{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:57:56Z","timestamp":1786996676131,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011037"],"award-info":[{"award-number":["2019A1515011037"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41877466"],"award-info":[{"award-number":["41877466"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.scitotenv.2024.170521","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T17:30:04Z","timestamp":1706463004000},"page":"170521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Neurotoxic effects induced by flunitrazepam and its metabolites in zebrafish: Oxidative stress, apoptosis, and histone hypoacetylation"],"prefix":"10.1016","volume":"917","author":[{"given":"Yingjun","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.scitotenv.2024.170521_bb0005","doi-asserted-by":"crossref","first-page":"17192","DOI":"10.1007\/s11356-015-4948-y","article-title":"Determination of the psychoactive drugs carbamazepine and diazepam in hospital effluent and identification of their metabolites","volume":"22","author":"de Almeida","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2024.170521_bb0010","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/02813430701726335","article-title":"The lesser evil? Initiating a benzodiazepine prescription in general practice","volume":"25","author":"Anthierens","year":"2007","journal-title":"Scand. J. Prim. Health Care"},{"issue":"6","key":"10.1016\/j.scitotenv.2024.170521_bb0015","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1007\/s11356-014-3477-4","article-title":"Psychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations","volume":"23","author":"Chiffre","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"6","key":"10.1016\/j.scitotenv.2024.170521_bb0020","article-title":"Neonicotinoid imidacloprid affects the social behavior of adult zebrafish by damaging telencephalon neurons through oxidation stress, inflammation, and apoptosis","volume":"13","author":"Chung","year":"2023","journal-title":"Life-Basel"},{"issue":"1","key":"10.1016\/j.scitotenv.2024.170521_bb0025","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2011.06.016","article-title":"Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3\u03b2","volume":"44","author":"Correa","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"7","key":"10.1016\/j.scitotenv.2024.170521_bb0030","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1017\/S0033291714002888","article-title":"A heavy burden on young minds: the global burden of mental and substance use disorders in children and youth","volume":"45","author":"Erskine","year":"2015","journal-title":"Psychol. Med."},{"issue":"2","key":"10.1016\/j.scitotenv.2024.170521_bb0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10072-013-1508-4","article-title":"Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy","volume":"35","author":"Fang","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuro.2017.11.003","article-title":"Manganese chloride induces histone acetylation changes in neuronal cells: its role in manganese-induced damage","volume":"65","author":"Guo","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0045","doi-asserted-by":"crossref","first-page":"132524","DOI":"10.1016\/j.jhazmat.2023.132524","article-title":"Synthetic azo-dye, Tartrazine induces neurodevelop mental toxicity via mitochondria-mediated apoptosis in zebrafish embryos","volume":"461","author":"Haridevamuthu","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0050","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.nbd.2016.03.017","article-title":"Role of histone acetylation in long-term neurobehavioral effects of neonatal exposure to sevoflurane in rats","volume":"91","author":"Jia","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"9","key":"10.1016\/j.scitotenv.2024.170521_bb0055","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.7150\/jca.72601","article-title":"Saponins of Marsdenia Tenacissima promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria then activating cytochrome C\/Caspase-9\/Caspase-3 pathway","volume":"13","author":"Jiang","year":"2022","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.scitotenv.2024.170521_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-29668-9","article-title":"Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish","volume":"13","author":"Johnson","year":"2023","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.scitotenv.2024.170521_bb0065","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1111\/jcmm.13524","article-title":"Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone","volume":"22","author":"Lin","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0070","article-title":"Flunitrazepam and its metabolites induced brain toxicity: insights from molecular dynamics simulation and transcriptomic analysis","volume":"133113","author":"Lin","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161541","article-title":"Integrate transcrip- tomic and metabolomic analysis reveals the underlying mechanisms of behavioral disorders in zebrafish (Danio rerio) induced by imidacloprid","volume":"870","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"17","key":"10.1016\/j.scitotenv.2024.170521_bb0080","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1016\/j.watres.2013.08.024","article-title":"EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents","volume":"47","author":"Loos","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113697","article-title":"Manganese chloride (MnCl2) induced novel model of Parkinson\u2019 s disease in adult zebrafish; involvement of oxidative stress, neuroinflammation and apoptosis pathway","volume":"155","author":"Nadig","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.scitotenv.2024.170521_bb0090","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41588-020-0696-0","article-title":"An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer\u2019s disease","volume":"52","author":"Nativio","year":"2020","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.scitotenv.2024.170521_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04019-6","article-title":"The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury","volume":"12","author":"Ning","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.scitotenv.2024.170521_bb1000","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138661","article-title":"Tracking the occurrence of psychotropic pharmaceuticals in Brazilian wastewater treatment plants and surface water, with assessment of environmental risks","author":"Pivetta","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0100","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.aquatox.2015.07.019","article-title":"Low environmental levels of neuro-active pharmaceuticals alter phototactic behaviour and reproduction in Daphnia magna","volume":"170","author":"Rivetti","year":"2016","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.scitotenv.2024.170521_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/genes14020347","article-title":"Histone modifications in Alzheimer\u2019s disease","volume":"14","author":"Santana","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.106002","article-title":"Long-term exposure to cyprodinil causes abnormal zebrafish aggressive and antipredator behavior through the hypothalamic-pituitary-interrenal axis","volume":"241","author":"Tang","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117826","article-title":"Effects of common environ- mental endocrine-disrupting chemicals on zebrafish behavior","volume":"208","author":"Tao","year":"2022","journal-title":"Water Res."},{"issue":"1\u20132","key":"10.1016\/j.scitotenv.2024.170521_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0021-9673(01)01205-5","article-title":"Determination of neutral pharmaceuticals in wastewater and rivers by liquid chromatography\u2013electrospray tandem mass spectrometry","volume":"938","author":"Ternes","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160094","article-title":"Enrofloxacin exposure induces anxiety-like behavioral responses in zebrafish by affecting the microbiota-gut-brain axis","volume":"858","author":"Tian","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0130","series-title":"Transcription","first-page":"23","article-title":"MOZ fusion proteins in acute myeloid leukaemia","author":"Troke","year":"2006"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0135","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.scitotenv.2016.03.045","article-title":"Bioaccumulation and bioconcentration of carbamazepine and other pharmaceuticals in fish under field and controlled laboratory experiments. Evidences of carbamazepine metabolization by fish","volume":"557","author":"Valdes","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.170521_bb0140","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2217\/epi.14.19","article-title":"Epigenetic modifications as novel therapeutic targets for Huntington's disease","volume":"6","author":"Wang","year":"2014","journal-title":"Epigenomics"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.envpol.2015.07.015","article-title":"Chronic bisphenol A exposure alters behaviors of zebrafish (Danio rerio)","volume":"206","author":"Wang","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0150","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.chemosphere.2018.09.103","article-title":"Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish","volume":"214","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.scitotenv.2024.170521_bb0155","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1039\/D2EN00757F","article-title":"Nickel oxide nanoparticles induce developmental neurotoxicity in zebrafish by triggering both apoptosis and ferroptosis","volume":"10","author":"Wang","year":"2023","journal-title":"Environ. Sci. Nano"},{"issue":"1","key":"10.1016\/j.scitotenv.2024.170521_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11010088","article-title":"HAT- and HDAC-targeted protein acetylation in the occurrence and treatment of epilepsy","volume":"11","author":"Wang","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0165","series-title":"The Zebrafish Book\u202f: A Guide for the Laboratory Use of Zebrafish (Danio rerio)","author":"Westerfield","year":"1995"},{"key":"10.1016\/j.scitotenv.2024.170521_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105259","article-title":"Neurotoxi- city of sanguinarine via inhibiting mitophagy and activating apoptosis in zebrafish and PC12 cells","volume":"188","author":"Yang","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"issue":"10","key":"10.1016\/j.scitotenv.2024.170521_bb0175","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20209861","article-title":"Enriched environment improves sevoflurane-induced cognitive impairment during late-pregnancy via hippocampal histone acetylation","volume":"53","author":"Yu","year":"2020","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.170521_bb0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nsmb.2470","article-title":"Regulation of nucleosome dynamics by histone modifications","volume":"20","author":"Zentner","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2024.170521_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143054","article-title":"Environmentally relevant concentration of cypermethrin or\/and sulfamethoxazole induce neurotoxicity of grass carp: involvement of blood-brain barrier, oxidative stress and apoptosis","volume":"762","author":"Zhao","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"19\u201320","key":"10.1016\/j.scitotenv.2024.170521_bb0190","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1089\/neu.2022.0128","article-title":"Epigenetic modifications and their potential contribution to traumatic brain injury pathobiology and outcome","volume":"39","author":"Zima","year":"2022","journal-title":"J. Neurotrauma"},{"issue":"9217","key":"10.1016\/j.scitotenv.2024.170521_bb0195","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(00)02270-4","article-title":"Presence of therapeutic drugs in the environment","volume":"355","author":"Zuccato","year":"2000","journal-title":"Lancet"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724006582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724006582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:59:50Z","timestamp":1785434390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724006582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":40,"alternative-id":["S0048969724006582"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170521","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurotoxic effects induced by flunitrazepam and its metabolites in zebrafish: Oxidative stress, apoptosis, and histone hypoacetylation","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170521"}}