{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:00:49Z","timestamp":1774292449130,"version":"3.50.1"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-05973"],"award-info":[{"award-number":["2018-05973"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["PATER 805057"],"award-info":[{"award-number":["PATER 805057"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.scitotenv.2024.170949","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:07:16Z","timestamp":1707955636000},"page":"170949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Male-transmitted transgenerational effects of the herbicide linuron on DNA methylation profiles in Xenopus tropicalis brain and testis"],"prefix":"10.1016","volume":"923","author":[{"given":"Mauricio","family":"Roza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas N.M.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"Svanholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.170949_bb0005","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13072-018-0205-1","article-title":"Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species","volume":"11","author":"Anastasiadi","year":"2018","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0015","first-page":"1","article-title":"Parental transgenerational epigenetic inheritance related to dietary crude oil exposure in Danio rerio","volume":"223","author":"Bautista","year":"2020","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0020","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvy010","article-title":"Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease","volume":"4","author":"Ben Maamar","year":"2018","journal-title":"Environ. Epigenet."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ydbio.2019.10.030","article-title":"Epigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations: epigenetic transgenerational parent-of-origin allelic transmission","volume":"458","author":"Ben Maamar","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0030","series-title":"Developmental Toxicology: Methods and Protocols, Methods in Molecular Biology","first-page":"73","article-title":"An amphibian model for studies of developmental reproductive toxicity","author":"Berg","year":"2012"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146404","article-title":"The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio)","volume":"779","author":"Blanc","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0040","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2015.12.012","article-title":"Zebrafish embryos as a screen for DNA methylation modifications after compound exposure","volume":"291","author":"Bouwmeester","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014524","article-title":"DNA methylation of the first exon is tightly linked to transcriptional silencing","volume":"6","author":"Brenet","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0050","series-title":"Molecular and Cellular Endocrinology, A Century of Thyroid Hormone Research - Vol. II: Evolution and Development of the Thyroid System","first-page":"64","article-title":"Xenopus metamorphosis as a model to study thyroid hormone receptor function during vertebrate developmental transitions","volume":"vol. 459","author":"Buchholz","year":"2017"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1017\/S0967199419000303","article-title":"Histone hyperacetylation and DNA methylation interplay during murine spermatogenesis","volume":"27","author":"Burliba\u015fa","year":"2019","journal-title":"Zygote"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0060","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/ejn.12122","article-title":"Estrogen-related receptor \u03b2 deletion modulates whole-body energy balance via estrogen-related receptor \u03b3 and attenuates neuropeptide Y gene expression","volume":"37","author":"Byerly","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0070","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1172\/JCI31516","article-title":"AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons","volume":"117","author":"Claret","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0075","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1093\/nar\/gkaa163","article-title":"Multi-omic analysis of gametogenesis reveals a novel signature at the promoters and distal enhancers of active genes","volume":"48","author":"Crespo","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0080","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s002449900519","article-title":"Sorption of nine pesticides to three aquatic macrophytes","volume":"37","author":"Crum","year":"1999","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0085","series-title":"Risks of Linuron Use to Federally Threatened California Red-Legged Frog","author":"Davy","year":"2008"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0090","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ijo.2016.44","article-title":"Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits","volume":"40","author":"Dong","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0095","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jez.b.22571","article-title":"Epigenetics, plasticity, and evolution: how do we link epigenetic change to phenotype?","volume":"322","author":"Duncan","year":"2014","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0100","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","article-title":"BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis","volume":"21","author":"Durinck","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0105","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integ- ration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0110","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-020-0439-x","article-title":"The nf-core framework for community-curated bioinformatics pipelines","volume":"38","author":"Ewels","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0115","series-title":"nf-core\/methylseq: nf-core\/methylseq Version 1.6.1 [Nauseous Serpent]","author":"Ewels","year":"2021"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0120","series-title":"Normal Table of Xenopus Laevis (Daudin): A Systematical and Chronological Survey of the Development From the Fertilized Egg Till the End of Metamorphosis","year":"1994"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107776","article-title":"Present and future challenges for the investigation of transgenerational epigenetic inheritance","volume":"172","author":"Fallet","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41576-021-00438-5","article-title":"Molecular mechanisms of transgenerational epigenetic inheritance","author":"Fitz-James","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2015.00056","article-title":"Distinct actions of ancestral vinclozolin and juvenile stress on neural gene expression in the male rat","volume":"6","author":"Gillette","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-61779-992-1_1","article-title":"Xenopus tropicalis as a model organism for genetics and genomics: past, present and future","volume":"917","author":"Grainger","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0145","series-title":"Epigenetic Transgenerational Effects of Endocrine Disruptors on Male Reproduction","first-page":"403","volume":"vol. 27","author":"Guerrero-Bosagna","year":"2009"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0150","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5152\/tud.2013.037","article-title":"The role of epigenetics in spermatogenesis","volume":"39","author":"G\u00fcne\u015f","year":"2013","journal-title":"Turk. J. Urol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0155","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.aquatox.2008.06.019","article-title":"Reproductive toxicity in Xenopus tropicalis after developmental exposure to environmental concentrations of ethynylestradiol","volume":"91","author":"Gyllenhammar","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0160","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035287","article-title":"Functional consequences of calcium-dependent synapse-to-nucleus communication: focus on transcription-dependent metabolic plasticity","volume":"12","author":"Hagenston","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113142","article-title":"Transgenerational effects of parental bisphenol S exposure on zebrafish (Danio rerio) reproduction","volume":"165","author":"Hao","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0170","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK - a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nmeth.3252","article-title":"Orchestrating high-throughput genomic analysis with Bioconductor","volume":"12","author":"Huber","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0180","series-title":"Global Assessment Report on Biodiversity and Ecosystem Services of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services","author":"IPBES","year":"2019"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0185","series-title":"IUCN Red List of Threatened Species [WWW Document]","author":"IUCN","year":"2022"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134847","article-title":"Prolonged exposure of azocyclotin induced inter- and transgenerational endocrine disruption on Danio rerio linked to transcriptomic and DNA methylomic alterations","volume":"302","author":"Jiao","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0195","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnc.2022.126254","article-title":"Current threats faced by amphibian populations in the southern cone of South America","volume":"69","author":"Kacoliris","year":"2022","journal-title":"J. Nat. Conserv."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0205","article-title":"Chemical safety and the exposome","volume":"9","author":"Karlsson","year":"2023","journal-title":"Emerg. Contam."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.170949_bb1000","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s40572-016-0092-1","article-title":"Environmental health and long non-coding RNAs","volume":"3","author":"Karlsson","year":"2016","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0210","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ije\/dyaa231","article-title":"The human exposome and health in the Anthropocene","volume":"50","author":"Karlsson","year":"2021","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145771","article-title":"Pesticide-induced multigenerational effects on amphibian reproduction and metabolism","volume":"775","author":"Karlsson","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0220","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tem.2020.02.009","article-title":"Epigenetic transgenerational inheritance of obesity susceptibility","volume":"31","author":"King","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0225","series-title":"Journal of Chromatography A, 9th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers","first-page":"16","article-title":"Amphibians as model to study endocrine disrupters","volume":"vol. 1130","author":"Kloas","year":"2006"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0230","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.taap.2017.05.033","article-title":"Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish","volume":"329","author":"Knecht","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-42860-0","article-title":"Assessment of glyphosate induced epigenetic transgenerational inheritance of pathologies and sperm epimutations: generational toxicology","volume":"9","author":"Kubsad","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0240","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1210\/en.2005-0711","article-title":"Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil","volume":"147","author":"Kuiper","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0245","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/ijms21010275","article-title":"On the modulatory roles of neuregulins\/ErbB signaling on synaptic plasticity","volume":"21","author":"Ledonne","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0250","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3390\/cells8121559","article-title":"Transgenerational inheritance of environmentally induced epigenetic alterations during mammalian development","volume":"8","author":"Legoff","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0255","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bib\/bbx019","article-title":"Genome-wide analysis reveals that exon methylation facilitates its selective usage in the human transcriptome","volume":"19","author":"Li","year":"2018","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0260","first-page":"1217","article-title":"Temporal variation in DNA methylation during gonadal development in a reptile with temperature-dependent sex determination\u2020","volume":"107","author":"Liu","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0408-0","article-title":"Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation","volume":"15","author":"Lou","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0270","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4161\/epi.3.1.5555","article-title":"Epigenetic mechanisms of gene regulation during mammalian spermatogenesis","volume":"3","author":"M. Khalil","year":"2008","journal-title":"Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0275","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.reprotox.2012.08.010","article-title":"Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations","volume":"34","author":"Manikkam","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0280","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.envpol.2009.05.015","article-title":"Amphibians and agricultural chemicals: review of the risks in a complex environment","volume":"157","author":"Mann","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0285","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1210\/en.2017-00248","article-title":"IGFBP4 is required for adipogenesis and influences the distribution of adipose depots","volume":"158","author":"Maridas","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0290","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/JOE-16-0673","article-title":"IGFBP-4 regulates adult skeletal growth in a sex-specific manner","volume":"233","author":"Maridas","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0295","series-title":"Generalized Linear Models","author":"McCullagh","year":"1989"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125527","article-title":"Developmental exposure to Pb2+ induces transgenerational changes to zebrafish brain transcriptome","volume":"244","author":"Meyer","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0305","doi-asserted-by":"crossref","DOI":"10.1038\/srep40372","article-title":"Estrogen related receptor is required for the testicular development and for the normal sperm axoneme\/mitochondrial derivatives in Drosophila males","volume":"7","author":"Misra","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0310","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ydbio.2019.03.015","article-title":"A chromosome-scale genome assembly and dense genetic map for Xenopus tropicalis","volume":"452","author":"Mitros","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0315","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1210\/en.2006-0609","article-title":"Deiodinase activity is present in Xenopus laevis during early embryogenesis","volume":"147","author":"Morvan Dubois","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0320","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/stem.1303","article-title":"Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors","volume":"31","author":"Nagamatsu","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0325","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jez.616","article-title":"The mechanism of sex determination in vertebrates\u2014are sex steroids the key-factor?","volume":"313A","author":"Nakamura","year":"2010","journal-title":"J. Exp. Zool. A Ecol. Genet. Physiol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0330","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13148-020-00888-4","article-title":"Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer","volume":"12","author":"Nam","year":"2020","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0335","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1080\/15592294.2018.1521223","article-title":"Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiency","volume":"13","author":"Nilsson","year":"2018","journal-title":"Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0340","article-title":"Scientific opinion on the state of the science on pesticide risk assessment for amphibians and reptiles","volume":"16","author":"Ockleford","year":"2018","journal-title":"EFSA J."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0345","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1038\/s41598-018-27161-2","article-title":"Exposure to an anti-androgenic herbicide negatively impacts reproductive physiology and fertility in Xenopus tropicalis","volume":"8","author":"Orton","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0350","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mce.2017.05.002","article-title":"Estrogen receptor-related receptor \u03b3 regulates testicular steroidogenesis through direct and indirect regulation of steroidogenic gene expression","volume":"452","author":"Park","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116864","article-title":"Transgenerational epigenetic sex determination: environment experienced by female fish affects offspring sex ratio","volume":"277","author":"Pierron","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0360","series-title":"Calcium Signaling, Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/978-3-030-12457-1_22","article-title":"Calcium signaling and gene expression","author":"Puri","year":"2020"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0365","series-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0370","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.3390\/cells11193163","article-title":"Multi- and transgenerational effects of environmental toxicants on mammalian reproduction","volume":"11","author":"Rebuzzini","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112063","article-title":"A cross-species comparative approach to assessing multi- and transgenerational effects of endocrine disrupting chemicals","volume":"204","author":"Robaire","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0380","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3803\/EnM.2021.1198","article-title":"Deiodinases and the three types of thyroid hormone deiodination reactions","volume":"36","author":"Sabatino","year":"2021","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0385","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00244-007-9085-2","article-title":"Aquatic risk assessment of herbicides in freshwater ecosystems of South Florida","volume":"54","author":"Schuler","year":"2008","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0390","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1261\/rna.064865.117","article-title":"The importance of DNA methylation of exons on alternative splicing","volume":"24","author":"Shayevitch","year":"2018","journal-title":"RNA"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0395","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2108\/zs160198","article-title":"Xenopus vasa homolog XVLG1 is essential for migration and survival of primordial germ cells","volume":"34","author":"Shimaoka","year":"2017","journal-title":"jzoo"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0400","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.devcel.2009.10.012","article-title":"The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline","volume":"17","author":"Shoji","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0405","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12038-019-9974-3","article-title":"Regulation of epigenetic state by non-histone chromatin proteins and transcription factors: implications in disease","volume":"45","author":"Sikder","year":"2020","journal-title":"J. Biosci."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0410","series-title":"Encyclopedia of Reproduction","first-page":"436","article-title":"Epigenetic transgenerational inheritance","author":"Skinner","year":"2018"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0415","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/1741-7015-11-228","article-title":"Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity","volume":"11","author":"Skinner","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0420","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00128-011-0361-5","article-title":"Occurrence and distribution of sulfonylurea and related herbicides in central Canadian surface waters 2006\u20132008","volume":"87","author":"Struger","year":"2011","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0425","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13148-015-0155-4","article-title":"Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health","volume":"7","author":"Stuppia","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0430","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/gcen.1994.1061","article-title":"Circulating thyroglobulin in tadpoles and adult frogs of Rana catesbeiana","volume":"94","author":"Suzuki","year":"1994","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115876","article-title":"Impaired spermatogenesis and associated endocrine effects of azole fungicides in peripubertal Xenopus tropicalis","volume":"270","author":"Svanholm","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0440","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-061008-103102","article-title":"Epigenetics, DNA methylation, and chromatin modifying drugs","volume":"49","author":"Szyf","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0445","first-page":"1","article-title":"The combined effects of temperature and aromatase inhibitor on metamorphosis, growth, locomotion, and sex ratio of tiger frog (Hoplobatrachus rugulosus) tadpoles","volume":"2020","author":"Tang","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.832982","article-title":"Epigenetic transgenerational modifications induced by xenobiotic exposure in zebrafish","volume":"10","author":"Terrazas-Salgado","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0455","doi-asserted-by":"crossref","first-page":"10356","DOI":"10.1523\/JNEUROSCI.4147-15.2016","article-title":"Thyroid hormone acts locally to increase neurogenesis, neuronal differentiation, and dendritic arbor elaboration in the tadpole visual system","volume":"36","author":"Thompson","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0460","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1210\/en.2016-1367","article-title":"AMPK\u03b12 in Kiss1 neurons is required for reproductive adaptations to acute metabolic challenges in adult female mice","volume":"157","author":"Torsoni","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116109","article-title":"Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis","volume":"269","author":"Usal","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118418","article-title":"Exposure to a mixture of benzo[a]pyrene and triclosan induces multi-and transgenerational metabolic disorders associated with decreased female investment in reproduction in Silurana (Xenopus) tropicalis","volume":"292","author":"Usal","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0475","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/bioinformatics\/btq650","article-title":"SLIM: a sliding linear model for estimating the proportion of true null hypotheses in datasets with dependence structures","volume":"27","author":"Wang","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0480","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3389\/fgene.2019.00962","article-title":"Essential role of histone replacement and modifications in male fertility","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0485","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1080\/15592294.2022.2086725","article-title":"Feminization of channel catfish with 17\u03b2-oestradiol involves methylation and expression of a specific set of genes independent of the sex determination region","volume":"17","author":"Wang","year":"2022","journal-title":"Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0490","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1210\/en.2019-00196","article-title":"Transgenerational bisphenol A causes deficits in social recognition and alters postsynaptic density genes in mice","volume":"160","author":"Wolstenholme","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0495","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2175\/106143014X13975035525861","article-title":"Assessment of herbicide transport and distribution in subsurface environments of an orange field","volume":"86","author":"Wu","year":"2014","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0500","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0505","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/hmg\/ddu557","article-title":"Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila","volume":"24","author":"Yu","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0510","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cbpc.2010.04.005","article-title":"Temporal expression and steroidal regulation of piRNA pathway genes (mael, piwi, vasa) during Silurana (Xenopus) tropicalis embryogenesis and early larval development","volume":"152","author":"Zhang","year":"2010","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.170949_bb0515","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/15592294.2020.1738026","article-title":"Promoter hypermethylation of PIWI\/piRNA pathway genes associated with diminished pachytene piRNA production in bovine hybrid male sterility","volume":"15","author":"Zhang","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.170949_bb0520","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2105-11-237","article-title":"ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data","volume":"11","author":"Zhu","year":"2010","journal-title":"BMC Bioinforma."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972401088X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004896972401088X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T16:46:59Z","timestamp":1758732419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004896972401088X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":105,"alternative-id":["S004896972401088X"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170949","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Male-transmitted transgenerational effects of the herbicide linuron on DNA methylation profiles in Xenopus tropicalis brain and testis","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.170949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"170949"}}