{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T20:10:11Z","timestamp":1786824611799,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004834","name":"Universitat Jaume I","doi-asserted-by":"publisher","award":["UJI-B2022-16"],"award-info":[{"award-number":["UJI-B2022-16"]}],"id":[{"id":"10.13039\/501100004834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigacion","doi-asserted-by":"publisher","award":["RYC2020-028936-I"],"award-info":[{"award-number":["RYC2020-028936-I"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"Fundaci\u00f3n La Caixa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.scitotenv.2024.171996","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T12:26:43Z","timestamp":1711456003000},"page":"171996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Understanding associations between antimicrobial agents usage and antimicrobial resistance genes prevalence at the community level using wastewater-based epidemiology: A Spanish pilot study"],"prefix":"10.1016","volume":"926","author":[{"given":"Lubertus","family":"Bijlsma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Like","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gracia-Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pitarch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roque","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kasprzyk-Hordern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.171996_bb0005","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.aba3432","article-title":"Using sewage for surveillance of antimicrobial resistance","volume":"367","author":"Aarestrup","year":"2020","journal-title":"Science (80-. )"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0010","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1080\/10643389.2019.1692611","article-title":"Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments: current knowledge and questions to be answered","volume":"50","author":"Amarasiri","year":"2020","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0015","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0020","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1021\/acs.est.0c02388","article-title":"Wastewater-based epidemiology: global collaborative to maximize contributions in the fight against COVID-19","volume":"54","author":"Bivins","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.watres.2019.06.039","article-title":"Antibiotic resistance genes in treated wastewater and in the receiving water bodies: a pan-European survey of urban settings","volume":"162","author":"Cacace","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.133405","article-title":"Occurrence and temporal variation of antibiotics and antibiotic resistance genes in hospital inpatient department wastewater: impacts of daily schedule of inpatients and wastewater treatment process","volume":"292","author":"Cai","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0035","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.chemosphere.2008.04.034","article-title":"Comparison of predicted and measured concentrations of selected pharmaceuticals, fragrances and hormones in Spanish sewage","volume":"72","author":"Carballa","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.scitotenv.2012.02.038","article-title":"Using biomarkers in sewage to monitor community-wide human health: isoprostanes as conceptual prototype","volume":"424","author":"Daughton","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0045","first-page":"1","article-title":"Decrease in community antibiotic consumption during the COVID-19 pandemic, EU\/EEA, 2020","volume":"26","author":"Diaz-H\u00f6gberg","year":"2021","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0050","author":"Drugbank"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106404","article-title":"Showcasing the potential of wastewater-based epidemiology to track pharmaceuticals consumption in cities: comparison against prescription data collected at fine spatial resolution","volume":"150","author":"Escol\u00e0 Casas","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0060","series-title":"Guidance Document on Analytical Quality Control and Method Validation for Pesticide Residues Analysis in Food and Feed SANTE 11312\/2021. Sante\/11312\/2021 1\u201357","author":"European Commission","year":"2021"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0065","series-title":"Directive of the European Parliament and of the Council Concerning Urban Wastewater Treatment","first-page":"1","volume":"vol. 541","author":"European Commission","year":"2022"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340739","article-title":"Analytical key issues and challenges in the LC-MS\/MS determination of antibiotics in wastewater","volume":"1239","author":"Fabregat-Safont","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154171","article-title":"Exploring antibiotic consumption between urban and sub-urban catchments using both parent drugs and related metabolites in wastewater-based epidemiology","volume":"827","author":"Gao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/add.14767","article-title":"Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring","volume":"115","author":"Gonz\u00e1lez-Mari\u00f1o","year":"2020","journal-title":"Addiction"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0085","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cmi.2020.09.055","article-title":"Antibiotic use in the COVID-19 crisis in Spain","volume":"27","author":"Gonzalez-Zorn","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.envint.2016.12.016","article-title":"Measuring biomarkers in wastewater as a new source of epidemiological information: current state and future perspectives","volume":"99","author":"Gracia-Lor","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140587","article-title":"Comprehensive study on the potential environmental risk of temporal antibiotic usage through wastewater discharges","volume":"346","author":"Gracia-Mar\u00edn","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0100","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1128\/AEM.01981-14","article-title":"Detection of pathogenic viruses in sewage provided early warnings of hepatitis A virus and norovirus outbreaks","volume":"80","author":"Hellm\u00e9r","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-08853-3","article-title":"Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage","volume":"10","author":"Hendriksen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0110","article-title":"Spatiotemporal urban water profiling for the assessment of environmental and public exposure to antimicrobials (antibiotics, antifungals, and antivirals) in the Eerste River Catchment","volume":"164","author":"Holton","year":"2022","journal-title":"South Africa. Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129001","article-title":"Quantifying community-wide antimicrobials usage via wastewater-based epidemiology","volume":"436","author":"Holton","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature13774","article-title":"High secondary aerosol contribution to particulate pollution during haze events in China","volume":"514","author":"Huang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph17062059","article-title":"Nine-year nationwide environmental surveillance of hepatitis E virus in urban wastewaters in Italy (2011\u20132019)","volume":"17","author":"Iaconelli","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0103705","article-title":"Abundances of tetracycline, sulphonamide and beta-lactam antibiotic resistance genes in conventional wastewater treatment plants (WWTPs) with different waste load","volume":"9","author":"Laht","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0135","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.cmi.2020.12.018","article-title":"Antibiotic prescribing in patients with COVID-19: rapid review and meta-analysis","volume":"27","author":"Langford","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0140","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/acs.estlett.0c00357","article-title":"Presence of SARS-Coronavirus-2 RNA in sewage and correlation with reported COVID-19 prevalence in the early stage of the epidemic in the Netherlands","volume":"7","author":"Medema","year":"2020","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127407","article-title":"Monitoring antibiotic resistance genes in wastewater environments: the challenges of filling a gap in the One-Health cycle","volume":"424","author":"Mi\u0142obedzka","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-34312-7","article-title":"Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance","volume":"13","author":"Munk","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121221","article-title":"Small-scale wastewater treatment plants as a source of the dissemination of antibiotic resistance genes in the aquatic environment","volume":"381","author":"Osi\u0144ska","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0160","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau9124","article-title":"Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence","volume":"5","author":"P\u00e4rn\u00e4nen","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0165","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijheh.2019.01.004","article-title":"The impact of on-site hospital wastewater treatment on the downstream communal wastewater system in terms of antibiotics and antibiotic resistance genes","volume":"222","author":"Paulus","year":"2019","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0170","article-title":"Focussing on resistance to front-line drugs is the most effective way to combat the antimicrobial resistance crisis","author":"Perry","year":"2018","journal-title":"bioRxiv"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0175","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.scitotenv.2013.11.039","article-title":"Sewage epidemiology and illicit drug research: the development of ethical research guidelines","volume":"472","author":"Prichard","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.watres.2014.11.021","article-title":"Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river","volume":"69","author":"Rodriguez-Mozaz","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131461","article-title":"Community infectious disease treatment with antimicrobial agents \u2013 a longitudinal one year study of antimicrobials in two cities via wastewater-based epidemiology","volume":"454","author":"Sims","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0190","series-title":"Community and Hospital Derived Antimicrobials and Resistance Genes in a Two-city One-year Longitudinal Study","author":"Sims","year":"2023"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0195","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2166\/wh.2022.021","article-title":"Monitoring the exposure and emissions of antibiotic resistance: co-occurrence of antibiotics and resistance genes in wastewater treatment plants","volume":"20","author":"Steenbeek","year":"2022","journal-title":"J. Water Health"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41396-018-0275-x","article-title":"Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera","volume":"13","author":"Wang","year":"2019","journal-title":"ISME J."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0205","author":"WHO"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0210","series-title":"Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2022","author":"World Health Organization","year":"2022"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.mimet.2019.105670","article-title":"Use of synthesized double-stranded gene fragments as qPCR standards for the quantification of antibiotic resistance genes","volume":"164","author":"Xu","year":"2019","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118942","article-title":"Assessment of community-wide antimicrobials usage in Eastern China using wastewater-based epidemiology","volume":"222","author":"Xu","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2024.171996_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127741","article-title":"Occurrence of antibiotics and antibiotic resistance genes in the Fuxian Lake and antibiotic source analysis based on principal component analysis-multiple linear regression model","volume":"262","author":"Zhao","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.171996_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106641","article-title":"Wastewater treatment plants as a reservoir of integrase and antibiotic resistance genes \u2013 an epidemiological threat to workers and environment","volume":"156","author":"Zieli\u0144ski","year":"2021","journal-title":"Environ. Int."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724021399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724021399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:26:55Z","timestamp":1785792415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724021399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":46,"alternative-id":["S0048969724021399"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171996","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding associations between antimicrobial agents usage and antimicrobial resistance genes prevalence at the community level using wastewater-based epidemiology: A Spanish pilot study","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"171996"}}