{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:44:04Z","timestamp":1776689044454,"version":"3.51.2"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000041"],"award-info":[{"award-number":["82000041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090015"],"award-info":[{"award-number":["82090015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M681325"],"award-info":[{"award-number":["2020M681325"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021T140459"],"award-info":[{"award-number":["2021T140459"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC0807202"],"award-info":[{"award-number":["2018YFC0807202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.scitotenv.2022.155642","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T06:36:18Z","timestamp":1651646178000},"page":"155642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury"],"prefix":"10.1016","volume":"836","author":[{"given":"Lifeng","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenchen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weining","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.155642_bb0005","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.181.2.569","article-title":"Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice","volume":"181","author":"Abraham","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0015","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1016\/j.febslet.2006.08.061","article-title":"Drug-induced phospholipidosis","volume":"580","author":"Anderson","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0020","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/adc.67.4_Spec_No.378","article-title":"Phosphatidylcholine composition of endotracheal tube aspirates of neonates and subsequent respiratory disease","volume":"67","author":"Ashton","year":"1992","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41580-019-0185-4","article-title":"Lysosomes as dynamic regulators of cell and organismal homeostasis","volume":"21","author":"Ballabio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0030","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1172\/JCI38061","article-title":"LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice","volume":"120","author":"Bridges","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0035","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1096\/fj.11-198853","article-title":"Ferritin couples iron and fatty acid metabolism","volume":"26","author":"Bu","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0040","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1023\/B:BOLI.0000042958.22066.6c","article-title":"Elevation of lung surfactant phosphatidylcholine in mouse models of Sandhoff and of Niemann-Pick a disease","volume":"27","author":"Buccoliero","year":"2004","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0045","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.jacc.2015.03.553","article-title":"Cardiopulmonary benefits of reducing indoor particles of outdoor origin: a randomized, double-blind crossover trial of air purifiers","volume":"65","author":"Chen","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0050","doi-asserted-by":"crossref","first-page":"14586","DOI":"10.1007\/s11356-020-11677-0","article-title":"Metabolomics identifying biomarkers of PM2.5 exposure for vulnerable population: based on a prospective cohort study","volume":"28","author":"Chu","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0055","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2009-11-253815","article-title":"Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway","volume":"116","author":"Cohen","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092128","article-title":"Aerosolized bovine lactoferrin counteracts infection, inflammation and iron dysbalance in a cystic fibrosis mouse model of Pseudomonas aeruginosa chronic lung infection","volume":"20","author":"Cutone","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0065-2776(10)05002-9","article-title":"The immunological functions of saposins","volume":"105","author":"Darmoise","year":"2010","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0070","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1056\/NEJMoa1702747","article-title":"Air pollution and mortality in the medicare population","volume":"376","author":"Di","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0075","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/j.1365-2222.2010.03508.x","article-title":"Lipocalin2 protects against airway inflammation and hyperresponsiveness in a murine model of allergic airway disease","volume":"40","author":"Dittrich","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120355","article-title":"Lactoferrin, a multi-functional glycoprotein: active therapeutic, drug nanocarrier & targeting ligand","volume":"263","author":"Elzoghby","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0085","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envres.2019.02.016","article-title":"Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh)","volume":"172","author":"Fernando","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0090","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1073\/pnas.0604636103","article-title":"The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2","volume":"103","author":"Fischbach","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1074\/jbc.RA119.010892","article-title":"Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids","volume":"295","author":"Frias","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115922","article-title":"The effect of toxic components on metabolomic response of male SD rats exposed to fine particulate matter","volume":"272","author":"Geng","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/all.15224","article-title":"World Health Organization global air quality guideline recommendations: executive summary","author":"Goshua","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0110","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2337\/db09-1735","article-title":"Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice","volume":"59","author":"Guo","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0115","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/EDE.0000000000000267","article-title":"Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"26","author":"Hajat","year":"2015","journal-title":"Epidemiology"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0120","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1128\/MCB.00286-15","article-title":"Phosphatidic acidincreases epidermal growth factor receptor expression by stabilizing mRNA decay and by inhibiting lysosomal and proteasomal degradation of the internalized receptor","volume":"35","author":"Hatton","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0125","article-title":"MetaboLights: a resource evolving in response to the needs of its scientific community","volume":"48","author":"Haug","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1096-9098(199705)65:1<10::AID-JSO3>3.0.CO;2-R","article-title":"Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells","volume":"65","author":"Higashiyama","year":"1997","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0135","doi-asserted-by":"crossref","first-page":"L518","DOI":"10.1152\/ajplung.00258.2002","article-title":"Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease","volume":"284","author":"Ikegami","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0140","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1096\/fj.10-165175","article-title":"Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure","volume":"25","author":"Jin","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0145","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0150","first-page":"207","article-title":"Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis","volume":"428","author":"Kasper","year":"1996","journal-title":"Virchows Arch."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jinorgbio.2010.11.007","article-title":"Hydrolysis of phosphatidylcholine by cerium(IV) releases significant amounts of choline and inorganic phosphate at lysosomal pH","volume":"105","author":"Kassai","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0160","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1042\/EBC20190089","article-title":"Phosphatidic acid: an emerging versatile class of cellular mediators","volume":"64","author":"Kim","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0170","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1016\/S0021-9258(18)82217-7","article-title":"Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase","volume":"268","author":"Kjeldsen","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.blre.2008.08.001","article-title":"Ferritin for the clinician","volume":"23","author":"Knovich","year":"2009","journal-title":"Blood Rev."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0180","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2337\/db09-1541","article-title":"Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity","volume":"59","author":"Law","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0185","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41556-018-0244-7","article-title":"The lysosome as a cellular centre for signalling, metabolism and quality control","volume":"21","author":"Lawrence","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe1433","article-title":"Prosaposin mediates inflammation in atherosclerosis","volume":"13","author":"van Leent","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0195","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/B:CLIN.0000024740.44602.b7","article-title":"Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications","volume":"21","author":"Leto","year":"2004","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0200","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis","volume":"49","author":"Li","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0205","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cmet.2006.03.007","article-title":"The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis","volume":"3","author":"Li","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137432","article-title":"PM2.5 exposure perturbs lung microbiome and its metabolic profile in mice","volume":"721","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116741","article-title":"Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles","volume":"233","author":"Liu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0220","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1172\/JCI128164","article-title":"Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice","volume":"129","author":"Liu","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0225","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.nu.15.070195.000521","article-title":"Lactoferrin: molecular structure and biological function","volume":"15","author":"Lonnerdal","year":"1995","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0230","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.1007\/s11356-020-12051-w","article-title":"Airway hyperresponsiveness development and the toxicity of PM2.5","volume":"28","author":"Lu","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0235","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1074\/jbc.M113.510883","article-title":"GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability","volume":"289","author":"Lundius","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0240","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky869","article-title":"iProX: an integrated proteome resource","volume":"47","author":"Ma","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.08.022","article-title":"The protective role of prosaposin and its receptors in the nervous system","volume":"1585","author":"Meyer","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0255","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.lfs.2018.01.002","article-title":"Multifunctional capacity and therapeutic potential of lactoferrin","volume":"195","author":"Moreno-Exposito","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0260","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.jacc.2020.10.020","article-title":"Cardiopulmonary impact of particulate air pollution in high-risk populations: JACC state-of-the-art review","volume":"76","author":"Newman","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0265","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1096\/fasebj.5.3.2001789","article-title":"Saposin proteins: structure, function, and role in human lysosomal storage disorders","volume":"5","author":"O'Brien","year":"1991","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0270","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47990","article-title":"Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity","volume":"8","author":"Petkevicius","year":"2019","journal-title":"elife"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0275","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115987","article-title":"Subchronic exposure to concentrated ambient PM2.5 perturbs gut and lung microbiota as well as metabolic profiles in mice","volume":"272","author":"Ran","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0285","doi-asserted-by":"crossref","first-page":"40262","DOI":"10.1007\/s11356-020-10029-2","article-title":"Exposure to fine particulate matter induces self-recovery and susceptibility of oxidative stress and inflammation in rat lungs","volume":"27","author":"Ren","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0290","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/10409238.2012.735643","article-title":"The role of phosphatidylcholine and choline metabolites to cell proliferation and survival","volume":"48","author":"Ridgway","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0295","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/08958378.2011.566290","article-title":"Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice","volume":"23","author":"Riva","year":"2011","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0300","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chest.2018.10.041","article-title":"Air pollution and noncommunicable diseases: a review by the forum of international respiratory societies' environmental committee, part 2: air pollution and organ systems","volume":"155","author":"Schraufnagel","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0305","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: a control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0310","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/brain\/awl107","article-title":"Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis","volume":"129","author":"Siintola","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0315","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1476-5381.2011.01528.x","article-title":"Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2","volume":"165","author":"Wang","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0320","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.plipres.2006.01.005","article-title":"Signaling functions of phosphatidic acid","volume":"45","author":"Wang","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0325","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.scitotenv.2017.03.064","article-title":"Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats","volume":"592","author":"Wang","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122439","article-title":"Ambient particulate matter triggers dysfunction of subcellular structures and endothelial cell apoptosis through disruption of redox equilibrium and calcium homeostasis","volume":"394","author":"Wang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0335","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nprot.2012.135","article-title":"Global metabolic profiling of animal and human tissues via UPLC-MS","volume":"8","author":"Want","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0340","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1476-069X-12-40","article-title":"PM2.5, oxidant defence and cardiorespiratory health: a review","volume":"12","author":"Weichenthal","year":"2013","journal-title":"Environ. Health"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0345","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.trsl.2010.06.001","article-title":"Lactoferrin modulation of mycobacterial cord factor trehalose 6\u20136'-dimycolate induced granulomatous response","volume":"156","author":"Welsh","year":"2010","journal-title":"Transl. Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0350","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.envpol.2019.01.118","article-title":"Metabolomics analysis of a mouse model for chronic exposure to ambient PM2.5","volume":"247","author":"Xu","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0355","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1021\/acsbiomaterials.0c00221","article-title":"Assessment of air pollutant PM2.5 pulmonary exposure using a 3D lung-on-chip model","volume":"6","author":"Xu","year":"2020","journal-title":"ACS Biomater Sci. Eng."},{"issue":"2067\u20132077","key":"10.1016\/j.scitotenv.2022.155642_bb0360","article-title":"Lipocalin-2 regulates epidermal growth factor receptor intracellular trafficking","volume":"29","author":"Yammine","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0365","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1007\/s11356-019-04372-2","article-title":"Fine particulate matter alters the microecology of the murine respiratory tract","volume":"26","author":"Yang","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0370","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s11307-019-01390-x","article-title":"Lactoferrin protects hyperoxia-induced lung and kidney systemic inflammation in an in vivo imaging model of NF-kappaB\/luciferase transgenic mice","volume":"22","author":"Yen","year":"2020","journal-title":"Mol. Imaging Biol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0375","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.7150\/thno.34065","article-title":"Carbon black nanoparticles induce cell necrosis through lysosomal membrane permeabilization and cause subsequent inflammatory response","volume":"10","author":"Yuan","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.scitotenv.2022.155642_bb0380","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.autrev.2007.01.016","article-title":"Ferritin in autoimmune diseases","volume":"6","author":"Zandman-Goddard","year":"2007","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0385","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fimmu.2019.00131","article-title":"Ferritin light chain confers protection against sepsis-induced inflammation and organ injury","volume":"10","author":"Zarjou","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0390","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1007\/s12035-020-02277-7","article-title":"New insights into the role of ferritin in iron homeostasis and neurodegenerative diseases","volume":"58","author":"Zhang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0395","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1194\/jlr.M027557","article-title":"Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis","volume":"53","author":"Zhao","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0400","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ecoenv.2018.10.068","article-title":"Serum metabolomics analysis of mice that received repeated airway exposure to a water-soluble PM2.5 extract","volume":"168","author":"Zhao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.155642_bb0405","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00011-012-0522-y","article-title":"Lactoferrin restrains allergen-induced pleurisy in mice","volume":"61","author":"Zimecki","year":"2012","journal-title":"Inflamm. Res."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722027383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722027383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:38:46Z","timestamp":1758724726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722027383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":81,"alternative-id":["S0048969722027383"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.155642","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.155642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"155642"}}