{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:18:54Z","timestamp":1792840734357,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.scitotenv.2023.165300","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T11:09:36Z","timestamp":1688468976000},"page":"165300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Water contamination by delorazepam induces epigenetic defects in the embryos of the clawed frog Xenopus laevis"],"prefix":"10.1016","volume":"896","author":[{"given":"Chiara","family":"Fogliano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Maria","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Acloque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bice","family":"Avallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Carotenuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb7000","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1038\/s41467-018-06482-w","article-title":"Publisher correction: hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer","volume":"9","author":"Arechederra","year":"2018","journal-title":"Nat. Comm."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exer.2013.03.007","article-title":"The homeobox gene Otx2 in development and disease","volume":"111","author":"Beby","year":"2013","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.165300_bb0015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0006-2952(00)00325-7","article-title":"Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines","volume":"60","author":"Beinlich","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0025","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00412-009-0221-9","article-title":"DNA methylation and methyl-CpG binding proteins: developmental requirements and function","volume":"118","author":"Bogdanovi\u0107","year":"2009","journal-title":"Chromosoma"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genet-021920-092410","article-title":"RAD51 gene family structure and function","volume":"54","author":"Bonilla","year":"2020","journal-title":"Annu. Rev. Genet."},{"issue":"10","key":"10.1016\/j.scitotenv.2023.165300_bb0040","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.2042-7158.2012.01475.x","article-title":"Epigenetics of psychoactive drugs","volume":"64","author":"Boyadjieva","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.165300_bb0045","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3390\/ijerph15081791","article-title":"Environmental carcinogenesis and transgenerational transmission of carcinogenic risk: from genetics to epigenetics","volume":"15","author":"Burgio","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"10","key":"10.1016\/j.scitotenv.2023.165300_bb0050","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.chemosphere.2009.09.021","article-title":"Psychiatric pharmaceuticals in the environment","volume":"77","author":"Calisto","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133233","article-title":"Toxic effects of SiO2NPs in early embryogenesis of Xenopus laevis","volume":"289","author":"Carotenuto","year":"2022","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.scitotenv.2023.165300_bb4040","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/emboj\/cdg216","article-title":"Methylation-induced G(2)\/M arrest requires a full complement of the mismatch repair protein hMLH1","volume":"22","author":"Cejka","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.scitotenv.2023.165300_bb5050","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.aquatox.2014.10.018","article-title":"Effects of cadmium on cell proliferation, apoptosis, and proto-oncogene expression in zebrafish liver cells","volume":"157","author":"Chen","year":"2014","journal-title":"Aqua. Toxicol. (Amsterdam, Netherlands)"},{"issue":"6","key":"10.1016\/j.scitotenv.2023.165300_bb0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1095\/biolreprod.114.119610","article-title":"Sperm DNA methylation analysis in swine reveals conserved and species-specific methylation patterns and highlights an altered methylation at the GNAS locus in infertile boars","volume":"91","author":"Congras","year":"2014","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.165300_bb0065","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/nar\/11.3.647","article-title":"Unmethylated domains in vertebrate DNA","volume":"11","author":"Cooper","year":"1983","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.165300_bb0070","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.mehy.2008.10.039","article-title":"Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology","volume":"73","author":"Csoka","year":"2009","journal-title":"Med. Hypotheses"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11356-018-3556-z","article-title":"Environmental risk assessment of psychoactive drugs in the aquatic environment","volume":"26","author":"Cunha","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.165300_bb0080","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/em.22269","article-title":"JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage","volume":"60","author":"Ding","year":"2019","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/302051","article-title":"Oxidative stress and DNA methylation in prostate cancer","volume":"2010","author":"Donkena","year":"2010","journal-title":"Obstet. Gynecol. Int."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0090","series-title":"Chromosomal Instability and Tumors Promoted by DNA Hypomethylation. Science (New York, N.Y.)","first-page":"455","volume":"vol. 300(5618)","author":"Eden","year":"2003"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0095","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chemosphere.2017.02.126","article-title":"Screening of benzodiazepines in thirty European rivers","volume":"176","author":"Fick","year":"2017","journal-title":"Chemosphere"},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2023.165300_bb0100","first-page":"69","article-title":"Mechanisms of cadmium induced genomic instability","volume":"733","author":"Filipi\u010d","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106244","article-title":"Environmental concentrations of a delorazepam-based drug impact on embryonic development of non-target Xenopus laevis","volume":"250","author":"Fogliano","year":"2022","journal-title":"Aquat. Toxicol. (Amsterdam, Netherlands)"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0110","article-title":"Behavioral alterations and gills damage in Mytilus galloprovincialis exposed to an environmental concentration of delorazepam","volume":"97","author":"Fogliano","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0115","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2008.02.026","article-title":"Oxidative stress, DNA methylation and carcinogenesis","volume":"266","author":"Franco","year":"2008","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.165300_bb0120","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/humupd\/dmp052","article-title":"Teratogenic mechanisms of medical drugs","volume":"16","author":"van Gelder","year":"2010","journal-title":"Hum. Reprod. Update"},{"issue":"6835","key":"10.1016\/j.scitotenv.2023.165300_bb0125","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ije\/dyr154","article-title":"Environmental chemical exposures and human epigenetics","volume":"41","author":"Hou","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.chemosphere.2019.03.096","article-title":"Epigenetic response profiles into environmental epigenotoxicant screening and health risk assessment: a critical review","volume":"226","author":"Hu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124150","article-title":"Metal contamination, bioaccumulation, ROS generation, and epigenotoxicity influences on zebrafish exposed to river water polluted by mining activities","volume":"405","author":"Hu","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0145","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00268-017-4299-6","article-title":"DNA mismatch repair deficiency promotes genomic instability in a subset of papillary thyroid cancers","volume":"42","author":"Javid","year":"2018","journal-title":"World J. Surg."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.165300_bb0150","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1073\/pnas.94.6.2103","article-title":"Altered DNA methylation and genome instability: a new pathway to cancer?","volume":"94","author":"Jones","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.165300_bb0155","article-title":"Effect of DNA methylation in various diseases and the probable protective role of nutrition: a mini-review","volume":"7","author":"Kandi","year":"2015","journal-title":"Cureus"},{"issue":"11","key":"10.1016\/j.scitotenv.2023.165300_bb9000","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.yexcr.2006.03.006","article-title":"LUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylation","volume":"312","author":"Karimi","year":"2006","journal-title":"Experiment. Cell Res."},{"key":"10.1016\/j.scitotenv.2023.165300_bb8000","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrg.2017.32","article-title":"Associating cellular epigenetic models with human phenotypes","volume":"18","author":"Lappalainen","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.120995","article-title":"Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: adverse effects on the nervous system during metamorphic development of Xenopus laevis","volume":"381","author":"Li","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0170","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.envint.2013.07.008","article-title":"Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population","volume":"59","author":"Lind","year":"2013","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.165300_bb6060","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego Calif.)"},{"issue":"5","key":"10.1016\/j.scitotenv.2023.165300_bb0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/14740338.2018.1457646","article-title":"Does high-dose benzodiazepine abuse really produce liver toxicity? Results from a series of 201 benzodiazepine monoabusers","volume":"17","author":"Lugoboni","year":"2018","journal-title":"Expert Opin. Drug Saf."},{"issue":"11","key":"10.1016\/j.scitotenv.2023.165300_bb0180","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1080\/17460441.2017.1367281","article-title":"Advances in the use of Xenopus for successful drug screening","volume":"12","author":"Maia","year":"2017","journal-title":"Expert Opin. Drug Discovery"},{"issue":"3","key":"10.1016\/j.scitotenv.2023.165300_bb5800","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/andr.12329","article-title":"DNA methylation imprinting errors in spermatogenic cells from maturation arrest azoospermic patients","volume":"5","author":"Marques","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jad.2022.07.017","article-title":"Benzodiazepines consumption may have increased during the COVID-19 pandemic","volume":"314","author":"Mattiuzzi","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0190","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/kfq396","article-title":"Changes in DNA methylation and gene expression during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced suppression of the lipopolysaccharide-stimulated IgM response in splenocytes","volume":"120","author":"McClure","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1084-9521(02)00137-4","article-title":"DNA methylation in animal development","volume":"14","author":"Meehan","year":"2003","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bse0370059","article-title":"DNA methylation and control of gene expression in vertebrate development","volume":"37","author":"Meehan","year":"2001","journal-title":"Essays Biochem."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110413","article-title":"Chronic exposure to lead and cadmium pollution results in genomic instability in a model biomonitor species (Apodemus flavicollis Melchior, 1834)","volume":"194","author":"Mitkovska","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0215","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.aquatox.2006.02.029","article-title":"Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae","volume":"78","author":"Mouchet","year":"2006","journal-title":"Aquat. Toxicol. (Amsterdam, Netherlands)"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0220","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/MCB.24.1.144-153.2004","article-title":"A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration","volume":"24","author":"Murphy","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0225","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1601-183X.2012.00865.x","article-title":"Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients","volume":"12","author":"Murphy","year":"2013","journal-title":"Genes Brain Behav."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0230","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/mol.106.027078","article-title":"Chromatin remodeling: a novel mechanism of psychotropic drug action","volume":"70","author":"Newton","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0235","series-title":"Environmental Pollution (Barking, Essex: 1987)","first-page":"522","article-title":"Are there pharmaceutical compounds in sediments or in water? Determination of the distribution coefficient of benzodiazepine drugs in aquatic environment","volume":"251","author":"Nunes","year":"2019"},{"issue":"4","key":"10.1016\/j.scitotenv.2023.165300_bb0240","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10024001-0033-2","article-title":"Human molecular embryogenesis: an overview","volume":"4","author":"Oligny","year":"2001","journal-title":"Pediatr. Dev. Pathol."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.165300_bb0245","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/acs.chemrev.8b00299","article-title":"Pharmaceuticals of emerging concern in aquatic systems: chemistry, occurrence, effects, and removal methods","volume":"119","author":"Patel","year":"2019","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.165300_bb0250","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3390\/molecules25051026","article-title":"Selected pharmaceuticals in different aquatic compartments: part I-source, fate and occurrence","volume":"25","author":"Pereira","year":"2020","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"6","key":"10.1016\/j.scitotenv.2023.165300_bb0265","article-title":"Benzodiazepine misuse: an epidemic within a pandemic","volume":"13","author":"Sarangi","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0270","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.addr.2014.02.004","article-title":"Engineering Xenopus embryos for phenotypic drug discovery screening","volume":"69-70","author":"Schmitt","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0275","doi-asserted-by":"crossref","first-page":"94","DOI":"10.9758\/cpn.2014.12.2.94","article-title":"Potential molecular and cellular mechanism of psychotropic drugs","volume":"12","author":"Seo","year":"2014","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0280","series-title":"Prim Care Companion CNS Disord","first-page":"21br03081","article-title":"Benzodiazepine interaction with COVID-19 drugs","volume":"23(6)","author":"Shah","year":"2021"},{"issue":"4","key":"10.1016\/j.scitotenv.2023.165300_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019159","article-title":"Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis","volume":"6","author":"Shen","year":"2011","journal-title":"PLoS One"},{"issue":"49","key":"10.1016\/j.scitotenv.2023.165300_bb3600","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1073\/pnas.0707258104","article-title":"DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status","volume":"104","author":"Sinclair","year":"2007","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0300","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/dbio.2001.0560","article-title":"DNA methylation at promoter regions regulates the timing of gene activation in Xenopus laevis embryos","volume":"243","author":"Stancheva","year":"2002","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0305","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfr024","article-title":"The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation","volume":"120","author":"Szyf","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.165300_bb0310","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ydbio.2016.04.009","article-title":"Expanding the genetic toolkit in Xenopus: approaches and opportunities for human disease modeling","volume":"426","author":"Tandon","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0320","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/nprot.2007.314","article-title":"DNA methylation analysis by pyrosequencing","volume":"2","author":"Tost","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0325","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pharmtox-030220-022920","article-title":"Epigenetic neuropharmacology: drugs affecting the epigenome in the brain","volume":"61","author":"Toth","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112495","article-title":"When pharmaceutical drugs become environmental pollutants: potential neural effects and underlying mechanisms","volume":"205","author":"Vaudin","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2023.165300_bb0340","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.chemosphere.2004.08.062","article-title":"Determination of diazepam in aquatic samples by capillary liquid chromatography\u2013electrospray tandem mass spectrometry","volume":"57","author":"van der Ven","year":"2004","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.165300_bb0350","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.drugalcdep.2019.02.033","article-title":"The epidemiology of benzodiazepine misuse: a systematic review","volume":"200","author":"Votaw","year":"2019","journal-title":"Drug Alcohol Depend."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.165300_bb0355","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/10643389.2015.1096876","article-title":"Ecotoxic pharmaceuticals, personal care products, and other emerging contaminants: a review of environmental, receptor-mediated, developmental, and epigenetic toxicity with discussion of proposed toxicity to humans","volume":"46","author":"Wilkinson","year":"2016","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.scitotenv.2023.165300_bb0360","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41588-022-01258-x","article-title":"Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development","volume":"55","author":"Yan","year":"2023","journal-title":"Nat. Genet."},{"issue":"60","key":"10.1016\/j.scitotenv.2023.165300_bb0365","doi-asserted-by":"crossref","first-page":"102381","DOI":"10.18632\/oncotarget.22057","article-title":"Benzodiazepine drug use and cancer risk: a dose-response meta analysis of prospective cohort studies","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.scitotenv.2023.165300_bb4000","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.molcel.2020.06.017","article-title":"METTL3 and N6-Methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation","volume":"79","author":"Zhang","year":"2020","journal-title":"Mol. Cell"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723039232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723039232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:19:35Z","timestamp":1787926775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969723039232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":70,"alternative-id":["S0048969723039232"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.165300","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Water contamination by delorazepam induces epigenetic defects in the embryos of the clawed frog Xenopus laevis","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.165300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"165300"}}