{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:14:31Z","timestamp":1780546471755,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971415"],"award-info":[{"award-number":["31971415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171492"],"award-info":[{"award-number":["32171492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.scitotenv.2022.161162","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T11:03:11Z","timestamp":1671793391000},"page":"161162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["BDE-209 induced spermatogenesis disorder by inhibiting SETD8\/H4K20me1 related histone methylation in mice"],"prefix":"10.1016","volume":"864","author":[{"given":"Xiangyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujian","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.scitotenv.2022.161162_bb0005","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.reprotox.2011.02.005","article-title":"Polybrominated diphenyl ethers and sperm quality","volume":"31","author":"Abdelouahab","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0010","first-page":"116165","article-title":"Exposure to polybrominated diphenyl ethers and phthalates in healthy men living in the greater Montreal area: a study of hormonal balance and semen quality","author":"Albert","year":"2018","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.161162_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.scitotenv.2022.161162_bb0020","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"11","key":"10.1016\/j.scitotenv.2022.161162_bb0025","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1021\/cb500515r","article-title":"Small-molecule inhibitors of SETD8 with cellular activity","volume":"9","author":"Blum","year":"2014","journal-title":"ACS Chem. Biol."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.161162_bb0030","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/abbs\/gmw050","article-title":"Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage","volume":"48","author":"Chen","year":"2016","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"18","key":"10.1016\/j.scitotenv.2022.161162_bb0035","doi-asserted-by":"crossref","first-page":"E2347","DOI":"10.1073\/pnas.1505683112","article-title":"Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis","volume":"112","author":"Endo","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2 Pt B","key":"10.1016\/j.scitotenv.2022.161162_bb0040","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijheh.2016.11.001","article-title":"In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: the CHAMACOS study","volume":"220","author":"Eskenazi","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"4","key":"10.1016\/j.scitotenv.2022.161162_bb0045","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molmed.2017.02.001","article-title":"p21: a two-faced genome guardian","volume":"23","author":"Georgakilas","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.reprotox.2016.07.011","article-title":"Environmental factors, epigenetics, and developmental origin of reproductive disorders","volume":"68","author":"Ho","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133902","article-title":"Polybrominated diphenyl ethers in the environment and human external and internal exposure in China: a review","volume":"696","author":"Jiang","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.scitotenv.2022.161162_bb0060","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1158\/0008-5472.CAN-16-2098","article-title":"The p53\/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins","volume":"77","author":"Kim","year":"2017","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2022.161162_bb0065","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/10409238.2019.1620676","article-title":"Preserving genome integrity and function: the DNA damage response and histone modifications","volume":"54","author":"Kim","year":"2019","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0070","first-page":"114303","article-title":"Influence of persistent organic pollutants on oxidative stress in population-based samples","author":"Kumar","year":"2014","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.scitotenv.2022.161162_bb0075","first-page":"1096","article-title":"Effects of extracellular regulated protein kinases protein and impairment of blood testis barriar stucturein of mice with exposure to decabromodiphenyl ether]","volume":"50","author":"Li","year":"2016","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"issue":"Pt 1","key":"10.1016\/j.scitotenv.2022.161162_bb0080","article-title":"BDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways","volume":"255","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"issue":"Pt A","key":"10.1016\/j.scitotenv.2022.161162_bb0085","article-title":"Impaired sperm quantity and motility in adult rats following gestational and lactational exposure to environmentally relevant levels of PBDE-47: a potential role of thyroid hormones disruption","volume":"268","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106307","article-title":"BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat","volume":"146","author":"Li","year":"2021","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.161162_bb0095","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0014-4835(03)00023-X","article-title":"Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration","volume":"76","author":"Liang","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0100","first-page":"176242","article-title":"Low dose carbendazim disrupts mouse spermatogenesis might be through estrogen receptor related histone and DNA methylation","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.161162_bb0105","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.4161\/cc.24216","article-title":"MBTD1 is associated with pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation","volume":"12","author":"Luo","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.scitotenv.2022.161162_bb0110","first-page":"230741","article-title":"Critical review of soil contamination by polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (NBFRs); concentrations, sources and congener profiles","author":"McGrath","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0115","first-page":"186749","article-title":"Absorption, tissue distribution, metabolism, and elimination of decabrominated diphenyl ether (BDE-209) in rats after multi-dose oral exposure","author":"Mi","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2022.161162_bb0120","first-page":"8102","article-title":"The emerging role of lysine methyltransferase SETD8 in human diseases","author":"Milite","year":"2016","journal-title":"Clin.Epigenet."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0125","first-page":"104243","article-title":"H3K9\/HP1 and Polycomb: two key epigenetic silencing pathways for gene regulation and embryo development","author":"Nestorov","year":"2013","journal-title":"Curr. Top. Dev. Biol."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.161162_bb0135","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1111\/jcmm.15080","article-title":"Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis","volume":"24","author":"Niu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.scitotenv.2022.161162_bb0140","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1182\/blood-2017-07-746396","article-title":"DNA damage responses and p53 in the aging process","volume":"131","author":"Ou","year":"2018","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.scitotenv.2022.161162_bb0145","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1101\/gad.2021311","article-title":"Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications","volume":"25","author":"Polo","year":"2011","journal-title":"Genes Dev."},{"issue":"40","key":"10.1016\/j.scitotenv.2022.161162_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4149","article-title":"Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis","volume":"6","author":"Popgeorgiev","year":"2020","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.161162_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/genes10020105","article-title":"Single and double strand sperm DNA damage: different reproductive effects on male fertility","volume":"10","author":"Ribas-Maynou","year":"2019","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.scitotenv.2022.161162_bb0160","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nm.2305","article-title":"Cancer epigenetics reaches mainstream oncology","volume":"17","author":"Rodr\u00edguez-Paredes","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.scitotenv.2022.161162_bb0165","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.canlet.2012.01.007","article-title":"DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis","volume":"332","author":"Roos","year":"2013","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.161162_bb0170","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2605.1993.tb01156.x","article-title":"Histological and histopathological evaluation of the testis","volume":"16","author":"Russell","year":"1993","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0175","first-page":"29083","article-title":"Inhibition of testicular steroidogenesis and impaired differentiation of Sertoli cells in peripubertal mice offspring following maternal exposure to BDE-209 during lactation suppress germ cell proliferation","author":"Sarkar","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0180","first-page":"23950","article-title":"Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice","author":"Sarkar","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0185","first-page":"31166","article-title":"Maternal BDE-209 exposure during lactation causes testicular and epididymal toxicity through increased oxidative stress in peripubertal mice offspring","author":"Sarkar","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.scitotenv.2013.02.038","article-title":"Levels of tetrabromobisphenol A, hexabromocyclododecanes and polybrominated diphenyl ethers in human milk from the general population in Beijing, China","volume":"452\u2013453","author":"Shi","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.scitotenv.2022.161162_bb0195","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/acel.12607","article-title":"The PPAR\u03b3-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence","volume":"16","author":"Shih","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.scitotenv.2022.161162_bb0200","first-page":"4180","article-title":"Oxidative stress: a concept in redox biology and medicine","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.scitotenv.2022.161162_bb0205","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1093\/nar\/gkaa631","article-title":"NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest","volume":"48","author":"Sun","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0210","first-page":"87263","article-title":"The MRE11-RAD50-NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair","author":"Syed","year":"2018","journal-title":"Annu. Rev. Biochem."},{"issue":"7","key":"10.1016\/j.scitotenv.2022.161162_bb0215","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/tox.20729","article-title":"Developmental exposure to decabrominated diphenyl ether (BDE-209): effects on sperm oxidative stress and chromatin DNA damage in mouse offspring","volume":"28","author":"Tseng","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0220","series-title":"The Eighth Meeting of the Conference of the Parties","article-title":"The stockholm convention on persistent organic pollutants","author":"UNEP","year":"2017"},{"issue":"11","key":"10.1016\/j.scitotenv.2022.161162_bb0225","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.chemosphere.2008.12.023","article-title":"Fish products available in polish market\u2013assessment of the nutritive value and human exposure to dioxins and other contaminants","volume":"74","author":"Usydus","year":"2009","journal-title":"Chemosphere"},{"issue":"23","key":"10.1016\/j.scitotenv.2022.161162_bb0230","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1158\/0008-5472.CAN-15-0563","article-title":"p53: protection against tumor growth beyond effects on cell cycle and apoptosis","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0235","first-page":"5801446","article-title":"Characterization of PBDEs and novel brominated flame retardants in seawater near a coastal mariculture area of the Bohai Sea, China","author":"Wang","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149353","article-title":"Health risk assessment and development of human health ambient water quality criteria for PBDEs in China","volume":"799","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2022.161162_bb0240","first-page":"666812","article-title":"Tetrabromobisphenol A, hexabromocyclododecane isomers and polybrominated diphenyl ethers in foodstuffs from Beijing, China: contamination levels, dietary exposure and risk assessment","author":"Wang","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2022.161162_bb0250","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13148-022-01251-5","article-title":"Roles for the methyltransferase SETD8 in DNA damage repair","volume":"14","author":"Xu","year":"2022","journal-title":"Clin.Epigenet."}],"updated-by":[{"DOI":"10.1016\/j.scitotenv.2024.172423","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000}}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722082651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969722082651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T15:17:19Z","timestamp":1758727039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969722082651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":49,"alternative-id":["S0048969722082651"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.161162","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.scitotenv.2024.172423","asserted-by":"object"}]},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDE-209 induced spermatogenesis disorder by inhibiting SETD8\/H4K20me1 related histone methylation in mice","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2022.161162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"161162"}}