{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:36:16Z","timestamp":1783200976077,"version":"3.54.6"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.scitotenv.2023.161505","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T16:10:09Z","timestamp":1673107809000},"page":"161505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Functional metagenomics reveals wildlife as natural reservoirs of novel \u03b2-lactamases"],"prefix":"10.1016","volume":"868","author":[{"given":"Hao","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruanyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/nyas.13257","article-title":"Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes","volume":"1388","author":"Adu-Oppong","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.161505_bb0010","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00758-19","article-title":"Repeated detection of carbapenemase-producing Escherichia coli in gulls inhabiting Alaska","volume":"63","author":"Ahlstrom","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0015","article-title":"Dairy products and dairy-processing environments as a reservoir of antibiotic resistance and quorum-quenching determinants as revealed through functional metagenomics","volume":"5","author":"Alexa","year":"2020","journal-title":"mSystems"},{"issue":"4","key":"10.1016\/j.scitotenv.2023.161505_bb0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrmicro2312","article-title":"Call of the wild: antibiotic resistance genes in natural environments","volume":"8","author":"Allen","year":"2010","journal-title":"Nat. Rev. Microbiol"},{"issue":"2","key":"10.1016\/j.scitotenv.2023.161505_bb0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ismej.2008.86","article-title":"Functional metagenomics reveals diverse \u03b2-lactamases in a remote Alaskan soil","volume":"3","author":"Allen","year":"2009","journal-title":"ISME J."},{"issue":"1036","key":"10.1016\/j.scitotenv.2023.161505_bb0030","first-page":"321","article-title":"The structure of beta-lactamases","volume":"289","author":"Ambler","year":"1980","journal-title":"Philos. Trans. R. Soc."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.161505_bb0035","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/jac\/48.5.717","article-title":"OXA-35 is an OXA-10-related \u03b2-lactamase from Pseudomonas aeruginosa","volume":"48","author":"Aubert","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2021.100298","article-title":"Antimicrobial resistance in wildlife and in the built environment in a wildlife rehabilitation center","volume":"13","author":"Baros Jorquera","year":"2021","journal-title":"One Health"},{"issue":"12","key":"10.1016\/j.scitotenv.2023.161505_bb0045","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.bcp.2007.05.021","article-title":"Metallo-\u03b2-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily","volume":"74","author":"Bebrone","year":"2007","journal-title":"Biochem. Pharmacol."},{"issue":"18","key":"10.1016\/j.scitotenv.2023.161505_bb0050","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals","volume":"112","author":"Boeckel","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0055","series-title":"Antibiotics: Methods and Protocols","first-page":"307","author":"Boolchandani","year":"2017"},{"issue":"10","key":"10.1016\/j.scitotenv.2023.161505_bb0060","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00397-20","article-title":"Metallo-\u03b2-lactamases: structure, function, epidemiology, treatment options, and the development pipeline","volume":"64","author":"Boyd","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Supplement_2","key":"10.1016\/j.scitotenv.2023.161505_bb0065","article-title":"Consumption of antibiotics in the community, European Union\/European Economic Area, 1997\u20132017","volume":"76","author":"Bruyndonckx","year":"2021","journal-title":"J. Antimicrob. Chemother."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40168-019-0781-8","article-title":"Metagenomic analysis reveals the microbiome and resistome in migratory birds","volume":"8","author":"Cao","year":"2020","journal-title":"Microbiome"},{"issue":"22","key":"10.1016\/j.scitotenv.2023.161505_bb0075","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1021\/es403818e","article-title":"Metagenomic profiles of antibiotic resistance genes (ARGs) between human impacted estuary and Deep Ocean sediments","volume":"47","author":"Chen","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.scitotenv.2023.161505_bb0080","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrmicro.2017.28","article-title":"Next-generation approaches to understand and combat the antibiotic resistome","volume":"15","author":"Crofts","year":"2017","journal-title":"Nat. Rev. Microbiol"},{"issue":"1725","key":"10.1016\/j.scitotenv.2023.161505_bb0085","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0167","article-title":"One health, emerging infectious diseases and wildlife: two decades of progress?","volume":"372","author":"Cunningham","year":"2017","journal-title":"Philos. Trans. R. Soc."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.161505_bb0090","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1104s17","article-title":"Assembling genomic DNA sequences with PHRAP","volume":"17","author":"de la Bastide","year":"2007","journal-title":"Curr. Protoc. Bioinformatics"},{"issue":"7","key":"10.1016\/j.scitotenv.2023.161505_bb0100","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1128\/AAC.00133-09","article-title":"Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2-lactamase","volume":"53","author":"Doi","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(18)30156-6","article-title":"Antibiotic resistance and one health: a mapping project","volume":"6","author":"Essack","year":"2018","journal-title":"Lancet Glob. Health"},{"issue":"2","key":"10.1016\/j.scitotenv.2023.161505_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/CMR.00117-13","article-title":"OXA \u03b2-lactamases","volume":"27","author":"Evans","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"issue":"11","key":"10.1016\/j.scitotenv.2023.161505_bb0115","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00483-19","article-title":"Validating the AMRFinder tool and resistance gene database by using antimicrobial resistance genotype-phenotype correlations in a collection of isolates","volume":"63","author":"Feldgarden","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0120","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1038\/s41467-021-26520-4","article-title":"Lateral transduction is inherent to the life cycle of the archetypical salmonella phage P22","volume":"12","author":"Fillol-Salom","year":"2021","journal-title":"Nat. Commun."},{"issue":"7502","key":"10.1016\/j.scitotenv.2023.161505_bb0125","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature13377","article-title":"Bacterial phylogeny structures soil resistomes across habitats","volume":"509","author":"Forsberg","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-017-0315-1","article-title":"Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken","volume":"5","author":"Gao","year":"2017","journal-title":"Microbiome"},{"issue":"13","key":"10.1016\/j.scitotenv.2023.161505_bb0135","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1093\/nar\/gkg556","article-title":"ESPript\/ENDscript: extracting and rendering sequence and 3D information from atomic structures of proteins","volume":"31","author":"Gouet","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1128\/AAC.01424-15","article-title":"The soil microbiota harbors a diversity of carbapenem-hydrolyzing b2-lactamases of potential clinical relevance","volume":"60","author":"Gudeta","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.161505_bb0145","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/bioinformatics\/btt086","article-title":"QUAST: quality assessment tool for genome assemblies","volume":"29","author":"Gurevich","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2023.161505_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149360","article-title":"Reducing tetracycline antibiotics residues in aqueous environments using Tet(X) degrading enzymes expressed in Pichia pastoris","volume":"799","author":"He","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.161505_bb0155","doi-asserted-by":"crossref","first-page":"811","DOI":"10.7589\/2014-11-257","article-title":"From whence they came\u2014antibiotic-resistant Escherichia coli in african wildlife","volume":"51","author":"Jobbins","year":"2015","journal-title":"J. Wildl. Dis."},{"issue":"11","key":"10.1016\/j.scitotenv.2023.161505_bb0160","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01495-17","article-title":"Evolution of antibiotic resistance without antibiotic exposure","volume":"61","author":"Kn\u00f6ppel","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.161505_bb0165","first-page":"399","article-title":"Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer","volume":"7","author":"Landan","year":"1990","journal-title":"Mol. Biol. Evol."},{"issue":"7895","key":"10.1016\/j.scitotenv.2023.161505_bb0170","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41586-021-04265-w","article-title":"Emergence of methicillin resistance predates the clinical use of antibiotics","volume":"602","author":"Larsen","year":"2022","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.scitotenv.2023.161505_bb0175","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00989-17","article-title":"Novel antibiotic resistance determinants from agricultural soil exposed to antibiotics widely used in human medicine and animal farming","volume":"83","author":"Lau","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0180","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s42003-022-03520-8","article-title":"Transmission of antibiotic resistance at the wildlife-livestock interface","volume":"5","author":"Lee","year":"2022","journal-title":"Commun. Biol."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.161505_bb0185","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1073\/pnas.1520300113","article-title":"Sensor histidine kinase is a \u03b2-lactam receptor and induces resistance to \u03b2-lactam antibiotics","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.161505_bb0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.161505_bb0195","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/nar\/25.6.1203","article-title":"Independent and tight regulation of transcriptional units in escherichia coli via the LacR\/O, the TetR\/O and AraC\/I1-I2 regulatory elements","volume":"25","author":"Lutz","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0200","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.envint.2017.12.036","article-title":"Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian River sediments contaminated with antibiotic production waste","volume":"112","author":"Marathe","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0205","first-page":"2","article-title":"Functional metagenomics reveals previously unrecognized diversity of antibiotic resistance genes in gulls","author":"Martiny","year":"2011","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.161505_bb0210","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.ARBA-0009-2017","article-title":"Antimicrobial resistance: a one health perspective","volume":"6","author":"McEwen","year":"2018","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0215","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40168-020-00863-4","article-title":"Freshwater viral metagenome reveals novel and functional phage-borne antibiotic resistance genes","volume":"8","author":"Moon","year":"2020","journal-title":"Microbiome"},{"issue":"11","key":"10.1016\/j.scitotenv.2023.161505_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078822","article-title":"Pediatric fecal Microbiota Harbor diverse and novel antibiotic resistance genes","volume":"8","author":"Moore","year":"2013","journal-title":"PLOS ONE"},{"issue":"3","key":"10.1016\/j.scitotenv.2023.161505_bb0225","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4161\/viru.28196","article-title":"Functional metagenomics for the investigation of antibiotic resistance","volume":"5","author":"Mullany","year":"2014","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0230","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2105-12-41","article-title":"RAIphy: phylogenetic classification of metagenomics samples using iterative refinement of relative abundance index profiles","volume":"12","author":"Nalbantoglu","year":"2011","journal-title":"BMC Bioinform"},{"issue":"11","key":"10.1016\/j.scitotenv.2023.161505_bb0235","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1074\/jbc.270.11.5729","article-title":"Molecular evolution of a class C \u03b2-lactamase extending its substrate specificity (\u2217)","volume":"270","author":"Nukaga","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.161505_bb0240","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025197","article-title":"The prehistory of antibiotic resistance","volume":"6","author":"Perry","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.161505_bb0245","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1128\/AAC.43.3.573","article-title":"Molecular and biochemical characterization of VEB-1, a novel class a extended-spectrum & #x3b2;-lactamase encoded by an Escherichia coli integron gene","volume":"43","author":"Poirel","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.161505_bb0250","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1128\/AAC.37.6.1324","article-title":"High specificity of cphA-encoded metallo-beta-lactamase from Aeromonas hydrophila AE036 for carbapenems and its contribution to beta-lactam resistance","volume":"37","author":"Segatore","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7376","key":"10.1016\/j.scitotenv.2023.161505_bb0255","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature10571","article-title":"Ecology drives a global network of gene exchange connecting the human microbiome","volume":"480","author":"Smillie","year":"2011","journal-title":"Nature"},{"issue":"52","key":"10.1016\/j.scitotenv.2023.161505_bb0260","doi-asserted-by":"crossref","first-page":"18239","DOI":"10.1074\/jbc.RA120.016103","article-title":"A drug-resistant b2;-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency","volume":"295","author":"Soeung","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.scitotenv.2023.161505_bb0265","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00698-18","article-title":"Diversity and proliferation of metallo-\u03b2-lactamases: a clarion call for clinically effective metallo-\u03b2-lactamase inhibitors","volume":"84","author":"Somboro","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"issue":"5944","key":"10.1016\/j.scitotenv.2023.161505_bb0270","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1126\/science.1176950","article-title":"Functional characterization of the antibiotic resistance reservoir in the human microflora","volume":"325","author":"Sommer","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0275","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41467-019-13995-5","article-title":"Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania","volume":"11","author":"Subbiah","year":"2020","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.scitotenv.2023.161505_bb0280","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41564-019-0496-4","article-title":"Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli","volume":"4","author":"Sun","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.161505_bb0285","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-micro-090816-093420","article-title":"Lessons from the environmental antibiotic resistome","volume":"71","author":"Surette","year":"2017","journal-title":"Annu. Rev. Microbiol."},{"issue":"18","key":"10.1016\/j.scitotenv.2023.161505_bb0290","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.jmb.2019.04.002","article-title":"\u03b2-Lactamases and \u03b2-Lactamase Inhibitors in the 21st Century","volume":"431","author":"Tooke","year":"2019","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.161505_bb0295","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41591-022-01752-z","article-title":"Tracing the origins of antibiotic resistance","volume":"28","author":"Vandenbroucke-Grauls","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144828","article-title":"Duck wastes as a potential reservoir of novel antibiotic resistance genes","volume":"771","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.161505_bb0305","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.mib.2005.08.016","article-title":"\u03b2-Lactam antibiotic resistance: a current structural perspective","volume":"8","author":"Wilke","year":"2005","journal-title":"Curr. Opin. Microbiol."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.161505_bb0310","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1101\/gr.074492.107","article-title":"Velvet: algorithms for de novo short read assembly using de Bruijn graphs","volume":"18","author":"Zerbino","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.scitotenv.2023.161505_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105120","article-title":"Novel clinically relevant antibiotic resistance genes associated with sewage sludge and industrial waste streams revealed by functional metagenomic screening","volume":"132","author":"Zhang","year":"2019","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.scitotenv.2023.161505_bb0320","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq275","article-title":"Ab initio gene identification in metagenomic sequences","volume":"38","author":"Zhu","year":"2010","journal-title":"Nucleic Acids Res."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723001201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723001201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T19:15:16Z","timestamp":1738610116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969723001201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":64,"alternative-id":["S0048969723001201"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.161505","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional metagenomics reveals wildlife as natural reservoirs of novel \u03b2-lactamases","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.161505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"161505"}}