{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:02:55Z","timestamp":1791442975418,"version":"4.3.3"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.scitotenv.2024.173009","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T02:48:00Z","timestamp":1715309280000},"page":"173009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Air pollutants, genetic susceptibility, and incident schizophrenia in later life: A prospective study in the UK Biobank"],"prefix":"10.1016","volume":"934","author":[{"given":"Qingli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.173009_bb0005","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S2542-5196(20)30004-8","article-title":"Exposure to air pollution during childhood and risk of developing schizophrenia: a national cohort study","volume":"4","author":"Antonsen","year":"2020","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tics.2011.11.015","article-title":"Cognition in schizophrenia: core psychological and neural mechanisms","volume":"16","author":"Barch","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atmosenv.2013.02.037","article-title":"Development of no2 and nox land use regression models for estimating air pollution exposure in 36 study areas in europe - the escape project","volume":"72","author":"Beelen","year":"2013","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0192623307313011","volume":"36","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.comppsych.2017.09.009","article-title":"Risk factors in early and late onset schizophrenia","volume":"80","author":"Chen","year":"2018","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0035","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCULATIONAHA.121.057179","article-title":"Hourly air pollutants and acute coronary syndrome onset in 1.29 million patients","volume":"145","author":"Chen","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0040","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.envpol.2017.09.082","article-title":"Pulmonary exposure to metal fume particulate matter cause sleep disturbances in shipyard welders","volume":"232","author":"Chuang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0045","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00777-2022","article-title":"Air pollutants, genetic suscepti- bility and risk of incident idiopathic pulmonary fibrosis","volume":"61","author":"Cui","year":"2023","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0050","series-title":"UK Biobank Release and Systematic Evaluation of Optimised Polygenic Risk Scores for 53 Diseases and Quantitative Traits","author":"Deborah","year":"2022"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0055","doi-asserted-by":"crossref","first-page":"11195","DOI":"10.1021\/es301948k","article-title":"Development of land use regression models for pm(2.5), pm(2.5) absorbance, pm(10) and pm(coarse) in 20 european study areas; results of the escape project","volume":"46","author":"Eeftens","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0060","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1289\/EHP10391","article-title":"Long-term air pollution, genetic susceptibility, and the risk of depression and anxiety: a prospective study in the UK biobank cohort","volume":"131","author":"Gao","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/schbul\/14.1.39","article-title":"Late-onset schizophrenia: an overview","volume":"14","author":"Harris","year":"1988","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0070","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2215-0366(17)30078-0","article-title":"Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis","volume":"4","author":"Hjorth\u00f8j","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1176\/appi.ajp.157.2.172","article-title":"Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. The international late-onset schizophrenia group","volume":"157","author":"Howard","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0080","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","article-title":"Air pollution, genetic factors, and the risk of lung cancer: a prospective study in the UK biobank","volume":"204","author":"Huang","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000353","article-title":"Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark","volume":"17","author":"Khan","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031660","article-title":"Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses","volume":"7","author":"Kirkbride","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0095","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41588-019-0512-x","article-title":"Comparative genetic architectures of schizophrenia in east asian and european populations","volume":"51","author":"Lam","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12916-023-02783-0","article-title":"Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK biobank","volume":"21","author":"Li","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0105","first-page":"118","article-title":"Air pollution interacts with genetic risk to influence cortical networks implicated in depression","author":"Li","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0110","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1002\/alz.13650","article-title":"Differential DNA methylation in the brain as potential mediator of the association between traffic-related pm(2.5) and neuropathology markers of Alzheimer\u2019s disease","volume":"20","author":"Li","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/epirev\/mxn001","article-title":"Schizophrenia: a concise overview of incidence, prevalence, and mortality","volume":"30","author":"McGrath","year":"2008","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/JGP.0b013e3182011b7f","article-title":"Schizophrenia spectrum disorders in later life: prevalence and distribution of age at onset and sex in a dutch catchment area","volume":"20","author":"Meesters","year":"2012","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2011.181","article-title":"From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment","volume":"37","author":"Moghaddam","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0130","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/EDE.0b013e3181e09b0b","article-title":"Relative excess risk due to interaction: resampling-based confidence intervals","volume":"21","author":"Nie","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/08958370490439597","article-title":"Translocation of inhaled ultrafine particles to the brain","volume":"16","author":"Oberd\u00f6rster","year":"2004","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/jamapediatrics.2018.3101","article-title":"Association of prenatal exposure to air pollution with autism spectrum disorder","volume":"173","author":"Pagalan","year":"2019","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-244X-6-2","article-title":"Urbanization and traffic related exposures as risk factors for schizophrenia","volume":"6","author":"Pedersen","year":"2006","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0920-9964(03)00062-8","article-title":"Air pollution from traffic and schizophrenia risk","volume":"66","author":"Pedersen","year":"2004","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0155","doi-asserted-by":"crossref","first-page":"e331","DOI":"10.1016\/S2542-5196(22)00017-1","article-title":"Associations of short-term exposure to air pollution and increased ambient temperature with psychiatric hospital admissions in older adults in the USA: a case-crossover study","volume":"6","author":"Qiu","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0160","article-title":"Short-term exposure to air pollution is an emerging but neglected risk factor for schizophrenia: a systematic review and meta-analysis","volume":"854","author":"Song","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"Uk biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0170","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizo- phrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.173009_bb0175","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s10654-013-9843-6","article-title":"Reconsidering the denominator of the attributable proportion for interaction","volume":"28","author":"VanderWeele","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0180","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/eurheartj\/ehaa1031","article-title":"Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK biobank","volume":"42","author":"Wang","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.scitotenv.2024.173009_bb0185","article-title":"Ambient air pollution and clinical dementia: systematic review and meta-analysis","volume":"381","author":"Wilker","year":"2023","journal-title":"BMJ"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724031565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724031565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T19:59:48Z","timestamp":1737575988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724031565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":37,"alternative-id":["S0048969724031565"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.173009","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Air pollutants, genetic susceptibility, and incident schizophrenia in later life: A prospective study in the UK Biobank","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.173009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"173009"}}