{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:17:11Z","timestamp":1762255031854,"version":"build-2065373602"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2022CXGC020515"],"award-info":[{"award-number":["2022CXGC020515"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.scitotenv.2025.178664","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T17:39:40Z","timestamp":1738431580000},"page":"178664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish"],"prefix":"10.1016","volume":"965","author":[{"given":"Siyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouqing","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanteng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanier Nu\u00f1ez","family":"Figueredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kechun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2025.178664_bb0005","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1021\/cn300077c","article-title":"Role of ABC transporters in the pathogenesis of Alzheimer\u2019s disease","volume":"3","author":"Abuznait","year":"2012","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0010","first-page":"23","article-title":"Experimental production of malformations due to acetyl salicylate and phenyl salicylate in rats","volume":"12","author":"Baba","year":"1966","journal-title":"Osaka City Med. J."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0015","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1242\/dev.01970","article-title":"Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development","volume":"132","author":"Beis","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0020","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP transgenic zebrafish","volume":"6","author":"Bernardos","year":"2006","journal-title":"Gene expression patterns: GEP"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0025","series-title":"Beta-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog","first-page":"417","volume":"513","author":"Bernedo","year":"2009"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0030","series-title":"Myelin Biology, Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics","first-page":"2169","volume":"18","author":"Bolino","year":"2021"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0035","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neuro.2016.03.003","article-title":"The effect of UV-filters on the viability of neuroblastoma (SH-SY5Y) cell line","volume":"54","author":"Broniowska","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0040","series-title":"t. neurology, Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease","first-page":"949","volume":"2","author":"Buddhala","year":"2015"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0045","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/s42003-023-05441-6","article-title":"Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral substantia nigra","volume":"6","author":"Burkert","year":"2023","journal-title":"Communications biology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0050","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1897\/07-541.1","article-title":"Hormesis: why it is important to toxicology and toxicologists","volume":"27","author":"Calabrese","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0536.1981.tb04046.x","article-title":"Allergy to phenyl salicylate","volume":"7","author":"Calnan","year":"1981","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0060","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/etc.1958","article-title":"Acute exposure to DE-71: effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae","volume":"31","author":"Chen","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0065","series-title":"Modeling Sporadic Alzheimer\u2019s Disease in Human Brain Organoids under Serum Exposure, Advanced Science (Weinheim, Baden-Wurttemberg, Germany)","first-page":"e2101462","volume":"vol. 8","author":"Chen","year":"2021"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0070","series-title":"Distribution, removal efficiencies and environmental risk assessment of benzophenone and salicylate UV filters in WWTPs and surface waters from Romania","first-page":"2478","volume":"45","author":"Chiriac","year":"2021"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0075","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3233\/JAD-160074","article-title":"CHRNA7 gene and Response to cholinesterase inhibitors in an Italian cohort of Alzheimer\u2019s disease patients","volume":"52","author":"Clarelli","year":"2016","journal-title":"Journal of Alzheimer\u2019s disease: JAD"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0080","series-title":"X-ray structures and mechanism of the human serotonin transporter","first-page":"334","volume":"532","author":"Coleman","year":"2016"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0085","first-page":"683","article-title":"Novel N-pyrazolylsalicylamides with antifungal activity","volume":"40","author":"Daidone","year":"1985","journal-title":"Il Farmaco; edizione scientifica"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0090","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/acschemneuro.0c00579","article-title":"Scope of \u03b2-secretase (BACE1)-targeted therapy in Alzheimer\u2019s disease: emphasizing the flavonoid based natural scaffold for BACE1 inhibition","volume":"11","author":"Das","year":"2020","journal-title":"ACS Chem. Nerosci."},{"year":"1970","series-title":"Studies on the Metabolism, Distribution and Mechanism of Teratogenic Action of Aspirin and its Conjugates in the Rat","author":"Davis","key":"10.1016\/j.scitotenv.2025.178664_bb0095"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2023.03.001","article-title":"Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies","volume":"110","author":"De Bastiani","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.904935","article-title":"Deleterious variation in BR serine\/threonine kinase 2 classified a subtype of autism","volume":"15","author":"Deng","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0110","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-\u03b2 deposition in models of Alzheimer's disease","volume":"618","author":"Depp","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153262","article-title":"Identification of proteome markers for drug-induced liver injury in zebrafish embryos","volume":"477","author":"Driessen","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0120","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/php.13208","article-title":"Materials science challenges in skin UV protection: A review","volume":"96","author":"Egambaram","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0256207","article-title":"Thyroid hormone deficiency during zebrafish development impairs central nervous system myelination","volume":"16","author":"Far\u00edas-Serratos","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1741-7007-11-69","article-title":"Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos","volume":"11","author":"Fischer","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0135","first-page":"649","article-title":"Changing perspectives regarding late-life dementia, nature reviews","volume":"5","author":"Fotuhi","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175950","article-title":"Neuroprotective effect of chlorogenic acid on Parkinson\u2019s disease like symptoms through boosting the autophagy in zebrafish","volume":"956","author":"Gao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0145","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0150","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","article-title":"The \u03b2-secretase BACE1 in Alzheimer\u2019s disease","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0155","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126329","article-title":"Myelin repair stimulated by CNS-selective thyroid hormone action","volume":"4","author":"Hartley","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0160","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2174\/138945012800398973","article-title":"\u03b17 nicotinic acetylcholine receptors in Alzheimer\u2019s disease: neuroprotective, neurotrophic or both?","volume":"13","author":"Hernandez","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0165","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1600-0536.1980.tb05604.x","article-title":"Phenyl salicylate (salol) in a lip salve","volume":"6","author":"Hindson","year":"1980","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40035-022-00321-1","article-title":"Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics","volume":"11","author":"Hirschfeld","year":"2022","journal-title":"Translational neurodegeneration"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0175","series-title":"ATP-Binding Cassette Transporters at the Zebrafish Blood-Brain Barrier and the Potential Utility of the Zebrafish as an In Vivo Model, Cancer Drug Resistance (Alhambra, Calif.)","first-page":"620","volume":"vol. 4","author":"Hotz","year":"2021"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0180","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00401-010-0718-6","article-title":"The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia","volume":"120","author":"Iadecola","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ntt.2009.04.066","article-title":"Acute neuroactive drug exposures alter locomotor activity in larval zebrafish","volume":"32","author":"Irons","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0190","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ecoenv.2019.01.104","article-title":"Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish","volume":"172","author":"Jin","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106179","article-title":"Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson\u2019s disease-like symptoms induced by zinc oxide nanorods","volume":"146","author":"Jin","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0200","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/dvdy.22166","article-title":"Visualization of myelination in GFP-transgenic zebrafish","volume":"239","author":"Jung","year":"2010","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0205","series-title":"Occurrence and Profiles of Organic Sun-Blocking Agents in Surface Waters and Sediments in Japanese Rivers and Lakes, Environmental Pollution (Barking, Essex: 1987)","first-page":"1570","volume":"159","author":"Kameda","year":"2011"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114509","article-title":"Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: implications for delaying parkinsonian signs","volume":"368","author":"Kasanga","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0215","series-title":"Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio)","first-page":"105607","volume":"227","author":"Kataba","year":"2020"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0220","article-title":"GFAP as a potential biomarker for Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"12","author":"Kim","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0225","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.nbd.2011.01.030","article-title":"Ndrg1 in development and maintenance of the myelin sheath","volume":"42","author":"King","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0230","series-title":"Oligodendrocytes in development, myelin generation and beyond","first-page":"1424","volume":"8","author":"Kuhn","year":"2019"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0235","series-title":"Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish","first-page":"305","volume":"79","author":"Kunz","year":"2006"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0240","series-title":"Effects of Ethanol on the Shoaling Behavior of Zebrafish (Danio rerio)","volume":"vol. 8","author":"Kurta","year":"2010"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102031","article-title":"Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer\u2019s disease","volume":"202","author":"La Barbera","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0250","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(00)03589-3","volume":"357","year":"2001","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0255","series-title":"Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling","first-page":"26","volume":"486","author":"Lange","year":"2022"},{"issue":"Suppl. 1","key":"10.1016\/j.scitotenv.2025.178664_bb0260","doi-asserted-by":"crossref","first-page":"S472","DOI":"10.1016\/j.fct.2007.09.062","article-title":"Fragrance material review on phenyl salicylate","volume":"45","author":"Lapczynski","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0265","article-title":"Melatonin regulates A\u03b2 production\/clearance balance and A\u03b2 neurotoxicity: A potential therapeutic molecule for Alzheimer's disease","volume":"132","author":"Li","year":"2020","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0270","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s12967-023-04324-y","article-title":"Identification of metabolism-related subtypes and feature genes in Alzheimer\u2019s disease","volume":"21","author":"Lian","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0275","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijbiomac.2022.05.055","article-title":"Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate","volume":"211","author":"Liang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0280","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1038\/s41467-019-10152-w","article-title":"A\u03b234 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer\u2019s disease progression","volume":"10","author":"Liebsch","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0290","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.chemosphere.2019.06.227","article-title":"A protective role of autophagy in Pb-induced developmental neurotoxicity in zebrafish","volume":"235","author":"Liu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0295","series-title":"Involvement of dopamine signaling pathway in neurodevelopmental toxicity induced by isoniazid in zebrafish","first-page":"129109","volume":"265","author":"Liu","year":"2021"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0285","series-title":"Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer\u2019s disease","first-page":"13805","volume":"28","author":"Liu","year":"2008"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0300","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.steroids.2018.01.006","article-title":"Photoprotection of ultraviolet-B filters: updated review of endocrine disrupting properties","volume":"131","author":"Lorigo","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0305","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.7150\/thno.53330","article-title":"Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish","volume":"11","author":"Lu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0310","series-title":"Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis","first-page":"1","volume":"24","author":"Lyness","year":"2003"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0315","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00510394","article-title":"Allergic contact dermatitis to various salols (phenyl salicylates). A structure-activity relationship study in man and in animal (guinea pig)","volume":"272","author":"Marchand","year":"1982","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0320","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/glia.24108","article-title":"N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination","volume":"70","author":"Marechal","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0325","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0733-8619(18)30060-4","article-title":"Oligodendrocytes and myelin","volume":"13","author":"McLaurin","year":"1995","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0330","doi-asserted-by":"crossref","first-page":"E4779","DOI":"10.1073\/pnas.1417294111","article-title":"The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants","volume":"111","author":"Mergy","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0335","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-981-32-9636-7_3","article-title":"Cytoskeletal signal-regulated oligodendrocyte myelination and Remyelination","volume":"1190","author":"Miyata","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0340","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-neuro-080317-061853","article-title":"Myelin plasticity and nervous system function","volume":"41","author":"Monje","year":"2018","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0345","doi-asserted-by":"crossref","first-page":"14727","DOI":"10.1038\/ncomms14727","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0350","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.watres.2014.07.018","article-title":"Study of the transformation of two salicylates used in personal care products in chlorinated water","volume":"65","author":"de Oliveira e S\u00e1","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0355","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00401-011-0883-2","article-title":"Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis","volume":"122","author":"Pfeiffer","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0360","first-page":"945","article-title":"Presence and distribution of Sun-blocking agents in the Danube River: implications for aquatic","volume":"16","author":"Pirvu","year":"2024","journal-title":"Ecosyst. Health"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0365","series-title":"A Survey of UV Filters Used in Sunscreen Cosmetics","first-page":"3302","volume":"14","author":"Pniewska","year":"2024"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153137","article-title":"Developmental toxicity of fenbuconazole in zebrafish: effects on mitochondrial respiration and locomotor behavior","volume":"470","author":"Qin","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0375","series-title":"The serotonergic system in ageing and Alzheimer's disease","first-page":"15","volume":"99","author":"Rodr\u00edguez","year":"2012"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0380","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010107","article-title":"Pathogenesis of Alzheimer\u2019s disease","volume":"24","author":"Rostagno","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0385","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fnins.2016.00228","article-title":"In utero and Lactational exposure to Acetamiprid induces abnormalities in socio-sexual and anxiety-related behaviors of male mice","volume":"10","author":"Sano","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0390","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tox.2004.06.043","article-title":"Endocrine activity and developmental toxicity of cosmetic UV filters--an update","volume":"205","author":"Schlumpf","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0395","first-page":"9","article-title":"Cerebral microbleeds as a biomarker in Alzheimer's disease?","volume":"10","author":"Shams","year":"2016","journal-title":"A review in the field, Biomarkers in medicine"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157922","article-title":"Morphological and behavioral alterations in zebrafish larvae after exposure to contaminated river sediments collected in different weather conditions","volume":"851","author":"Shuliakevich","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0405","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.nmd.2020.11.010","article-title":"Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D","volume":"31","author":"Skedsmo","year":"2021","journal-title":"Neuromuscular disorders: NMD"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155268","article-title":"Benzoresorcinol induces developmental neurotoxicity and injures exploratory, learning and memorizing abilities in zebrafish","volume":"834","author":"Song","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0415","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1600-0536.1986.tb05273.x","article-title":"Dermatitis from phenyl salicylate in safety spectacle frames","volume":"14","author":"Sonnex","year":"1986","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0420","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00031.2018","article-title":"Myelin in the central nervous system: structure, function, and pathology","volume":"99","author":"Stadelmann","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0425","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0141-1136(02)00119-8","article-title":"Tolerance and hormesis--increased resistance to copper in hydroids linked to hormesis","volume":"54","author":"Stebbing","year":"2002","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0430","series-title":"Interpreting \u2018dose-response\u2019 Curves Using Homeodynamic Data: With an Improved Explanation for Hormesis, Dose-Response: A Publication of International Hormesis Society","first-page":"221","volume":"vol. 7","author":"Stebbing","year":"2009"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131124","article-title":"Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos","volume":"282","author":"Sun","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0440","series-title":"The role of brain vasculature in neurodegenerative disorders","first-page":"1318","volume":"21","author":"Sweeney","year":"2018"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0445","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.scitotenv.2018.08.117","article-title":"Concentrations and tissue-specific distributions of organic ultraviolet absorbents in wild fish from a large subtropical lake in China","volume":"647","author":"Tang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0450","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1007\/s11357-023-00927-x","article-title":"Vascular senescence and leak are features of the early breakdown of the blood-brain barrier in Alzheimer's disease models","volume":"45","author":"Ting","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0455","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbrc.2016.01.079","article-title":"Vesicular monoamine transporter 2 (Vmat2) knockdown elicits anxiety-like behavior in zebrafish","volume":"470","author":"Wang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0460","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresbull.2018.05.003","article-title":"Myelin injury in the central nervous system and Alzheimer\u2019s disease","volume":"140","author":"Wang","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161296","article-title":"Chronic environmental inorganic arsenic exposure causes social behavioral changes in juvenile zebrafish (Danio rerio)","volume":"867","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0470","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.phrs.2009.02.007","article-title":"Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human","volume":"59","author":"Warren","year":"2009","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0475","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2007.11.012","article-title":"Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish","volume":"314","author":"Wen","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0480","series-title":"Role for the oligodendrocyte cytoskeleton in myelination","first-page":"439","volume":"22","author":"Wilson","year":"1989"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0485","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","article-title":"Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke","volume":"18","author":"Yang","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.heha.2022.100021","article-title":"Establishment of a behavioral model to study effects of typical chemicals toward zebrafish larvae","volume":"4","author":"Yuan","year":"2022","journal-title":"Hygiene and Environmental Health Advances"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0495","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuro.2021.10.004","article-title":"Exposure of particulate matter (PM(10)) induces neurodevelopmental toxicity in zebrafish embryos","volume":"87","author":"Zhang","year":"2021","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.scitotenv.2025.178664_bb0500","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.7150\/ijbs.57078","article-title":"Interaction between A\u03b2 and tau in the pathogenesis of Alzheimer\u2019s disease","volume":"17","author":"Zhang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.scitotenv.2025.178664_bb0505","article-title":"Identification and validation of aging-related genes in Alzheimer\u2019s disease","volume":"16","author":"Zhang","year":"2022","journal-title":"Front. Neurosci."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725002980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725002980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:34:40Z","timestamp":1762227280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969725002980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":101,"alternative-id":["S0048969725002980"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.178664","relation":{},"ISSN":["0048-9697"],"issn-type":[{"type":"print","value":"0048-9697"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenyl salicylate induces neurotoxicity and early Alzheimer's disease-like symptoms through ndrg1-regulated myelin damage, increasing bace1 in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.178664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178664"}}