{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:26:14Z","timestamp":1789611974147,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["ZD2022C005"],"award-info":[{"award-number":["ZD2022C005"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.scitotenv.2023.169730","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T21:11:38Z","timestamp":1703884298000},"page":"169730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS\/P53"],"prefix":"10.1016","volume":"913","author":[{"given":"Dongliu","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pervez Ahmed","family":"Khoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2023.169730_bb0005","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differentiation"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0010","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.3382\/ps\/pey405","article-title":"Oxidative metabolism and efficiency: the delicate balancing act of mitochondria","volume":"98","author":"Bottje","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0015","doi-asserted-by":"crossref","DOI":"10.1177\/1559325815598304","article-title":"Environmental effects of BPA: focus on aquatic species","volume":"13","author":"Canesi","year":"2015","journal-title":"Dose-Response"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0020","article-title":"Deoxynivalenol induces carp neutrophil apoptosis and necroptosis via CYP450s\/ROS\/PI3K\/AKT pathway","volume":"545","author":"Chang","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117567","article-title":"Effects of bisphenol A exposure during cardiac cell differentiation","volume":"286","author":"Escarda-Castro","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108254","article-title":"Bisphenol A contamination in infant rats: molecular, structural, and physiological cardiovascular changes and the protective role of kefir","volume":"75","author":"Friques","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0035","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0045-6535(00)00507-5","article-title":"Identification and quantification of chlorinated bisphenol A in wastewater from wastepaper recycling plants","volume":"44","author":"Fukazawa","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12011-017-0953-y","article-title":"Glutathione peroxidase 1, selenoprotein K, and selenoprotein H may play important roles in chicken testes in response to selenium deficiency","volume":"179","author":"Gao","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0045","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1139\/apnm-2020-0005","article-title":"PGC-1\u03b1-mediated regulation of mitochondrial function and physiological implications","volume":"45","author":"Halling","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fct.2018.09.078","article-title":"Bisphenol A exhibits cytotoxic or genotoxic potential via oxidative stress-associated mitochondrial apoptotic pathway in murine macrophages","volume":"122","author":"Huang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134681","article-title":"Metabonomics reveals bisphenol A affects fatty acid and glucose metabolism through activation of LXR in the liver of male mice","volume":"703","author":"Ji","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0065","article-title":"Effects of selenium supplementation on the growth performance, slaughter characteristics, and blood biochemistry of naked neck chicken","volume":"102","author":"Khan","year":"2022","journal-title":"Poult. Sci."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167201","article-title":"Porcine \u03b2-defensin-2 alleviates aflatoxin B1 induced intestinal mucosal damage via ROS-Erk signaling pathway","volume":"905","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0075","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/jcp.31007","article-title":"Bisphenol A aggravate selenium deficiency-induced apoptosis via miR-215-3p\/Dio1 to activate ROS\/PI3K\/AKT pathway in chicken arterial","volume":"238","author":"Li","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/jcb.20700","article-title":"Regulation of the p53 transcriptional activity","volume":"97","author":"Liu","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0085","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.freeradbiomed.2008.01.011","article-title":"ROS and p53: a versatile partnership","volume":"44","author":"Liu","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0090","first-page":"23","article-title":"Exposure to bisphenol a caused hepatoxicity and intestinal flora disorder in rats","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109135","article-title":"Protective effects of sulforaphane on inflammation, oxidative stress and intestinal dysbacteriosis induced by triphenyltin in Cyprinus carpio haematopterus","volume":"142","author":"Ma","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb2430","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s00204-017-2150-3","article-title":"Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts","volume":"92","author":"Mahemuti","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00204-017-2038-2","article-title":"Consequences of bisphenol a perinatal exposure on immune responses and gut barrier function in mice","volume":"92","author":"Malais\u00e9","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0105","doi-asserted-by":"crossref","first-page":"16202","DOI":"10.1074\/jbc.275.21.16202","article-title":"Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling","volume":"275","author":"Marchenko","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2023.169730_bb2410","first-page":"47","article-title":"p53, p63 and p73--solos, alliances and feuds among family members","volume":"1552","author":"Moll","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0110","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.3390\/ijms22137189","article-title":"Bisphenol a modulates autophagy and exacerbates chronic kidney damage in mice","volume":"22","author":"Priego","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.lfs.2018.07.040","article-title":"Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK\/AKT pathways","volume":"208","author":"Qu","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0120","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.molcel.2011.08.044","article-title":"PGC-1\u03b1, a key modulator of p53, promotes cell survival upon metabolic stress","volume":"44","author":"Sen","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153678","article-title":"Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2\/HO-1 and Akt\/mTOR pathways","volume":"500","author":"Shen","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109146","article-title":"Alleviative effects of quercetin of Botrytis cinerea-induced toxicity in zebrafish (Danio rerio) larvae","volume":"142","author":"Shi","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160431","article-title":"Maternal exposure to 4-vinylcyclohexene diepoxide during pregnancy induces subfertility and birth defects of offspring in mice","volume":"859","author":"Song","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116129","article-title":"Diazinon exposure produces histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in crucian carp (Carassius auratus gibelio)","volume":"269","author":"Tang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2023.169730_bb2425","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrc864","article-title":"Live or let die: the cell\u2019s response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.scitotenv.2023.169730_bb2420","first-page":"13693","article-title":"microRNA-33-3p involved in selenium deficiency-induced apoptosis via targeting ADAM10 in the chicken kidney","volume":"234","author":"Wan","year":"2019","journal-title":"J. Cell."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111270","article-title":"Environmental contaminant BPA causes intestinal damage by disrupting cellular repair and injury homeostasis in vivo and in vitro","volume":"137","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0150","article-title":"Peroxiredoxin 3 inhibits acetaminophen-induced liver pyroptosis through the regulation of mitochondrial ROS","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102992","article-title":"Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1\/PGC-1\u03b1 signaling pathway","volume":"102","author":"Wang","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0160","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1021\/acs.jafc.2c08378","article-title":"Cannabidiol alleviates perfluorooctanesulfonic acid-induced cardiomyocyte apoptosis by maintaining mitochondrial dynamic balance and energy metabolic homeostasis","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0165","article-title":"Low-se diet increased mitochondrial ROS to suppress myoblasts proliferation and promote apoptosis in broilers via miR-365-3p\/SelT signaling axis","author":"Wu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.scitotenv.2023.169730_bb2415","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00709-013-0548-1","article-title":"P53 protein in proliferation, repair and apoptosis of cells","volume":"251","author":"Wawryk-Gawda","year":"2014","journal-title":"Protoplasma"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0170","article-title":"Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress","volume":"912","author":"Wu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2023.169730_bb2400","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1038\/s41467-022-34993-0","article-title":"SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation","volume":"13","author":"Yan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0175","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10534-013-9610-x","article-title":"Selenium effect on selenoprotein transcriptome in chondrocytes","volume":"26","author":"Yan","year":"2013","journal-title":"Biometals"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2022.12.081","article-title":"Melatonin attenuates bisphenol A-induced colon injury by dual targeting mitochondrial dynamics and Nrf2 antioxidant system via activation of SIRT1\/PGC-1\u03b1 signaling pathway","volume":"195","author":"Yao","year":"2023","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0185","first-page":"14","article-title":"Nutrient-sensing ghrelin receptor in macrophages modulates bisphenol A-induced intestinal inflammation in mice","author":"Ye","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126026","article-title":"In vitro oxidative stress, mitochondrial impairment and G1 phase cell cycle arrest induced by alkyl-phosphorus-containing flame retardants","volume":"248","author":"Yuan","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0195","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jcp.29836","article-title":"Selenium deficiency induced necroptosis, Th1\/Th2 imbalance, and inflammatory responses in swine ileum","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0200","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s10695-022-01140-x","article-title":"Selenium improved mitochondrial quality and energy supply in the liver of high-fat diet-fed grass carp (Ctenopharyngodon idella) after heat stress","volume":"48","author":"Zhang","year":"2022","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.scitotenv.2023.169730_bb2405","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112772","article-title":"Bisphenol A induces pyroptotic cell death via ROS\/NLRP3\/Caspase-1 pathway in osteocytes MLO-Y4","volume":"159","author":"Zhang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155034","article-title":"Protective effect of Xinmai\u2019an tablets via mediation of the AMPK\/SIRT1\/PGC-1\u03b1 signaling pathway on myocardial ischemia-reperfusion injury in rats","volume":"120","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0210","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.biopha.2019.01.007","article-title":"Bisphenol A inhibits mucin 2 secretion in intestinal goblet cells through mitochondrial dysfunction and oxidative stress","volume":"111","author":"Zhao","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.scitotenv.2023.169730_bb0215","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/biof.1762","article-title":"Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine","volume":"47","author":"Zheng","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.scitotenv.2023.169730_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154444","article-title":"Bisphenol chemicals disturb intestinal homeostasis via Notch\/Wnt signaling and induce mucosal barrier dysregulation and inflammation","volume":"828","author":"Zhu","year":"2022","journal-title":"Sci. Total Environ."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723083602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969723083602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:31:35Z","timestamp":1785947495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969723083602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":51,"alternative-id":["S0048969723083602"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169730","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS\/P53","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"169730"}}