{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:51Z","timestamp":1790836791984,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-Sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.scitotenv.2023.165112","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T04:10:48Z","timestamp":1687666248000},"page":"165112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2.5 exposure"],"prefix":"10.1016","volume":"895","author":[{"given":"Shuangjian","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixian","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Zeeshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chun","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-Chuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2023.165112_bb0005","first-page":"10","article-title":"Lipid profiling of Alzheimer\u2019s disease brain highlights enrichment in glycerol(phospho)lipid, and sphingolipid metabolism","author":"Akyol","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0010","article-title":"Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer\u2019s disease","volume":"1","author":"Baloni","year":"2020","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0015","first-page":"9","article-title":"Complement and coagulation system crosstalk in synaptic and neural conduction in the central and peripheral nervous systems","author":"Berkowitz","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ygeno.2020.12.025","article-title":"Identifying circRNA- and lncRNA-associated-ceRNA networks in the hippocampi of rats exposed to PM(2.5) using RNA-seq analysis","volume":"113","author":"Chen","year":"2021","journal-title":"Genomics"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107523","article-title":"Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders","volume":"210","author":"Costa","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0030","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11064-015-1776-x","article-title":"The lipoxygenases: their regulation and implication in Alzheimer\u2019s disease","volume":"41","author":"Czapski","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128653","article-title":"PM(2.5) induced weight loss of mice through altering the intestinal microenvironment: mucus barrier, gut microbiota, and metabolic profiling","volume":"431","author":"Dai","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0040","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1021\/acs.analchem.7b03929","article-title":"Annotation: a computational solution for streamlining metabolomics analysis","volume":"90","author":"Domingo-Almenara","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0045","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1021\/acssensors.0c01524","article-title":"A membrane-free liver-gut-on-Chip platform for the assessment on dysregulated mechanisms of cholesterol and bile acid metabolism induced by PM(2.5)","volume":"5","author":"Duan","year":"2020","journal-title":"ACS Sens"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0050","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.toxrep.2020.10.014","article-title":"Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air","volume":"7","author":"Frydas","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jes.2021.10.007","article-title":"An integrative analysis of miRNA and mRNA expression in the brains of Alzheimer\u2019s disease transgenic mice after real-world PM(2.5) exposure","volume":"122","author":"Fu","year":"2022","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127129","article-title":"Exposure to ambient fine particulate matter impedes the function of spleen in the mouse metabolism of high-fat diet","volume":"423","author":"He","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1021\/acschemneuro.5b00265","article-title":"Pro-inflammatory S100A9 protein as a robust biomarker differentiating early stages of cognitive impairment in Alzheimer\u2019s disease","volume":"7","author":"Horvath","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108311","article-title":"Bile acids and neurological disease","volume":"240","author":"Hurley","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1750-1172-7-66","article-title":"An international registry for neurodegeneration with brain iron accumulation","volume":"7","author":"Kalman","year":"2012","journal-title":"Orphanet. J. Rare Dis."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115431","article-title":"Neuroprotective and immunomodulatory action of the endocannabinoid system under neuroinflammation","volume":"22","author":"Kasatkina","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0085","first-page":"9","article-title":"Targeted lipidomics of mitochondria in a cellular Alzheimer\u2019s disease model","author":"Kurokin","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135603","article-title":"Brain lipid profiles in the spontaneously hypertensive rat after subchronic real-world exposure to ambient fine particulate matter","volume":"707","author":"Lee","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semcdb.2020.07.017","article-title":"Lipid metabolism in astrocytic structure and function","volume":"112","author":"Lee","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0100","first-page":"838","article-title":"Distinct brain lipid signatures in response to low-level PM2.5 exposure in a 3xTg-Alzheimer\u2019s disease mouse inhalation model","author":"Lee","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-020-00354-2","article-title":"Caloric restriction attenuates C57BL\/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure","volume":"17","author":"Li","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0110","doi-asserted-by":"crossref","first-page":"12136","DOI":"10.1007\/s11356-021-16496-5","article-title":"Differential expression of long non-coding RNAs in the hippocampus of mice exposed to PM(2.5) in Dalian, China","volume":"29","author":"Li","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153225","article-title":"Maternal urban particulate matter exposure and signaling pathways in fetal brains and neurobehavioral development in offspring","volume":"474","author":"Li","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.967174","article-title":"A review of respirable fine particulate matter (PM(2.5))-induced brain damage","volume":"15","author":"Li","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13195-022-00994-w","article-title":"Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer\u2019s disease","volume":"14","author":"Liu","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0130","first-page":"319","article-title":"Aggregation of the inflammatory S100A8 precedes A\u03b2 plaque formation in transgenic APP mice: positive feedback for S100A8 and A\u03b2 productions","volume":"72","author":"Lodeiro","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jalz.2018.07.217","article-title":"Altered bile acid profile associates with cognitive impairment in Alzheimer\u2019s disease-an emerging role for gut microbiome","volume":"15","author":"MahmoudianDehkordi","year":"2019","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0140","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1083\/jcb.201706010","article-title":"De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination","volume":"217","author":"Montani","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ecoenv.2018.08.080","article-title":"Comprehensive hippocampal metabolite responses to PM(2.5) in young mice","volume":"165","author":"Ning","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152881","article-title":"Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells","volume":"60","author":"Panossian","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0300-483X(02)00545-0","article-title":"Inflammatory mediators induced by coarse (PM2.5-10) and fine (PM2.5) urban air particles in RAW 264.7 cells","volume":"183","author":"Pozzi","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0160","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/em.22469","article-title":"Proteomic analysis of serum in workers exposed to diesel engine exhaust","volume":"63","author":"Rahman","year":"2022","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biomaterials.2016.03.036","article-title":"Ultra-trace graphene oxide in a water environment triggers Parkinson\u2019s disease-like symptoms and metabolic disturbance in zebrafish larvae","volume":"93","author":"Ren","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116575","article-title":"Cigarette smoke during lactation in rat female progeny: late effects on endocannabinoid and dopaminergic systems","volume":"232","author":"Soares","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0175","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1007\/s12035-016-9968-1","article-title":"Dietary linoleic acid lowering reduces lipopolysaccharide-induced increase in brain arachidonic acid metabolism","volume":"54","author":"Taha","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jgg.2019.11.009","article-title":"Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression","volume":"47","author":"Wang","year":"2020","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0185","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12974-020-01869-3","article-title":"25-Hydroxycholesterol amplifies microglial IL-1\u03b2 production in an apoE isoform-dependent manner","volume":"17","author":"Wong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0190","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s12035-014-8884-5","article-title":"Integrating genome-wide association study and brain expression data highlights cell adhesion molecules and purine metabolism in Alzheimer\u2019s disease","volume":"52","author":"Xiang","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0195","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/tox.23586","article-title":"PM(2) (.5) exposure-induced ferroptosis in neuronal cells via inhibiting ERK\/CREB pathway","volume":"37","author":"Xiong","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.152","article-title":"Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study","volume":"7","author":"Yang","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0205","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/ana.20558","article-title":"Elevation of 12\/15 lipoxygenase products in AD and mild cognitive impairment","volume":"58","author":"Yao","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0210","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/thx.2009.122747","article-title":"15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer","volume":"65","author":"Yuan","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.scitotenv.2023.165112_bb0215","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1021\/acs.jproteome.0c00255","article-title":"Hippocampus proteomics and brain lipidomics reveal network dysfunction and lipid molecular abnormalities in APP\/PS1 mouse model of Alzheimer\u2019s disease","volume":"19","author":"Zhang","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.scitotenv.2023.165112_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.984338","article-title":"Network approaches for omics studies of neurodegenerative diseases","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Genet."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972303735X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972303735X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T16:05:32Z","timestamp":1758729932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896972303735X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":44,"alternative-id":["S004896972303735X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.165112","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2.5 exposure","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.165112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"165112"}}