{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:23:54Z","timestamp":1792859034805,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973001"],"award-info":[{"award-number":["81973001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173480"],"award-info":[{"award-number":["82173480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273590"],"award-info":[{"award-number":["82273590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.scitotenv.2024.171101","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T03:37:30Z","timestamp":1708486650000},"page":"171101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Gestational exposure to PM2.5 disrupts fetal development by suppressing placental trophoblast syncytialization via progranulin\/mTOR signaling"],"prefix":"10.1016","volume":"921","author":[{"given":"Yirun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rucheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.171101_bb0005","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1016\/S2542-5196(23)00052-9","article-title":"Exposure-response relationships for personal exposure to fine particulate matter (PM2.5), carbon monoxide, and black carbon and birthweight: an observational analysis of the multicountry Household Air Pollution Intervention Network (HAPIN) trial","volume":"7","author":"Balakrishnan","year":"2023","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0010","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1029","article-title":"Exposure to ambient particulate matter during specific gestational periods produces adverse obstetric consequences in mice","volume":"125","author":"Blum","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0015","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1016\/S2542-5196(22)00200-5","article-title":"Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies","volume":"6","author":"Bongaerts","year":"2022","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0020","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1038\/s41467-019-11654-3","article-title":"Ambient black carbon particles reach the fetal side of human placenta","volume":"10","author":"Bov\u00e9","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0025","doi-asserted-by":"crossref","first-page":"20140066","DOI":"10.1098\/rstb.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0030","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1038\/s41467-023-42709-1","article-title":"Cumulative effect of PM2.5 components is larger than the effect of PM2.5 mass on child health in India","volume":"14","author":"Chaudhary","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0035","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41467-021-27088-9","article-title":"Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression","volume":"13","author":"Cheung","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117629","article-title":"Ambient fine particulate matter air pollution and the risk of preterm birth: a multicenter birth cohort study in China","volume":"287","author":"Chu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2015.10.005","article-title":"The endocrine function of human placenta: an overview","volume":"32","author":"Costa","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0050","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvdy.10341","article-title":"Progranulin (acrogranin\/PC cell-derived growth factor\/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development","volume":"227","author":"Daniel","year":"2003","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0055","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1289\/ehp.1306837","article-title":"Outdoor air pollution, preterm birth, and low birth weight: analysis of the world health organization global survey on maternal and perinatal health","volume":"122","author":"Fleischer","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0060","doi-asserted-by":"crossref","first-page":"45808","DOI":"10.1007\/s11356-021-18233-4","article-title":"Effect of PM2.5 exposure on gestational hypertension, fetal size in preeclampsia-like rats","volume":"29","author":"Gao","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0065","article-title":"Ambient and household PM2.5 pollution and adverse perinatal outcomes: a meta-regression and analysis of attributable global burden for 204 countries and territories","volume":"18","author":"Ghosh","year":"2021","journal-title":"PLoS Med."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0070","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1016\/j.febslet.2012.07.077","article-title":"Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K\/Akt\/mTOR pathway","volume":"586","author":"Hu","year":"2012","journal-title":"FEBS Lett."},{"issue":"23","key":"10.1016\/j.scitotenv.2024.171101_bb0075","article-title":"Progranulinopathy: a diverse realm of disorders linked to progranulin imbalances","volume":"S1359-6101","author":"Huang","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0080","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.3390\/ijms23148003","article-title":"Human chorionic villous differentiation and placental development","volume":"23","author":"Kojima","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0085","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.3390\/nu15122736","article-title":"Classification and special nutritional needs of SGA onfants and neonates of multiple pregnancies","volume":"15","author":"Kosmeri","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0090","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s13224-011-0092-x","article-title":"Placental insufficiency and fetal growth restriction","volume":"61","author":"Krishna","year":"2011","journal-title":"J. Obstet. Gynaecol. India"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0095","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajog.2021.11.1357","article-title":"Clinical opinion: the diagnosis and management of suspected fetal growth restriction: an evidence-based approach","volume":"226","author":"Lees","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113680","article-title":"Ambient fine particulate matter exposure disrupts placental autophagy and fetal development in gestational mice","volume":"239","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85944","article-title":"PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9\/CYP1A1 transcriptional axis","volume":"12","author":"Li","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136246","article-title":"The associations of particulate matters with fetal growth in utero and birth weight: a birth cohort study in Beijing, China","volume":"709","author":"Lin","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0115","doi-asserted-by":"crossref","first-page":"21260","DOI":"10.1038\/srep21260","article-title":"Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0120","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.12659\/MSM.897808","article-title":"Effect of fine particulate matter (PM2.5) on rat placenta pathology and perinatal outcomes","volume":"22","author":"Liu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0125","doi-asserted-by":"crossref","first-page":"S855","DOI":"10.1016\/j.ajog.2017.12.004","article-title":"Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy","volume":"218","author":"McCowan","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0130","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3390\/nano10071309","article-title":"Uptake of cerium dioxide nanoparticles and impact on viability, differentiation and functions of primary trophoblast cells from human placenta","volume":"10","author":"Nedder","year":"2020","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/ijms23010036","article-title":"Genetic background of fetal growth restriction","volume":"23","author":"Nowakowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0140","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2131\/jts.47.309","article-title":"Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells","volume":"47","author":"Ogushi","year":"2022","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081003","article-title":"Trophoblast cell fusion and differentiation are mediated by both the protein kinase C and a pathways","volume":"8","author":"Omata","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0150","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.3390\/antiox12111916","article-title":"Effect of particulate matter 2.5 on fetal growth in male and preterm infants through oxidative stress","volume":"12","author":"Park","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0155","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1095\/biolreprod.105.040030","article-title":"Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse","volume":"73","author":"Qin","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0160","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1080\/17435390.2022.2162994","article-title":"Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells","volume":"16","author":"Sakahashi","year":"2022","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017092118","article-title":"Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply","volume":"118","author":"Shao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0170","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.3109\/14767058.2016.1152249","article-title":"Intrauterine growth restriction-part 1","volume":"29","author":"Sharma","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1262\/jrd.10-073K","article-title":"Expression pattern of progranulin in the human placenta and its effect on cell proliferation in the choriocarcinoma cell line BeWo","volume":"57","author":"Stubert","year":"2011","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0180","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1515\/jpm-2011-0277","article-title":"Trophoblastic progranulin expression is upregulated in cases of fetal growth restriction and preeclampsia","volume":"40","author":"Stubert","year":"2012","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113512","article-title":"Maternal exposure to ambient PM2.5 causes fetal growth restriction via the inhibition of spiral artery remodeling in mice","volume":"237","author":"Tao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064989","article-title":"Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model","volume":"8","author":"Toh","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0195","article-title":"The role of syncytin in placental angiogenesis and fetal growth","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0200","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12013-014-0183-2","article-title":"Elevated expression of secreted autocrine growth factor progranulin increases cervical cancer growth","volume":"71","author":"Wei","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140369","article-title":"Gestational exposure to ambient fine particulate matter disrupts maternal hepatic lipid metabolism","volume":"344","author":"Wu","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0210","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ceb.2020.08.010","article-title":"Progress in deciphering trophoblast cell differentiation during human placentation","volume":"67","author":"Xiao","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0215","first-page":"3482","article-title":"Abnormal angiogenesis of placenta in progranulin-deficient mice","volume":"22","author":"Xu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0220","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/S2542-5196(20)30268-0","article-title":"Estimation of pregnancy losses attributable to exposure to ambient fine particles in south Asia: an epidemiological case-control study","volume":"5","author":"Xue","year":"2021","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0225","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scitotenv.2019.02.101","article-title":"Gestational exposure to PM2.5 impairs vascularization of the placenta","volume":"665","author":"Yue","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154564","article-title":"Ambient PM2.5 exposures and systemic inflammation in women with early pregnancy","volume":"829","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.171101_bb0235","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.scib.2020.08.036","article-title":"Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy","volume":"66","author":"Zhao","year":"2021","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0240","doi-asserted-by":"crossref","first-page":"1107182","DOI":"10.3389\/fendo.2023.1107182","article-title":"Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.scitotenv.2024.171101_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111281","article-title":"Maternal PM2.5 exposure and abnormal placental nutrient transport","volume":"207","author":"Zhu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724012403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724012403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:35:28Z","timestamp":1786030528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724012403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":49,"alternative-id":["S0048969724012403"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171101","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational exposure to PM2.5 disrupts fetal development by suppressing placental trophoblast syncytialization via progranulin\/mTOR signaling","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"171101"}}