{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:37:09Z","timestamp":1793450229258,"version":"4.5.0"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771566"],"award-info":[{"award-number":["81771566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071632"],"award-info":[{"award-number":["82071632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["CYB22210"],"award-info":[{"award-number":["CYB22210"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.scitotenv.2023.166258","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T01:52:43Z","timestamp":1691805163000},"page":"166258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"special_numbering":"C","title":["Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions"],"prefix":"10.1016","volume":"903","author":[{"given":"Yifan","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengde","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2023.166258_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1178434","article-title":"NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity","volume":"14","author":"Alijagic","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152665","article-title":"Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats","volume":"449","author":"An","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105652","article-title":"Estimating polybrominated diphenyl ether (PBDE) exposure through seafood consumption in Switzerland using international food trade data","volume":"138","author":"Bedi","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0020","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41580-020-0270-8","article-title":"Emerging connectivity of programmed cell death pathways and its physiological implications","volume":"21","author":"Bedoui","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0025","doi-asserted-by":"crossref","first-page":"1110572","DOI":"10.3389\/fendo.2023.1110572","article-title":"Revisiting the gonadotropic regulation of mammalian spermatogenesis: evolving lessons during the past decade","volume":"14","author":"Bhattacharya","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13643-017-0644-y","article-title":"Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study","volume":"6","author":"Bramer","year":"2017","journal-title":"Syst. Rev."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0035","first-page":"12","article-title":"Assessing the NLRP3 inflammasome activating potential of a large panel of micro- and nanoplastics in THP-1 cells","author":"Busch","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mce.2016.10.010","article-title":"Leydig cell stem cells: identification, proliferation and differentiation","volume":"445","author":"Chen","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0045","first-page":"12","article-title":"In vitro nano-polystyrene toxicity: metabolic dysfunctions and cytoprotective responses of human spermatozoa","author":"Contino","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112040","article-title":"Effects of endocrine disrupting chemicals on gonad development: mechanistic insights from fish and mammals","volume":"204","author":"Delbes","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105916","article-title":"Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut","volume":"143","author":"Deng","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124644","article-title":"Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)","volume":"406","author":"Deng","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119269","article-title":"Endocrine disrupting chemicals impact on ovarian aging: evidence from epidemiological and experimental evidence","volume":"305","author":"Ding","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0070","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.7150\/ijbs.82191","article-title":"Application of single-cell RNA sequencing on human testicular samples: a comprehensive review","volume":"19","author":"Dong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0075","first-page":"10","article-title":"Novel gene regulation in normal and abnormal spermatogenesis","author":"Du","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0080","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3727\/096368908785096033","article-title":"Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells","volume":"17","author":"Dufour","year":"2008","journal-title":"Cell Transplant."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0085","doi-asserted-by":"crossref","first-page":"97006","DOI":"10.1289\/EHP10873","article-title":"Uptake, transport, and toxicity of pristine and weathered micro- and nanoplastics in human placenta cells","volume":"130","author":"Dusza","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111913","article-title":"Plastic pollution in the world\u2019s oceans: more than 5 trillion plastic pieces weighing over 250,000 tons afloat at sea","volume":"9","author":"Eriksen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/nn900002m","article-title":"Impact of nanotechnology on drug delivery","volume":"3","author":"Farokhzad","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113966","article-title":"Co-exposure to polystyrene microplastics and lead aggravated ovarian toxicity in female mice via the PERK\/eIF2\u03b1 signaling pathway","volume":"243","author":"Feng","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0105","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105753","article-title":"Pore formation in regulated cell death","volume":"39","author":"Flores-Romero","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12989-020-00385-9","article-title":"Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy","volume":"17","author":"Fournier","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0115","doi-asserted-by":"crossref","first-page":"1020470","DOI":"10.3389\/fcell.2022.1020470","article-title":"Editorial: intra- and extra-environment and reproduction","volume":"10","author":"Ge","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2019.110871","article-title":"Estimation of plastic waste inputs from land into the Caspian Sea: a significant unseen marine pollution","volume":"151","author":"Ghayebzadeh","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0125","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12978-020-01048-w","article-title":"Dropout of infertility treatments and related factors among infertile couples","volume":"17","author":"Ghorbani","year":"2020","journal-title":"Reprod. Health"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0130","doi-asserted-by":"crossref","first-page":"34594","DOI":"10.1007\/s11356-021-18218-3","article-title":"Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat","volume":"29","author":"Haddadi","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0135","doi-asserted-by":"crossref","DOI":"10.1177\/09603271231173378","article-title":"Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albino rats","volume":"42","author":"Hamza","year":"2023","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152354","article-title":"Microplastics and bisphenol A hamper gonadal development of whiteleg shrimp (Litopenaeus vannamei) by interfering with metabolism and disrupting hormone regulation","volume":"810","author":"Han","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0145","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.est.8b05297","article-title":"Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris","volume":"53","author":"Hartmann","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfda.2018.12.002","article-title":"The current application of nanotechnology in food and agriculture","volume":"27","author":"He","year":"2019","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143986","article-title":"Enhanced toxicity of triphenyl phosphate to zebrafish in the presence of micro- and nano-plastics","volume":"756","author":"He","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112889","article-title":"Exposure to DEHP induces testis toxicity and injury through the ROS\/mTOR\/NLRP3 signaling pathway in immature rats","volume":"227","author":"Hong","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: in vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/Caspase-1 signaling pathway in rats","volume":"212","author":"Hou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109444","article-title":"Polystyrene microplastics induce apoptosis in chicken testis via crosstalk between NF-\u03baB and Nrf2 pathways","volume":"262","author":"Hou","year":"2022","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105452","article-title":"Characterization of primary canine Sertoli cells as a model to test male reproductive toxicant","volume":"84","author":"Hsiao","year":"2022","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0185","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.reprotox.2021.10.002","article-title":"Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice","volume":"106","author":"Hu","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114332","article-title":"Polystyrene nanoplastics promote CHIP-mediated degradation of tight junction proteins by activating IRE1\u03b1\/XBP1s pathway in mouse Sertoli cells","volume":"248","author":"Hu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0195","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/gb-2004-5-7-r47","article-title":"Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes","volume":"5","author":"Huang","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142042","article-title":"Microplastics aggravate the joint toxicity to earthworm Eisenia fetida with cadmium by altering its availability","volume":"753","author":"Huang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112803","article-title":"Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring","volume":"160","author":"Huang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114371","article-title":"Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells","volume":"249","author":"Huang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0215","doi-asserted-by":"crossref","DOI":"10.1177\/15593258211019882","article-title":"Dose-dependent effect of polystyrene microplastics on the testicular tissues of the male Sprague Dawley rats","volume":"19","author":"Ijaz","year":"2021","journal-title":"Dose-Response"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114686","article-title":"Pinostrobin alleviates testicular and spermatological damage induced by polystyrene microplastics in adult albino rats","volume":"162","author":"Ijaz","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0225","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mce.2017.12.013","article-title":"Recent progress in understanding the mechanisms of Leydig cell differentiation","volume":"468","author":"Inoue","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0230","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.envpol.2019.03.085","article-title":"Reproductive toxicity of primary and secondary microplastics to three cladocerans during chronic exposure","volume":"249","author":"Jaikumar","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0235","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1260352","article-title":"Marine pollution. Plastic waste inputs from land into the ocean","volume":"347","author":"Jambeck","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127815","article-title":"Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny","volume":"426","author":"Jeong","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12199-020-00870-9","article-title":"Health impacts of environmental contamination of micro- and nanoplastics: a review","volume":"25","author":"Jiang","year":"2020","journal-title":"Environ. Health Prev. Med."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0250","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0255","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/cdd.2017.171","article-title":"Deconstructing networks of p53-mediated tumor suppression in vivo","volume":"25","author":"Kaiser","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0260","first-page":"20","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","author":"Kajarabille","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0265","doi-asserted-by":"crossref","first-page":"13478","DOI":"10.1007\/s11356-021-16701-5","article-title":"Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure","volume":"29","author":"Kang","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0270","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/nchembio.2205","article-title":"A photoactivatable Cre-loxP recombination system for optogenetic genome engineering","volume":"12","author":"Kawano","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121810","article-title":"Biochar alleviated the toxic effects of PVC microplastic in a soil-plant system by upregulating soil enzyme activities and microbial abundance","volume":"332","author":"Khalid","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0280","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s10815-019-01620-9","article-title":"Influence of graft size, histocompatibility,and cryopreservation on reproductive outcome following ovary transplantation in mice","volume":"36","author":"Kolbe","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0285","first-page":"14","article-title":"Wear and tear of tyres: a stealthy source of microplastics in the environment","author":"Kole","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0290","doi-asserted-by":"crossref","DOI":"10.1111\/and.14411","article-title":"Repression of Mafb promotes foreskin fibroblast proliferation through upregulation of CDK2, cyclin E and PCNA","volume":"54","author":"Kong","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5334\/aogh.4056","article-title":"The Minderoo-Monaco Commission on Plastics and Human Health","volume":"89","author":"Landrigan","year":"2023","journal-title":"Ann. Glob. Health"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118190","article-title":"Environmental microplastic and nanoplastic: exposure routes and effects on coagulation and the cardiovascular system","volume":"291","author":"Lett","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0305","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s00204-019-02593-5","article-title":"Review of high-content screening applications in toxicology","volume":"93","author":"Li","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0310","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fendo.2020.00447","article-title":"Bisphenols and Leydig cell development and function","volume":"11","author":"Li","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114104","article-title":"Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice","volume":"245","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113071","article-title":"Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1\u03b1 signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells","volume":"164","author":"Li","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127754","article-title":"Microplastics increase the accumulation of phenanthrene in the ovaries of marine medaka (Oryzias melastigma) and its transgenerational toxicity","volume":"424","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0330","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12989-021-00414-1","article-title":"Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis","volume":"18","author":"Liang","year":"2021","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162664","article-title":"Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish","volume":"876","author":"Lin","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0340","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.envpol.2018.07.051","article-title":"Microplastic and mesoplastic pollution in farmland soils in suburbs of Shanghai, China","volume":"242","author":"Liu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113342","article-title":"Co-exposure of polystyrene microplastics and iron aggravates cognitive decline in aging mice via ferroptosis induction","volume":"233","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127629","article-title":"Polystyrene microplastics induced female reproductive toxicity in mice","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0355","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1016\/j.apsb.2021.01.007","article-title":"CRISPR-Cas9: a method for establishing rat models of drug metabolism and pharmacokinetics","volume":"11","author":"Lu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126770","article-title":"Size-dependent effects of polystyrene nanoplastics on autophagy response in human umbilical vein endothelial cells","volume":"421","author":"Lu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0365","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s40572-023-00391-x","article-title":"A systematic review of the placental translocation of micro- and nanoplastics","volume":"10","author":"Medley","year":"2023","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0370","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0375","doi-asserted-by":"crossref","first-page":"62237","DOI":"10.1007\/s11356-023-26469-5","article-title":"Therapeutic effect of gossypetin against paraquat-induced testicular damage in male rats: a histological and biochemical study","volume":"30","author":"Mustafa","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0380","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ajog.2022.09.040","article-title":"Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm","volume":"228","author":"O\u2019Neill","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0385","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/atmos10020099","article-title":"Evaluation of tire wear contribution to PM2.5 in urban environments","volume":"10","author":"Panko","year":"2019","journal-title":"Atmosphere"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0390","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envpol.2017.11.043","article-title":"Airborne microplastics: consequences to human health?","volume":"234","author":"Prata","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental exposure to microplastics: an overview on possible human health effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0400","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12989-020-00358-y","article-title":"The plastic brain: neurotoxicity of micro- and nanoplastics","volume":"17","author":"Pr\u00fcst","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0405","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-genet-022020-023434","article-title":"Canary in the coal mine? Male infertility as a marker of overall health","volume":"54","author":"Punjani","year":"2020","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0410","doi-asserted-by":"crossref","first-page":"63185","DOI":"10.1007\/s11356-023-26565-6","article-title":"Reproductive and metabolic toxic effects of polystyrene microplastics in adult female Wistar rats: a mechanistic study","volume":"30","author":"Saeed","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0415","article-title":"Microplastics and their additives in the indoor environment","volume":"61","author":"Salthammer","year":"2022","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112179","article-title":"Challenges and opportunities in sustainable management of microplastics and nanoplastics in the environment","volume":"207","author":"Sarkar","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111820","article-title":"Microplastic\u2019s story","volume":"162","author":"Schmid","year":"2021","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0430","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool: a prospective case series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.128136","article-title":"Shape, size, and polymer dependent effects of microplastics on Daphnia magna","volume":"426","author":"Schwarzer","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0440","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41467-018-08182-x","article-title":"Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella","volume":"10","author":"Shen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107273","article-title":"Disturbed gut-liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance","volume":"164","author":"Shi","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.106049","article-title":"Microplastics hamper the fertilization success of a broadcast spawning bivalve through reducing gamete collision and gamete fusion efficiency","volume":"242","author":"Shi","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133169","article-title":"Micro (nano) plastics in wastewater: a critical review on toxicity risk assessment, behaviour, environmental impact and challenges","volume":"290","author":"Singh","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0460","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.fertnstert.2022.05.018","article-title":"Estimates of infertility in the United States: 1995-2019","volume":"118","author":"Snow","year":"2022","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113634","article-title":"Polystyrene nanoplastics inhibit StAR expression by activating HIF-1\u03b1 via ERK1\/2 MAPK and AKT pathways in TM3 Leydig cells and testicular tissues of mice","volume":"173","author":"Sui","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114796","article-title":"Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells","volume":"255","author":"Sun","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103869","article-title":"In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells","volume":"93","author":"Sychrov\u00e1","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0480","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.advms.2019.12.008","article-title":"Proven and unproven methods for diagnosis and treatment of infertility","volume":"65","author":"Szamatowicz","year":"2020","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0485","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/tox.22559","article-title":"Di-(2-ethylhexyl) phthalate (DEHP)-induced testicular toxicity through Nrf2-mediated Notch1 signaling pathway in Sprague-Dawley rats","volume":"33","author":"Tang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0490","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1007\/s10815-021-02240-y","article-title":"\u03b2-Estradiol promotes the growth of primary human fetal spermatogonial stem cells via the induction of stem cell factor in Sertoli cells","volume":"38","author":"Tao","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.138724","article-title":"Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure","volume":"330","author":"Tu","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0500","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1172\/JCI89927","article-title":"Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance","volume":"127","author":"Tung","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0505","article-title":"A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals","volume":"13","author":"Ullah","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129593","article-title":"A new source of representative secondary PET nanoplastics. Obtention, characterization, and hazard evaluation","volume":"439","author":"Villacorta","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0515","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2011.11.015","article-title":"Cryptorchidism and endocrine disrupting chemicals","volume":"355","author":"Virtanen","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0520","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nrurol.2016.261","article-title":"Semen quality in the 21(st) century","volume":"14","author":"Virtanen","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0525","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1530\/REP-15-0546","article-title":"Establishment and applications of male germ cell and Sertoli cell lines","volume":"152","author":"Wang","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132312","article-title":"Polystyrene microplastics increase estrogenic effects of 17\u03b1-ethynylestradiol on male marine medaka (Oryzias melastigma)","volume":"287","author":"Wang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2021.113289","article-title":"Porous microplastics enhance polychlorinated biphenyls-induced thyroid disruption in juvenile Japanese flounder (Paralichthys olivaceus)","volume":"174","author":"Wang","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0545","first-page":"11","article-title":"Polystyrene microplastics induced ovarian toxicity in juvenile rats associated with oxidative stress and activation of the PERK-eIF2\u03b1-ATF4-CHOP signaling pathway","author":"Wang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117904","article-title":"Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-mediated imbalance of mTORC1 and mTORC2","volume":"289","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113780","article-title":"Single-cell transcriptomic dissection of the toxic impact of di(2-ethylhexyl) phthalate on immature testicular development at the neonatal stage","volume":"176","author":"Wei","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119789","article-title":"Microplastics-perturbed gut microbiota triggered the testicular disorder in male mice: via fecal microbiota transplantation","volume":"309","author":"Wen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144059","article-title":"Bisphenol S perturbs Sertoli cell junctions in male rats via alterations in cytoskeletal organization mediated by an imbalance between mTORC1 and mTORC2","volume":"762","author":"Wu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161962","article-title":"Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production","volume":"871","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0580","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/acs.est.0c00245","article-title":"Primary and secondary plastic particles exhibit limited acute toxicity but chronic effects on Daphnia magna","volume":"54","author":"Xu","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134699","article-title":"Microplastics in aquatic environments: occurrence, accumulation, and biological effects","volume":"703","author":"Xu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131470","article-title":"Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice","volume":"454","author":"Xu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0595","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.06-070342","article-title":"Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells","volume":"22","author":"Yan","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0600","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jhazmat.2018.12.048","article-title":"Toxicity-based toxicokinetic\/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice","volume":"366","author":"Yang","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114105","article-title":"Gender difference in hepatic AMPK pathway activated lipid metabolism induced by aged polystyrene microplastics exposure","volume":"245","author":"Yang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164389","article-title":"Effects of fibrous microplastics on the accumulation of tris(2,3-dibromopropyl) isocyanurate and behavior of zebrafish via water- and foodborne exposure routes","volume":"892","author":"Yang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114030","article-title":"Microplastics from agricultural plastic mulch films: a mini-review of their impacts on the animal reproductive system","volume":"244","author":"Yuan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114941","article-title":"The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice","volume":"257","author":"Zeng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110976","article-title":"Current research and perspective of microplastics (MPs) in soils (dusts), rivers (lakes), and marine environments in China","volume":"202","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0630","doi-asserted-by":"crossref","DOI":"10.1177\/15579883221096549","article-title":"Microplastics may be a significant cause of male infertility","volume":"16","author":"Zhang","year":"2022","journal-title":"Am. J. Mens Health"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135854","article-title":"Phytotoxicity and accumulation of BPS to Pistia stratiotes under the influence of microplastics","volume":"307","author":"Zhang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128453","article-title":"Environmental contamination by microplastics originating from textiles: emission, transport, fate and toxicity","volume":"430","author":"Zhang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0645","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/13880209.2023.2168705","article-title":"Repair mechanism of Yishen Tongluo formula on mouse sperm DNA fragmentation caused by polystyrene microplastics","volume":"61","author":"Zhang","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121482","article-title":"Reproductive toxicity of microplastics in female mice and their offspring from induction of oxidative stress","volume":"327","author":"Zhang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162713","article-title":"Detection and characterization of microplastics in the human testis and semen","volume":"877","author":"Zhao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0660","article-title":"The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms","author":"Zheng","year":"2022","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0665","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2023.02.067","article-title":"Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes","volume":"654","author":"Zheng","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0670","first-page":"11","article-title":"Action and interaction between retinoic acid signaling and blood-testis barrier function in the spermatogenesis cycle","author":"Zhou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0675","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s00018-019-03101-9","article-title":"The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis","volume":"76","author":"Zhou","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107220","article-title":"Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles","volume":"163","author":"Zhou","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126764","article-title":"Perfluoroalkyl substances cause Leydig cell dysfunction as endocrine disruptors","volume":"253","author":"Zhu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.166258_bb0690","doi-asserted-by":"crossref","first-page":"40084","DOI":"10.1007\/s11356-022-25093-z","article-title":"Microplastics in polystyrene-made food containers from China: abundance, shape, size, and human intake","volume":"30","author":"Zhu","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.166258_bb0695","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723048830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723048830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:40:00Z","timestamp":1787668800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969723048830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":139,"alternative-id":["S0048969723048830"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.166258","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.166258","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166258"}}