{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:05:18Z","timestamp":1785927918890,"version":"3.56.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012905","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["J18KA105"],"award-info":[{"award-number":["J18KA105"]}],"id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21477067"],"award-info":[{"award-number":["21477067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21777088"],"award-info":[{"award-number":["21777088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21876103"],"award-info":[{"award-number":["21876103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1806216"],"award-info":[{"award-number":["U1806216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018597","name":"Ministry of Education of the People's Republic of China Cultivation Fund of the Key Scientific and Technical Innovation Project","doi-asserted-by":"publisher","award":["708058"],"award-info":[{"award-number":["708058"]}],"id":[{"id":"10.13039\/501100018597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.scitotenv.2022.157583","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T01:36:41Z","timestamp":1658540201000},"page":"157583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Ferric ions release from iron-binding protein: Interaction between acrylamide and human serum transferrin and the underlying mechanisms of their binding"],"prefix":"10.1016","volume":"847","author":[{"given":"Falin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansong","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.157583_bb0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0009-2614(89)85118-8","article-title":"TURBOMOLE is a program package developed by the quantum chemistry Group at the University of Karlsruhe","volume":"162","author":"Ahlrichs","year":"1989","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jmau.2015.03.001","article-title":"The impact of vitamin E against acrylamide induced toxicity on skeletal muscles of adult male albino rat tongue: light and electron microscopic study","volume":"3","author":"Al-Serwi","year":"2015","journal-title":"J. Microsc. Ultrastruct."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90349-6","article-title":"Transferrin-modified liposomes triggered with ultrasound to treat HeLa cells","volume":"11","author":"AlSawaftah","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-73698-6","article-title":"Acrylamide alters CREB and retinoic acid signalling pathways during differentiation of the human neuroblastoma SH-SY5Y cell line","volume":"10","author":"Attoff","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0025","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1021\/bi00415a061","article-title":"Molecular structure of serum transferrin at 3.3-a resolution","volume":"27","author":"Bailey","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0030","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1021\/jp910077h","article-title":"Study on the interaction of cationic lipids with bovine serum albumin","volume":"114","author":"Charbonneau","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0035","doi-asserted-by":"crossref","first-page":"9976","DOI":"10.1021\/bi980274n","article-title":"Toward understanding tryptophan fluorescence in proteins","volume":"37","author":"Chen","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0040","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/genes11030285","article-title":"Heterologous expression of SvMBD5 from Salix viminalis L. Promotes flowering in Arabidopsis thaliana L","volume":"11","author":"Cheng","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0045","doi-asserted-by":"crossref","first-page":"10262","DOI":"10.1021\/jf101417w","article-title":"Binding of oxytetracycline to bovine serum albumin: spectroscopic and molecular modeling investigations","volume":"58","author":"Chi","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0050","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2217\/nnm.13.118","article-title":"Current trends in the use of liposomes for tumor targeting","volume":"8","author":"Deshpande","year":"2013","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0055","doi-asserted-by":"crossref","first-page":"W665","DOI":"10.1093\/nar\/gkh381","article-title":"PDB2PQR: an automated pipeline for the setup of poisson-boltzmann electrostatics calculations","volume":"32","author":"Dolinsky","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0060","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrmicro1930","article-title":"Viral infection and iron metabolism","volume":"6","author":"Drakesmith","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1179\/1476830513Y.0000000065","article-title":"Acrylamide neurotoxicity","volume":"17","author":"Erkekoglu","year":"2014","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0070","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/10937400600681430","article-title":"A review of the toxicology of acrylamide","volume":"9","author":"Exon","year":"2006","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0075","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1039\/C5AN00599J","article-title":"Selective enrichment of metal-binding proteins based on magnetic core\/shell microspheres functionalized with metal cations","volume":"140","author":"Fang","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0080","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1038\/s41598-018-26343-2","article-title":"Acrylamide acute neurotoxicity in adult zebrafish","volume":"8","author":"Faria","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118644","article-title":"Acrylamide-hemoglobin adduct: a spectroscopic study","volume":"241","author":"Favinha","year":"2020","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0090","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.molliq.2019.04.134","article-title":"Probing the toxicity of long-chain fluorinated surfactants: interaction mechanism between perfluorodecanoic acid and lysozyme","volume":"285","author":"Gao","year":"2019","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1359-6446(04)03333-1","article-title":"Transferrin: structure, function and potential therapeutic actions","volume":"10","author":"Gomme","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/acsomega.9b02340","article-title":"Computational analysis of the silver nanoparticle-human serum albumin complex","volume":"5","author":"Hazarika","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116460","article-title":"Binding interactions of acrylamide with lysozyme and its underlying mechanisms based on multi-spectra, isothermal titration microcalorimetry and docking simulation","volume":"337","author":"He","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126302","article-title":"Toxic mechanism on phenanthrene-induced cytotoxicity, oxidative stress and activity changes of superoxide dismutase and catalase in earthworm (Eisenia foetida): a combined molecular and cellular study","volume":"418","author":"He","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153167","article-title":"Toxic mechanism on phenanthrene-triggered cell apoptosis, genotoxicity, immunotoxicity and activity changes of immunity protein in eisenia fetida: combined analysis at cellular and molecular levels","volume":"819","author":"He","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0120","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.foodchem.2016.11.124","article-title":"Binding properties of the natural red dye carthamin with human serum albumin: surface plasmon resonance, isothermal titration microcalorimetry, and molecular docking analysis","volume":"221","author":"He","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/foods10010002","article-title":"Effects of cavitation jet treatment on the structure and emulsification properties of oxidized soy protein isolate","volume":"10","author":"He","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0130","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.foodchem.2007.11.073","article-title":"Kinetics of formation of acrylamide and schiff base intermediates from asparagine and glucose","volume":"108","author":"Hedegaard","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0135","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3109\/10408440903524254","article-title":"The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research","volume":"40","author":"Hogervorst","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0140","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jhazmat.2018.01.016","article-title":"Characterization of acrylamide-induced oxidative stress and cardiovascular toxicity in zebrafish embryos","volume":"347","author":"Huang","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0145","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1039\/C7MD00094D","article-title":"Interaction of indomethacin with calf thymus DNA: a multi-spectroscopic, thermodynamic and molecular modelling approach","volume":"8","author":"Husain","year":"2017","journal-title":"Medchemcomm"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139567","article-title":"Catalase and superoxide dismutase response and the underlying molecular mechanism for naphthalene","volume":"736","author":"Jing","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.saa.2016.04.008","article-title":"Binding of copper to lysozyme: spectroscopic, isothermal titration calorimetry and molecular docking studies","volume":"164","author":"Jing","year":"2016","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0160","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/jf8004492","article-title":"Acrylamide carcinogenicity","volume":"56","author":"Klaunig","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0165","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jhazmat.2018.11.023","article-title":"In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish","volume":"365","author":"Komoike","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126781","article-title":"Discrepancy of apoptotic events in mouse hepatocytes and catalase performance: size-dependent cellular and molecular toxicity of ultrafine carbon black","volume":"421","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2021.02.006","article-title":"Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps","volume":"101","author":"Lindeman","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.chembiol.2020.11.002","article-title":"Systematic activity maturation of a single-domain antibody with non-canonical amino acids through chemical mutagenesis","volume":"28","author":"Lindstedt","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0185","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/00000542-200504000-00016","article-title":"Weak polar interactions confer albumin binding site selectivity for haloether anesthetics","volume":"102","author":"Liu","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0190","doi-asserted-by":"crossref","first-page":"7735","DOI":"10.1021\/acsami.6b14733","article-title":"Double recognition and selective extraction of glycoprotein based on the molecular imprinted graphene oxide and boronate affinity","volume":"9","author":"Luo","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0195","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/0748233710394235","article-title":"Toxicological effects of acrylamide on the reproductive system of weaning male rats","volume":"27","author":"Ma","year":"2011","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0200","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1021\/jp973084f","article-title":"All-atom empirical potential for molecular modeling and dynamics studies of proteins","volume":"102","author":"MacKerell","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0205","first-page":"1127","article-title":"Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles","volume":"3","author":"Mahmoudi","year":"2011","journal-title":"Nanoscale"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0210","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1039\/FT9918702995","article-title":"Thermodynamics of solvation of ions. Part 5. \u2014Gibbs free energy of hydration at 298.15 K","volume":"87","author":"Marcus","year":"1991","journal-title":"J. Chem. Soc. Faraday Trans."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.toxlet.2013.03.031","article-title":"Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells","volume":"219","author":"Martyniuk","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0220","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/toxsci\/kfq069","article-title":"The genotoxicity of acrylamide and glycidamide in big blue rats","volume":"115","author":"Mei","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0225","first-page":"101","article-title":"ChemShell\u2014a modular software package for QM\/MM simulations","volume":"4","author":"Metz","year":"2014","journal-title":"Wiley Interdiscip. Rev.: Comput. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0230","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/419448a","article-title":"Acrylamide is formed in the maillard reaction","volume":"419","author":"Mottram","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0235","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.3390\/ijms22073518","article-title":"Developmental and neurotoxicity of acrylamide to zebrafish","volume":"22","author":"Park","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0240","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.fct.2007.08.027","article-title":"Minireview on the toxicity of dietary acrylamide","volume":"46","author":"Parzefall","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0245","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1126\/science.7638615","article-title":"Resonance light scattering: a new technique for studying chromophore aggregation","volume":"269","author":"Pasternack","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0250","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/0-387-24980-X_5","article-title":"Exposure to acrylamide: placing exposure in context","volume":"561","author":"Petersen","year":"2005","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0255","first-page":"1254","article-title":"Evidence of acrylamide induced oxidative stress and neurotoxicity in Drosophila melanogaster \u2013 its amelioration with spice active enrichment: relevance to neuropathy","volume":"33","author":"Prasad","year":"2012","journal-title":"Neuro Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.112780","article-title":"Exploring the toxic effects and mechanism of lead-loaded ultrafine carbon black on lysozyme","volume":"305","author":"Qu","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0265","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/0971-6580.97216","article-title":"Evaluation of protective effect of vitamin e on acrylamide induced testicular toxicity in wister rats","volume":"19","author":"Rahangadale","year":"2012","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0270","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bmc.2008.10.062","article-title":"Effect of methyl substitution in a ligand on the selectivity and binding affinity for a nucleobase: a case study with isoxanthopterin and its derivatives","volume":"17","author":"Rajendar","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0275","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1016\/S0006-3495(03)74769-9","article-title":"A computational study of the open and closed forms of the N-lobe human serum transferrin apoprotein","volume":"85","author":"Rinaldo","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0280","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jnutbio.2010.10.005","article-title":"Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway","volume":"22","author":"Rodr\u00edguez-Ramiro","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0285","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1021\/bi00514a017","article-title":"Thermodynamics of protein association reactions: forces contributing to stability","volume":"20","author":"Ross","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0290","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ijbiomac.2010.08.002","article-title":"Investigation on the interaction between tamoxifen and human holo-transferrin: determination of the binding mechanism by fluorescence quenching, resonance light scattering and circular dichroism methods","volume":"47","author":"Sarzehi","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0295","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/biom9090495","article-title":"Unraveling binding mechanism of Alzheimer's drug rivastigmine tartrate with human transferrin: molecular docking and multi-spectroscopic approach towards neurodegenerative diseases","volume":"9","author":"Shamsi","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0300","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijbiomac.2021.09.017","article-title":"Spectroscopic, calorimetric and in silico insight into the molecular interactions of memantine with human transferrin: implications of Alzheimer's drugs","volume":"190","author":"Shamsi","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0305","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ijbiomac.2016.07.068","article-title":"The changes of secondary structures and properties of lysozyme along with the egg storage","volume":"92","author":"Sheng","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0310","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/10408440600851377","article-title":"Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effects","volume":"36","author":"Shipp","year":"2006","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0315","doi-asserted-by":"crossref","first-page":"21353","DOI":"10.1074\/jbc.M111.226449","article-title":"Conserved interaction between transferrin and transferrin-binding proteins from porcine pathogens","volume":"286","author":"Silva","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0320","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0278-6915(99)00156-8","article-title":"\"IARC group 2A Carcinogens\" reported in cigarette mainstream smoke","volume":"38","author":"Smith","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0325","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1515\/REVEH.1991.9.4.215","article-title":"Acrylamide and polyacrylamide: a review of production, use, environmental fate and neurotoxicity","volume":"9","author":"Smith","year":"1991","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0330","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0263-7855(96)00043-4","article-title":"DL_POLY_2.0: a general-purpose parallel molecular dynamics simulation package","volume":"14","author":"Smith","year":"1996","journal-title":"J. Mol. Graph."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0335","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000069715","article-title":"Acrylamide: increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans","volume":"48","author":"S\u00f6rgel","year":"2002","journal-title":"Chemotherapy"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0340","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ijbiomac.2018.11.007","article-title":"Immobilization of \u03b2-galactosidase by complexation: effect of interaction on the properties of the enzyme","volume":"122","author":"Souza","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0345","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/abio.2000.4880","article-title":"Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set","volume":"287","author":"Sreerama","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0350","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/bip.21690","article-title":"Interactions of \u03b2-lactoglobulin with serotonin and arachidonyl serotonin","volume":"95","author":"Taheri-Kafrani","year":"2011","journal-title":"Biopolymers"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0355","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/tx9901938","article-title":"Acrylamide: a cooking carcinogen?","volume":"13","author":"Tareke","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0360","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1021\/jf020302f","article-title":"Analysis of acrylamide, a carcinogen formed in heated foodstuffs","volume":"50","author":"Tareke","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0365","doi-asserted-by":"crossref","first-page":"24934","DOI":"10.1074\/jbc.M604592200","article-title":"The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding","volume":"281","author":"Wally","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0370","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.reprotox.2009.11.002","article-title":"Reproductive toxicity of acrylamide-treated male rats","volume":"29","author":"Wang","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0375","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fmicb.2020.00361","article-title":"Single-cell analysis of foot-and-mouth disease virus","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0380","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1039\/C5CP06100H","article-title":"Molecular mechanism investigation of the neutralization of cadmium toxicity by transferrin","volume":"18","author":"Wang","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0385","article-title":"Probing the binding interaction between cadmium (II) chloride and lysozyme","volume":"40","author":"Wang","year":"2016","journal-title":"New J. Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109981","article-title":"In vitro toxicity and molecular interacting mechanisms of chloroacetic acid to catalase","volume":"189","author":"Wang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117143","article-title":"Exploring the conformational changes in fibrinogen by forming protein corona with CdTe quantum dots and the related cytotoxicity","volume":"220","author":"Wang","year":"2019","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0400","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/tx200446z","article-title":"N7-glycidamide-guanine DNA adduct formation by orally ingested acrylamide in rats: a dose-response study encompassing human diet-related exposure levels","volume":"25","author":"Watzek","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0405","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-008-0217-4","article-title":"Potential enzyme toxicity of perfluorooctanoic acid","volume":"38","author":"Wu","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0410","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.chemosphere.2018.03.200","article-title":"Characterizing the binding interactions of PFOA and PFOS with catalase at the molecular level","volume":"203","author":"Xu","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0415","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/acs.jafc.9b07072","article-title":"Probing the cell apoptosis pathway induced by perfluorooctanoic acid and perfluorooctane sulfonate at the subcellular and molecular levels","volume":"68","author":"Xu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0420","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envres.2019.05.008","article-title":"PFOA and PFOS interact with superoxide dismutase and induce cytotoxicity in mouse primary hepatocytes: a combined cellular and molecular methods","volume":"175","author":"Xu","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0425","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.chemosphere.2019.02.014","article-title":"Characterization of the interaction between carbon black and three important antioxidant proteins using multi spectroscopy and modeling simulations","volume":"222","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0430","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jphotobiol.2016.08.011","article-title":"Deciphering the toxicity of bisphenol a to Candida rugosa lipase through spectrophotometric methods","volume":"163","author":"Zhang","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.scitotenv.2022.157583_bb0435","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jhazmat.2010.06.131","article-title":"Binding of bisphenol a and acrylamide to BSA and DNA: insights into the comparative interactions of harmful chemicals with functional biomacromolecules","volume":"182","author":"Zhang","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0440","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.ijbiomac.2018.06.189","article-title":"Study on interaction between human salivary \u03b1-amylase and sorghum procyanidin tetramer: binding characteristics and structural analysis","volume":"118","author":"Zhao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0445","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1039\/C6RA26431J","article-title":"Characterization of the interaction between triclosan and catalase","volume":"7","author":"Zou","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.scitotenv.2022.157583_bb0450","doi-asserted-by":"crossref","first-page":"10179","DOI":"10.1021\/jf051944g","article-title":"Binding of the pepper alkaloid piperine to bovine \u03b2-lactoglobulin: circular dichroism spectroscopy and molecular modeling study","volume":"53","author":"Zsila","year":"2005","journal-title":"J. Agric. Food Chem."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722046812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722046812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:03:31Z","timestamp":1785863011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722046812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":90,"alternative-id":["S0048969722046812"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157583","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferric ions release from iron-binding protein: Interaction between acrylamide and human serum transferrin and the underlying mechanisms of their binding","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"157583"}}