{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:06:47Z","timestamp":1793106407497,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["20ykzd09"],"award-info":[{"award-number":["20ykzd09"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["SKLOD2020OF03"],"award-info":[{"award-number":["SKLOD2020OF03"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010476"],"award-info":[{"award-number":["2021A1515010476"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010339"],"award-info":[{"award-number":["2023A1515010339"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771056"],"award-info":[{"award-number":["81771056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972533"],"award-info":[{"award-number":["81972533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.scitotenv.2023.164787","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T02:35:16Z","timestamp":1686623716000},"page":"164787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction"],"prefix":"10.1016","volume":"893","author":[{"given":"Renjie","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huigen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengchao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiya","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baicheng","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.scitotenv.2023.164787_bb0005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.ATV.21.5.863","article-title":"Cadmium accumulation in aortas of smokers","volume":"21","author":"Abu-Hayyeh","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.164787_bb0010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10661-015-4353-5","article-title":"Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers","volume":"187","author":"Afridi","year":"2015","journal-title":"Environ. Monit. Assess."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.164787_bb0015","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1359\/jbmr.2000.15.8.1579","article-title":"Low-level cadmium exposure and osteoporosis","volume":"15","author":"Alfv\u00e9n","year":"2000","journal-title":"J. Bone Miner. Res."},{"issue":"24","key":"10.1016\/j.scitotenv.2023.164787_bb0020","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1364\/AO.54.007342","article-title":"Detection of toxic elements using laser-induced breakdown spectroscopy in smokers\u2019 and nonsmokers\u2019 teeth and investigation of periodontal parameters","volume":"54","author":"Alhasmi","year":"2015","journal-title":"Appl. Opt."},{"issue":"1\u20133","key":"10.1016\/j.scitotenv.2023.164787_bb0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.scitotenv.2006.04.023","article-title":"Lead and cadmium in human teeth from Jordan by atomic absorption spectrometry: some factors influencing their concentrations","volume":"369","author":"Alomary","year":"2006","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.164787_bb0030","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1289\/ehp.10947","article-title":"Association of environmental cadmium exposure with pediatric dental caries","volume":"116","author":"Arora","year":"2008","journal-title":"Environ. Health Perspect."},{"issue":"12","key":"10.1016\/j.scitotenv.2023.164787_bb0035","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2337\/db21-0573","article-title":"Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage-dependent miR-150-FNDC5\/pyroptosis axis","volume":"71","author":"Behera","year":"2022","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.scitotenv.2023.164787_bb0040","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.bone.2004.07.010","article-title":"Low-level lifetime exposure to cadmium decreases skeletal mineralization and enhances bone loss in aged rats","volume":"35","author":"Brz\u00f3ska","year":"2004","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.scitotenv.2023.164787_bb0045","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.fct.2005.04.008","article-title":"Bone mineral density, chemical composition and biomechanical properties of the tibia of female rats exposed to cadmium since weaning up to skeletal maturity","volume":"43","author":"Brz\u00f3ska","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108539","article-title":"Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data","volume":"176","author":"Buha","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6750-12-5","article-title":"An improved method for isolation of RNA from bone","volume":"12","author":"Carter","year":"2012","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0060","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.scitotenv.2018.05.050","article-title":"Dietary cadmium intake from rice and vegetables and potential health risk: a case study in Xiangtan, southern China","volume":"639","author":"Chen","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.164787_bb0065","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.freeradbiomed.2010.12.032","article-title":"Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death","volume":"50","author":"Chen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.164787_bb0070","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1471-4159.2011.07493.x","article-title":"CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death","volume":"119","author":"Chen","year":"2011","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.164787_bb0075","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00244-011-9685-8","article-title":"Bone-prognostic status after cessation of cadmium exposure for one month in male rats","volume":"62","author":"Chen","year":"2012","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.164787_bb0080","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12973","article-title":"NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation","volume":"54","author":"Chen","year":"2021","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.164787_bb0085","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nprot.2006.83","article-title":"The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on","volume":"1","author":"Chomczynski","year":"2006","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.164787_bb0090","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.scitotenv.2023.164787_bb0095","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nri3532","article-title":"Autophagy in infection, inflammation and immunity","volume":"13","author":"Deretic","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.164787_bb0100","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1182\/blood.V58.4.699.699","article-title":"Molecular and cell biologic aspects of erythropoiesis in long-term bone marrow cultures","volume":"58","author":"Dexter","year":"1981","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.scitotenv.2023.164787_bb0105","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bone.2012.03.018","article-title":"Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women","volume":"50","author":"Engstr\u00f6m","year":"2012","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.scitotenv.2023.164787_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031768","article-title":"Is cadmium toxicity tissue-specific? Toxicogenomics studies reveal common and specific pathways in pulmonary, hepatic, and neuronal cell models","volume":"23","author":"Forcella","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.scitotenv.2023.164787_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17113782","article-title":"The effects of cadmium toxicity","volume":"17","author":"Genchi","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2023.164787_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115017","article-title":"Cadmium induced immunosuppression through TLR-I\u03baB\u03b1-NF\u03baB signaling by promoting autophagic degradation","volume":"259","author":"Gu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0125","article-title":"Epigenetic mechanisms of cadmium-induced nephrotoxicity","volume":"32","author":"Guo","year":"2022","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0130","doi-asserted-by":"crossref","unstructured":"He, S., Zhuo, L., Cao, Y., Liu, G., Zhao, H., Song, R., & Liu, Z. (2020). Effect of cadmium on osteoclast differentiation during bone injury in female mice. Environ. Toxicol., 35(4), 487\u2013494. https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/tox.22884.","DOI":"10.1002\/tox.22884"},{"key":"10.1016\/j.scitotenv.2023.164787_bb0135","article-title":"Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes","volume":"1\u201319","author":"Hegdekar","year":"2023","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.scitotenv.2023.164787_bb0140","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s00198-020-05429-6","article-title":"Exposure to heavy metals and the risk of osteopenia or osteoporosis: a systematic review and meta-analysis","volume":"31","author":"Jalili","year":"2020","journal-title":"Osteoporos. Int."},{"issue":"10","key":"10.1016\/j.scitotenv.2023.164787_bb0145","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2183\/pjab.85.500","article-title":"Mechanism of cadmium induced crystal defects in developing rat tooth enamel","volume":"85","author":"Kakei","year":"2009","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.164787_bb0150","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1083\/jcb.201503023","article-title":"TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity","volume":"210","author":"Kimura","year":"2015","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.164787_bb0155","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12597","article-title":"Melatonin prevents cadmium-induced bone damage: first evidence on an improved osteogenic\/adipogenic differentiation balance of mesenchymal stem cells as underlying mechanism","volume":"67","author":"Knani","year":"2019","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.164787_bb0160","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/15376516.2019.1701595","article-title":"Melatonin protects bone against cadmium-induced toxicity via activation of Wnt\/\u03b2-catenin signaling pathway","volume":"30","author":"Knani","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.164787_bb0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13075-022-02802-0","article-title":"Ketogenic diet ameliorates inflammation by inhibiting the NLRP3 inflammasome in osteoarthritis","volume":"24","author":"Kong","year":"2022","journal-title":"Arthr. Res. Ther."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.164787_bb0170","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jbmr.4014","article-title":"Smoking-induced risk of osteoporosis is partly mediated by cadmium from tobacco smoke: the MrOS Sweden study","volume":"35","author":"Li","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0175","article-title":"Pyroptosis in bone loss","volume":"1-20","author":"Li","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.scitotenv.2023.164787_bb0180","article-title":"Autophagy: an important target for natural products in the treatment of bone metabolic diseases","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109236","article-title":"Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1\/2 signaling","volume":"219","author":"Liu","year":"2022","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.164787_bb0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1089\/bio.2014.0090","article-title":"Comparison of six different pretreatment methods for blood RNA extraction","volume":"13","author":"Liu","year":"2015","journal-title":"Biopreserv. Biobank"},{"key":"10.1016\/j.scitotenv.2023.164787_bb0195","doi-asserted-by":"crossref","unstructured":"Liu, X., Li, M., Chen, Z., Yu, Y., Shi, H., Yu, Y., Wang, Y., Chen, R., & Ge, J. (2022a). Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. Basic Res. Cardiol., 117(1), 40. https:\/\/doi.org\/https:\/\/doi.org\/10.1007\/s00395-022-00948-1.","DOI":"10.1007\/s00395-022-00948-1"},{"key":"10.1016\/j.scitotenv.2023.164787_bb0200","article-title":"The inflammasome contributes to depletion of the ovarian reserve during aging in mice","volume":"8","author":"Lliberos","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118043","article-title":"Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-\u03baB pathway and mitochondrial dysfunction","volume":"290","author":"Luo","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124251","article-title":"The effect of P2X7 on cadmium-induced osteoporosis in mice","volume":"405","author":"Ma","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"21","key":"10.1016\/j.scitotenv.2023.164787_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113491","article-title":"The effect of oxidative stress-induced autophagy by cadmium exposure in kidney, liver, and bone damage, and neurotoxicity","volume":"23","author":"Ma","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.164787_bb0220","doi-asserted-by":"crossref","first-page":"37003","DOI":"10.1289\/EHP3655","article-title":"Early-life cadmium exposure and bone-related biomarkers: a longitudinal study in children","volume":"127","author":"Malin Igra","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"7634","key":"10.1016\/j.scitotenv.2023.164787_bb0225","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(69)90865-4","article-title":"Cadmium content of cigarettes","volume":"2","author":"Nandi","year":"1969","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.164787_bb0230","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc7409","article-title":"Inhibition of the NLRP3 inflammasome prevents ovarian aging","volume":"7","author":"Navarro-Pando","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.164787_bb0235","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41467-023-35977-4","article-title":"Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF\/mTOR\/autophagy axis","volume":"14","author":"Pei","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0240","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"issue":"10","key":"10.1016\/j.scitotenv.2023.164787_bb0245","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/nprot.2012.113","article-title":"Evaluation of bone regeneration using the rat critical size calvarial defect","volume":"7","author":"Spicer","year":"2012","journal-title":"Nat. Protoc."},{"issue":"9159","key":"10.1016\/j.scitotenv.2023.164787_bb0250","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0140-6736(98)09356-8","article-title":"Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group","volume":"353","author":"Staessen","year":"1999","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.scitotenv.2023.164787_bb0255","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.freeradbiomed.2011.01.033","article-title":"Molecular cross-talk between the NRF2\/KEAP1 signaling pathway, autophagy, and apoptosis","volume":"50","author":"St\u0119pkowski","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.164787_bb0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13547500902730698","article-title":"Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure","volume":"14","author":"Suwazono","year":"2009","journal-title":"Biomarkers"},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2023.164787_bb0265","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tox.2006.10.011","article-title":"Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels","volume":"229","author":"Thijssen","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2023.164787_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115768","article-title":"Low-level cadmium exposure is associated with decreased cortical thickness, cortical area and trabecular bone volume fraction in elderly men: the MrOS Sweden study","volume":"143","author":"Wallin","year":"2021","journal-title":"Bone"},{"issue":"14","key":"10.1016\/j.scitotenv.2023.164787_bb0275","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.7150\/ijbs.46627","article-title":"The role of autophagy and mitophagy in bone metabolic disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.164787_bb0280","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4161\/auto.23628","article-title":"Autophagy regulates inflammation following oxidative injury in diabetes","volume":"9","author":"Wang","year":"2013","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.scitotenv.2023.164787_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019052","article-title":"Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK\/mTOR network","volume":"6","author":"Xu","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.scitotenv.2023.164787_bb0290","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41419-021-04349-5","article-title":"RelA\/MicroRNA-30a\/NLRP3 signal axis is involved in rheumatoid arthritis via regulating NLRP3 inflammasome in macrophages","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.164787_bb0295","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jhep.2016.12.018","article-title":"HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1\u03b2 production via suppressing the NF-\u03baB pathway and ROS production","volume":"66","author":"Yu","year":"2017","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.scitotenv.2023.164787_bb0300","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1177\/0022034520933533","article-title":"Targeting NLRP3 Inflammasome reduces age-related experimental alveolar bone loss","volume":"99","author":"Zang","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143570","article-title":"Cadmium and molybdenum co-exposure triggers autophagy via CYP450s\/ROS pathway in duck renal tubular epithelial cells","volume":"759","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0310","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cellsig.2018.12.008","article-title":"Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells","volume":"55","author":"Zhang","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.scitotenv.2023.164787_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116241","article-title":"Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes","volume":"270","author":"Zhou","year":"2021","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.164787_bb0320","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/jbmr.4756","article-title":"STAT3\/mitophagy axis coordinates macrophage NLRP3 Inflammasome activation and inflammatory bone loss","volume":"38","author":"Zhu","year":"2023","journal-title":"J. Bone Miner. Res."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723034101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723034101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:18:46Z","timestamp":1787851126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969723034101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":64,"alternative-id":["S0048969723034101"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164787","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"164787"}}