{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:06:48Z","timestamp":1787314008419,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41877466"],"award-info":[{"award-number":["41877466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011037"],"award-info":[{"award-number":["2019A1515011037"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.scitotenv.2022.157360","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T02:15:16Z","timestamp":1657851316000},"page":"157360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Toxic effects of four cardiovascular drugs on the development and epigenetics of zebrafish (Danio rerio)"],"prefix":"10.1016","volume":"846","author":[{"given":"Senwen","family":"Ping","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiliang","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.157360_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2020.105776","article-title":"Dataset of pesticides, pharmaceuticals and personal care products occurrence in wetlands of Saudi Arabia","volume":"31","author":"\u00c1lvarez-Ruiz","year":"2020","journal-title":"Data Brief"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.144049","article-title":"Role of epigenetics in zebrafish development","volume":"718","author":"Balasubramanian","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aquatox.2018.05.020","article-title":"Influence of pH on the uptake and toxicity of \u03b2-blockers in embryos of zebrafish, Danio rerio","volume":"201","author":"Bittner","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.chemosphere.2015.04.078","article-title":"Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment","volume":"134","author":"Blair","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0025","first-page":"220","article-title":"Epigenetic inheritance of disease and disease risk","volume":"38","author":"Bohacek","year":"2013","journal-title":"Neuropsychopharmacology (New York, N.Y.)"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.envpol.2016.05.059","article-title":"TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish","volume":"216","author":"Chen","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112615","article-title":"Environmentally relevant concentrations of tralopyril affect carbohydrate metabolism and lipid metabolism of zebrafish (Danio rerio) by disrupting mitochondrial function","volume":"223","author":"Chen","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aag0245","article-title":"Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration","volume":"9","author":"Chen","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0045","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/carcin\/14.4.551","article-title":"Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency","volume":"14","author":"Christman","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0050","first-page":"28","article-title":"Function of the p53 gene: Choice between life and death","volume":"65","author":"Chumakov","year":"2000","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0055","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.envpol.2010.03.012","article-title":"The \u03b2-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha","volume":"158","author":"Contardo-Jara","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0060","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ecoenv.2019.03.102","article-title":"Teratogenicity and accumulation of triclosan in the early life stages of four food fish during the bioassay","volume":"176","author":"Dar","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0065","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/ijms18040710","article-title":"Triazole fungicides inhibit zebrafish hatching by blocking the secretory function of hatching gland cells","volume":"18","author":"De la Paz","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"8\u20139","key":"10.1016\/j.scitotenv.2022.157360_bb0356","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1515\/bchm.1998.379.8-9.1113","article-title":"Role of the ras-MAPK signaling pathway in the DNA methyltransferase response to DNA hypomethylation","volume":"379","author":"Deng","year":"1998","journal-title":"Biol. Chem."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0075","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.scitotenv.2018.09.354","article-title":"Ecotoxicity of the lipid-lowering drug bezafibrate on the bioenergetics and lipid metabolism of the diatom Phaeodactylum tricornutum","volume":"650","author":"Duarte","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.watres.2010.08.019","article-title":"Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater","volume":"45","author":"Escher","year":"2011","journal-title":"Water Res. (Oxford)"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yjmcc.2021.01.011","article-title":"Clinical epigenomics for cardiovascular disease: Diagnostics and therapies","volume":"154","author":"Fischer","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147021","article-title":"Environmental risk assessment and bioaccumulation of pharmaceuticals in a large urbanized estuary","volume":"783","author":"Fonseca","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0095","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1038\/s41598-021-89482-z","article-title":"Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa","volume":"11","author":"Ganzen","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0100","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S204017441500121X","article-title":"The developmental environment, epigenetic biomarkers and long-term health","volume":"6","author":"Godfrey","year":"2015","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0105","doi-asserted-by":"crossref","first-page":"9740","DOI":"10.1111\/jcmm.16922","article-title":"Nitazoxanide induced myocardial injury in zebrafish embryos by activating oxidative stress response","volume":"25","author":"Gong","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jtherbio.2004.06.002","article-title":"Combined effects of temperature and cadmium on developmental parameters and biomarker responses in zebrafish (Danio rerio) embryos","volume":"30","author":"Hallare","year":"2005","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/carcin\/bgh285","article-title":"Role of peroxisome proliferator-activated receptor-alpha (PPAR\u03b1) in bezafibrate-induced hepatocarcinogenesis and cholestasis","volume":"26","author":"Hays","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0120","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/dvdy.21447","article-title":"Expression of the eight AMPA receptor subunit genes in the developing central nervous system and sensory organs of zebrafish","volume":"237","author":"Hoppmann","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfy044","article-title":"Making waves: New developments in toxicology with the zebrafish","volume":"163","author":"Horzmann","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.aquatox.2011.10.006","article-title":"Venlafaxine and atenolol disrupt epinephrine-stimulated glucose production in rainbow trout hepatocytes","volume":"106\u2013107","author":"Ings","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0135","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/jnci\/85.15.1235","article-title":"Increased cytosine DNA-methyltransferase activity during colon cancer progression","volume":"85","author":"Issa","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ecoenv.2004.11.011","article-title":"Excretion and ecotoxicity of pharmaceutical and personal care products in the environment","volume":"63","author":"Jjemba","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0145","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2131\/jts.34.227","article-title":"Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)","volume":"34","author":"Kim","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0155","series-title":"Methods in Cell Biology","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/B978-0-12-374814-0.00023-9","article-title":"Chapter 23 - advances in zebrafish husbandry and management","author":"Lawrence","year":"2011"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0160","doi-asserted-by":"crossref","first-page":"8552","DOI":"10.1021\/es201099s","article-title":"Effect-directed analysis of municipal landfill soil reveals novel developmental toxicants in the zebrafish Danio rerio","volume":"45","author":"Legler","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0165","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.4049\/jimmunol.1001437","article-title":"Peroxisome proliferator-activated receptor \u03b1 and \u03b3 agonists together with TGF-\u03b2 convert human CD4+CD25- T cells into functional Foxp3+ regulatory T cells","volume":"185","author":"Lei","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0170","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/acs.est.0c06052","article-title":"Metformin-induced epigenetic toxicity in zebrafish: Experimental and molecular dynamics simulation studies","volume":"55","author":"Lin","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0175","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1093\/ajhp\/55.21.2253","article-title":"Atorvastatin: a hydroxymethylglutaryl-coenzyme A reductase inhibitor","volume":"55","author":"Malinowski","year":"1998","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00018-003-3216-3","article-title":"Peroxisome proliferator-activated receptor \u03b1 target genes","volume":"61","author":"Mandard","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0185","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2018.02.012","article-title":"Metoprolol induces oxidative damage in common carp (Cyprinus carpio)","volume":"197","author":"Mart\u00ednez-Rodr\u00edguez","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134703","article-title":"Using a high-throughput zebrafish embryo screening approach to support environmental hazard ranking for cardiovascular agents","volume":"702","author":"Meng","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0195","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/j.jacc.2019.10.009","article-title":"The global burden of cardiovascular diseases and risk factors: 2020 and beyond","volume":"74","author":"Mensah","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0200","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2004.07.095","article-title":"Expression of zebrafish glutamate receptor \u03b42 in neurons with cerebellum-like wiring","volume":"322","author":"Mikami","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0205","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1897\/08-486.1","article-title":"Bridging levels of pharmaceuticals in river water with biological community structure in the llobregat river basin (northeast Spain)","volume":"28","author":"Mu\u00f1oz","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0210","series-title":"Guide for the Care And Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111510","article-title":"Assessing pharmaceutical contamination along the Mediterranean and Red Sea coasts of Israel: ascidians (Chordata, Ascidiacea) as bioindicators","volume":"160","author":"Navon","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0357","series-title":"Fish Physiol","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1546-5098(10)02903-1","article-title":"3 - Zebrafish vision: Structure and function of the zebrafish visual system","volume":"29","author":"Neuhauss","year":"2010"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0225","series-title":"Test No. 236: Fish Embryo Acute Toxicity (FET) Test","author":"OECD","year":"2013"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0230","series-title":"Data Warehouse","author":"OECD","year":"2014"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0235","doi-asserted-by":"crossref","first-page":"10573","DOI":"10.3390\/ijms221910573","article-title":"The PPAR\u03b1 and PPAR\u03b3 epigenetic landscape in cancer and immune and metabolic disorders","volume":"22","author":"Porcuna","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0240","article-title":"Fipronil-induced enantioselective developmental toxicity to zebrafish embryo-larvae involves changes in DNA methylation","volume":"7","author":"Qian","year":"2017","journal-title":"Sci. Rep. UK"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0245","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0250","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0255","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S","article-title":"Time course of the development of motor behaviors in the zebrafish embryo","volume":"37","author":"Saint-Amant","year":"1998","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0260","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00128-017-2196-1","article-title":"Drifting away of a FET endpoint: The heart rate in Danio rerio embryos is extremely sensitive to variation in ambient temperature","volume":"99","author":"Schweizer","year":"2017","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0265","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ecoenv.2019.04.056","article-title":"Acute exposure to triphenyl phosphate (TPhP) disturbs ocular development and muscular organization in zebrafish larvae","volume":"179","author":"Shi","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0270","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chemosphere.2011.07.051","article-title":"Occurrence and distribution of pharmaceuticals in surface water, suspended solids and sediments of the Ebro river basin, Spain","volume":"85","author":"Silva","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0275","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1432-1327.1999.00603.x","article-title":"Feedback regulation of DNA methyltransferase gene expression by methylation","volume":"264","author":"Slack","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0280","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10741-011-9293-8","article-title":"Age-related cardiovascular disease and the beneficial effects of calorie restriction","volume":"17","author":"Sung","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0285","doi-asserted-by":"crossref","first-page":"169","DOI":"10.22159\/ajpcr.2017.v10i4.16429","article-title":"Curcuminoid and toxicity levels of ethanol extract of javanese ginger (Curcuma xanthorrhiza) on brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos","volume":"10","author":"Syahbirin","year":"2017","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0290","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.drup.2003.10.002","article-title":"DNA methylation and cancer therapy","volume":"6","author":"Szyf","year":"2003","journal-title":"Drug Resist. Update"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0295","series-title":"Behavioral and Neural Genetics of Zebrafish","first-page":"17","article-title":"Chapter 2 - maintenance and breeding of zebrafish, with some ethological and ecological considerations in mind","author":"Tsang","year":"2020"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0300","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.intimp.2017.08.027","article-title":"The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells","volume":"52","author":"Usui-Ouchi","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0305","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.chemosphere.2010.10.041","article-title":"Analysis of the presence of cardiovascular and analgesic\/anti-inflammatory\/antipyretic pharmaceuticals in river- and drinking-water of the Madrid Region in Spain","volume":"82","author":"Valc\u00e1rcel","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0310","first-page":"1","article-title":"Seasonal monitoring of cardiovascular and antiulcer agents' concentrations in stream waters encompassing a capital city","volume":"2013","author":"Varga","year":"2013","journal-title":"J. Pharm."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0315","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquatox.2011.05.018","article-title":"Bezafibrate, a lipid-lowering pharmaceutical, as a potential endocrine disruptor in male zebrafish (Danio rerio)","volume":"105","author":"Velasco-Santamar\u00eda","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0320","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jenvman.2016.07.049","article-title":"Removal of pharmaceuticals and personal care products (PPCPs) from wastewater: A review","volume":"182","author":"Wang","year":"2016","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0325","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/mol.113.091462","article-title":"Characterization of the zebrafish ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases","volume":"86","author":"Wang","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117879","article-title":"Atorvastatin causes oxidative stress and alteration of lipid metabolism in estuarine goby Mugilogobius abei","volume":"289","author":"Wang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0335","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/toxsci\/67.1.11","article-title":"Epigenetics and DNA methylation come of age in toxicology","volume":"67","author":"Watson","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0340","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.chemosphere.2017.05.054","article-title":"Effects of ibuprofen, diclofenac and paracetamol on hatch and motor behavior in developing zebrafish (Danio rerio)","volume":"182","author":"Xia","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157360_bb0345","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.4049\/jimmunol.159.3.1303","article-title":"Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity","volume":"159","author":"Yang","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0350","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.scitotenv.2018.03.302","article-title":"Thifluzamide affects lipid metabolism in zebrafish (Danio reio)","volume":"633","author":"Yang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157360_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138770","article-title":"Cardiovascular drugs and lipid regulating agents in surface waters at global scale: Occurrence, ecotoxicity and risk assessment","volume":"729","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722044588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722044588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:51:04Z","timestamp":1758725464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722044588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":71,"alternative-id":["S0048969722044588"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157360","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic effects of four cardiovascular drugs on the development and epigenetics of zebrafish (Danio rerio)","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"157360"}}