{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:32:19Z","timestamp":1791232339401,"version":"4.1.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3706600"],"award-info":[{"award-number":["2023YFC3706600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0750200"],"award-info":[{"award-number":["XDB0750200"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22193051"],"award-info":[{"award-number":["22193051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22006103"],"award-info":[{"award-number":["22006103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225605"],"award-info":[{"award-number":["22225605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.scitotenv.2024.176885","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T20:50:01Z","timestamp":1729025401000},"page":"176885","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Arsenic induces ferroptosis in HTR-8\/SVneo cells and placental damage"],"prefix":"10.1016","volume":"955","author":[{"given":"Jingcun","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2024.176885_bb0005","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fnins.2018.00466","article-title":"Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration","volume":"12","author":"Abdalkader","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0010","doi-asserted-by":"crossref","first-page":"22816","DOI":"10.1002\/jbt.22816","article-title":"Developmental toxicity of lead in rats after gestational exposure and the protective role of taurine","volume":"35","author":"Aglan","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0015","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3945\/ajcn.117.155804","article-title":"Current understanding of iron homeostasis","volume":"106","author":"Anderson","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","article-title":"Iron homeostasis","volume":"69","author":"Andrews","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0025","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s00204-022-03317-y","article-title":"Ferroptosis as a mechanism of non-ferrous metal toxicity","volume":"96","author":"Aschner","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.reprotox.2016.07.006","article-title":"Chromium VI - induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins","volume":"68","author":"Banu","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0035","doi-asserted-by":"crossref","first-page":"13020","DOI":"10.1111\/aji.13020","article-title":"Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta","volume":"80","author":"Barke","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.placenta.2021.03.007","article-title":"Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome","volume":"108","author":"Beharier","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0045","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijheh.2010.09.001","article-title":"Spontaneous pregnancy loss in humans and exposure to arsenic in drinking water","volume":"213","author":"Bloom","year":"2010","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0050","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3390\/nu9121327","article-title":"Iron supplementation during pregnancy and infancy: uncertainties and implications for research and policy","volume":"9","author":"Brannon","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4004(81)80034-3","article-title":"Isolation of a transferrin receptor structure from sodium deoxycholate-solubilized human placental syncytiotrophoblast plasma-membrane","volume":"2","author":"Brown","year":"1981","journal-title":"Placenta"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0060","first-page":"47","article-title":"Maternal serum levels and placental expression of hepcidin in preeclampsia","volume":"11","author":"Cardaropoli","year":"2018","journal-title":"Pregnancy Hypertension-an International Journal of Womens Cardiovascular Health"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0065","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3390\/ijms24021607","article-title":"Prospects for anti-tumor mechanism and potential clinical application based on glutathione peroxidase 4 mediated ferroptosis","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/ijms20010039","article-title":"A dual role of heme oxygenase-1 in cancer cells","volume":"20","author":"Chiang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0075","doi-asserted-by":"crossref","first-page":"995047","DOI":"10.4161\/23723556.2014.995047","article-title":"Glutathione peroxidase 4 (Gpx4) and ferroptosis: what\u2019s so special about it?","volume":"2","author":"Conrad","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0080","doi-asserted-by":"crossref","first-page":"1694S","DOI":"10.3945\/ajcn.117.156075","article-title":"U-shaped curve for risk associated with maternal hemoglobin, iron status, or iron supplementation","volume":"106","author":"Dewey","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0085","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1097\/CM9.0000000000002533","article-title":"Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism","volume":"136","author":"Ding","year":"2023","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev-cancerbio-030518-055844","article-title":"The hallmarks of ferroptosis","volume":"3","author":"Dixon","year":"2019","journal-title":"Annual Review of Cancer Biology"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0095","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12964-024-01520-1","article-title":"Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis","volume":"22","author":"Du","year":"2024","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/01926233211042270","article-title":"Histology atlas of the developing mouse placenta","volume":"50","author":"Elmore","year":"2022","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0115","doi-asserted-by":"crossref","first-page":"1226044","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0120","doi-asserted-by":"crossref","first-page":"25010587","DOI":"10.3390\/ijms25010587","article-title":"Role of SLC7A11\/xCT in ovarian cancer","volume":"25","author":"Fantone","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0125","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1007\/s11033-022-07497-9","article-title":"Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis","volume":"49","author":"Feng","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0130","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.gendis.2022.10.016","article-title":"The LIFR-targeting small molecules EC330\/EC359 are potent ferroptosis inducers","volume":"10","author":"Feng","year":"2023","journal-title":"Genes & Diseases"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0135","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3945\/ajcn.117.155812","article-title":"Iron homeostasis during pregnancy","volume":"106","author":"Fisher","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","article-title":"Mechanisms controlling cellular and systemic iron homeostasis","volume":"25","author":"Galy","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0145","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s10571-023-01388-8","article-title":"The mechanisms of ferroptosis under hypoxia","volume":"43","author":"Gao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0150","first-page":"3826","article-title":"Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells","volume":"22","author":"Geng","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0155","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41420-022-01218-8","article-title":"Role of ferroptosis on tumor progression and immunotherapy","volume":"8","author":"Gong","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0160","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/bdr2.2063","article-title":"Abnormal growth and morphogenesis of placenta at term is linked to adverse fetal development after perigestational alcohol consumption up to early gestation in mouse","volume":"114","author":"Gualdoni","year":"2022","journal-title":"Birth Defects Research"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2022.126950","article-title":"Maternal iron supplementation during pregnancy affects placental function and iron status in offspring","volume":"71","author":"Guo","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0170","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/toxsci\/kfm162","article-title":"Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion","volume":"99","author":"He","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0175","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s00204-020-02772-9","article-title":"Biotransformation of arsenic and toxicological implication of arsenic metabolites","volume":"94","author":"Hirano","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0180","first-page":"127","article-title":"Effect of dietary iron on fetal growth in pregnant mice","volume":"63","author":"Hubbard","year":"2013","journal-title":"Comp. Med."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0185","series-title":"Apoptotic and Non-Apoptotic Cell Death","first-page":"143","article-title":"Lipid proxidation-dependent cell death regulated by GPx4 and ferroptosis","volume":"403","author":"Imai","year":"2017"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0190","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.3390\/ijms241210021","article-title":"ACSL4-mediated Ferroptosis and its potential role in central nervous system diseases and injuries","volume":"24","author":"Jia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153831","article-title":"NCOA4-mediated ferritinophagy participates in cadmium-triggered ferroptosis in spermatogonia","volume":"505","author":"Jia","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0200","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.envres.2005.11.006","article-title":"Arsenic speciation transported through the placenta from mother mice to their newborn pups","volume":"101","author":"Jin","year":"2006","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0205","doi-asserted-by":"crossref","first-page":"1329147","DOI":"10.3389\/fcell.2023.1329147","article-title":"Understanding the unique mechanism of ferroptosis: a promising therapeutic target","volume":"11","author":"Kong","year":"2024","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038249","article-title":"Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development","volume":"7","author":"Kozul-Horvath","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0215","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/BJ20120936","article-title":"Haem oxygenase-1 overexpression alters intracellular iron distribution","volume":"449","author":"Lanceta","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0220","first-page":"303","article-title":"Cadmium: placental mechanisms of fetal toxicity","volume":"3","author":"Levin","year":"1981","journal-title":"Placenta Suppl."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0225","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1159\/000451025","article-title":"Increased Heme Oxygenase-1 and nuclear factor erythroid 2-related Factor-2 in the placenta have a cooperative action on preeclampsia","volume":"81","author":"Li","year":"2016","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113595","article-title":"Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction","volume":"238","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102312","article-title":"Hypoxia-induced HIF-1\u03b1\/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer","volume":"52","author":"Lin","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0240","doi-asserted-by":"crossref","first-page":"2208063","DOI":"10.1002\/smll.202208063","article-title":"2D MoS2 nanosheets induce ferroptosis by promoting NCOA4-dependent Ferritinophagy and inhibiting ferroportin","volume":"19","author":"Liu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0245","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.envpol.2018.02.012","article-title":"Maternal arsenic exposure and birth outcomes: a birth cohort study in Wuhan, China","volume":"236","author":"Liu","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0250","doi-asserted-by":"crossref","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"2022","journal-title":"Annals of Translational Medicine"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0255","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.12659\/MSM.897808","article-title":"Effect of fine particulate matter (PM2.5) on rat placenta pathology and perinatal outcomes","volume":"22","author":"Liu","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188890","article-title":"GPX4: the hub of lipid oxidation, ferroptosis, disease and treatment","volume":"1878","author":"Liu","year":"2023","journal-title":"Biochimica Et Biophysica Acta-Reviews on Cancer"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171378","article-title":"C5b-9 promotes ferritinophagy leading to ferroptosis in renal tubular epithelial cells of trichloroethylene-sensitized mice","volume":"923","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0270","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1039\/D1FO01036K","article-title":"Toward improved human health: Nrf2 plays a critical role in regulating ferroptosis","volume":"12","author":"Lu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0275","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0280","first-page":"149","article-title":"Iron and cancer: recent insights","volume":"1368","author":"Manz","year":"2016","journal-title":"Cooley\u2019s Anemia."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0285","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/metabo12020129","article-title":"Iron metabolism in normal and pathological pregnancies and fetal consequences","volume":"12","author":"Megier","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110360","article-title":"Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis","volume":"194","author":"Meng","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0295","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/01.ede.0000147105.94041.e6","article-title":"Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh","volume":"16","author":"Milton","year":"2003","journal-title":"Epidemiology"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0300","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3390\/ijerph14060556","article-title":"A review of the effects of chronic arsenic exposure on adverse pregnancy outcomes","volume":"14","author":"Milton","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0305","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41420-022-01117-y","article-title":"Interplay of Nrf2 and BACH1 in inducing ferroportin expression and enhancing resistance of human macrophages towards ferroptosis","volume":"8","author":"Namgaladze","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0310","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/biom13010120","article-title":"The placentas of women who suffer an episode of psychosis during pregnancy have increased lipid peroxidation with evidence of ferroptosis","volume":"13","author":"Ortega","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0315","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/antiox13050591","article-title":"Oxidative stress, lipid peroxidation and ferroptosis are major pathophysiological signatures in the placental tissue of women with late-onset preeclampsia","volume":"13","author":"Ortega","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0320","doi-asserted-by":"crossref","first-page":"14180","DOI":"10.7717\/peerj.14180","article-title":"Overexpression of LINC00551 promotes autophagy-dependent ferroptosis of lung adenocarcinoma via upregulating DDIT4 by sponging miR-4328","volume":"10","author":"Peng","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0325","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1289\/ehp.1307894","article-title":"Association of arsenic with adverse pregnancy outcomes\/infant mortality: a systematic review and meta-analysis","volume":"123","author":"Quansah","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0330","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1210\/me.2007-0257","article-title":"Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-\u03b2) dehydrogenase 2 gene","volume":"22","author":"Rantakari","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0335","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fnins.2019.00238","article-title":"NCOA4-mediated ferritinophagy: a potential link to neurodegeneration","volume":"13","author":"del Rey","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0340","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00404-023-07032-6","article-title":"Molecular insights into placental iron transfer mechanisms and maternofetal regulation","volume":"309","author":"Santhakumar","year":"2023","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0345","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","article-title":"The chemistry and biology of ferroptosis","volume":"27","author":"Stockwell","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0350","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0355","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/2096-2924.320885","article-title":"Syncytin-a knockout induces placental developmental abnormalities partially through calpain1-apoptosis-inducing factor-mediated trophoblast apoptosis","volume":"5","author":"Sun","year":"2021","journal-title":"Reproductive and Developmental Medicine"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0360","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0365","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuro.2018.04.012","article-title":"Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure","volume":"67","author":"Tang","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0370","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1128\/MCB.23.14.5043-5055.2003","article-title":"Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death","volume":"23","author":"Thumkeo","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0375","doi-asserted-by":"crossref","first-page":"143","DOI":"10.31083\/j.fbl2807143","article-title":"Cellular modulators of the NRF2\/KEAP1 signaling pathway in prostate cancer","volume":"28","author":"Tossetta","year":"2023","journal-title":"Frontiers in Bioscience-Landmark"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0380","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.3390\/cells12111545","article-title":"Modulation of NRF2\/KEAP1 signaling in preeclampsia","volume":"12","author":"Tossetta","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0385","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.reprotox.2009.05.003","article-title":"Arsenite exposure compromises early embryonic development in the Golden hamster","volume":"28","author":"Unis","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0390","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-nutr-080508-141102","article-title":"Effects of arsenic on maternal and fetal health","volume":"29","author":"Vahter","year":"2009","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0395","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphar.2014.00082","article-title":"Pathophysiology of the Belgrade rat","volume":"5","author":"Veuthey","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0400","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2018.07.030","article-title":"Maternal serum arsenic level during pregnancy is positively associated with adverse pregnant outcomes in a Chinese population","volume":"356","author":"Wang","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0405","doi-asserted-by":"crossref","DOI":"10.1177\/09603271211064537","article-title":"Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells","volume":"41","author":"Wang","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109824","article-title":"Ferroptosis mediated by the interaction between Mfn2 and IRE\u03b1 promotes arsenic-induced nonalcoholic steatohepatitis","volume":"188","author":"Wei","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121390","article-title":"Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway","volume":"384","author":"Wei","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0420","first-page":"799","article-title":"Safety evaluation of certain contaminants in food: prepared by the seventy-second meeting of the Joint FAO\/WHO Expert Committee on Food Additives (JECFA)","volume":"63","author":"WHO","year":"2011","journal-title":"World Health Organization Food additives series"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0425","first-page":"23","article-title":"Role of hepcidin in physiology and pathophysiology. Emerging experimental and clinical evidence","volume":"72","author":"Wojciechowska","year":"2021","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0430","first-page":"468","article-title":"Ferroptosis patterns in SH-SY5Y cells induced by sodium arsenite","volume":"37","author":"Xia","year":"2020","journal-title":"Chinese Journal of Environmental & Occupational Medicine"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112114","article-title":"Arsenite induces ferroptosis in the neuronal cells via activation of ferritinophagy","volume":"151","author":"Xiao","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0440","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejogrb.2014.03.053","article-title":"Study on the pathogenesis of autoimmune-type recurrent spontaneous abortion by establishing a new mouse model","volume":"178","author":"Xiao","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0445","doi-asserted-by":"crossref","first-page":"2843990","DOI":"10.1155\/2022\/2843990","article-title":"MicroRNA-147a targets SLC40A1 to induce ferroptosis in human glioblastoma","volume":"2022","author":"Xu","year":"2022","journal-title":"Anal. Cell. Pathol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0450","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/tox.24008","article-title":"Assessing the mechanisms and adjunctive therapy for arsenic-induced liver injury in rats","volume":"39","author":"Xu","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110538","article-title":"The crosstalk between classic cell signaling pathways, non-coding RNAs and ferroptosis in drug resistance of tumors","volume":"102","author":"Yang","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0460","article-title":"The cardinal roles of ferroportin and its partners in controlling cellular iron in and out","volume":"258","author":"Yang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0465","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0470","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1021\/cr200084z","article-title":"Free radical lipid peroxidation: mechanisms and analysis","volume":"111","author":"Yin","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0475","doi-asserted-by":"crossref","first-page":"25703","DOI":"10.1074\/jbc.M602329200","article-title":"Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development","volume":"281","author":"Yoon","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115141","article-title":"Materno-fetal iron transfer and the emerging role of ferroptosis pathways","volume":"202","author":"Zaugg","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115141","article-title":"Materno-fetal iron transfer and the emerging role of ferroptosis pathways","volume":"202","author":"Zaugg","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0490","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2009.03.006","article-title":"A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.09.093","article-title":"NCOA4-mediated ferritinophagy aggravate intestinal oxidative stress and ferroptosis after traumatic brain injury","volume":"688","author":"Zhang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0500","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10565-021-09684-z","article-title":"Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222\/TFRC axis","volume":"39","author":"Zhang","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0505","doi-asserted-by":"crossref","first-page":"9395","DOI":"10.3390\/ijms23169395","article-title":"Iron metabolism and ferroptosis in physiological and pathological pregnancy","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0510","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1644","article-title":"SLC40A1 in iron metabolism, ferroptosis, and disease: a review","volume":"16","author":"Zhang","year":"2024","journal-title":"Wires Mechanisms of Disease"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0515","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13071-024-06262-0","article-title":"Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPAR\u03b3\/miR-7b-5p\/Sp1 signaling pathway","volume":"17","author":"Zhong","year":"2024","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.scitotenv.2024.176885_bb0520","doi-asserted-by":"crossref","first-page":"4213401","DOI":"10.1155\/2022\/4213401","article-title":"MicroRNA-4735-3p facilitates ferroptosis in clear cell renal cell carcinoma by targeting SLC40A1","volume":"2022","author":"Zhu","year":"2022","journal-title":"Anal. Cell. Pathol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0525","article-title":"Huaier suppresses pancreatic cancer progression via activating cell autophagy induced ferroptosis","volume":"12","author":"Zhu","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.scitotenv.2024.176885_bb0530","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Cent. Sci."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724070426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969724070426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:51:56Z","timestamp":1787928716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969724070426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":106,"alternative-id":["S0048969724070426"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.176885","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arsenic induces ferroptosis in HTR-8\/SVneo cells and placental damage","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2024.176885","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176885"}}