{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:10:22Z","timestamp":1793376622717,"version":"4.5.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015600","name":"Guangdong Ocean University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.scitotenv.2024.170664","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T11:18:46Z","timestamp":1706872726000},"page":"170664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Differences in toxicity induced by the various polymer types of nanoplastics on HepG2 cells"],"prefix":"10.1016","volume":"918","author":[{"given":"Lihua","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-165X","authenticated-orcid":false,"given":"Chengyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.170664_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155833","article-title":"Is there tea complemented with the appealing flavor of microplastics? A pioneering study on plastic pollution in commercially available tea bags in Bangladesh","volume":"837","author":"Afrin","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0092-8674(00)00010-6","article-title":"Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage","volume":"102","author":"Agami","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160954","article-title":"The hazardous impact of true-to-life PET nanoplastics in Drosophila","volume":"863","author":"Alaraby","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2023.503705","article-title":"Nanoplastics from ground polyethylene terephthalate food containers: genotoxicity in human lung epithelial A549 cells","volume":"892","author":"Alzaben","year":"2023","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131899","article-title":"The release of polylactic acid nanoplastics (PLA-NPLs) from commercial teabags. Obtention, characterization, and hazard effects of true-to-life PLA-NPLs","volume":"458","author":"Banaei","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155621","article-title":"Effects of polystyrene micro\/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period","volume":"836","author":"Banerjee","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.marpolbul.2018.05.047","article-title":"Marine microplastic debris: an emerging issue for food security, food safety and human health","volume":"133","author":"Barboza","year":"2018","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0040","first-page":"13","article-title":"A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo","author":"Bashirova","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0045","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/hh0701.089955","article-title":"Reactive oxygen species and death","volume":"88","author":"Bennett","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0050","doi-asserted-by":"crossref","first-page":"eaax1157","DOI":"10.1126\/sciadv.aax1157","article-title":"White and wonderful? Microplastics prevail in snow from the Alps to the Arctic","volume":"5","author":"Bergmann","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0055","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1021\/acsomega.8b00785","article-title":"Controlled dye aggregation in sodium dodecylsulfate-stabilized poly(methylmethacrylate) nanoparticles as fluorescent imaging probes","volume":"3","author":"Bhargava","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0060","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/17435390.2017.1306130","article-title":"Carbon nanopowder acts as a Trojan-horse for benzo(\u03b1)pyrene in Danio rerio embryos","volume":"11","author":"Binelli","year":"2017","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0065","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ecss.2015.12.003","article-title":"Microplastics as vector for heavy metal contamination from the marine environment","volume":"178","author":"Brennecke","year":"2016","journal-title":"Estuar. Coast. Shelf Sci."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131345","article-title":"An inverted in vitro triple culture model of the healthy and inflamed intestine: adverse effects of polyethylene particles","volume":"284","author":"Busch","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0075","article-title":"Microplastic pollution in wild and aquacultured Mediterranean mussels from the Sea of Marmara: abundance, characteristics, and health risk estimations","volume":"242","author":"Can Tun\u00e7elli","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/jat.3915","article-title":"Potential health impact of environmental micro- and nanoplastics pollution","volume":"40","author":"Chang","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0085","article-title":"The mechanism of two benzaldehydes from Aspergillus terreus C23-3 improve neuroinflammatory and neuronal damage to delay the progression of Alzheimer\u2019s disease","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.chemphyslip.2014.04.001","article-title":"Mitochondrial alterations in apoptosis","volume":"181","author":"Cosentino","year":"2014","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0095","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1021\/acs.est.9b01517","article-title":"Human consumption of microplastics","volume":"53","author":"Cox","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0100","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7171","article-title":"Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis","volume":"128","author":"Danopoulos","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165076","article-title":"The emerging role of microplastics in systemic toxicity: involvement of reactive oxygen species (ROS)","volume":"895","author":"Das","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0110","first-page":"7","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163144","article-title":"The detrimental effects of micro-and nano-plastics on digestive system: an overview of oxidative stress-related adverse outcome pathway","volume":"878","author":"Ding","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0120","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1021\/acs.est.2c05772","article-title":"Aging of nanoplastics significantly affects protein Corona composition thus enhancing macrophage uptake","volume":"57","author":"Du","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165659","article-title":"The hepatotoxicity assessment of micro\/nanoplastics: a preliminary study to apply the adverse outcome pathways","volume":"902","author":"Ge","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s11658-018-0083-3","article-title":"MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1","volume":"23","author":"Gong","year":"2018","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121385","article-title":"Recent trends on microplastics abundance and risk assessment in coastal Antarctica: regional meta-analysis","volume":"324","author":"Gurumoorthi","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140301","article-title":"Microplastics and additives in patients with preterm birth: the first evidence of their presence in both human amniotic fluid and placenta","volume":"343","author":"Halfar","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128485","article-title":"Toxic effects of nanoplastics with different sizes and surface charges on epithelial-to-mesenchymal transition in A549 cells and the potential toxicological mechanism","volume":"430","author":"Halimu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.freeradbiomed.2012.11.009","article-title":"Metal interaction with redox regulation: an integrating concept in metal carcinogenesis?","volume":"55","author":"Hartwig","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115814","article-title":"The effect of polystyrene nanoplastics on arsenic-induced apoptosis in HepG2 cells","volume":"269","author":"He","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138180","article-title":"Cytotoxic effects of polystyrene nanoplastics with different surface functionalization on human HepG2 cells","volume":"723","author":"He","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0165","doi-asserted-by":"crossref","first-page":"12300","DOI":"10.1021\/acs.est.9b02540","article-title":"Plastic teabags release billions of microparticles and nanoparticles into tea","volume":"53","author":"Hernandez","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104610","article-title":"Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro","volume":"61","author":"Hesler","year":"2019","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0175","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.redox.2013.07.006","article-title":"Biological markers of oxidative stress: applications to cardiovascular research and practice","volume":"1","author":"Ho","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics detected in cirrhotic liver tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101620","article-title":"Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways","volume":"37","author":"Hu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115447","article-title":"Biological interactions of polystyrene nanoplastics: their cytotoxic and immunotoxic effects on the hepatic and enteric systems","volume":"264","author":"Huang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0195","article-title":"Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism","author":"Jiang","year":"2023","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0200","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1039\/D0NA00888E","article-title":"Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells","volume":"3","author":"Johnson","year":"2021","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4939-7477-1_9","article-title":"Cell death and survival assays","author":"Kabakov","year":"2018","journal-title":"Chaperones"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137232","article-title":"Smaller-sized micro-plastics (MPs) contamination in single-use PET-bottled water in Thailand","volume":"717","author":"Kankanige","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137232","article-title":"Smaller-sized micro-plastics (MPs) contamination in single-use PET-bottled water in Thailand","volume":"717","author":"Kankanige","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0220","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.scitotenv.2017.09.005","article-title":"Microplastic and mesoplastic contamination in canned sardines and sprats","volume":"612","author":"Karami","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194970","article-title":"Anthropogenic contamination of tap water, beer, and sea salt","volume":"13","author":"Kosuth","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0230","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1128\/AAC.44.7.1954-1960.2000","article-title":"Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: comparative sensitivity of primary human vaginal keratinocytes","volume":"44","author":"Krebs","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0235","first-page":"11","article-title":"Uptake of breathable nano- and micro-sized polystyrene particles: comparison of virgin and oxidised nps\/mps in human alveolar cells","author":"Lagan\u00e0","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126454","article-title":"Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea)","volume":"419","author":"Lai","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0245","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s43016-020-00171-y","article-title":"Microplastic release from the degradation of polypropylene feeding bottles during infant formula preparation","volume":"1","author":"Li","year":"2020","journal-title":"Nature Food"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0250","doi-asserted-by":"crossref","first-page":"26227","DOI":"10.1021\/acsami.2c21485","article-title":"Exosome-like nanovesicles derived from the mucilage of Pinctada martensii exhibit antitumor activity against 143B osteosarcoma cells","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126025","article-title":"Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload","volume":"417","author":"Li","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127508","article-title":"In vitro study on the toxicity of nanoplastics with different charges to murine splenic lymphocytes","volume":"424","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110502","article-title":"ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells","volume":"379","author":"Li","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113984","article-title":"Impact of food matrices on the characteristics and cellular toxicities of ingested nanoplastics in a simulated digestive tract","volume":"179","author":"Li","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0275","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1080\/19440049.2013.843025","article-title":"Non-pollen particulates in honey and sugar","volume":"30","author":"Liebezeit","year":"2013","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0280","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1080\/19440049.2014.945099","article-title":"Synthetic particles as contaminants in German beers","volume":"31","author":"Liebezeit","year":"2014","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112885","article-title":"Nanoplastics aggravate the toxicity of arsenic to AGS cells by disrupting ABC transporter and cytoskeleton","volume":"227","author":"Lin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0290","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1039\/D1EN00688F","article-title":"Do polystyrene nanoplastics aggravate the toxicity of single contaminants (okadaic acid)? Using AGS cells as a biological model","volume":"8","author":"Lin","year":"2021","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0295","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12011-023-03683-3","article-title":"Zinc oxide nanoparticles induce renal injury by initiating oxidative stress, mitochondrial damage and apoptosis in renal tubular epithelial cells","volume":"202","author":"Liu","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127629","article-title":"Polystyrene microplastics induced female reproductive toxicity in mice","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2023.02.035","article-title":"Molecular mechanisms of toxicity and detoxification in rice (Oryza sativa L.) exposed to polystyrene nanoplastics","volume":"199","author":"Lu","year":"2023","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0310","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1021\/nn2000756","article-title":"Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line","volume":"5","author":"Lunov","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0315","series-title":"In Situ Surface-enhanced Raman Spectroscopy for Detecting Microplastics and Nanoplastics in Aquatic Environments","author":"Lv","year":"2020"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0320","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.envpol.2016.10.061","article-title":"Effects of nanoplastics and microplastics on toxicity, bioaccumulation, and environmental fate of phenanthrene in fresh water","volume":"219","author":"Ma","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0325","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1021\/acs.chemrestox.0c00391","article-title":"Comparison of genotoxicity and cytotoxicity of polyvinyl chloride and poly(methyl methacrylate) nanoparticles on normal human lung cell lines","volume":"34","author":"Mahadevan","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0330","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1038\/s41598-020-80708-0","article-title":"Understanding the interactions of poly(methyl methacrylate) and poly(vinyl chloride) nanoparticles with BHK-21 cell line","volume":"11","author":"Mahadevan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0335","first-page":"11","article-title":"Understanding the interactions of poly(methyl methacrylate) and poly(vinyl chloride) nanoparticles with BHK-21 cell line","author":"Mahadevan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0340","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1021\/es0010498","article-title":"Plastic resin pellets as a transport medium for toxic chemicals in the marine environment","volume":"35","author":"Mato","year":"2001","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0345","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/es5053655","article-title":"Altered behavior, physiology, and metabolism in fish exposed to polystyrene nanoparticles","volume":"49","author":"Mattsson","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0350","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1039\/C5EM00227C","article-title":"Nano-plastics in the aquatic environment","volume":"17","author":"Mattsson","year":"2015","journal-title":"Environ Sci Process Impacts"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0355","first-page":"11","article-title":"Identification and evaluation of microplastics from tea filter bags based on Raman imaging","author":"Mei","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/foods11182871","article-title":"Identification and evaluation of microplastics from tea filter bags based on Raman imaging","volume":"11","author":"Mei","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2021.01.152","article-title":"Biological effects of formation of protein corona onto nanoparticles","volume":"175","author":"Mishra","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0370","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mrrev.2014.09.001","article-title":"Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles","volume":"762","author":"M\u00f8ller","year":"2014","journal-title":"Mutation Research\/Reviews in Mutation Research"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0375","first-page":"9","article-title":"Cyclin D1 in cancer: a molecular connection for cell cycle control, adhesion and invasion in tumor and stroma","author":"Montalto","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132944","article-title":"Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice","volume":"291","author":"Mu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109677","article-title":"Micro- and nano-plastics in edible fruit and vegetables. The first diet risks assessment for the general population","volume":"187","author":"Oliveri Conti","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162954","article-title":"Micro- and nanoplastic toxicity: a review on size, type, source, and test-organism implications","volume":"878","author":"Pelegrini","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0395","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1172\/JCI0215387","article-title":"Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype","volume":"110","author":"Pullinger","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0400","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1039\/D0NR09053K","article-title":"The differences of the impact of a lipid and protein corona on the colloidal stability, toxicity, and degradation behavior of iron oxide nanoparticles","volume":"13","author":"Rabel","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0405","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1039\/C9EN00365G","article-title":"A novel and simple method for polyethylene terephthalate (PET) nanoparticle production","volume":"6","author":"Rodr\u00edguez-Hern\u00e1ndez","year":"2019","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0410","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12989-015-0091-7","article-title":"Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells","volume":"12","author":"Ruenraroengsak","year":"2015","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0415","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/07482337211065832","article-title":"Differences in sensitivity of human lymphocytes and fish lymphocytes to polyvinyl chloride microplastic toxicity","volume":"38","author":"Salimi","year":"2022","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2022.113832","article-title":"A review on microplastics and nanoplastics in the environment: their occurrence, exposure routes, toxic studies, and potential effects on human health","volume":"181","author":"Sangkham","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0425","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature08011","article-title":"F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage","volume":"459","author":"Santra","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0430","doi-asserted-by":"crossref","first-page":"12246","DOI":"10.1021\/acs.est.7b02368","article-title":"Export of plastic debris by rivers into the sea","volume":"51","author":"Schmidt","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0435","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of various microplastics in human stool","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0440","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.watres.2017.11.011","article-title":"Analysis of microplastics in water by micro-Raman spectroscopy: release of plastic particles from different packaging into mineral water","volume":"129","author":"Schymanski","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107628","article-title":"Aggregation kinetics of polystyrene nanoplastics in gastric environments: effects of plastic properties, solution conditions, and gastric constituents","volume":"170","author":"Shao","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118960","article-title":"Mechanistic toxicity assessment of differently sized and charged polystyrene nanoparticles based on human placental cells","volume":"223","author":"Shen","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0455","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.fct.2012.01.017","article-title":"Nickel oxide nanoparticles induce cytotoxicity, oxidative stress and apoptosis in cultured human cells that is abrogated by the dietary antioxidant curcumin","volume":"50","author":"Siddiqui","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0460","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1080\/09593330.2021.1934560","article-title":"A global pollutant (PVC-polyvinyl chloride) applied as heavy metal binder from aqueous samples: green principles from synthesis to application","volume":"43","author":"Silva","year":"2021","journal-title":"Environ. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113844","article-title":"Sorption of PAHs to microplastic and their bioavailability and toxicity to marine copepods under co-exposure conditions","volume":"258","author":"S\u00f8rensen","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0470","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cotox.2021.10.001","article-title":"Micro- and nanoplastic transfer, accumulation, and toxicity in humans","volume":"28","author":"Stapleton","year":"2021","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.105021","article-title":"Uptake and cellular effects of PE, PP, PET and PVC microplastic particles","volume":"70","author":"Stock","year":"2021","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0480","article-title":"Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62\/Keap1\/Nrf2 pathway","volume":"912","author":"Sun","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0485","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.toxrep.2023.07.003","article-title":"Incidence and exposure to microplastics in table salt present in the Iran market","volume":"11","author":"Taghipour","year":"2023","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126493","article-title":"Occurrence and identification of microplastics in tap water from China","volume":"252","author":"Tong","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0495","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124536","article-title":"Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid","volume":"410","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0505","first-page":"11","article-title":"Microplastics in the lung tissues associated with blood test index","author":"Wang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0510","doi-asserted-by":"crossref","first-page":"14127","DOI":"10.1021\/acs.est.3c02769","article-title":"Nanoplastic exposure at environmental concentrations disrupts hepatic lipid metabolism through oxidative stress induction and endoplasmic reticulum homeostasis perturbation","volume":"57","author":"Wang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107173","article-title":"Nanoplastics affect the inflammatory cytokine release by primary human monocytes and dendritic cells","volume":"163","author":"Weber","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130599","article-title":"Comparative proteomic analysis reveals the different hepatotoxic mechanisms of human hepatocytes exposed to silver nanoparticles","volume":"445","author":"Wong","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0525","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12989-022-00512-8","article-title":"Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-\u03baB pathway due to mitochondrial damage","volume":"20","author":"Woo","year":"2023","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0530","first-page":"249","article-title":"DEHP degradation and dechlorination of polyvinyl chloride waste in subcritical water with alkali and ethanol: a comparative study","author":"Xiu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.158111","article-title":"A review of potential human health impacts of micro- and nanoplastics exposure","volume":"851","author":"Xu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133794","article-title":"Internalization and toxicity: a preliminary study of effects of nanoplastic particles on human lung epithelial cell","volume":"694","author":"Xu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0545","article-title":"Polystyrene nanoplastics promote the apoptosis in Caco-2 cells induced by okadaic acid more than microplastics","volume":"249","author":"Yan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112837","article-title":"In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model","volume":"226","author":"Yang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0555","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.freeradbiomed.2023.08.010","article-title":"Cationic nanoplastic causes mitochondrial dysfunction in neural progenitor cells and impairs hippocampal neurogenesis","volume":"208","author":"Yang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146919","article-title":"Mechanism of the inhibition and detoxification effects of the interaction between nanoplastics and microalgae Chlorella pyrenoidosa","volume":"783","author":"Yang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153730","article-title":"Human health concerns regarding microplastics in the aquatic environment - from marine to food systems","volume":"823","author":"Yuan","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107177","article-title":"Pulmonary toxicology assessment of polyethylene terephthalate nanoplastic particles in vitro","volume":"162","author":"Zhang","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107177","article-title":"Pulmonary toxicology assessment of polyethylene terephthalate nanoplastic particles in vitro","volume":"162","author":"Zhang","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0580","article-title":"Migration mechanism of chlorine during hydrothermal treatment of rigid PVC plastics","volume":"16","author":"Zhang","year":"2023","journal-title":"Materials"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.129479","article-title":"Microplastics in different tissues of wild crabs at three important fishing grounds in China","volume":"271","author":"Zhang","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143634","article-title":"Microplastics in glaciers of the Tibetan plateau: evidence for the long-range transport of microplastics","volume":"758","author":"Zhang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0595","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00109-018-1649-2","article-title":"CFTR prevents neuronal apoptosis following cerebral ischemia reperfusion via regulating mitochondrial oxidative stress","volume":"96","author":"Zhang","year":"2018","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.scitotenv.2024.170664_bb0600","first-page":"12","article-title":"The applications and mechanisms of superoxide dismutase in medicine, food, and cosmetics","author":"Zheng","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.scitotenv.2024.170664_bb0605","doi-asserted-by":"crossref","first-page":"110579","DOI":"10.1007\/s11356-023-30155-x","article-title":"Polystyrene nanoplastics induce apoptosis of human kidney proximal tubular epithelial cells via oxidative stress and MAPK signaling pathways","volume":"30","author":"Zhu","year":"2023","journal-title":"Environ. Sci. Pollut. Res."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724008039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724008039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T16:43:30Z","timestamp":1758732210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724008039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":121,"alternative-id":["S0048969724008039"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170664","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences in toxicity induced by the various polymer types of nanoplastics on HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"170664"}}