{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:45:00Z","timestamp":1788745500771,"version":"build-2803163510"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["IT18262"],"award-info":[{"award-number":["IT18262"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["Qiankehejichu-ZK[2022]yiban541"],"award-info":[{"award-number":["Qiankehejichu-ZK[2022]yiban541"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.scitotenv.2022.157815","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:56:06Z","timestamp":1659488166000},"page":"157815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids"],"prefix":"10.1016","volume":"849","author":[{"given":"Xudong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2022.157815_bb0005","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3762\/bjnano.10.91","article-title":"The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model","volume":"10","author":"Ain","year":"2019","journal-title":"Beilstein J. Nanotechnol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0010","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1007\/s00018-020-03523-w","article-title":"A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles","volume":"77","author":"Almeida","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41398-020-01029-4","article-title":"Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids","volume":"10","author":"Arzua","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chemosphere.2018.09.028","article-title":"Zinc oxide nanoparticles induce toxicity by affecting cell wall integrity pathway, mitochondrial function and lipid homeostasis in Saccharomyces cerevisiae","volume":"213","author":"Babele","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2020.08.008","article-title":"Immunometabolism in the brain: how metabolism shapes microglial function","author":"Bernier","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000513536","article-title":"Integrated RNA sequencing reveals epigenetic impacts of diesel particulate matter exposure in human cerebral organoids","volume":"42","author":"Bilinovich","year":"2020","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201900147","article-title":"An increase in membrane cholesterol by graphene oxide disrupts calcium homeostasis in primary astrocytes","volume":"15","author":"Bramini","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0040","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1021\/acsnano.6b03438","article-title":"Graphene oxide nanosheets disrupt lipid composition, Ca(2+) homeostasis, and synaptic transmission in primary cortical neurons","volume":"10","author":"Bramini","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111643","article-title":"Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids","volume":"144","author":"Bu","year":"2020","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuro.2022.05.004","article-title":"The uses of 3D human brain organoids for neurotoxicity evaluations: a review","volume":"91","author":"Cao","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153253","article-title":"Nutrient molecule corona: an update for nanomaterial-food component interactions","volume":"476","author":"Cao","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15376516.2020.1828521","article-title":"Modeling better in vitro models for the prediction of nanoparticle toxicity: a review","volume":"31","author":"Cao","year":"2021","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.lfs.2017.08.003","article-title":"A review of endoplasmic reticulum (ER) stress and nanoparticle (NP) exposure","volume":"186","author":"Cao","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114801","article-title":"Pharmacological and toxicological aspects of carbon nanotubes (CNTs) to vascular system: a review","volume":"385","author":"Cao","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0075","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/jat.4182","article-title":"A comparative study of toxicity of graphdiyne and graphene oxide to human umbilical vein endothelial cells","volume":"41","author":"Cao","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128611","article-title":"Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae","volume":"270","author":"Cao","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0085","doi-asserted-by":"crossref","first-page":"eabe8244","DOI":"10.1126\/science.abe8244","article-title":"From cohorts to molecules: adverse impacts of endocrine disrupting mixtures","volume":"375","author":"Caporale","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0090","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jat.4037","article-title":"Neurotoxicity of metal-containing nanoparticles and implications in glial cells","volume":"41","author":"Chang","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0095","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in metabolism: key lipotoxic players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0100","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1039\/C8MO00162F","article-title":"Lipidomics reveals insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line","volume":"15","author":"Chavez Soria","year":"2019","journal-title":"Mol. Omics"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0105","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1007\/s00216-018-0940-y","article-title":"Intelligent testing strategy and analytical techniques for the safety assessment of nanomaterials","volume":"410","author":"Chen","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0110","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jat.4114","article-title":"Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids","volume":"41","author":"Cheng","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0115","doi-asserted-by":"crossref","first-page":"75303","DOI":"10.1088\/1361-6528\/ab4bff","article-title":"Organ distribution and biological compatibility of surface-functionalized reduced graphene oxide","volume":"31","author":"Cherian","year":"2020","journal-title":"Nanotechnology"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0120","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.drudis.2019.11.010","article-title":"CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening","volume":"25","author":"Chhibber","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0125","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41593-020-00730-3","article-title":"Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo","volume":"23","author":"Chiaradia","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0130","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11064-020-03167-z","article-title":"Graphene oxide ameliorates the cognitive impairment through inhibiting PI3K\/Akt\/mTOR pathway to induce autophagy in AD mouse model","volume":"46","author":"Chu","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0135","article-title":"Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring","volume":"8","author":"Cui","year":"2021","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Ger."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010271","article-title":"Neuron-like cells generated from human umbilical cord lining-derived mesenchymal stem cells as a new in vitro model for neuronal toxicity screening: using magnetite nanoparticles as an example","volume":"21","author":"De Simone","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101379","article-title":"Environmental and health effects of graphene-family nanomaterials: potential release pathways, transformation, environmental fate and health risks","volume":"42","author":"Ding","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.yrtph.2017.01.011","article-title":"A review of toxicity studies on graphene-based nanomaterials in laboratory animals","volume":"85","author":"Ema","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.etap.2018.11.006","article-title":"Carbon nanotubes and central nervous system: environmental risks, toxicological aspects and future perspectives","volume":"65","author":"Facciol\u00e0","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0160","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1021\/acsnano.8b04758","article-title":"Safety assessment of graphene-based materials: focus on human health and the environment","volume":"12","author":"Fadeel","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0165","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.chemosphere.2018.06.183","article-title":"Assessment of the effects of graphene exposure in Danio rerio: a molecular, biochemical and histological approach to investigating mechanisms of toxicity","volume":"210","author":"Fernandes","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2019.100989","article-title":"The biogenesis of lipid droplets: lipids take center stage","volume":"75","author":"Gao","year":"2019","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0175","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.scitotenv.2018.02.312","article-title":"Silica nanoparticles promote oxLDL-induced macrophage lipid accumulation and apoptosis via endoplasmic reticulum stress signaling","volume":"631\u2013632","author":"Guo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020247","article-title":"Differential immunomodulatory effect of graphene oxide and vanillin-functionalized graphene oxide nanoparticles in human acute monocytic leukemia cell line (THP-1)","volume":"20","author":"Gurunathan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119701","article-title":"Carbon nanostructures: the drug and the delivery system for brain disorders","volume":"587","author":"Henna","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149043","article-title":"Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids","volume":"797","author":"Huang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157047","article-title":"Silver nanoparticles exposure induces developmental neurotoxicity in hiPSC-derived cerebral organoids","volume":"845","author":"Huang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148583","article-title":"Instructive analysis of engineered carbon materials for potential application in water and wastewater treatment","volume":"793","author":"Jain","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0205","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.envpol.2019.01.072","article-title":"Nanotoxicity of different sizes of graphene (G) and graphene oxide (GO) in vitro and in vivo","volume":"247","author":"Jia","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.141384","article-title":"Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids","volume":"748","author":"Jiang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/mi10040234","article-title":"Functionalized carbon materials for electronic devices: a review","volume":"10","author":"Kamran","year":"2019","journal-title":"Micromachines"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0220","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1016\/j.biomaterials.2014.04.066","article-title":"Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations","volume":"35","author":"Kanakia","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105297","article-title":"Effects of graphene oxide nanomaterial exposures on the marine bivalve Crassostrea virginica","volume":"216","author":"Khan","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0230","doi-asserted-by":"crossref","first-page":"2002096","DOI":"10.1002\/adma.202002096","article-title":"Organ-level functional 3D tissue constructs with complex compartments and their preclinical applications","volume":"32","author":"Lee","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0235","article-title":"Lipid metabolism in astrocytic structure and function","author":"Lee","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0240","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12989-019-0307-3","article-title":"Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery","volume":"16","author":"Leite","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127704","article-title":"TiO2 nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2","volume":"424","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0250","article-title":"The cytotoxicity of zinc oxide nanoparticles to 3D brain organoids results from excessive intracellular zinc ions and defective autophagy","author":"Liu","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0255","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/jat.4084","article-title":"Transcriptomic-based toxicological investigations of ethanol to human umbilical vein endothelial cells","volume":"41","author":"Liu","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2021.100333","article-title":"Comparison of multi-walled carbon nanotubes and halloysite nanotubes on lipid profiles in human umbilical vein endothelial cells","volume":"23","author":"Liu","year":"2021","journal-title":"NanoImpact"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0265","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1080\/17435390.2019.1597204","article-title":"Multi-walled carbon nanotubes (MWCNTs) promoted lipid accumulation in THP-1 macrophages through modulation of endoplasmic reticulum (ER) stress","volume":"13","author":"Long","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0270","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fphys.2020.00393","article-title":"Lipid and lipoprotein metabolism in microglia","volume":"11","author":"Loving","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0275","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1021\/acs.chemrestox.9b00391","article-title":"Mechanistic insights into the cytotoxicity of graphene oxide derivatives in mammalian cells","volume":"33","author":"Lu","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0280","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cobme.2018.06.001","article-title":"Graphene-based neurotechnologies for advanced neural interfaces","volume":"6","author":"Lu","year":"2018","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110714","article-title":"Graphene oxide size-dependently altered lipid profiles in THP-1 macrophages","volume":"199","author":"Luo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109325","article-title":"Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells","volume":"333","author":"Luo","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0295","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/toxres\/tfab091","article-title":"Transcriptomic-based toxicological investigations of graphene oxide with modest cytotoxicity to human umbilical vein endothelial cells: changes of toll-like receptor signaling pathways","volume":"10","author":"Luo","year":"2021","journal-title":"Toxicol. Res. (Camb)"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0300","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12989-020-00380-0","article-title":"Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE(-\/-) mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage","volume":"17","author":"Ma","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0305","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cbi.2019.04.036","article-title":"Toxicity of carbon-based nanomaterials: reviewing recent reports in medical and biological systems","volume":"307","author":"Madannejad","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0310","doi-asserted-by":"crossref","first-page":"34664","DOI":"10.1007\/s11356-021-13058-7","article-title":"Pristine graphene and graphene oxide induce multi-organ defects in zebrafish (Danio rerio) larvae\/juvenile: an in vivo study","volume":"28","author":"Manjunatha","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145669","article-title":"Uptake and effects of graphene oxide nanomaterials alone and in combination with polycyclic aromatic hydrocarbons in zebrafish","volume":"775","author":"Mart\u00ednez-\u00c1lvarez","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0320","doi-asserted-by":"crossref","first-page":"77001","DOI":"10.1289\/EHP8580","article-title":"Gene-environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human brain spheres","volume":"129","author":"Modafferi","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0325","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11356-019-06930-0","article-title":"Estimation of genomic instability and mutation induction by graphene oxide nanoparticles in mice liver and brain tissues","volume":"27","author":"Mohamed","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0330","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chempr.2017.12.017","article-title":"Graphene oxide elicits membrane lipid changes and neutrophil extracellular trap formation","volume":"4","author":"Mukherjee","year":"2018","journal-title":"Chem"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0335","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jat.4206","article-title":"Organoids: a new approach in toxicity testing of nanotherapeutics","volume":"42","author":"Nabi","year":"2022","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0340","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-016-0168-y","article-title":"Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms","volume":"13","author":"Ou","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0345","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.chemosphere.2019.02.156","article-title":"Ecotoxic impact assessment of graphene oxide on lipid peroxidation at mitochondrial level and redox modulation in fresh water fish Anabas testudineus","volume":"224","author":"Paital","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0350","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.taap.2018.02.003","article-title":"Rotenone exerts developmental neurotoxicity in a human brain spheroid model","volume":"354","author":"Pamies","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0355","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1126\/science.aaw7894","article-title":"Organoids-on-a-chip","volume":"364","author":"Park","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0360","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/10915818211056633","article-title":"Influences of unmodified and carboxylated carbon nanotubes on lipid profiles in THP-1 macrophages: a lipidomics study","volume":"41","author":"Pei","year":"2022","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0365","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202004029","article-title":"Intracerebral injection of graphene oxide nanosheets mitigates microglial activation without inducing acute neurotoxicity: a pilot comparison to other nanomaterials","author":"Portioli","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0370","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.msec.2018.05.018","article-title":"Advances on graphene-based nanomaterials for biomedical applications","volume":"90","author":"Qu","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0375","article-title":"Size-dependent pulmonary impact of thin graphene oxide sheets in mice: toward safe-by-design","volume":"7","author":"Rodrigues","year":"2020","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg), Ger."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0380","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800525","article-title":"Carbon-based nanomaterials for cancer therapy via targeting tumor microenvironment","volume":"7","author":"Saleem","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125029","article-title":"Effect of three types of thermal processing methods on the lipidomics profile of tilapia fillets by UPLC-Q-extractive orbitrap mass spectrometry","volume":"298","author":"Shi","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0390","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.actbio.2020.04.023","article-title":"Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model","volume":"111","author":"Sokolova","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8070210","article-title":"Endoplasmic reticulum stress in macrophages: the vicious circle of lipid accumulation and pro-inflammatory response","volume":"8","author":"Sukhorukov","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0400","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.adgen.2015.11.004","article-title":"Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases","volume":"93","author":"Sun","year":"2016","journal-title":"Adv. Genet."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0405","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biomaterials.2017.03.043","article-title":"Raman spectroscopy for the detection of organ distribution and clearance of PEGylated reduced graphene oxide and biological consequences","volume":"131","author":"Syama","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0410","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1242\/bio.015610","article-title":"Effects of TiO2 nanoparticles on nutrition metabolism in silkworm fat body","volume":"5","author":"Tian","year":"2016","journal-title":"Biol. Open"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0415","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cbi.2019.01.021","article-title":"Microarray assisted toxicological investigations of boron carbide nanoparticles on human primary alveolar epithelial cells","volume":"300","author":"T\u00fcrkez","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0420","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.nano.2016.02.022","article-title":"Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis","volume":"12","author":"van der Valk","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175250","article-title":"Polyethylene glycol-functionalized poly (Lactic acid-co-glycolic Acid) and graphene oxide nanoparticles induce pro-inflammatory and apoptotic responses in Candida albicans-infected vaginal epithelial cells","volume":"12","author":"Wagner","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jobab.2021.11.004","article-title":"Biobased materials for food packaging","volume":"7","author":"Wang","year":"2022","journal-title":"J. Bioresour. Bioprod."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.impact.2020.100270","article-title":"Transcriptomic analysis revealed that multi-walled carbon nanotubes diameter-dependently induced pyroptosis in THP-1 macrophages","volume":"20","author":"Wang","year":"2020","journal-title":"NanoImpact"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0440","first-page":"5801","article-title":"Graphene oxide regulates endoplasmic reticulum stress: autophagic pathways in nasopharyngeal carcinoma cells","volume":"11","author":"Xiao","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0445","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00204-020-02717-2","article-title":"Toxicology data of graphene-family nanomaterials: an update","volume":"94","author":"Xiaoli","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0450","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cclet.2021.06.049","article-title":"MoS2 nanosheets and bulk materials altered lipid profiles in 3D Caco-2 spheroids","volume":"33","author":"Xie","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0455","doi-asserted-by":"crossref","first-page":"333ra48","DOI":"10.1126\/scitranslmed.aad0623","article-title":"Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity","volume":"8","author":"Xu","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0460","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/17435390.2018.1530389","article-title":"Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses","volume":"13","author":"Yang","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0465","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.7150\/thno.50616","article-title":"Graphene oxide improves postoperative cognitive dysfunction by maximally alleviating amyloid beta burden in mice","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126347","article-title":"Robust, functionalized reduced graphene-based nanofibrous membrane for contaminated water purification","volume":"404","author":"Zhang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0475","doi-asserted-by":"crossref","first-page":"1801983","DOI":"10.1002\/smll.201801983","article-title":"Electroactive scaffolds for neurogenesis and myogenesis: graphene-based nanomaterials","volume":"14","author":"Zhang","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.scitotenv.2022.157815_bb0480","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fct.2018.08.033","article-title":"Lipid accumulation in multi-walled carbon nanotube-exposed HepG2 cells: possible role of lipophagy pathway","volume":"121","author":"Zhao","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.157815_bb0485","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1039\/C7IB00105C","article-title":"Probing impaired neurogenesis in human brain organoids exposed to alcohol","volume":"9","author":"Zhu","year":"2017","journal-title":"Integr. Biol. (U. K.)"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722049142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722049142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T02:41:53Z","timestamp":1731724913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722049142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":97,"alternative-id":["S0048969722049142"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157815","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157815","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"157815"}}