{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:05Z","timestamp":1787841365734,"version":"build-2784847793"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019926","name":"Netherlands Organization for Applied Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019926","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["15763"],"award-info":[{"award-number":["15763"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["142118"],"award-info":[{"award-number":["142118"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.scitotenv.2023.167439","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T12:06:11Z","timestamp":1695816371000},"page":"167439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Characterization of urban sources of antibiotics and antibiotic-resistance genes in a Dutch sewer catchment"],"prefix":"10.1016","volume":"905","author":[{"given":"Daniel J.","family":"Duarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Zillien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Kox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Oldenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"van der Zaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Roex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad M.J.","family":"Ragas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"D1","key":"10.1016\/j.scitotenv.2023.167439_bb0010","first-page":"D517","article-title":"CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database","volume":"48","author":"Alcock","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"12 Suppl 2","key":"10.1016\/j.scitotenv.2023.167439_bb0015","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.1093\/infdis\/jiaa497","article-title":"The gut microbiome as a reservoir for antimicrobial resistance","volume":"223","author":"Anthony","year":"2021","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0020","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.scitotenv.2017.06.153","article-title":"Sewers as potential reservoirs of antibiotic resistance","volume":"605","author":"Auguet","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"16","key":"10.1016\/j.scitotenv.2023.167439_bb0025","doi-asserted-by":"crossref","first-page":"9033","DOI":"10.1021\/acs.est.8b01219","article-title":"Tracking the sources of antibiotic resistance genes in an urban stream during wet weather using shotgun metagenomic analyses","volume":"52","author":"Baral","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0030","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.167439_bb0035","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"7","key":"10.1016\/j.scitotenv.2023.167439_bb0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/femsec\/fiy087","article-title":"Limited influence of hospital wastewater on the microbiome and resistome of wastewater in a community sewerage system","volume":"94","author":"Buelow","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0045","doi-asserted-by":"crossref","first-page":"142217","DOI":"10.1016\/j.scitotenv.2020.142217","article-title":"Occurrence of emerging sulfonamide resistance (sul1 and sul2) associated with mobile integrons-integrase (intI1 and intI2) in riverine systems","volume":"751","author":"Chaturvedi","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0050","first-page":"19(19)","article-title":"Impact of anthropogenic activities on the dissemination of ARGs in the environment - a review","author":"Czatzkowska","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.scitotenv.2023.167439_bb0055","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijheh.2011.08.002","article-title":"Emerging pollutants in wastewater: a review of the literature","volume":"214","author":"Deblonde","year":"2011","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0060","doi-asserted-by":"crossref","first-page":"116097","DOI":"10.1016\/j.watres.2020.116097","article-title":"Modelling the fate of micropollutants in integrated urban wastewater systems: extending the applicability to pharmaceuticals","volume":"184","author":"Delli Compagni","year":"2020","journal-title":"Water Res."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.167439_bb0065","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4161\/mge.22967","article-title":"Integrons: vehicles and pathways for horizontal dissemination in bacteria","volume":"2","author":"Domingues","year":"2012","journal-title":"Mob. Genet. Elem."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0070","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.scitotenv.2018.12.233","article-title":"Modelling environmental antibiotic-resistance gene abundance: a meta-analysis","volume":"659","author":"Duarte","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0075","series-title":"Pharmaceutical Strategy for Europe. Communication From the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions","author":"EU","year":"2020"},{"issue":"6285","key":"10.1016\/j.scitotenv.2023.167439_bb0080","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.aad3503","article-title":"Population-level analysis of gut microbiome variation","volume":"352","author":"Falony","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0085","first-page":"1543","article-title":"Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances","volume":"6","author":"Francino","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0090","series-title":"Policy priorities for Germany's G7 Presidency in 2022. Group of Seven - Presidency Programme","first-page":"12","author":"G7","year":"2022"},{"issue":"7907","key":"10.1016\/j.scitotenv.2023.167439_bb0095","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41586-022-04567-7","article-title":"Environmental factors shaping the gut microbiome in a Dutch population","volume":"604","author":"Gacesa","year":"2022","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.scitotenv.2023.167439_bb0100","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/ismej.2014.226","article-title":"Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution","volume":"9","author":"Gillings","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0105","series-title":"Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in the Netherlands in 2020","first-page":"74","article-title":"Consumption of antimicrobial agents and antimicrobial resistance among medically important bacteria in the Netherlands in 2020 \/ MARAN 2021","volume":"2021","author":"de Greeff","year":"2021"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0110","series-title":"Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in the Netherlands in 2021","first-page":"76","article-title":"Consumption of antimicrobial agents and antimicrobial resistance among medically important bacteria in the Netherlands in 2021 \/ MARAN 2022","volume":"2022","author":"de Greeff","year":"2022"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0115","doi-asserted-by":"crossref","first-page":"140804","DOI":"10.1016\/j.scitotenv.2020.140804","article-title":"Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: a systematic review","volume":"743","author":"Hassoun-Kheir","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0120","doi-asserted-by":"crossref","first-page":"116733","DOI":"10.1016\/j.envpol.2021.116733","article-title":"Investigating the effects of municipal and hospital wastewaters on horizontal gene transfer","volume":"276","author":"Hutinel","year":"2021","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.167439_bb0125","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/23744235.2020.1839672","article-title":"Few bacterial co-infections but frequent empiric antibiotic use in the early phase of hospitalized patients with COVID-19: results from a multicentre retrospective cohort study in the Netherlands","volume":"53","author":"Karami","year":"2021","journal-title":"Infect. Dis. (Lond)"},{"issue":"17","key":"10.1016\/j.scitotenv.2023.167439_bb0130","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1021\/acs.est.1c01274","article-title":"Diagnosing down-the-drain disposal of unused pharmaceuticals at a river catchment level: unrecognized sources of environmental contamination that require nontechnological solutions","volume":"55","author":"Kasprzyk-Hordern","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.scitotenv.2023.167439_bb0135","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00128-020-03098-z","article-title":"intI1 type mobile genetic elements co-selected antibiotic-resistant genes in untreated hospital wastewaters","volume":"106","author":"Kayali","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"5","key":"10.1016\/j.scitotenv.2023.167439_bb0140","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/acsinfecdis.1c00081","article-title":"Antibiotic therapy and the gut microbiome: investigating the effect of delivery route on gut pathogens","volume":"7","author":"Kelly","year":"2021","journal-title":"ACS Infect. Dis."},{"issue":"14","key":"10.1016\/j.scitotenv.2023.167439_bb0145","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1021\/es400708w","article-title":"Elimination of micropollutants during post-treatment of hospital wastewater with powdered activated carbon, ozone, and UV","volume":"47","author":"Kovalova","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.167439_bb0150","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/microorganisms7060180","article-title":"Antibiotic pollution in the environment: from microbial ecology to public policy","volume":"7","author":"Kraemer","year":"2019","journal-title":"Microorganisms"},{"issue":"12","key":"10.1016\/j.scitotenv.2023.167439_bb0155","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1128\/AAC.01556-16","article-title":"Occurrences and characterization of antibiotic-resistant bacteria and genetic determinants of hospital wastewater in a tropical country","volume":"60","author":"Le","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0160","doi-asserted-by":"crossref","first-page":"117827","DOI":"10.1016\/j.watres.2021.117827","article-title":"Wastewater bypass is a major temporary point-source of antibiotic resistance genes and multi-resistance risk factors in a Swiss river","volume":"208","author":"Lee","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0165","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.envint.2015.02.013","article-title":"Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters","volume":"82","author":"Leonard","year":"2015","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.scitotenv.2023.167439_bb0170","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s11356-014-3665-2","article-title":"Antibiotic-resistant genes and antibiotic-resistant bacteria in the effluent of urban residential areas, hospitals, and a municipal wastewater treatment plant system","volume":"22","author":"Li","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0175","doi-asserted-by":"crossref","first-page":"117985","DOI":"10.1016\/j.watres.2021.117985","article-title":"Sequential combination of photocatalysis and microalgae technology for promoting the degradation and detoxification of typical antibiotics","volume":"210","author":"Li","year":"2022","journal-title":"Water Res."},{"issue":"17","key":"10.1016\/j.scitotenv.2023.167439_bb0180","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1021\/acs.est.9b02867","article-title":"Urban Stormwater: an overlooked pathway of extensive mixed contaminants to surface and groundwaters in the United States","volume":"53","author":"Masoner","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0210","doi-asserted-by":"crossref","DOI":"10.1111\/bcp.15509","article-title":"The Dutch chain approach on pharmaceuticals in water: stakeholders acting together to reduce the environmental impact of pharmaceuticals","author":"Moermond","year":"2022","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0185","series-title":"Conventional and Advanced Processes for the Removal of Pharmaceuticals and Their Human Metabolites from Wastewater, in Integrated and Sustainable Environmental Remediation","first-page":"15","author":"Montemurro","year":"2018"},{"issue":"8","key":"10.1016\/j.scitotenv.2023.167439_bb0190","first-page":"33","article-title":"Pharmaceutical approaches on antimicrobial resistance: prospects and challenges","volume":"10","author":"Nainu","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.02200","article-title":"Characterization of metagenomes in urban aquatic compartments reveals high prevalence of clinically relevant antibiotic resistance genes in wastewaters","volume":"8","author":"Ng","year":"2017","journal-title":"Front. Microbiol."},{"issue":"45","key":"10.1016\/j.scitotenv.2023.167439_bb0200","doi-asserted-by":"crossref","first-page":"63878","DOI":"10.1007\/s11356-021-12440-9","article-title":"Harmonized assessment of nutrient pollution from urban systems including losses from sewer exfiltration: a case study in Germany","volume":"28","author":"Nguyen","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"12","key":"10.1016\/j.scitotenv.2023.167439_bb0205","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/microorganisms9122542","article-title":"Microbiome compositions and resistome levels after antibiotic treatment of critically ill patients: an observational cohort study","volume":"9","author":"Nielsen","year":"2021","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.167439_bb0215","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/emph\/eoab020","article-title":"Species interactions drive the spread of ampicillin resistance in human-associated gut microbiota","volume":"9","author":"O'Brien","year":"2021","journal-title":"Evol. Med. Public Health"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0005","series-title":"Antimicrobial Resistance in the EU\/EEA: A One Health Response","first-page":"25","author":"OECD","year":"2022"},{"issue":"8","key":"10.1016\/j.scitotenv.2023.167439_bb0225","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/add.12570","article-title":"Spatial differences and temporal changes in illicit drug use in Europe quantified by wastewater analysis","volume":"109","author":"Ort","year":"2014","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.scitotenv.2023.167439_bb0230","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau9124","article-title":"Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence","volume":"5","author":"Parnanen","year":"2019","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.167439_bb0235","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijheh.2019.01.004","article-title":"The impact of on-site hospital wastewater treatment on the downstream communal wastewater system in terms of antibiotics and antibiotic resistance genes","volume":"222","author":"Paulus","year":"2019","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"9","key":"10.1016\/j.scitotenv.2023.167439_bb0240","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1128\/AAC.35.9.1840","article-title":"Genetic analyses of sulfonamide resistance and its dissemination in gram-negative bacteria illustrate new aspects of R plasmid evolution","volume":"35","author":"Radstrom","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0245","series-title":"R: A Language and Environment for Statistical Computing","author":"RCoreTeam","year":"2019"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0250","doi-asserted-by":"crossref","first-page":"140242","DOI":"10.1016\/j.scitotenv.2020.140242","article-title":"Correlation between antimicrobial resistance and faecal contamination in small urban streams and bathing waters","volume":"739","author":"Reynolds","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0255","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.scitotenv.2013.01.032","article-title":"Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review","volume":"447","author":"Rizzo","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0260","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.watres.2014.11.021","article-title":"Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river","volume":"69","author":"Rodriguez-Mozaz","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0265","doi-asserted-by":"crossref","first-page":"105733","DOI":"10.1016\/j.envint.2020.105733","article-title":"Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment","volume":"140","author":"Rodriguez-Mozaz","year":"2020","journal-title":"Environ. Int."},{"issue":"6435","key":"10.1016\/j.scitotenv.2023.167439_bb0270","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau4679","article-title":"The challenge of antimicrobial resistance: What economics can contribute","volume":"364","author":"Roope","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0275","doi-asserted-by":"crossref","first-page":"140199","DOI":"10.1016\/j.scitotenv.2020.140199","article-title":"Fate of antibiotics and antibiotic resistance genes during conventional and additional treatment technologies in wastewater treatment plants","volume":"741","author":"Sabri","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.scitotenv.2023.167439_bb0280","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ijheh.2019.03.006","article-title":"Antibiotic resistant bacteria and resistance genes in biofilms in clinical wastewater networks","volume":"222","author":"Sib","year":"2019","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0285","series-title":"Onderzoek en veldpilot van passive sampling met partitie- en adsorptie-samplers. MM16: KPP Project 2012","first-page":"40","author":"Smedes","year":"2012"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0290","doi-asserted-by":"crossref","first-page":"24","DOI":"10.7554\/eLife.62474","article-title":"Integron activity accelerates the evolution of antibiotic resistance","volume":"10","author":"Souque","year":"2021","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.scitotenv.2023.167439_bb0295","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1365-2958.1989.tb00153.x","article-title":"A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons","volume":"3","author":"Stokes","year":"1989","journal-title":"Mol. Microbiol."},{"issue":"12","key":"10.1016\/j.scitotenv.2023.167439_bb0300","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1093\/bioinformatics\/btl117","article-title":"Pvclust: an R package for assessing the uncertainty in hierarchical clustering","volume":"22","author":"Suzuki","year":"2006","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.scitotenv.2023.167439_bb0305","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s10311-020-00998-8","article-title":"Passive and grab sampling methods to assess pesticide residues in water. A review","volume":"18","author":"Valenzuela","year":"2020","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0310","doi-asserted-by":"crossref","first-page":"125032","DOI":"10.1016\/j.chemosphere.2019.125032","article-title":"Association between antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in anthropogenic wastewater - an evaluation of clinical influences","volume":"241","author":"Voigt","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0315","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.scitotenv.2017.10.128","article-title":"Occurrence and diversity of antibiotic resistance in untreated hospital wastewater","volume":"621","author":"Wang","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0320","doi-asserted-by":"crossref","first-page":"140997","DOI":"10.1016\/j.scitotenv.2020.140997","article-title":"Occurrence and fate of antibiotics, antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARB) in municipal wastewater treatment plant: an overview","volume":"744","author":"Wang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0325","doi-asserted-by":"crossref","first-page":"119870","DOI":"10.1016\/j.envpol.2022.119870","article-title":"Distribution, sources, and potential risks of antibiotic resistance genes in wastewater treatment plant: a review","volume":"310","author":"Wang","year":"2022","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.scitotenv.2023.167439_bb0330","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1073\/pnas.2113947119","article-title":"Pharmaceutical pollution of the world\u2019s rivers","volume":"119","author":"Wilkinson","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0220","series-title":"A WHO Practical Toolkit","first-page":"71","article-title":"Antimicrobial stewardship programmes in health-care facilities in low- and middle-income countries","author":"World Health Organization (WHO)","year":"2019"},{"issue":"1","key":"10.1016\/j.scitotenv.2023.167439_bb0335","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12864-020-6665-2","article-title":"The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice","volume":"21","author":"Xu","year":"2020","journal-title":"BMC Genomics"},{"issue":"8","key":"10.1016\/j.scitotenv.2023.167439_bb0340","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1128\/AAC.00670-13","article-title":"Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiota","volume":"57","author":"Zhang","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0345","doi-asserted-by":"crossref","first-page":"712843","DOI":"10.3389\/fmicb.2021.712843","article-title":"Metagenomic survey reveals more diverse and abundant antibiotic resistance genes in municipal wastewater than Hospital wastewater","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.scitotenv.2023.167439_bb0350","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.apsb.2020.09.013","article-title":"The influence of the gut microbiota on the bioavailability of oral drugs","volume":"11","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.scitotenv.2023.167439_bb0355","doi-asserted-by":"crossref","first-page":"105372","DOI":"10.1016\/j.envint.2019.105372","article-title":"Clinical class 1 integron-integrase gene - a promising indicator to monitor the abundance and elimination of antibiotic resistance genes in an urban wastewater treatment plant","volume":"135","author":"Zheng","year":"2020","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.scitotenv.2023.167439_bb0360","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/jssc.201200750","article-title":"Matrix effect in high-performance liquid chromatography-tandem mass spectrometry analysis of antibiotics in environmental water samples","volume":"36","author":"Zhou","year":"2013","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133733","article-title":"Risk-management tool for environmental prioritization of pharmaceuticals based on emissions from hospitals","volume":"694","author":"Zillien","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.167439_bb0370","series-title":"Dutch National Health Care Institute","author":"ZIN, Medicines and Resources Information Project Database (GIPdatabank)","year":"2021"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723060667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723060667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:52:00Z","timestamp":1787838720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969723060667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":74,"alternative-id":["S0048969723060667"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.167439","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of urban sources of antibiotics and antibiotic-resistance genes in a Dutch sewer catchment","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.167439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167439"}}