Biol. Cell"},{"issue":"7","key":"10.1016\/j.scitotenv.2022.155058_bb0210","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/2472555220928004","article-title":"Phenotypic profiling of reference chemicals across biologically diverse cell types using the cell painting assay","volume":"25","author":"Willis","year":"2020","journal-title":"SLAS Discov. Adv. Sci. Drug Discov."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722021519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722021519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:12:27Z","timestamp":1758723147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722021519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":42,"alternative-id":["S0048969722021519"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.155058","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.02.10.479889","asserted-by":"object"}]},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.155058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"155058"}}