{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:18:21Z","timestamp":1789435101658,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.scitotenv.2024.175878","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:56:24Z","timestamp":1725152184000},"page":"175878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Metastatic effects of hydroxy-polycyclic aromatic hydrocarbons on liver cancer cells mediated by estrogen receptor \u03b1"],"prefix":"10.1016","volume":"952","author":[{"given":"Xia","family":"Ning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.175878_bb0005","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10311-017-0697-0","article-title":"Polycyclic aromatic hydrocarbon derivatives in airborne particulate matter: sources, analysis and toxicity","volume":"16","author":"Abbas","year":"2018","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atmosenv.2016.05.041","article-title":"Particulate hydroxy-PAH emissions from a residential wood log stove using different fuels and burning conditions","volume":"140","author":"Avagyan","year":"2016","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0015","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.atmosenv.2011.11.056","article-title":"PM2.5-bound PAHs and hydroxy-PAHs in atmospheric aerosol samples: correlations with season and with physical and chemical factors","volume":"49","author":"Barrado","year":"2012","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fuel.2007.03.047","article-title":"Characterization of molecular markers in smoke from residential coal combustion in China","volume":"87","author":"Bi","year":"2008","journal-title":"Fuel"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0025","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108647","article-title":"Dynamic EMT: a multi-tool for tumor progression","volume":"40","author":"Brabletz","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2022.109036","article-title":"Estrogen receptor expression is modulated in human and mouse prostate epithelial cells during cancer progression","volume":"184","author":"Gadkar","year":"2022","journal-title":"Steroids"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0035","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.scitotenv.2019.07.334","article-title":"Hydroxylated polycyclic aromatic hydrocarbons in surface soil in an emerging urban conurbation in South China","volume":"692","author":"Gao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0040","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.scitotenv.2019.04.420","article-title":"PM2.5-associated nitro-PAH exposure promotes tumor cell metastasis through hippo-YAP mediated transcriptional regulation","volume":"678","author":"Gao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0045","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.scitotenv.2009.11.021","article-title":"Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males","volume":"408","author":"Han","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0050","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3389\/fendo.2019.00573","article-title":"Pathways to endocrine therapy resistance in breast cancer","volume":"10","author":"Haque","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0055","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1248\/jhs.53.562","article-title":"Estrogenic\/antiestrogenic activities of polycyclic aromatic hydrocarbons and their monohydroxylated derivatives by yeast two-hybrid assay","volume":"53","author":"Hayakawa","year":"2007","journal-title":"J. Health Sci."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-015-0048-3","article-title":"EMT and tumor metastasis","volume":"4","author":"Heerboth","year":"2015","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0065","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/minf.201100135","article-title":"Free energy calculations by the molecular mechanics Poisson-Boltzmann surface area method","volume":"31","author":"Homeyer","year":"2012","journal-title":"Mol. Inform."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0070","first-page":"214","article-title":"Clinical significance of Stathmin1 expression and epithelial-mesenchymal transition in curatively resected gastric cancer","volume":"10","author":"Ke","year":"2019","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0075","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.envres.2008.01.013","article-title":"Concentration and profile of 22 urinary polycyclic aromatic ydrocarbon metabolites in the US population","volume":"107","author":"Li","year":"2008","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0080","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1289\/ehp.0901457","article-title":"Hormone activity of hydroxylated polybrominated diphenyl ethers on human thyroid receptor-\u03b2: in vitro and in silico investigations","volume":"118","author":"Li","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105000","article-title":"Hepatotoxic effects of inhalation exposure to polycyclic aromatic hydrocarbons on lipid metabolism of C57BL\/6 mice","volume":"134","author":"Li","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0090","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1021\/es200673q","article-title":"Factors affecting phase i stereoselective biotransformation of chiral polychlorinated biphenyls by rat cytochrome P-450 2B1 isozyme","volume":"45","author":"Lu","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0095","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1021\/ct300418h","article-title":"MMPBSA.py: an efficient program for end-state free energy calculations","volume":"8","author":"Miller","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0100","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial mesenchymal transition in tumor metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu. Rev. Pathol.: Mech. Dis."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0105","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0110","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/jcb.27681","article-title":"Extracellular matrix (ECM) stiffness and degradation as cancer drivers","volume":"120","author":"Najafi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"EMT: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122611","article-title":"Risk assessment of the lipid metabolism-disrupting effects of nitro-PAHs","volume":"396","author":"Ning","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-15976-8_1","article-title":"Tackling exascale software challenges in molecular dynamics simulations with GROMACS","volume":"8759","author":"Pall","year":"2015","journal-title":"Lect. Notes Comput. Sci"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107763","article-title":"Placental transcriptomic signatures of prenatal exposure to hydroxy-polycyclic aromatic hydrocarbons","volume":"172","author":"Paquette","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0135","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1016\/j.chroma.2009.05.068","article-title":"Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in human hair by gas chromatography-negative chemical ionization mass spectrometry","volume":"1216","author":"Schummer","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/jhep.2001.25758","article-title":"Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas","volume":"34","author":"Th\u00e9ret","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0145","doi-asserted-by":"crossref","first-page":"11629","DOI":"10.1021\/es502675p","article-title":"Polycyclic aromatic hydrocarbon metabolites in Arctic cod (Boreogadus saida) from the Beaufort Sea and associative fish health effects","volume":"48","author":"Tomy","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0150","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jmgm.2017.03.002","article-title":"Molecular dynamics simulation studies of novel \u03b2-lactamase inhibitor","volume":"74","author":"Ul Haq","year":"2017","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.107039","article-title":"Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior","volume":"159","author":"Wallace","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.atmosenv.2006.07.033","article-title":"Identification, abundance and seasonal variation of anthropogenic organic aerosols from a mega-city in China","volume":"41","author":"Wang","year":"2007","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.tox.2009.06.015","article-title":"A structure-based investigation on the binding interaction of hydroxylated polycyclic aromatic hydrocarbons with DNA","volume":"262","author":"Wang","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0175","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.talanta.2016.06.011","article-title":"Fully automatic single-drop microextraction with one-setp extraction and derivatization and its application for rapid analysis of hydroxylated polycyclic aromatic hydrocarbons in seawaters","volume":"164","author":"Wang","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.scitotenv.2024.175878_bb0180","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1016\/j.scitotenv.2010.09.024","article-title":"Evaluation of the noncovalent binding interactions between polycyclic aromatic hydrocarbon metabolites and human p53 cDNA","volume":"408","author":"Wei","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0185","article-title":"circSPECC1 promotes proliferation and migration of LNCaP prostate cancer cells by affecting their epithelial-mesenchymal transition","volume":"27","author":"Xie","year":"2023","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0190","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1016\/j.scitotenv.2010.07.034","article-title":"Studying associations between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases in the United States","volume":"408","author":"Xu","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0195","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/path.4009","article-title":"Oestrogen attenuates tumour progression in hepatocellular carcinoma","volume":"228","author":"Xu","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxlet.2018.05.005","article-title":"Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF","volume":"294","author":"Yang","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0205","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/1878-0261.12017","article-title":"Epithelial-mesenchymal transition in tumor metastasis","volume":"11","author":"Yeung","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0210","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.1021\/acs.est.7b02857","article-title":"Sulfate aerosols promote lung cancer metastasis by epigenetically regulating the epithelial-to-mesenchymal transition (EMT)","volume":"51","author":"Yun","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2024.175878_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118077","article-title":"Associations of polycyclic aromatic hydrocarbons exposure and its interaction with XRCC1 genetic polymorphism with lung cancer: a case-control study","volume":"290","author":"Zhou","year":"2021","journal-title":"Environ. Pollut."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724060340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724060340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T19:53:16Z","timestamp":1726775596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724060340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":43,"alternative-id":["S0048969724060340"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.175878","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metastatic effects of hydroxy-polycyclic aromatic hydrocarbons on liver cancer cells mediated by estrogen receptor \u03b1","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.175878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"175878"}}