{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:46:57Z","timestamp":1793296017788,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020YQ60"],"award-info":[{"award-number":["ZR2020YQ60"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.scitotenv.2025.178886","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:41:12Z","timestamp":1740109272000},"page":"178886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Spatial metabolomics revealed multi-organ toxicity and visualize metabolite changes induced by borneol in zebrafish"],"prefix":"10.1016","volume":"968","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqinyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashuo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2025.178886_bb0005","first-page":"869","article-title":"Drug localizations in tissue by mass spectrometry imaging","volume":"No. 9 vo 9","author":"\u00c1kos","year":"2015","journal-title":"Biomark. Med."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0010","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuro.2022.12.009","article-title":"Investigating the neurotoxicity of environmental pollutants using zebrafish as a model organism: a review and recommendations for future work","volume":"94","author":"Anon","year":"2023","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138707","article-title":"Zebrafish: an emerging model to study microplastic and nanoplastic toxicity","volume":"728","author":"Bhagat","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.scitotenv.2025.178886_bb0020","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.fct.2008.06.054","article-title":"Fragrance material review on L-Borneol","volume":"46","author":"Bhatia","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.scitotenv.2025.178886_bb0025","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00204-021-03069-1","article-title":"Infections at the Nexus of metabolic-associated fatty liver disease","volume":"95","author":"Boeckmans","year":"2021","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12951-016-0217-6","article-title":"Zebrafish: a complete animal model to enumerate the nanoparticle toxicity","volume":"14","author":"Chakraborty","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156380","article-title":"Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging","volume":"838","author":"Chen","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.178886_bb0040","article-title":"Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease","volume":"14","author":"Chen","year":"2024","journal-title":"J. Pharma. Anal."},{"issue":"13","key":"10.1016\/j.scitotenv.2025.178886_bb0045","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1111\/bph.13135","article-title":"Future technology insight: mass spectrometry imaging as a tool in drug research and development","volume":"172","author":"Cobice","year":"2015","journal-title":"British J. Pharmacol."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.178886_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101116","article-title":"NADPH and glutathione redox link TCA cycle activity to endoplasmic reticulum homeostasis","volume":"23","author":"Gansemer","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175950","article-title":"Neuroprotective effect of chlorogenic acid on Parkinson\u2019s disease like symptoms through boosting the autophagy in zebrafish","volume":"956","author":"Gao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.scitotenv.2025.178886_bb0060","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.jasms.2010.08.002","article-title":"The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles","volume":"21","author":"Goto-Inoue","year":"2010","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"19","key":"10.1016\/j.scitotenv.2025.178886_bb0065","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.3390\/ijms231911932","article-title":"Diflubenzuron induces cardiotoxicity in zebrafish embryos","volume":"23","author":"Han","year":"2022","journal-title":"IJMS"},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/13880209.2012.700718","article-title":"Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells","volume":"51","author":"Hur","year":"2013","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7272808","article-title":"Toxicity assessment of herbal medicine using zebrafish embryos: a systematic review","volume":"2019","author":"Jayasinghe","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103329","article-title":"Analgesic and anti-inflammatory effects and mechanism of action of Borneol on photodynamic therapy of acne","volume":"75","author":"Ji","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"9","key":"10.1016\/j.scitotenv.2025.178886_bb0085","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41419-022-05209-6","article-title":"Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-\u03b2 receptors","volume":"13","author":"Kieu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0090","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1038\/s41598-022-12293-3","article-title":"Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation","volume":"12","author":"Kondo","year":"2022","journal-title":"Sci. Rep."},{"issue":"2\u20133","key":"10.1016\/j.scitotenv.2025.178886_bb0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/JMN:16:2-3:201","article-title":"Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain","volume":"16","author":"Lagarde","year":"2001","journal-title":"JMN"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0100","article-title":"Progress in Borneol intervention for ischemic stroke: a systematic review","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105627","article-title":"Borneol in cardio-cerebrovascular diseases: pharmacological actions, mechanisms, and therapeutics","volume":"169","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114240","article-title":"Brain targeted Borneol-Baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1\u03b1\/VEGF\/eNOS\/NO signal pathway","volume":"160","author":"Long","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2021.112000","article-title":"Impacts of urban land morphology on PM2.5 concentration in the urban agglomerations of China","volume":"283","author":"Ouyang","year":"2021","journal-title":"J. Environ. Manage."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.178886_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/bdrb.20260","article-title":"Morphological score assignment guidelines for the dechorionated zebrafish teratogenicity assay","volume":"89","author":"Panzica-Kelly","year":"2010","journal-title":"Birth Defects Res. Pt B"},{"issue":"7","key":"10.1016\/j.scitotenv.2025.178886_bb0125","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.3390\/ijms22073518","article-title":"Developmental and neurotoxicity of acrylamide to zebrafish","volume":"22","author":"Park","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12944-023-01832-0","article-title":"Serum lipidomics reveals phosphatidylethanolamine and phosphatidylcholine disorders in patients with myocardial infarction and post-myocardial infarction-heart failure","volume":"22","author":"Rong","year":"2023","journal-title":"Lipids Health Dis."},{"issue":"22","key":"10.1016\/j.scitotenv.2025.178886_bb0135","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.3390\/ijms222212393","article-title":"Unravel the local complexity of biological environments by MALDI mass spectrometry imaging","volume":"22","author":"Sgobba","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115080","article-title":"Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging","volume":"201","author":"Spruill","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0145","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41467-022-28242-7","article-title":"Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity","volume":"13","author":"Umansky","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.scitotenv.2025.178886_bb0150","article-title":"Grouper Tsh\u03b2 promoter-driven transgenic zebrafish marks proximal kidney tubule development","volume":"9","author":"Wang","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101410","article-title":"Sexual dimorphism in glutathione metabolism and glutathione-dependent responses","volume":"31","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00418-021-02030-8","article-title":"Fat causes necrosis and inflammation in parenchymal cells in human steatotic liver","volume":"157","author":"Wisse","year":"2022","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116411","article-title":"miR-218-5p promotes hepatic lipogenesis through targeting Elovl5 in non-alcoholic fatty liver disease","volume":"226","author":"Wu","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115378","article-title":"Borneol-modified chitosan: antimicrobial adhesion properties and application in skin flora protection","volume":"228","author":"Xin","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.scitotenv.2025.178886_bb0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/svn-2018-000221","article-title":"Safety and efficacy of Edaravone Dexborneol versus Edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose","volume":"4","author":"Xu","year":"2019","journal-title":"Active-Controlled Clinical Trial. Stroke Vasc Neurol"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0180","first-page":"373","article-title":"Cardiotoxicity of (-)-Borneol, (+)-Borneol, and Isoborneol in zebrafish embryos is associated with Na+ \/K+ -ATPase and Ca2+ -ATPase inhibition","volume":"No. 3 vo 43","author":"Xuan","year":"2022","journal-title":"J. Appl. Toxicol.: JAT"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105259","article-title":"Neurotoxicity of Sanguinarine via inhibiting mitophagy and activating apoptosis in zebrafish and PC12 cells","volume":"188","author":"Yang","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.178886_bb0190","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10695-022-01138-5","article-title":"Appropriate dietary phenylalanine improved growth, protein metabolism and lipid metabolism, and glycolysis in largemouth bass (Micropterus Salmoides)","volume":"50","author":"Yi","year":"2024","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.scitotenv.2025.178886_bb0195","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.vascn.2016.12.002","article-title":"A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish","volume":"84","author":"Zhang","year":"2017","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0200","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.chemosphere.2018.01.092","article-title":"Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos","volume":"197","author":"Zhang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2025.178886_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116030","article-title":"Mass spectrometry imaging-based metabolomics highlights spatial metabolic alterations in three types of liver injuries","volume":"242","author":"Zhu","year":"2024","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725005212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725005212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T03:40:12Z","timestamp":1762227612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969725005212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":41,"alternative-id":["S0048969725005212"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.178886","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial metabolomics revealed multi-organ toxicity and visualize metabolite changes induced by borneol in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.178886","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178886"}}