{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:27:52Z","timestamp":1786487272339,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42377371"],"award-info":[{"award-number":["42377371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.scitotenv.2024.175525","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T13:00:54Z","timestamp":1723554054000},"page":"175525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Liver damage and lipid metabolic dysregulation in adult zebrafish (Danio rerio) induced by spirotetramat"],"prefix":"10.1016","volume":"951","author":[{"given":"Xunyue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenze","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.175525_bb0005","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cropro.2009.06.015","article-title":"Movento\u00ae,an innovative ambimobile insecticide for sucking insect pest control in agriculture: Biological profile and field performance","volume":"28","author":"Br\u00fcck","year":"2009","journal-title":"Crop Protection Guildford."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0010","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jat.4433","article-title":"Protective effects of lycopene on TiO2 nanoparticle-induced damage in the liver of mice","volume":"6","author":"Chang","year":"2023","journal-title":"J. Appl. Toxicol."},{"issue":"24","key":"10.1016\/j.scitotenv.2024.175525_bb0015","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-018-2462-8","article-title":"Environmental behaviors of spirotetramat in water","volume":"25","author":"Chen","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0020","author":"China Pesticide Information Network"},{"issue":"5","key":"10.1016\/j.scitotenv.2024.175525_bb0025","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.cell.2017.09.029","article-title":"Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation","volume":"171","author":"Dang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0030","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13060","article-title":"Factors regulating growth pattern and condition factor of an amphibious fish Periophthalmus gracilis living in the Mekong Delta","volume":"10","author":"Dinh","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0035","doi-asserted-by":"crossref","first-page":"7303","DOI":"10.2147\/IJN.S185348","article-title":"Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro","volume":"13","author":"Duan","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0040","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0045","article-title":"Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for spirotetramat in light of confirmatory data","volume":"14","author":"EFSA","year":"2017","journal-title":"EFSA Supporting Publications"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0050","author":"European Commission"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.31083\/j.fbl2801006","article-title":"Lipophagy: molecular mechanisms and implications in hepatic lipid metabolism","volume":"28","author":"Feng","year":"2023","journal-title":"Frontiers in Bioscience-Landmark"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/MOL.0000000000000819","article-title":"CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis","volume":"33","author":"Glatz","year":"2022","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105282","article-title":"The spirotetramat inhibits growth and reproduction of silkworm by interfering with the fatty acid metabolism","volume":"188","author":"He","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0070","first-page":"141","article-title":"Architectural pattern, tissue and cellular morphology in livers of fishes: relationship to experimentally-induced neoplastic responses","volume":"86","author":"Hinton","year":"1998","journal-title":"Experientia Supplementum"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123242","article-title":"Insights into spirotetramat-induced thyroid disruption during zebrafish (Danio rerio) larval development: an integrated approach with in vivo, in vitro, and in silico analyses","volume":"343","author":"Jiao","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0085","first-page":"498","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"49","author":"Kerstin","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0090","first-page":"123","article-title":"Tumor necrosis factor and liver","volume":"03","author":"Li","year":"1994","journal-title":"Chinese Journal of Clinical Gastroenterology"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0095","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/j.apsb.2021.03.018","article-title":"Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease","volume":"11","author":"Li","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ibmb.2014.09.010","article-title":"The cyclic keto-enol insecticide spirotetramat inhibits insect and spider mite acetyl-CoA carboxylases by interfering with the carboxyltransferase partial reaction","volume":"55","author":"L\u00fcmmen","year":"2014","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0110","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00128-011-0494-6","article-title":"An efficient analytical method for analysis of spirotetramat and its metabolite spirotetramat-enol by HPLC","volume":"88","author":"Mohapatra","year":"2012","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0115","first-page":"61","article-title":"Biological profile of spirotetramat (Movento\u223cR) - a new two-way systemic insecticide against sucking pest species","author":"Nauen","year":"2008","journal-title":"Bayer CropScience Journal"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0120","series-title":"OECD Guidelines for the Testing of Chemicals","first-page":"1","article-title":"Test no. 203: fish, acute toxicity test","volume":"1","author":"OECD","year":"1992"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00441-022-03607-y","article-title":"Comparative study on a novel lobule structure of the zebrafish liver and that of the mammalian liver","volume":"388","author":"Ota","year":"2022","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-nutr-071812-161220","article-title":"Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism","volume":"34","author":"Pepino","year":"2014","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0135","first-page":"1272","article-title":"Expression profile of acetyl CoA carboxylase beta (ACACB) gene during the pre and post-hatch period in chicken","volume":"57","author":"Prasad","year":"2023","journal-title":"Indian journal of Animal Research"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0140","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"R\u00f6hrig","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0145","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.3390\/nu13082654","article-title":"Curcumin and biochemical parameters in metabolic-associated fatty liver disease (MAFLD)-a review","volume":"13","author":"R\u00f3\u017ca\u0144ski","year":"2021","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.scitotenv.2024.175525_bb0150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-2008-1073116","article-title":"Acute liver failure: mechanisms of hepatocyte injury and regeneration","volume":"28","author":"Rutherford","year":"2008","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143859","article-title":"Embryonic exposure to prothioconazole induces oxidative stress and apoptosis in zebrafish (Danio rerio) early life stage","volume":"756","author":"Shen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0160","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.chemosphere.2019.06.207","article-title":"Occurrence of pesticides in Dutch drinking water sources","volume":"235","author":"Sjerps","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117100","article-title":"Pesticides in surface waters of tropical river basins draining areas with rice-vegetable rotations in Hainan, China: occurrence, relation to environmental factors, and risk assessment","volume":"283","author":"Tan","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0170","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.addr.2020.06.027","article-title":"The hepatic lipidome: from basic science to clinical translation","volume":"159","author":"Ten","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0175","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"21","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0180","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"9","key":"10.1016\/j.scitotenv.2024.175525_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009889","article-title":"Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral production","volume":"17","author":"Wang","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0190","article-title":"Acetyl-CoA carboxylases and diseases","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0195","series-title":"Toxicity and Toxic Mechanism of Spirotetramat in Male Rats","author":"Wu","year":"2013"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0200","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ecoenv.2018.08.020","article-title":"Biochemical and histological alterations in adult zebrafish (Danio rerio) ovary following exposure to the tetronic acid insecticide spirotetramat","volume":"164","author":"Wu","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0205","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejphar.2014.06.006","article-title":"Treatment with baicalein attenuates methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats","volume":"738","author":"Xin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0210","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1084\/jem.20181554","article-title":"Kr\u00fcppel-like factor 3 inhibition by mutated lncRNA Reg1cp results in human high bone mass syndrome","volume":"216","author":"Yang","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105262","article-title":"Probing the hepatotoxicity mechanisms of novel chlorinated polyfluoroalkyl sulfonates to zebrafish larvae: implication of structural specificity","volume":"133","author":"Yi","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0220","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.etap.2014.04.016","article-title":"Effects of spirotetramat on the acute toxicity, oxidative stress, and lipid peroxidation in Chinese toad (Bufo bufo gargarizans) tadpoles","volume":"37","author":"Yin","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0225","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/hepr.12157","article-title":"Interleukin-1\u03b2 induces tumor necrosis factor-\u03b1 secretion from rat hepatocytes","volume":"44","author":"Yoshigai","year":"2014","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0230","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.2527\/jas.2009-2597","article-title":"Porcine peroxisome proliferator-activated receptor \u03b4 mediates the lipolytic effects of dietary fish oil to reduce body fat deposition1","volume":"88","author":"Yu","year":"2010","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0235","series-title":"Integrative Assessment of Potential Toxicities of Typical Pyrethroids","author":"Zhang","year":"2012"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0240","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.2337\/diabetes.51.10.2929","article-title":"Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP","volume":"51","author":"Zhang","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0245","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.chemosphere.2015.05.091","article-title":"Toxicological effects of soil contaminated with spirotetramat to the earthworm Eisenia fetida","volume":"139","author":"Zhang","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.175525_bb0250","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.aquatox.2015.11.028","article-title":"Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved","volume":"170","author":"Zhang","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0255","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.envpol.2019.02.035","article-title":"The lipid metabolism alteration of three spirocyclic tetramic acids on zebrafish (Danio rerio) embryos","volume":"248","author":"Zhang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124900","article-title":"Dysregulation of endocrine disruption, apoptosis and the transgenerational toxicity induced by spirotetramat","volume":"240","author":"Zhang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.175525_bb5000","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105938","article-title":"Effects of sublethal concentration of metamifop on hepatic lipid metabolism in adult zebrafish (Danio rerio)","volume":"238","author":"Zhao","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.175525_bb0265","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10695-024-01313-w","article-title":"Ppar\u03b2 regulates lipid catabolism by mediating acox and cpt-1 genes in Scophthalmus maximus under heat stress","volume":"50","author":"Zhao","year":"2024","journal-title":"Fish Physiol. Biochem."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724056754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724056754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:34:18Z","timestamp":1786484058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724056754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":54,"alternative-id":["S0048969724056754"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.175525","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver damage and lipid metabolic dysregulation in adult zebrafish (Danio rerio) induced by spirotetramat","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.175525","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"175525"}}