{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:01:17Z","timestamp":1791334877842,"version":"4.3.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["NE\/N019776"],"award-info":[{"award-number":["NE\/N019776"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000270","name":"Natural Environment Research Council","doi-asserted-by":"publisher","award":["NE\/N020626"],"award-info":[{"award-number":["NE\/N020626"]}],"id":[{"id":"10.13039\/501100000270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.scitotenv.2022.157512","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T22:52:39Z","timestamp":1658443959000},"page":"157512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Bioavailability of potentially toxic elements influences antibiotic resistance gene and mobile genetic element abundances in urban and rural soils"],"prefix":"10.1016","volume":"847","author":[{"given":"Katie","family":"Robins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare M.","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Qiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.157512_bb0005","doi-asserted-by":"crossref","DOI":"10.2136\/sssaj1999.6361650x","article-title":"Development and assessment of a sequential extraction procedure for the fractionation of soil cadmium","author":"Ahnstrom","year":"1999","journal-title":"Soil Sci. Soc. Am. J."},{"issue":"9\u201310","key":"10.1016\/j.scitotenv.2022.157512_bb0010","first-page":"1507","article-title":"Sequential extraction of heavy metals in soils irrigated with wastewater","volume":"30","author":"Ahumada","year":"2008","journal-title":"Comm. Soil Sci. Plant Analysis"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/S0048-9697(97)84058-2","article-title":"Heavy metal contamination in freshwater fish from the border region between Norway and Russia","author":"Amundsen","year":"1997","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116602","article-title":"Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids","volume":"275","author":"Arya","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.tim.2006.02.006","article-title":"Co-selection of antibiotic and metal resistance","author":"Baker-Austin","year":"2006","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0030","series-title":"BT - International AAAI Conference on Weblogs and Social","article-title":"Gephi: An open source software for exploring and manipulating networks","author":"Bastian","year":"2009"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0035","doi-asserted-by":"crossref","DOI":"10.1080\/10643380490434128","article-title":"Distribution and bioavailability of trace elements in livestock and poultry manure by-products","author":"Bolan","year":"2004","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0040","first-page":"1","article-title":"Microbial transformation of trace elements in soils in relation to bioavailability and remediation","volume":"225","author":"Bolan","year":"2013","journal-title":"Rev. Environ. Contamin. Toxicol."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.157512_bb5005","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.soilbio.2010.01.008","article-title":"Development of pollution-induced community tolerance is linked to structural and functional resilience of a soil bacterial community following a five-year field exposure to copper","volume":"42","author":"Brandt","year":"2010","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.coph.2011.07.007","article-title":"Co-resistance: an opportunity for the bacteria and resistance genes","volume":"11","author":"Cant\u00f3n","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0050","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10388","article-title":"Antibiotic resistance is ancient","volume":"477","author":"Dcosta","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105117","article-title":"Heavy metal pollution and co-selection for antibiotic resistance: a microbial palaeontology approach","volume":"132","author":"Dickinson","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0060","series-title":"UK Soil and Herbage Pollutant Survey - UKSHS Report No. 8","year":"2007"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0065","series-title":"ArcMap 10.6.1. ESRI","author":"ESRI","year":"2018"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0070","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/ismej.2014.226","article-title":"Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution","volume":"9","author":"Gillings","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/nyas.14036","article-title":"Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems","volume":"1441","author":"Graham","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.scitotenv.2022.157512_bb5010","doi-asserted-by":"crossref","first-page":"21550","DOI":"10.1038\/srep21550","article-title":"Appearance of \u03b2-lactam resistance genes in agricultural soils and clinical isolates over the 20th century","volume":"6","author":"Graham","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10533-014-9997-7","article-title":"Soil geochemistry confines microbial abundances across an arctic landscape; implications for net carbon exchange with the atmosphere","volume":"120","author":"Gray","year":"2014","journal-title":"Biogeochemistry"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119326","article-title":"Effects of heavy metals pollution on the co-selection of metal and antibiotic resistance in urban rivers in the UK and India","volume":"306","author":"Gupta","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2005.02.010","article-title":"Trace elements in agroecosystems and impacts on the environment","author":"He","year":"2005","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.scitotenv.2022.157512_bb5015","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1086\/344656","article-title":"The global impact of drug resistance","volume":"36","author":"Howard","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2010.03.022","article-title":"Determination of commonly used azole antifungals in various waters and sewage sludge using ultra-high performance liquid chromatography-tandem mass spectrometry","author":"Huang","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0100","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/es901221x","article-title":"Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940","volume":"44","author":"Knapp","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027300","article-title":"Antibiotic resistance gene abundances correlate with metal and geochemical conditions in archived Scottish soils","volume":"6","author":"Knapp","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0110","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1007\/s11356-016-7997-y","article-title":"Relationship between antibiotic resistance genes and metals in residential soil samples from Western Australia","volume":"24","author":"Knapp","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0115","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1120238109","article-title":"In-feed antibiotic effects on the swine intestinal microbiome","author":"Looft","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0120","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/acs.est.6b05887","article-title":"The prevalence of integrons as the carrier of antibiotic resistance genes in natural and man-made environments","volume":"51","author":"Ma","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0125","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.envint.2019.01.034","article-title":"Understanding drivers of antibiotic resistance genes in high Arctic soil ecosystems","volume":"125","author":"McCann","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0130","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.02110s5745","article-title":"Arsenate reductases in prokaryotes and eukaryotes","author":"Mukhopadhyay","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-015-2153-5","article-title":"Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential","volume":"16","author":"Pal","year":"2015","journal-title":"BMC Genomics"},{"issue":"22","key":"10.1016\/j.scitotenv.2022.157512_bb5020","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.3390\/ijerph16224446","article-title":"It's time to replace the term \u201cheavy metals\u201d with \u201cpotentially toxic elements\u201d when reporting environmental research","volume":"16","author":"Pourret","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7","key":"10.1016\/j.scitotenv.2022.157512_bb0140","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1007\/s11356-013-2457-4","article-title":"Potentially toxic element fractionation in technosoils using two sequential extraction schemes","volume":"21","author":"Qasim","year":"2014","journal-title":"Environ. Sci. Poll. Res."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/S0045-6535(02)00226-6","article-title":"Chemical speciation and extractability of Zn, Cu and Cd in two contrasting biosolids-amended clay soils","author":"Qiao","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0150","series-title":"A Language and Environment for Statistical Computing","year":"2018"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0155","doi-asserted-by":"crossref","DOI":"10.1093\/trstmh\/trw048","article-title":"Antibiotic resistance is the quintessential one health issue","author":"Robinson","year":"2016","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0160","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jenvman.2008.04.007","article-title":"Heavy metal distribution and chemical speciation in tailings and soils around a pb-zn mine in Spain","volume":"90","author":"Rodr\u00edguez","year":"2009","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0165","series-title":"Land Cover Map 2015. NERC Environ. Inf. Data Cent","author":"Rowland","year":"2017"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2012.00399","article-title":"Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture","author":"Seiler","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2006.01.018","article-title":"Heavy metal sequential extraction methods-a modification for tropical soils","author":"Silveira","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0180","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.6b05342","article-title":"Comparison of metals and tetracycline as selective agents for development of tetracycline resistant bacterial communities in agricultural soil","author":"Song","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0185","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1574-6976.2011.00273.x","article-title":"Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into gram-negative pathogens","volume":"35","author":"Stokes","year":"2011","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0190","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1081\/ESE-120016906","article-title":"Beryllium in the environment: a review","volume":"38","author":"Taylor","year":"2003","journal-title":"J. Environ. Sci. Health, Part A: Tox Hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0195","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1021\/ac50043a017","article-title":"Sequential extraction procedure for the speciation of particulate trace metals","volume":"51","author":"Tessier","year":"1979","journal-title":"Anal. Chem."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0200","series-title":"Census Boundary Data [WWW Document]. Census Support","year":"2019"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02772240410001665553","article-title":"A comparative study of three different methods for the sequential extraction of heavy metals in soil","volume":"87","author":"Vilar","year":"2005","journal-title":"Toxicol. Environ. Chem."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0210","doi-asserted-by":"crossref","first-page":"8560","DOI":"10.3390\/ijerph18168560","article-title":"Bioavailability assessment of heavy metals using various multi-element extractants in an indigenous zinc smelting contaminated site, southwestern China","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0215","doi-asserted-by":"crossref","DOI":"10.1007\/s10393-019-01415-5","article-title":"Critical importance of a one health approach to antimicrobial resistance","author":"White","year":"2019","journal-title":"EcoHealth"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0220","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1574-6941.2006.00154.x","article-title":"Bacterial tolerances to metals and antibiotics in metal-contaminated and reference streams","volume":"58","author":"Wright","year":"2006","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb5025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/ismej.2008.8","article-title":"Influence of industrial contamination on mobile genetic elements: class 1 integron abundance and gene cassette structure in aquatic bacterial communities","volume":"2","author":"Wright","year":"2008","journal-title":"ISME J."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0225","series-title":"Heavy Metals in Contaminated Soils: A Review of Sources, Chemistry, Risks and Best Available Strategies for Remediation","author":"Wuana","year":"2011"},{"key":"10.1016\/j.scitotenv.2022.157512_bb0230","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.scitotenv.2018.11.372","article-title":"Evidence for co-selection of antibiotic resistance genes and mobile genetic elements in metal polluted urban soils","volume":"656","author":"Zhao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121838","article-title":"Arsenic and cadmium as predominant factors shaping the distribution patterns of antibiotic resistance genes in polluted paddy soils","volume":"389","author":"Zhao","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0240","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.1222743110","article-title":"Diverse and abundant antibiotic resistance genes in Chinese swine farms","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2016.270","article-title":"Continental-scale pollution of estuaries with antibiotic resistance genes","volume":"2","author":"Zhu","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.157512_bb5030","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105059","article-title":"Soil biota, antimicrobial resistance and planetary health","volume":"131","author":"Zhu","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.157512_bb0250","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/387803","article-title":"Heavy metal and trace metal analysis in soil by sequential extraction: a review of procedures","author":"Zimmerman","year":"2010","journal-title":"Int. J. Anal. Chem."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722046101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722046101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:51:16Z","timestamp":1785862276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722046101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":56,"alternative-id":["S0048969722046101"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157512","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioavailability of potentially toxic elements influences antibiotic resistance gene and mobile genetic element abundances in urban and rural soils","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157512","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"157512"}}