{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:25:23Z","timestamp":1794266723886,"version":"4.9.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018978","name":"Zhejiang Office of Philosophy and Social Science","doi-asserted-by":"publisher","award":["21NDJC127YB"],"award-info":[{"award-number":["21NDJC127YB"]}],"id":[{"id":"10.13039\/100018978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.scitotenv.2024.172354","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:18:04Z","timestamp":1713233884000},"page":"172354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Behavioral toxicity and neurotoxic mechanisms of PLA-PBAT biodegradable microplastics in zebrafish"],"prefix":"10.1016","volume":"928","author":[{"given":"Deyong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.scitotenv.2024.172354_bb0005","first-page":"21","article-title":"The diverse ways to determine experimental dose in animals[J]","volume":"5","author":"Arya","year":"2022","journal-title":"Hos Pal Med IntJnl"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0010","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/B978-0-12-803581-8.10799-4","article-title":"Tailor-made bioplastics for environmentally friendly food packaging: a methodological approach to a challenging problem[J]","volume":"4","author":"Aversa","year":"2020","journal-title":"Encyclopedia of Renewable and Sustainable Materials."},{"issue":"4","key":"10.1016\/j.scitotenv.2024.172354_bb0015","doi-asserted-by":"crossref","first-page":"1700048","DOI":"10.1002\/gch2.201700048","article-title":"Fate of so-called biodegradable polymers in seawater and freshwater[J]","volume":"1","author":"Bagheri","year":"2017","journal-title":"Global Chall."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130279","article-title":"Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio)[J]","volume":"277","author":"Chagas","year":"2021","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.scitotenv.2024.172354_bb0025","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/aba326","article-title":"Does the inion OTPStm absorbable plating system induce higher foreign-body reaction than titanium implants? An experimental randomized comparative study in rabbits[J]","volume":"15","author":"Chalidis","year":"2020","journal-title":"Biomed. Mater."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.172354_bb0030","first-page":"166","article-title":"Influence of aluminum chloride exposure on embryonic development of zebrafish and neurobehavior of juvenile fish[J]","volume":"35","author":"Chen","year":"2017","journal-title":"Chinese Journal of Industrial Hygiene and Occupational Diseases"},{"issue":"22","key":"10.1016\/j.scitotenv.2024.172354_bb0035","doi-asserted-by":"crossref","first-page":"16506","DOI":"10.3390\/ijms242216506","article-title":"Dynamic regulation of brsk2 in the social and motor development of zebrafish: a developmental behavior analysis[J]","volume":"24","author":"Deng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136895","article-title":"Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio)[J]","volume":"310","author":"F\u00e9lix","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170405","article-title":"Sub-chronic exposure to paroxetine disrupts ecologically relevant behaviours in fish[J]","volume":"917","author":"Ferreira","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.scitotenv.2024.172354_bb0050","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/etc.4951","article-title":"Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: from behavior to molecular mechanisms[J]","volume":"40","author":"Fitzgerald","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0055","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1007\/s11999-010-1388-3","article-title":"Delayed foreign-body reaction to absorbable implants in metacarpal fracture treatment[J]","volume":"468","author":"Givissis","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0060","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.envpol.2015.10.010","article-title":"Effects of conventional and biodegradable microplastics on a marine ecosystem engineer (Arenicola marina) and sediment nutrient cycling[J]","volume":"208","author":"Green","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169495","article-title":"Neurobehavioral toxic effects and mechanisms of 2-aminobenzothiazole exposure on zebrafish[J]","volume":"913","author":"Gu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2024.172354_bb0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11033-023-08960-x","article-title":"Brain targeted luteolin-graphene oxide nanoparticle abrogates polyethylene terephthalate induced altered neurological response in zebrafish[J]","volume":"51","author":"Guru","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.scitotenv.2024.172354_bb0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1021808317416","article-title":"Effects of temperature and relative humidity on polylactic acid plastic degradation","volume":"7","author":"Ho","year":"1999","journal-title":"Journal of Environmental Polymer Degradation."},{"issue":"Database issue","key":"10.1016\/j.scitotenv.2024.172354_bb0080","first-page":"480","article-title":"KEGG for linking genomes to life and the environment[J]","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.172354_bb0085","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/ijom.2003.0510","article-title":"Are there any complications with bioabsorbable fixation devices?: a 10 year review in orthognathic surgery[J]","volume":"33","author":"Laine","year":"2004","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0090","series-title":"Genetic Identification of Neural Circuits Essential for Active Avoidance Fear Conditioning in Adult Zebrafish[M]\/\/Zebrafish: Methods and Protocols","first-page":"169","author":"Lal","year":"2023"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0095","first-page":"1","article-title":"Alternation of social behaviors for zebrafish (Danio rerio) in response to acute cold stress[J]","author":"Liu","year":"2024","journal-title":"Fish Physiol. Biochem."},{"issue":"31","key":"10.1016\/j.scitotenv.2024.172354_bb0100","doi-asserted-by":"crossref","first-page":"2304632","DOI":"10.1002\/advs.202304632","article-title":"Polylactide degradation activates immune cells by metabolic reprogramming[J]","volume":"10","author":"Maduka","year":"2023","journal-title":"Adv. Sci."},{"issue":"21","key":"10.1016\/j.scitotenv.2024.172354_bb0105","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","article-title":"Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary[J]","volume":"2005","author":"Mao","year":"2005","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.scitotenv.2024.172354_bb0110","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1039\/C3GC42604A","article-title":"Marine-degradable polylactic acid","volume":"16","author":"Martin","year":"2014","journal-title":"Green Chem."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114125","article-title":"Acute exposure to microplastics induces metabolic disturbances and gut dysbiosis in adult zebrafish (Danio rerio)[J]","volume":"245","author":"Medriano","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.scitotenv.2024.172354_bb0120","first-page":"374","article-title":"Perspectives of bioplastics-a review","volume":"9","author":"Muniyandi","year":"2020","journal-title":"Int. J. Sci. Technol. Res."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0125","article-title":"A review on fate and ecotoxicity of biodegradable microplastics in aquatic system: are biodegradable plastics truly safe for the environment?[J]","volume":"123399","author":"Mut","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0130","article-title":"Neurotoxic effects of 2-ethylhexyl diphenyl phosphate exposure on zebrafish larvae: insight into inflammation-driven changes in early motor behavior[J]","volume":"170131","author":"Ni","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0135","doi-asserted-by":"crossref","first-page":"8387","DOI":"10.1007\/s11356-023-31689-w","article-title":"Biobased, biodegradable and compostable plastics: chemical nature, biodegradation pathways and environmental strategy[J]","volume":"31","author":"Nizamuddin","year":"2024","journal-title":"Environ SciPollut Res"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124152","article-title":"Behavioral and biochemical consequences of Danio rerio larvae exposure to polylactic acid bioplastic[J]","volume":"404","author":"de Oliveira","year":"2021","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.172354_bb0145","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.indcrop.2010.12.031","article-title":"Degradation behaviour of poly(lactic acid) films and fibres in soil under Mediterranean field conditions and laboratory simulations testing","volume":"33","author":"Rudnik","year":"2011","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113926","article-title":"Microplastics and copper induce apoptosis, alter neurocircuits, and cause behavioral changes in zebrafish (Danio rerio) brain[J]","volume":"242","author":"Santos","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.scitotenv.2024.172354_bb0155","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41598-023-51072-6","article-title":"\u03b2-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish[J]","volume":"14","author":"Scatterty","year":"2024","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.scitotenv.2024.172354_bb0160","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jiac.2023.08.014","article-title":"Evaluation of virulence of Klebsiella pneumoniae using zebrafish behavior as a biological indicator[J]","volume":"29","author":"Shen","year":"2023","journal-title":"J. Infect. Chemother."},{"issue":"4","key":"10.1016\/j.scitotenv.2024.172354_bb0165","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s10924-013-0604-0","article-title":"PLA and Organoclays nanocomposites: degradation process and evaluation of ecotoxicity using Allium cepa as test organism[J]","volume":"21","author":"Souza","year":"2013","journal-title":"Journal of Polymers & the Environment."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0170","article-title":"Research advances on the toxicity of biodegradable plastics derived micro\/nanoplastics in the environment: a review[J]","volume":"170299","author":"Tao","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.scitotenv.2024.172354_bb0175","first-page":"381","article-title":"Behavioural assessments of neurotoxic effects and neurodegeneration in zebrafish[J]","volume":"1812","author":"Tierney","year":"2011","journal-title":"Biochimicaet Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0180","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.toxrep.2022.06.010","article-title":"Evaluation of the effects of Loxosceles intermedia\u2019s venom in zebrafish[J]","volume":"9","author":"Tozzi","year":"2022","journal-title":"Toxicol. Rep."},{"issue":"5","key":"10.1016\/j.scitotenv.2024.172354_bb0185","first-page":"492","article-title":"Typical degradation properties of biodegradable polyester in seawater[J]","volume":"33","author":"Wang","year":"2020","journal-title":"J. Funct. Polym."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0190","article-title":"Biological-based techniques for real-time water-quality studies: assessment of non-invasive (swimming consistency and respiration) and toxicity (antioxidants) biomarkers of zebrafish[J]","volume":"141268","author":"Wang","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109826","article-title":"Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models[J]","volume":"98","author":"Wronikowskaa","year":"2020","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.scitotenv.2024.172354_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120939","article-title":"Microplastics induce neurotoxicity in aquatic animals at environmentally realistic concentrations: a meta-analysis[J]","volume":"318","author":"Xiong","year":"2023","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.scitotenv.2024.172354_bb0205","doi-asserted-by":"crossref","first-page":"R14.92","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias[J]","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"issue":"20","key":"10.1016\/j.scitotenv.2024.172354_bb0210","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.1021\/acs.est.9b04168","article-title":"Chemical composition and toxicity of particles emitted from a consumer-level 3D printer using various materials[J]","volume":"53","author":"Zhang","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.172354_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169430","article-title":"Co-exposure of nanoplastics and arsenic causes neurotoxicity in zebrafish (Danio rerio) through disrupting homeostasis of microbiota\u2013intestine\u2013brain axis[J]","volume":"912","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"29","key":"10.1016\/j.scitotenv.2024.172354_bb0220","doi-asserted-by":"crossref","first-page":"2301799","DOI":"10.1002\/adhm.202301799","article-title":"Exposure to polystyrene nanoplastics led to learning and memory deficits in zebrafish by inducing oxidative damage and aggravating brain aging[J]","volume":"12","author":"Zhou","year":"2023","journal-title":"Adv. Healthc. Mater."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724024975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724024975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:35:30Z","timestamp":1785432930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724024975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":44,"alternative-id":["S0048969724024975"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.172354","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Behavioral toxicity and neurotoxic mechanisms of PLA-PBAT biodegradable microplastics in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.172354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172354"}}