{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:16:33Z","timestamp":1790622993917,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"India Ministry of Science &amp; Technology Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.scitotenv.2022.158195","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T21:46:42Z","timestamp":1660945602000},"page":"158195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":109,"special_numbering":"P2","title":["Antibiotics in sewage treatment plants, receiving water bodies and groundwater of Chennai city and the suburb, South India: Occurrence, removal efficiencies, and risk assessment"],"prefix":"10.1016","volume":"851","author":[{"given":"Sija","family":"Arun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omkar","family":"Gaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Neppolian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paromita","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.scitotenv.2022.158195_bb0005","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1007\/s10661-014-3926-z","article-title":"Pharmaceuticals as emerging organic contaminants in Umgeni River water system, KwaZulu-NatalSouth Africa","volume":"186","author":"Agunbiade","year":"2014","journal-title":"Environ. Monit. Assess."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.158195_bb0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrmicro3270","article-title":"Microbiological effects of sublethal levels of antibiotics","volume":"12","author":"Andersson","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.scitotenv.2022.158195_bb0020","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1007\/s11356-014-3617-x","article-title":"Occurrence of PPCPs in the marine environment: a review","volume":"23","author":"Arpin-Pont","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103410","article-title":"Occurrence, sources and risk assessment of fluoroquinolones in dumpsite soil and sewage sludge from Chennai,India","volume":"79","author":"Arun","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0030","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","article-title":"Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: a review","volume":"169","author":"Ben","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0040","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.chemosphere.2015.04.078","article-title":"Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment","volume":"134","author":"Blair","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb1000","article-title":"Status of Water Supply, Wastewater Generation, and Treatment in Class-I Cities & Class-II Towns of India","author":"Board, I.C.P.C.","year":"2010","journal-title":"Ministry of Environment and Forests"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123448","article-title":"Occurrence of antibiotics and antibiotic resistant bacteria in subtropical urban rivers in Brazil","volume":"402","author":"B\u00f6ger","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"12","key":"10.1016\/j.scitotenv.2022.158195_bb0050","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1289\/ehp.8315","article-title":"Household disposal of pharmaceuticals as a pathway for aquatic contamination in the United Kingdom","volume":"113","author":"Bound","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0055","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.scitotenv.2017.09.012","article-title":"Towards the understanding of antibiotic occurrence and transport in groundwater: findings from the Baix Fluvi\u00e0 alluvial aquifer (NE Catalonia, Spain)","volume":"612","author":"Boy-Roura","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146252","article-title":"First surveillance of SARS-CoV-2 and organic tracers in community wastewater during post lockdown in Chennai, South India: methods, occurrence and concurrence","volume":"778","author":"Chakraborty","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.158195_bb0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/jac\/dks355","article-title":"Patterns of antibiotic use in the community and challenges of antibiotic surveillance in a lower-middle-income country setting: a repeated cross-sectional study in Vellore, South India","volume":"68","author":"Chandy","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0070","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.scitotenv.2017.11.054","article-title":"Characterization of antibiotics in a large-scale river system of China: occurrence pattern, spatiotemporal distribution and environmental risks","volume":"618","author":"Chen","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0075","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.chemosphere.2013.09.119","article-title":"Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China","volume":"95","author":"Chen","year":"2014","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.scitotenv.2022.158195_bb0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/aheh.200390014","article-title":"Determination of antibiotic residues in manure, soil, and surface waters","volume":"31","author":"Christian","year":"2003","journal-title":"Acta Hydrochim. Hydrobiol."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.158195_bb0085","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijheh.2008.08.003","article-title":"Aquaculture: environmental, toxicological, and health issues","volume":"212","author":"Cole","year":"2009","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0095","author":"FDA"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0100","first-page":"513","article-title":"Directive 2008\/105\/EC of the European Parliament and of the Council of 16 December 2008 on environmental quality standards in the field of water policy, amending and subsequently repealing Council Directives 82\/176","volume":"83","author":"Union","year":"2008","journal-title":"EEC"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0105","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.scitotenv.2018.04.351","article-title":"Occurrence and ecotoxicological assessment of pharmaceuticals: is there a risk for the Mediterranean aquatic environment?","volume":"639","author":"Desbiolles","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.chemosphere.2016.10.106","article-title":"Occurrence of antibiotics in rural catchments","volume":"168","author":"Dinh","year":"2017","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.scitotenv.2022.158195_bb0115","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3390\/ijerph15061281","article-title":"Seasonal variations in water-quality, antibiotic residues, resistant bacteria and antibiotic resistance genes of Escherichia coli isolates from water and sediments of the Kshipra River in Central India","volume":"15","author":"Diwan","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.scitotenv.2022.158195_bb0120","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquat. Toxicol."},{"issue":"12","key":"10.1016\/j.scitotenv.2022.158195_bb0125","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1897\/09-073.1","article-title":"Contamination of surface, ground, and drinking water from pharmaceutical production","volume":"28","author":"Fick","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"issue":"6","key":"10.1016\/j.scitotenv.2022.158195_bb0130","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.chemosphere.2011.11.019","article-title":"Occurrence of antibiotics in eight sewage treatment plants in Beijing,China","volume":"86","author":"Gao","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.123145","article-title":"Energy-saving photo-degradation of three fluoroquinolone antibiotics under VUV\/UV irradiation: kinetics, mechanism, and antibacterial activity reduction","volume":"383","author":"Geng","year":"2020","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.158195_bb0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10661-007-9965-y","article-title":"Evaluation of the seasonal variation on the geochemical parameters and quality assessment of the groundwater in the proximity of River Cooum, ChennaiIndia","volume":"143","author":"Giridharan","year":"2008","journal-title":"Environ. Monit. Assess."},{"issue":"2\u20133","key":"10.1016\/j.scitotenv.2022.158195_bb0145","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.scitotenv.2006.07.039","article-title":"Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies","volume":"372","author":"G\u00f6bel","year":"2007","journal-title":"Sci. Total Environ."},{"issue":"17","key":"10.1016\/j.scitotenv.2022.158195_bb0150","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1021\/es0256212","article-title":"Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley WatershedSwitzerland","volume":"36","author":"Golet","year":"2002","journal-title":"Environ. Sci. Technol"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0155","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.chemosphere.2014.03.132","article-title":"Seasonal changes in antibiotics, antidepressants\/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant","volume":"111","author":"Golovko","year":"2014","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.scitotenv.2022.158195_bb0160","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/512810","article-title":"Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries","volume":"44","author":"Goossens","year":"2007","journal-title":"Clin. Infect. Dis."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.158195_bb0165","doi-asserted-by":"crossref","DOI":"10.1061\/(ASCE)HZ.2153-5515.0000346","article-title":"Occurrence of high levels of fluoroquinolones in aquatic environment due to effluent discharges from bulk drug manufacturers","volume":"21","author":"Gothwal","year":"2017","journal-title":"J. Hazard. Toxic Radioact. Waste"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0170","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.scitotenv.2019.03.393","article-title":"Spatial distribution, source apportionment and risk assessment of antibiotics in the surface water and sediments of the Yangtze Estuary","volume":"671","author":"Guo","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.158195_bb0175","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/etc.5620170305","article-title":"Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater","volume":"17","author":"Hartmann","year":"1998","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0180","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.scitotenv.2018.10.021","article-title":"Occurrence of antibiotics, estrogenic hormones, and UV-filters in water, sediment, and oyster tissue from the Chesapeake Bay","volume":"650","author":"He","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.158195_bb0185","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","article-title":"Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments","volume":"69","author":"Hernando","year":"2006","journal-title":"Talanta"},{"issue":"15","key":"10.1016\/j.scitotenv.2022.158195_bb0190","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1016\/j.scitotenv.2011.04.030","article-title":"Antibiotic contamination and occurrence of antibiotic-resistant bacteria in aquatic environments of northern Vietnam","volume":"409","author":"Hoa","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0195","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.psep.2017.12.003","article-title":"Occurrence and fate of antibiotics in a wastewater treatment plant and their biological effects on receiving waters in Guizhou","volume":"113","author":"Hu","year":"2018","journal-title":"Process Saf. Environ. Prot."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2022.158195_bb0200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2004.11.017","article-title":"Toxic and genotoxic evaluation of six antibiotics on non-target organisms","volume":"346","author":"Isidori","year":"2005","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0205","series-title":"Occurrence of Antibiotics in River Water: A Case Study of Vrishabhavathi River Near Bangalore, India","first-page":"25","author":"Iyanee","year":"2013"},{"issue":"6","key":"10.1016\/j.scitotenv.2022.158195_bb0210","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.chemosphere.2010.11.028","article-title":"Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai,China","volume":"82","author":"Jiang","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0215","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.chemosphere.2014.04.075","article-title":"Distribution and ecological risk of antibiotics in a typical effluent\u2013receiving river (Wangyang River) in north China","volume":"112","author":"Jiang","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137580","article-title":"Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments","volume":"720","author":"Kairigo","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2022.158195_bb0225","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.scitotenv.2005.06.030","article-title":"Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA","volume":"361","author":"Karthikeyan","year":"2006","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.158195_bb0230","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00216-008-1854-x","article-title":"Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography\u2013electrospray tandem mass spectrometry","volume":"391","author":"Kasprzyk-Hordern","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"issue":"6","key":"10.1016\/j.scitotenv.2022.158195_bb0235","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1021\/cr020441w","article-title":"Human pharmaceuticals in the aquatic environment: a challenge to green chemistry","volume":"107","author":"Khetan","year":"2007","journal-title":"Chem. Rev."},{"issue":"15","key":"10.1016\/j.scitotenv.2022.158195_bb0240","doi-asserted-by":"crossref","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","article-title":"Global increase and geographic convergence in antibiotic consumption between 2000 and 2015","volume":"115","author":"Klein","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.158195_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-11-99","article-title":"Trends in antibiotic use among outpatients in New Delhi,India","volume":"11","author":"Kotwani","year":"2011","journal-title":"BMC Infect. Dis."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.158195_bb0255","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1128\/AAC.05490-11","article-title":"Blood, tissue, and intracellular concentrations of erythromycin and its metabolite anhydroerythromycin during and after therapy","volume":"56","author":"Krasniqi","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"17","key":"10.1016\/j.scitotenv.2022.158195_bb0260","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1016\/j.watres.2012.07.042","article-title":"Distribution of antidepressant residues in wastewater and biosolids following different treatment processes by municipal wastewater treatment plants in Canada","volume":"46","author":"Lajeunesse","year":"2012","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0265","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.scitotenv.2012.06.002","article-title":"Occurrence and sorption of fluoroquinolones in poultry litters and soils from S\u00e3o Paulo State, Brazil","volume":"432","author":"Leal","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0270","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.scitotenv.2017.05.174","article-title":"Contribution of bacteriophage and plasmid DNA to the mobilization of antibiotic resistance genes in a river receiving treated wastewater discharges","volume":"601","author":"Lekunberri","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2011.03.004","article-title":"Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China","volume":"42","author":"Leung","year":"2012","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.scitotenv.2022.158195_bb0280","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.chemosphere.2011.03.002","article-title":"Mass flows and removal of antibiotics in two municipal wastewater treatment plants","volume":"83","author":"Li","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2019.109396","article-title":"Occurrence and ecological risk assessment of selected antibiotics in the freshwater lakes along the middle and lower reaches of Yangtze River Basin","volume":"249","author":"Li","year":"2019","journal-title":"J. Environ. Manag."},{"issue":"11","key":"10.1016\/j.scitotenv.2022.158195_bb0290","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.chemosphere.2012.05.079","article-title":"Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China","volume":"89","author":"Li","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0295","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.envpol.2018.12.005","article-title":"Occurrence and fate of antibiotics and antibiotic resistance genes in typical urban water of Beijing, China","volume":"246","author":"Liu","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0300","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.envpol.2012.11.022","article-title":"Occurrence of 95 pharmaceuticals and transformation products in urban groundwaters underlying the metropolis of Barcelona, Spain","volume":"174","author":"L\u00f3pez-Serna","year":"2013","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.158195_bb0305","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.trac.2007.01.002","article-title":"Water sampling: traditional methods and new approaches in water sampling strategy","volume":"26","author":"Madrid","year":"2007","journal-title":"TrAC Trends Anal. Chem."},{"issue":"23","key":"10.1016\/j.scitotenv.2022.158195_bb0310","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1021\/es0709021","article-title":"Distribution of macrolides, sulfonamides, and trimethoprim in tropical waters: ubiquitous occurrence of veterinary antibiotics in the Mekong Delta","volume":"41","author":"Managaki","year":"2007","journal-title":"Environ.Sci.Technol."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.158195_bb0315","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.marpolbul.2009.02.004","article-title":"Antibiotics in the Hong Kong metropolitan area: ubiquitous distribution and fate in Victoria Harbour","volume":"58","author":"Minh","year":"2009","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0320","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.chemosphere.2016.06.047","article-title":"Occurrence and fate of pharmaceuticals in WWTPs in India and comparison with a similar study in the United States","volume":"159","author":"Mohapatra","year":"2016","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.scitotenv.2022.158195_bb0325","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.etap.2008.11.004","article-title":"Environmental risk and toxicology of human and veterinary waste pharmaceutical exposure to wild aquatic host\u2013parasite relationships","volume":"27","author":"Morley","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0330","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ecoenv.2019.06.004","article-title":"Distribution and ecological risk of pharmaceuticals in surface water of the Yeongsan river, Republic of Korea","volume":"181","author":"Na","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.158195_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131855","article-title":"Occurrence and dissipation of the antibiotics sulfamethoxazole, sulfadiazine, trimethoprim, and enrofloxacin in the Mekong Delta, Vietnam","volume":"10","author":"Nguyen Dang Giang","year":"2015","journal-title":"Plos one"},{"issue":"42","key":"10.1016\/j.scitotenv.2022.158195_bb0340","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/j.chroma.2010.08.048","article-title":"Development of a multi-residue analytical method, based on liquid chromatography\u2013tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples","volume":"1217","author":"N\u00f6dler","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0345","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jenvman.2019.02.100","article-title":"Emerging pollutants in the urban water cycle in Latin America: a review of the current literature","volume":"237","author":"Pe\u00f1a-Guzm\u00e1n","year":"2019","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0350","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.scitotenv.2014.05.068","article-title":"Occurrence and ecological potential of pharmaceuticals and personal care products in groundwater and reservoirs in the vicinity of municipal landfills in China","volume":"490","author":"Peng","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.scitotenv.2022.158195_bb0355","doi-asserted-by":"crossref","first-page":"8679","DOI":"10.1007\/s11356-015-5968-3","article-title":"Removal rates of antibiotics in four sewage treatment plants in South India","volume":"23","author":"Prabhasankar","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2022.158195_bb0360","first-page":"151","article-title":"Determination of antibiotics in aquatic environment by solid-phase extraction followed by liquid chromatography\u2013electrospray ionization mass spectrometry","volume":"1187","author":"Rao","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149340","article-title":"Spatio-temporal distribution of pharmaceutically active compounds in the River Cauvery and its tributaries, South India","volume":"800","author":"Renganathan","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129262","article-title":"Legacy and new chlorinated persistent organic pollutants in the rivers of south India: occurrences, sources, variations before and after the outbreak of the COVID-19 pandemic","volume":"437","author":"Rex","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0375","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.scitotenv.2014.03.080","article-title":"Impact of approach used to determine removal levels of drugs of abuse during wastewater treatment","volume":"487","author":"Rodayan","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"14","key":"10.1016\/j.scitotenv.2022.158195_bb0385","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.1021\/es501452a","article-title":"Fluoroquinolones and qnr genes in sediment, water, soil, and human fecal flora in an environment polluted by manufacturing discharges","volume":"48","author":"Rutgersson","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.158195_bb0390","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0395","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.scitotenv.2018.07.235","article-title":"Health and ecological risk assessment of emerging contaminants (pharmaceuticals, personal care products, and artificial sweeteners) in surface and groundwater (drinking water) in the Ganges River Basin, India","volume":"646","author":"Sharma","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"10","key":"10.1016\/j.scitotenv.2022.158195_bb0400","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1007\/s10661-014-3881-8","article-title":"Occurrence of pharmaceuticals in urban wastewater of north Indian cities and risk assessment","volume":"186","author":"Singh","year":"2014","journal-title":"Environ. Monit. Assess."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.158195_bb0405","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.jece.2015.09.031","article-title":"Mass loading and removal of pharmaceuticals and personal care products, including psychoactive and illicit drugs and artificial sweeteners, in five sewage treatment plants in India","volume":"3","author":"Subedi","year":"2015","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0410","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.chemosphere.2016.10.026","article-title":"Mass loading and removal of pharmaceuticals and personal care products including psychoactives, antihypertensives, and antibiotics in two sewage treatment plants in southern India","volume":"167","author":"Subedi","year":"2017","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.scitotenv.2022.158195_bb0415","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ieam.4141","article-title":"Science-based targets for antibiotics in receiving waters from pharmaceutical manufacturing operations","volume":"15","author":"Tell","year":"2019","journal-title":"Integr. Environ. Assess. Manag."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0420","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.scitotenv.2014.07.068","article-title":"Occurrence of antibiotics in the aquatic environment of Jianghan Plain, central China","volume":"497","author":"Tong","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"25","key":"10.1016\/j.scitotenv.2022.158195_bb0425","doi-asserted-by":"crossref","first-page":"31995","DOI":"10.1007\/s11356-020-09487-5","article-title":"Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake,China","volume":"27","author":"Tong","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0430","series-title":"Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations","first-page":"227","author":"Topp","year":"2010"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0435","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.watres.2017.12.029","article-title":"Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions-a review","volume":"133","author":"Tran","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0445","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2012.04.028","article-title":"Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment\u2014a review","volume":"429","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.158195_bb0455","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.watres.2006.12.017","article-title":"Elimination of pharmaceuticals in sewage treatment plants in Finland","volume":"41","author":"Vieno","year":"2007","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.158195_bb0460","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1021\/es506081z","article-title":"Relationships between antibiotics and antibiotic resistance gene levels in municipal solid waste leachates in ShanghaiChina","volume":"49","author":"Wu","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.158195_bb0465","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2134\/jeq2005.0091","article-title":"Occurrence and fate of pharmaceuticals and personal care products (PPCPs) in biosolids","volume":"34","author":"Xia","year":"2005","journal-title":"J. Environ. Qual."},{"issue":"19","key":"10.1016\/j.scitotenv.2022.158195_bb0470","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1016\/j.watres.2007.06.023","article-title":"Occurrence and elimination of antibiotics at four sewage treatment plants in the Pearl River Delta (PRD)South China","volume":"41","author":"Xu","year":"2007","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.158195_bb0475","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2175\/106143008X325719","article-title":"A preliminary investigation on the occurrence and distribution of antibiotics in the Yellow River and its tributaries,China","volume":"81","author":"Xu","year":"2009","journal-title":"Water Environ. Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.158195_bb0480","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.envpol.2006.05.038","article-title":"Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"145","author":"Xu","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0485","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envpol.2012.12.008","article-title":"Antibiotics in the surface water of the Yangtze Estuary: occurrence, distribution and risk assessment","volume":"175","author":"Yan","year":"2013","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.158195_bb0490","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/03601234.2011.540540","article-title":"Spatial and seasonal distribution of selected antibiotics in surface waters of the Pearl Rivers, China","volume":"46","author":"Yang","year":"2011","journal-title":"J. Environ. Sci. Health B"},{"key":"10.1016\/j.scitotenv.2022.158195_bb0495","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chemosphere.2018.10.087","article-title":"Occurrence and distribution of trace levels of antibiotics in surface waters and soils driven by non-point source pollution and anthropogenic pressure","volume":"216","author":"Yi","year":"2019","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.scitotenv.2022.158195_bb0500","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1039\/c0em00602e","article-title":"Occurrence and behavior of pharmaceuticals, steroid hormones, and endocrine-disrupting personal care products in wastewater and the recipient river water of the Pearl River Delta, South China","volume":"13","author":"Yu","year":"2011","journal-title":"J. Environ. Monit."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116455","article-title":"Antibiotics and antibiotic resistant genes (ARGs) in groundwater: a global review on dissemination, sources, interactions, environmental and human health risks","volume":"187","author":"Zainab","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0510","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ecoenv.2012.03.002","article-title":"Occurrence and risks of antibiotics in the Laizhou Bay, China: impacts of river discharge","volume":"80","author":"Zhang","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0515","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envpol.2012.11.008","article-title":"Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China: occurrence, distribution and ecological risks","volume":"174","author":"Zhang","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.158195_bb0520","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.marenvres.2012.03.007","article-title":"Occurrence and distribution of antibiotics in the Beibu Gulf, China: impacts of river discharge and aquaculture activities","volume":"78","author":"Zheng","year":"2012","journal-title":"Mar. Environ. Res."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2022.158195_bb0525","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jhazmat.2010.03.110","article-title":"Source, occurrence and fate of antibiotics in the Italian aquatic environment","volume":"179","author":"Zuccato","year":"2010","journal-title":"J. Hazard. Mater."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722052949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722052949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T15:09:21Z","timestamp":1758726561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722052949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":100,"alternative-id":["S0048969722052949"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.158195","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotics in sewage treatment plants, receiving water bodies and groundwater of Chennai city and the suburb, South India: Occurrence, removal efficiencies, and risk assessment","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.158195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"158195"}}