{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:45:03Z","timestamp":1786117503219,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["29-01"],"award-info":[{"award-number":["29-01"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005365","name":"Ehime University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H02989"],"award-info":[{"award-number":["16H02989"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K19975"],"award-info":[{"award-number":["20K19975"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26220103"],"award-info":[{"award-number":["26220103"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.scitotenv.2022.156490","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T11:19:19Z","timestamp":1654255159000},"page":"156490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Health impact assessment of pet cats caused by organohalogen contaminants by serum metabolomics and thyroid hormone analysis"],"prefix":"10.1016","volume":"842","author":[{"given":"Kei","family":"Nomiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazuki","family":"Mizukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Takiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouta M.M.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ikenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.156490_bb0005","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1021\/es0720863","article-title":"Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafish","volume":"42","author":"van Boxtel","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0010","article-title":"Cat serum contamination by phthalates, PCBs, and PBDEs versus food and indoor air","volume":"1\u201311","author":"Braouezec","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0015","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/cem.1006","article-title":"OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification","volume":"20","author":"Bylesjo","year":"2006","journal-title":"J. Chemometr."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cvsm.2004.10.002","article-title":"Feline hepatic lipidosis","volume":"35","author":"Center","year":"2005","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0025","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/bioinformatics\/btr001","article-title":"MBRole: enrichment analysis of metabolomic data","volume":"27","author":"Chagoyen","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0030","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jcpa.2017.03.006","article-title":"Obesity and associated comorbidities in people and companion animals: a one health perspective","volume":"156","author":"Chandler","year":"2017","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0035","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cvsm.2016.04.004","article-title":"Metabolic effects of obesity and its interaction with endocrine diseases","volume":"46","author":"Clark","year":"2016","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0040","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cvsm.2013.05.002","article-title":"Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms","volume":"43","author":"Court","year":"2013","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0045","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1080\/15287394.2015.1098580","article-title":"Polybrominated diphenyl ether (PBDE)-induced suppression of phosphoenolpyruvate carboxykinase (PEPCK) decreases hepatic glyceroneogenesis and disrupts hepatic lipid homeostasis","volume":"78","author":"Cowens","year":"2015","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chemosphere.2018.10.196","article-title":"Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction","volume":"217","author":"Deng","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0055","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.envint.2013.04.004","article-title":"Organohalogenated contaminants in domestic cats' plasma in relation to spontaneous acromegaly and type 2 diabetes mellitus: a clue for endocrine disruption in humans?","volume":"57\u201358","author":"Dirtu","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0065","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.1021\/es0708159","article-title":"Elevated PBDE levels in pet cats: sentinels for humans?","volume":"41","author":"Dye","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0070","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envint.2012.05.003","article-title":"Different profiles of anthropogenic and naturally produced organohalogen compounds in serum from residents living near a coastal area and e-waste recycling workers in India","volume":"47","author":"Eguchi","year":"2012","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.156490_bb0075","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2131\/jts.41.667","article-title":"The effects of early postnatal exposure to a low dose of decabromodiphenyl ether (BDE209) on serum metabolites in male mice","volume":"41","author":"Eguchi","year":"2016","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0080","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.envpol.2018.06.071","article-title":"Alterations in urinary metabolomic profiles due to lead exposure from a lead-acid battery recycling site","volume":"242","author":"Eguchi","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1289\/ehp.1408522","article-title":"Characterizing the peroxisome proliferator-activated receptor (PPAR\u03b3) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust","volume":"123","author":"Fang","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/toxsci\/kfr262","article-title":"Comparative metabolomic and genomic analyses of TCDD-elicited metabolic disruption in mouse and rat liver","volume":"125","author":"Forgacs","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0095","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s11745-997-0118-9","article-title":"Effects of oxidative stress on glycerolipid acyl turnover in rat hepatocytes","volume":"32","author":"Gir\u00f3n-Calle","year":"1997","journal-title":"Lipids"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0100","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nm780","article-title":"A futile metabolic cycle activated in adipocytes by antidiabetic agents","volume":"8","author":"Guan","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/etc.1700","article-title":"High polybrominated diphenyl ether levels in California house cats: house dust a primary source?","volume":"31","author":"Guo","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0110","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/mnfr.200700104","article-title":"Brouwer, A.; Bergman, \u00c5. Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2\u2032,4,4\u2032-tetrabromodiphenyl ether (BDE-47)","volume":"52","author":"Hamers","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0115","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/taap.1999.8883","article-title":"Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues","volume":"163","author":"Hood","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2105-7-109","article-title":"VANTED: a system for advanced data analysis and visualization in the context of biological networks","volume":"7","author":"Junker","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0135","article-title":"Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure","volume":"226","author":"Khidkhan","year":"2019","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0140","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.envpol.2004.12.039","article-title":"Contamination status and accumulation features of persistent organochlorines in pet dogs and cats from Japan","volume":"136","author":"Kunisue","year":"2005","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0145","doi-asserted-by":"crossref","first-page":"10140","DOI":"10.1021\/es203002a","article-title":"Analysis of thyroid hormones in serum of baikal seals and humans by liquid chromatography-tandem mass spectrometry (LC-MS\/MS) and immunoassay methods: application of the LC-MS\/MS method to wildlife tissues","volume":"45","author":"Kunisue","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0150","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.scitotenv.2009.10.038","article-title":"Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish","volume":"408","author":"Letcher","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0155","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijms.2010.06.012","article-title":"LC\/MS-based non-targeted metabolomics for the investigation of general toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL\/6J and DBA\/2J mice","volume":"301","author":"Lin","year":"2011","journal-title":"Int. J. Mass Spectrom."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131815","article-title":"Study on toxicity effects of environmental pollutants based on metabolomics: a review","volume":"286","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0165","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.envpol.2012.11.004","article-title":"Species-specific differences in the accumulation features of organohalogen contaminants and their metabolites in the blood of japanese terrestrial mammals","volume":"174","author":"Mizukawa","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0170","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1021\/acs.est.5b04216","article-title":"Organohalogen compounds in pet dog and cat: do pets biotransform natural brominated products in food to harmful hydroxlated substances?","volume":"50","author":"Mizukawa","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.biochem.75.103004.142512","article-title":"Obesity-related derangements in metabolic regulation","volume":"75","author":"Muoio","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2016.09.018","article-title":"Metabolomics and metabolic diseases: where do we stand?","volume":"25","author":"Newgard","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0185","doi-asserted-by":"crossref","first-page":"13530","DOI":"10.1021\/es5043386","article-title":"Toxicological assessment of polychlorinated biphenyls and their metabolites in the liver of baikal seal (Pusa sibirica)","volume":"48","author":"Nomiyama","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114620","article-title":"Targeted metabolome analysis of the dog brain exposed to PCBs suggests inhibition of oxidative phosphorylation by hydroxylated PCBs","volume":"377","author":"Nomiyama","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00244-012-9750-y","article-title":"Decabromobiphenyl, polybrominated diphenyl ethers, and brominated phenolic compounds in serum of cats diagnosed with the endocrine disease feline hyperthyroidism","volume":"63","author":"Norrgran","year":"2012","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0200","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1021\/acs.est.5b00234","article-title":"Higher PBDE serum concentrations may be associated with feline hyperthyroidism in swedish cats","volume":"49","author":"Norrgran","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0205","first-page":"4","article-title":"Comparison of visceral fat accumulation and metabolome markers among cats of varying BCS and novel crassification of feline obesity and metabolic syndrome","volume":"14","author":"Okada","year":"2017","journal-title":"Front Vet. Sci."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0210","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1021\/es305345u","article-title":"Metabolomic profiling of in vivo plasma responses to dioxin-associated dietary contaminant exposure in rats: implications for identification of sources of animal and human exposure","volume":"47","author":"O'Kane","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0215","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/1098612X12464462","article-title":"Hyperthyroidism in cats: what's causing this epidemic of thyroid disease and can we prevent it?","volume":"14","author":"Peterson","year":"2012","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0220","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/er.2008-0007","article-title":"Glycerolipid metabolism and signaling in health and disease","volume":"29","author":"Prentki","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0225","doi-asserted-by":"crossref","first-page":"209","DOI":"10.14573\/altex.2013.2.209","article-title":"van Ravenzwaay, B.; Leist, M. Metabolomics in toxicology and preclinical research","volume":"30","author":"Ramirez","year":"2013","journal-title":"ALTEX"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0230","first-page":"1","article-title":"Cellular thiols and redox-regulated signal transduction","volume":"36","author":"Sen","year":"2000","journal-title":"Curr. Top. Cell. Regul."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018046","article-title":"Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory","volume":"6","author":"Shrestha","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0240","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1021\/ac900675k","article-title":"Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry","volume":"81","author":"Soga","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0245","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.3748\/wjg.v18.i29.3775","article-title":"Alanine and aspartate aminotransferase and glutamine-cycling pathway: their roles in pathogenesis of metabolic syndrome","volume":"18","author":"Sookoian","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0250","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1021\/es0486824","article-title":"Polybrominated diphenyl ethers in house dust and clothes dryer lint","volume":"39","author":"Stapleton","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0255","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1021\/es802599d","article-title":"Existence state of bromine as an indicator of the source of brominated flame retardants in indoor dust","volume":"43","author":"Suzuki","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0260","first-page":"358","article-title":"Increased lipogenesis in cancer cells: new players, novel targets","volume":"9","author":"Swinnen","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0265","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.scitotenv.2019.06.300","article-title":"Effects of PCB exposure on serum thyroid hormone levels in dogs and cats","volume":"688","author":"Takaguchi","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0270","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chroma.2018.01.044","article-title":"Determination of free thyroid hormones in animal serum\/plasma using ultrafiltration in combination with ultra-fast liquid chromatography-tandem mass spectrometry","volume":"1539","author":"Tanoue","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0275","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1126\/science.1106882","article-title":"Two abundant bioaccumulated halogenated compounds are natural products","volume":"307","author":"Teuten","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2022.156490_bb0280","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/toxsci\/kfn240","article-title":"Recombinant transthyretin purification and competitive binding with organohalogen compounds in two gull species (Larus argentatus and Larus hyperboreus)","volume":"107","author":"Uc\u00e1n-Marin","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0285","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1021\/es1043529","article-title":"Flame retardants in the serum of pet dogs and in their food","volume":"45","author":"Venier","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0290","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ecoenv.2019.02.080","article-title":"A comparison of the thyroid disruption induced by decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats","volume":"174","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0295","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0300","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nprot.2012.024","article-title":"A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue","volume":"7","author":"Yuan","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.scitotenv.2022.156490_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142936","article-title":"Decabromodiphenyl ether disturbs hepatic glycolipid metabolism by regulating the PI3K\/AKT\/GLUT4 and mTOR\/PPAR\u03b3\/RXR\u03b1 pathway in mice and L02 cells","volume":"763","author":"Zhu","year":"2021","journal-title":"Sci. Total Environ."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722035872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722035872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:56:24Z","timestamp":1786024584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722035872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":61,"alternative-id":["S0048969722035872"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.156490","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Health impact assessment of pet cats caused by organohalogen contaminants by serum metabolomics and thyroid hormone analysis","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.156490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"156490"}}