{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:46:11Z","timestamp":1786117571406,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004300"],"award-info":[{"award-number":["2018YFC1004300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004304"],"award-info":[{"award-number":["2018YFC1004304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.scitotenv.2022.156785","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T11:13:34Z","timestamp":1655896414000},"page":"156785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Molecular mechanism of ethylparaben on zebrafish embryo cardiotoxicity based on transcriptome analyses"],"prefix":"10.1016","volume":"842","author":[{"given":"Zunpan","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaochen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.156785_bb0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.scitotenv.2019.03.358","article-title":"Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish","volume":"671","author":"Bereketoglu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0010","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.scitotenv.2019.03.261","article-title":"An insight into toxicity and human-health-related adverse consequences of cosmeceuticals - a review","volume":"670","author":"Bilal","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envint.2014.02.007","article-title":"Parabens. From environmental studies to human health","volume":"67","author":"Bledzka","year":"2014","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.156785_bb0020","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/acs.est.8b04281","article-title":"Cardiovascular effects and molecular mechanisms of bisphenol A and its metabolite MBP in zebrafish","volume":"53","author":"Brown","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.156785_bb0025","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ncb2512","article-title":"miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics","volume":"14","author":"Cao","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.156785_bb0030","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1525-1594.2011.01381.x","article-title":"Analysis of left ventricular impedance in comparison with ultrasound images","volume":"36","author":"Choi","year":"2012","journal-title":"Artif. Organs"},{"issue":"5","key":"10.1016\/j.scitotenv.2022.156785_bb0035","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3109\/17435390.2015.1102981","article-title":"Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos","volume":"10","author":"Duan","year":"2016","journal-title":"Nanotoxicology"},{"issue":"Pt 4","key":"10.1016\/j.scitotenv.2022.156785_bb0040","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1242\/jcs.071274","article-title":"Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle","volume":"124","author":"Ferrante","year":"2011","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.156785_bb0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/DER.0000000000000429","article-title":"Parabens","volume":"30","author":"Fransway","year":"2019","journal-title":"Dermatitis"},{"issue":"3","key":"10.1016\/j.scitotenv.2022.156785_bb0050","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/jes.2010.6","article-title":"Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS\/MS)","volume":"21","author":"Frederiksen","year":"2011","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/112_2016_5","article-title":"The zebrafish heart as a model of mammalian cardiac function","volume":"171","author":"Genge","year":"2016","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/dev.167502","article-title":"Retinoic acid signaling pathways","volume":"146","author":"Ghyselinck","year":"2019","journal-title":"Development"},{"issue":"Pt 7","key":"10.1016\/j.scitotenv.2022.156785_bb0065","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1242\/jcs.023861","article-title":"Intraflagellar transport at a glance","volume":"122","author":"Hao","year":"2009","journal-title":"J. Cell Sci."},{"issue":"Pt A","key":"10.1016\/j.scitotenv.2022.156785_bb0070","article-title":"Exposure to oxadiazon-butachlor causes cardiac toxicity in zebrafish embryos","volume":"265","author":"Huang","year":"2020","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.156785_bb0075","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.talanta.2011.01.075","article-title":"A new liquid chromatography-tandem mass spectrometry method for determination of parabens in human placental tissue samples","volume":"84","author":"Jimenez-Diaz","year":"2011","journal-title":"Talanta"},{"key":"10.1016\/j.scitotenv.2022.156785_bb0080","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.envint.2013.04.001","article-title":"Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure","volume":"57\u201358","author":"Liao","year":"2013","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.156785_bb0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.taap.2007.04.013","article-title":"Toxicity and cardiac effects of carbaryl in early developing zebrafish (Danio rerio) embryos","volume":"222","author":"Lin","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"Pt 1","key":"10.1016\/j.scitotenv.2022.156785_bb0090","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.envpol.2017.05.072","article-title":"The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health","volume":"231","author":"Liu","year":"2017","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.156785_bb0095","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/toxsci\/kft020","article-title":"Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor","volume":"133","author":"McGee","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103504","article-title":"Toxicological assessment and developmental abnormalities induced by butylparaben and ethylparaben exposure in zebrafish early-life stages","volume":"80","author":"Merola","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.scitotenv.2022.156785_bb0105","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/jat.4171","article-title":"Behavioural effects of early-life exposure to parabens in zebrafish larvae","volume":"41","author":"Merola","year":"2021","journal-title":"J. Appl. Toxicol."},{"issue":"Suppl. 2","key":"10.1016\/j.scitotenv.2022.156785_bb0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/obr.12107","article-title":"Ultra-processed products are becoming dominant in the global food system","volume":"14","author":"Monteiro","year":"2013","journal-title":"Obes. Rev."},{"issue":"7\u20138","key":"10.1016\/j.scitotenv.2022.156785_bb0115","article-title":"Retinoic acid signaling in heart development","volume":"57","author":"Nakajima","year":"2019","journal-title":"Genesis"},{"key":"10.1016\/j.scitotenv.2022.156785_bb0120","series-title":"Standards for Uses of Food Additives","volume":"vol. GB2760-2014","year":"2014"},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2022.156785_bb0125","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chroma.2008.10.105","article-title":"Determination of parabens in environmental solid samples by ultrasonic-assisted extraction and liquid chromatography with triple quadrupole mass spectrometry","volume":"1214","author":"Nunez","year":"2008","journal-title":"J. Chromatogr. A"},{"issue":"4","key":"10.1016\/j.scitotenv.2022.156785_bb0130","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jat.3921","article-title":"Sublethal exposure to propylparaben leads to lipid metabolism impairment in zebrafish early-life stages","volume":"40","author":"Perugini","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.envint.2015.08.012","article-title":"Maternal and fetal exposure to parabens in a multiethnic urban U.S. population","volume":"84","author":"Pycke","year":"2015","journal-title":"Environ. Int."},{"issue":"2\u20133","key":"10.1016\/j.scitotenv.2022.156785_bb0140","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.jhazmat.2010.12.037","article-title":"GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers","volume":"186","author":"Ramaswamy","year":"2011","journal-title":"J. Hazard. Mater."},{"issue":"20","key":"10.1016\/j.scitotenv.2022.156785_bb0145","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1021\/es0264596","article-title":"Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust","volume":"37","author":"Rudel","year":"2003","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.scitotenv.2022.156785_bb0150","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1242\/dev.105874","article-title":"Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm","volume":"141","author":"Rydeen","year":"2014","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.scitotenv.2022.156785_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122123","article-title":"Zebrafish as a vertebrate model system to evaluate effects of environmental toxicants on cardiac development and function","volume":"17","author":"Sarmah","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2020.02.003","article-title":"Alpha-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish","volume":"324","author":"Shang","year":"2020","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.156785_bb0165","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/dvdy.425","article-title":"Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos","volume":"251","author":"Silic","year":"2022","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.scitotenv.2022.156785_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110235","article-title":"Profiles of parabens and their metabolites in paired maternal-fetal serum, urine and amniotic fluid and their implications for placental transfer","volume":"191","author":"Song","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.156785_bb0175","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.fct.2005.01.020","article-title":"Safety assessment of esters of p-hydroxybenzoic acid (parabens)","volume":"43","author":"Soni","year":"2005","journal-title":"Food Chem. Toxicol."},{"issue":"5554","key":"10.1016\/j.scitotenv.2022.156785_bb0180","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1063654","article-title":"Organogenesis\u2013heart and blood formation from the zebrafish point of view","volume":"295","author":"Thisse","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2022.156785_bb0185","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1542\/peds.2018-1410","article-title":"Food additives and child health","volume":"142","author":"Trasande","year":"2018","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.scitotenv.2022.156785_bb0190","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3760\/cma.j.issn.0366-6999.20121249","article-title":"Retinol dehydrogenase, RDH1l, is essential for the heart development and cardiac performance in zebrafish","volume":"126","author":"Wang","year":"2013","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.156785_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2016.01.006","article-title":"TNNT1, TNNT2, and TNNT3: isoform genes, regulation, and structure-function relationships","volume":"582","author":"Wei","year":"2016","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.156785_bb0200","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/acs.est.8b01857","article-title":"Repeated measurements of paraben exposure during pregnancy in relation to fetal and early childhood growth","volume":"53","author":"Wu","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"05","key":"10.1016\/j.scitotenv.2022.156785_bb0205","first-page":"1563","article-title":"Comparison study on regulation standards of food preservatives between two sides of Taiwan Strait %J","volume":"4","author":"Xu","year":"2013","journal-title":"J. Food Saf. Qual."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.156785_bb0210","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.coph.2008.11.004","article-title":"Neuregulin-1\/ErbB signaling: a druggable target for treating heart failure","volume":"9","author":"Xu","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.156785_bb0215","article-title":"Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function","volume":"10","author":"Xu","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.scitotenv.2022.156785_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/biom9110650","article-title":"Disease associated mutations in KIR proteins linked to aberrant inward rectifier channel trafficking","volume":"9","author":"Zangerl-Plessl","year":"2019","journal-title":"Biomolecules"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722038827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722038827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:06:26Z","timestamp":1786025186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722038827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":44,"alternative-id":["S0048969722038827"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.156785","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanism of ethylparaben on zebrafish embryo cardiotoxicity based on transcriptome analyses","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.156785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"156785"}}