{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:34:28Z","timestamp":1791207268214,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013318","name":"Shanxi Province Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.scitotenv.2024.170761","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T16:30:20Z","timestamp":1707409820000},"page":"170761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Associations between per- and polyfluoroalkyl substances exposure and thyroid hormone levels in the elderly"],"prefix":"10.1016","volume":"920","author":[{"given":"Kai","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QingQuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongfang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.170761_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104929","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery","volume":"130","author":"Aimuzi","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0010","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1021\/es4027634","article-title":"Persistent organic pollutants and transthyretin-bound thyroxin in plasma of Inuit women of childbearing age","volume":"47","author":"Audet-Delage","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envint.2016.10.015","article-title":"Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: a systematic review of epidemiologic studies","volume":"99","author":"Ballesteros","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0020","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1097\/EDE.0000000000000247","article-title":"Models with transformed variables: interpretation and software","volume":"26","author":"Barrera-G\u00f3mez","year":"2015","journal-title":"Epidemiology"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1289\/EHP152","article-title":"Persistent organic pollutants and the association with maternal and infant thyroid homeostasis: a multipollutant assessment","volume":"125","author":"Berg","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/MED.0b013e3283305af7","article-title":"Main K M, Feldt-Rasmussen U. Environmental chemicals and thyroid function: an update","volume":"16","author":"Boas","year":"2009","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0035","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1172\/JCI105434","article-title":"Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages","volume":"45","author":"Braverman","year":"1966","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0040","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.biopha.2009.08.003","article-title":"Thyroid hormones and the cardiovascular system: pathophysiology and interventions","volume":"63","author":"Cini","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104855","article-title":"Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: a case study with phthalates","volume":"66","author":"Clewell","year":"2020","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0050","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1021\/es9001604","article-title":"Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada)","volume":"43","author":"Dallaire","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0055","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1289\/ehp.0900633","article-title":"Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults","volume":"117","author":"Dallaire","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108922","article-title":"Association between mixture of persistent organic pollutants and thyroid pathologies in a Belgian population","volume":"181","author":"Dufour","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0065","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijheh.2008.04.007","article-title":"Perfluorinated compounds-exposure assessment for the general population in Western countries","volume":"212","author":"Fromme","year":"2009","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0070","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1289\/ehp.7569","article-title":"Aging and the environment: a research framework","volume":"113","author":"Geller","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0075","doi-asserted-by":"crossref","first-page":"17015","DOI":"10.1289\/EHP5911","article-title":"Transthyretin-binding activity of complex mixtures representing the composition of thyroid-hormone disrupting contaminants in house dust and human serum","volume":"128","author":"Hamers","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0080","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1021\/es802827u","article-title":"Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples","volume":"43","author":"Haug","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0085","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.envint.2010.05.016","article-title":"Diet and particularly seafood are major sources of perfluorinated compounds in humans","volume":"36","author":"Haug","year":"2010","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105139","article-title":"Association between perfluoroalkyl substance exposure and thyroid hormone\/thyroid antibody levels in maternal and cord blood: the Hokkaido study","volume":"133","author":"Itoh","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.envres.2013.08.006","article-title":"Association between thyroid profile and perfluoroalkyl acids: data from NHNAES 2007\u20132008","volume":"126","author":"Jain","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0100","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.envint.2012.03.007","article-title":"Serum concentrations of major perfluorinated compounds among the general population in Korea: dietary sources and potential impact on thyroid hormones","volume":"45","author":"Ji","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0105","article-title":"Association between perfluoroalkyl substances exposure and thyroid function in adults: a meta-analysis","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0110","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2131\/jts.36.403","article-title":"Perfluorocarbon exposure, gender and thyroid function in the C8 health project","volume":"36","author":"Knox","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0115","doi-asserted-by":"crossref","first-page":"26001","DOI":"10.1289\/EHP2207","article-title":"Statistical methodology in studies of prenatal exposure to mixtures of endocrine-disrupting chemicals: a review of existing approaches and new alternatives","volume":"127","author":"Lazarevic","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0120","doi-asserted-by":"crossref","first-page":"43380","DOI":"10.1038\/srep43380","article-title":"Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0125","series-title":"Associations of per\u2212\/Polyfluoroalkyl Substances with Thyroid Hormone, Estrogen, and Infant Growth","author":"Liu","year":"2019"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105636","article-title":"Associations of per\u2212\/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns","volume":"140","author":"Liu","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124378","article-title":"Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China","volume":"407","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0140","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1021\/es9002229","article-title":"Geographical distribution of perfluorinated compounds in human blood from Liaoning Province","volume":"43","author":"Liu","year":"2009","journal-title":"China. Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0145","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1289\/ehp.1509755","article-title":"Polybrominated diphenyl ether exposure and thyroid function tests in north American adults","volume":"124","author":"Makey","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0150","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1002\/anie.201601116","article-title":"Chemistry and biology in the biosynthesis and action of thyroid hormones","volume":"55","author":"Mondal","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0155","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0160","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/etc.342","article-title":"Concentrations of perfluorinated compounds in human blood from twelve cities in China","volume":"29","author":"Pan","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0165","doi-asserted-by":"crossref","first-page":"28","DOI":"10.14310\/horm.2002.1111035","article-title":"Thyroid hormones and aging","volume":"7","author":"Peeters","year":"2008","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2041-210X.2010.00061.x","article-title":"Using false discovery rates for multiple comparisons in ecology and evolution","volume":"2","author":"Pike","year":"2011","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105673","article-title":"Organizing mechanism-related information on chemical interactions using a framework based on the aggregate exposure and adverse outcome pathways","volume":"138","author":"Price","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0180","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacc.2018.02.045","article-title":"Thyroid hormones and cardiovascular function and diseases","volume":"71","author":"Razvi","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0185","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2016.08.011","article-title":"Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications","volume":"366-367","author":"Ren","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.envint.2015.05.003","article-title":"Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: results from the prospective investigation of the vasculature in Uppsala seniors (PIVUS)","volume":"82","author":"Salihovic","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0195","series-title":"Perfluorinated Compounds, Thyroid Function, and Neuropsychological Status in Older Residents of Upper Hudson River Communities[D]","author":"Shrestha","year":"2017"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0200","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.envint.2014.11.018","article-title":"Perfluoroalkyl substances and thyroid function in older adults","volume":"75","author":"Shrestha","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0205","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.chemosphere.2017.06.023","article-title":"Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes","volume":"184","author":"Siebenaler","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0210","author":"Stockholm convention"},{"key":"10.1016\/j.scitotenv.2024.170761_bb0215","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.beem.2009.06.005","article-title":"Sex steroids and the thyroid","volume":"23","author":"Tahboub","year":"2009","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0220","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfp055","article-title":"Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin","volume":"109","author":"Weiss","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0225","doi-asserted-by":"crossref","first-page":"21699","DOI":"10.1038\/srep21699","article-title":"Placental transfer of perfluoroalkyl substances and associations with thyroid hormones: Beijing prenatal exposure study","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106621","article-title":"Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: a prospective cohort study","volume":"156","author":"Yu","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0240","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1021\/es1002132","article-title":"Perfluorinated compounds in whole blood samples from infants, children, and adults in China","volume":"44","author":"Zhang","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0245","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1007\/s11356-014-3725-7","article-title":"PFOS and PFOA in paired urine and blood from general adults and pregnant women: assessment of urinary elimination","volume":"22","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2024.170761_bb0250","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10098-011-0375-z","article-title":"Masunaga S. Progress and perspective of perfluorinated compound risk assessment and management in various countries and institutes","volume":"14","author":"Zushi","year":"2012","journal-title":"Clean Techn. Environ. Policy"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724009008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724009008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T15:43:02Z","timestamp":1733931782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724009008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":49,"alternative-id":["S0048969724009008"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170761","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between per- and polyfluoroalkyl substances exposure and thyroid hormone levels in the elderly","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"170761"}}