{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:35:40Z","timestamp":1792956940907,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571549"],"award-info":[{"award-number":["31571549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101743"],"award-info":[{"award-number":["82101743"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["BYSYSZKF2023030"],"award-info":[{"award-number":["BYSYSZKF2023030"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.scitotenv.2024.175877","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T17:47:56Z","timestamp":1725212876000},"page":"175877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Benzo(a)pyrene exposure during pregnancy leads to germ cell apoptosis in male mice offspring via affecting histone modifications and oxidative stress levels"],"prefix":"10.1016","volume":"952","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Zhi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Long","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.175877_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8040561","article-title":"Environment and male fertility: effects of benzo-\u03b1-pyrene and resveratrol on human sperm function in vitro","volume":"8","author":"Alamo","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jnutbio.2016.04.003","article-title":"Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 mapk\/atf2\/inos signaling","volume":"34","author":"Banerjee","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413453","article-title":"Influence of benzo(a)pyrene on different epigenetic processes","volume":"22","author":"Bukowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116348","article-title":"Benzo[a]pyrene-environmental occurrence, human exposure, and mechanisms of toxicity","volume":"23","author":"Bukowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153596","article-title":"Deciphering the roles of aryl hydrocarbon receptor (ahr) in regulating carcinogenesis","volume":"495","author":"Chong","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914578","article-title":"Resveratrol and 3,3\u2032-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha activity through multiple transcriptomic targets in mcf-7 human breast cancer cells","volume":"24","author":"Das","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0035","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/15592294.2017.1382786","article-title":"Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats","volume":"12","author":"Dumasia","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1756-8935-2-5","article-title":"The histone 3 lysine 4 methyltransferase, mll2, is only required briefly in development and spermatogenesis","volume":"2","author":"Glaser","year":"2009","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126719","article-title":"Aryl hydrocarbon receptor in oxidative stress as a double agent and its biological and therapeutic significance","volume":"23","author":"Grishanova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0050","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1021\/acs.est.1c08885","article-title":"Low levels of perfluorooctanoic acid exposure activates steroid hormone biosynthesis through repressing histone methylation in rats","volume":"56","author":"Han","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0055","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1242\/jcs.00739","article-title":"Apoptosis - the p53 network","volume":"116","author":"Haupt","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0060","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2022.01.006","article-title":"Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity","volume":"55","author":"Hezaveh","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0890-6238(03)00071-6","article-title":"Disruption of testicular steroidogenesis and epididymal function by inhaled benzo(a)pyrene","volume":"17","author":"Inyang","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0070","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.reprotox.2021.01.011","article-title":"Parental exposure to benzo(a)pyrene in the peripubertal period impacts reproductive aspects of the f1 generation in rats","volume":"100","author":"Jorge","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128016","article-title":"Exposure to benzo(a)pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats","volume":"263","author":"Jorge","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0080","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1124\/mol.105.021832","article-title":"Novel compound 2-methyl-2h-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (ch-223191) prevents 2,3,7,8-tcdd-induced toxicity by antagonizing the aryl hydrocarbon receptor","volume":"69","author":"Kim","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0085","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.cell.2013.01.052","article-title":"H3k4me3 interactions with taf3 regulate preinitiation complex assembly and selective gene activation","volume":"152","author":"Lauberth","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0090","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nature04021","article-title":"An essential role for corest in nucleosomal histone 3 lysine 4 demethylation","volume":"437","author":"Lee","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0095","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.envpol.2017.12.099","article-title":"Tert regulates telomere-related senescence and apoptosis through DNA damage response in male germ cells exposed to bpde in vitro and to b[a]p in vivo","volume":"235","author":"Ling","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0100","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.semcdb.2015.07.006","article-title":"Developmental windows of susceptibility for epigenetic inheritance through the male germline","volume":"43","author":"Ly","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0105","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1128\/MCB.25.13.5317-5328.2005","article-title":"Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters","volume":"25","author":"Matthews","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1289\/EHP211","article-title":"In utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice","volume":"125","author":"Meier","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0115","doi-asserted-by":"crossref","first-page":"20340","DOI":"10.1074\/jbc.M412081200","article-title":"Transcriptional regulation of nf-e2 p45-related factor (nrf2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase i and ii drug-metabolizing enzymes","volume":"280","author":"Miao","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0120","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/humrep\/deq205","article-title":"The transgenerational impact of benzo(a)pyrene on murine male fertility","volume":"25","author":"Mohamed el","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1117155","article-title":"Human sperm proteome reveals the effect of environmental borne seminal polyaromatic hydrocarbons exposome in etiology of idiopathic male factor infertility","volume":"11","author":"Nayak","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature06236","article-title":"Histone demethylase jhdm2a is critical for tnp1 and prm1 transcription and spermatogenesis","volume":"450","author":"Okada","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125791","article-title":"Multigenerational impacts of gestational bisphenol a exposure on the sperm function and fertility of male mice","volume":"416","author":"Rahman","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0140","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/tx034036r","article-title":"Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action","volume":"16","author":"Safe","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dev.050849","article-title":"Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells","volume":"139","author":"Saitou","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0150","article-title":"Analysis by metabolomics and transcriptomics for the energy metabolism disorder and the aryl hydrocarbon receptor activation in male reproduction of mice and gc-2spd cells exposed to pm(2.5)","volume":"12","author":"Shi","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0155","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1128\/MCB.00915-07","article-title":"Nrf2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis","volume":"27","author":"Shin","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145403","article-title":"A review of human and animals exposure to polycyclic aromatic hydrocarbons: health risk and adverse effects, photo-induced toxicity and regulating effect of microplastics","volume":"773","author":"Sun","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112652","article-title":"Intrauterine exposure to 2,3\u2032,4,4\u2032,5-pentachlorobiphenyl alters spermatogenesis and testicular DNA methylation levels in f1 male mice","volume":"224","author":"Tao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0170","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s004209900112","article-title":"Indoor exposure to polycyclic aromatic hydrocarbons and carbon monoxide in traditional houses in Burundi","volume":"73","author":"Viau","year":"2000","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0175","first-page":"584","article-title":"The role of metabolism in toxicity of polycyclic aromatic hydrocarbons and their non-genotoxic modes of action","volume":"22","author":"Vondr\u00e1\u010dek","year":"2021","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0180","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","article-title":"Goplot: an r package for visually combining expression data with functional analysis","volume":"31","author":"Walter","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.abb.2013.06.001","article-title":"The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of nad(p)h:Quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"537","author":"Wang","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.130547","article-title":"2,3\u2032,4,4\u2032,5-pentachlorobiphenyl induces mitochondria-dependent apoptosis mediated by ahr\/cyp1a1 in mouse germ cells","volume":"445","author":"Wang","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110085","article-title":"Exposure to benzo(a)pyrene damages mitochondrial function via suppressing mitochondrial melatonin receptors in ovarian corpus luteum during early pregnancy","volume":"365","author":"Yang","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167907","article-title":"Crosstalk between aryl hydrocarbon receptor and wnt\/\u03b2-catenin signaling pathway: possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae","volume":"907","author":"Yang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"Clusterprofiler: an r package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.scitotenv.2024.175877_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfab050","article-title":"Converging roles of the aryl hydrocarbon receptor in early embryonic development, maintenance of stemness, and tissue repair","volume":"182","author":"Zablon","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2024.175877_bb0215","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1096\/fj.201700514r","article-title":"Bap exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility","volume":"32","author":"Zhang","year":"2018","journal-title":"FASEB J."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724060339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724060339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:10:03Z","timestamp":1777471803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724060339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":43,"alternative-id":["S0048969724060339"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.175877","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzo(a)pyrene exposure during pregnancy leads to germ cell apoptosis in male mice offspring via affecting histone modifications and oxidative stress levels","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.175877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"175877"}}