{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:41:39Z","timestamp":1792442499303,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.scitotenv.2025.180414","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:34:40Z","timestamp":1757378080000},"page":"180414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Analysis of the toxicity and mechanisms of osteoporosis caused by cigarette toxicants using network toxicology and molecular docking techniques"],"prefix":"10.1016","volume":"1000","author":[{"given":"Wenbo","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Database issue","key":"10.1016\/j.scitotenv.2025.180414_bb0005","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180414_bb0010","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/jaba.522","article-title":"Comparing self-directed methods for training staff to create graphs using Graphpad prism","volume":"52","author":"Berkman","year":"2019","journal-title":"J. Appl. Behav. Anal."},{"issue":"9","key":"10.1016\/j.scitotenv.2025.180414_bb0015","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/em.22412","article-title":"Heritable hazards of smoking: applying the \u201cclean sheet\u201d framework to further science and policy","volume":"61","author":"Bline","year":"2020","journal-title":"Environ. Mol. Mutagen."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180414_bb0020","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1210\/jc.2014-2190","article-title":"Smoking as an effect modifier of the association of calcium intake with bone mineral density","volume":"100","author":"Breitling","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180414_bb0025","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s11914-015-0278-8","article-title":"Skeletal effects of smoking","volume":"13","author":"Cusano","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180414_bb0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0032-1326946","article-title":"Nicotine increases osteoblast activity of induced bone marrow stromal cells in a dose-dependent manner: an in vitro cell culture experiment","volume":"2","author":"Daffner","year":"2012","journal-title":"Global Spine J."},{"issue":"W1","key":"10.1016\/j.scitotenv.2025.180414_bb0035","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"32","key":"10.1016\/j.scitotenv.2025.180414_bb0040","article-title":"A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes","volume":"11","author":"Del Giudice","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180414_bb0045","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180414_bb0050","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jacc.2017.11.060","article-title":"Reply: graphing ratio measures on Forest plot","volume":"71","author":"Echouffo-Tcheugui","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180414_bb0055","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1227\/neu.0000000000002412","article-title":"The effects of nicotine- and cigarette-related products on osteogenesis, bone formation, and bone mineralization: a systematic review","volume":"93","author":"Gruber","year":"2023","journal-title":"Neurosurgery"},{"issue":"10","key":"10.1016\/j.scitotenv.2025.180414_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3214","article-title":"Evaluation of genetic variants in IL-1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population","volume":"22","author":"He","year":"2020","journal-title":"J. Gene Med."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1074574","article-title":"Associations between smoke exposure and osteoporosis or osteopenia in a US NHANES population of elderly individuals","volume":"14","author":"Hou","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"6","key":"10.1016\/j.scitotenv.2025.180414_bb0070","doi-asserted-by":"crossref","first-page":"399","DOI":"10.26599\/1671-5411.2023.06.001","article-title":"Report on cardiovascular health and diseases in China 2021: an updated summary","volume":"20","author":"In China","year":"2023","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49979","article-title":"The hazards of smoking and the benefits of cessation: a critical summation of the epidemiological evidence in high-income countries","volume":"9","author":"Jha","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.scitotenv.2025.180414_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102922","article-title":"Tobacco toxins induce osteoporosis through ferroptosis","volume":"67","author":"Jing","year":"2023","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180414_bb0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1517\/14740338.2013.770471","article-title":"The in vitro and in vivo effects of nicotine on bone, bone cells and fracture repair","volume":"12","author":"Kallala","year":"2013","journal-title":"Expert Opin. Drug Saf."},{"issue":"D1","key":"10.1016\/j.scitotenv.2025.180414_bb0090","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180414_bb0095","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4143\/crt.2020.974","article-title":"LASSO-based machine learning algorithm for prediction of lymph node metastasis in T1 colorectal Cancer","volume":"53","author":"Kang","year":"2021","journal-title":"Cancer Res. Treat."},{"issue":"D1","key":"10.1016\/j.scitotenv.2025.180414_bb0100","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180414_bb0105","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1359\/jbmr.1999.14.2.215","article-title":"Smoking increases bone loss and decreases intestinal calcium absorption","volume":"14","author":"Krall","year":"1999","journal-title":"J. Bone Miner. Res."},{"issue":"7112","key":"10.1016\/j.scitotenv.2025.180414_bb0110","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/bmj.315.7112.841","article-title":"A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect","volume":"315","author":"Law","year":"1997","journal-title":"Bmj"},{"key":"10.1016\/j.scitotenv.2025.180414_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113179","article-title":"Carcinogenic components of tobacco and tobacco smoke: a 2022 update","volume":"165","author":"Li","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.freeradbiomed.2018.01.017","article-title":"Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H(2)O(2) and entailing glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: implication for smokers-related osteoporosis","volume":"117","author":"Marinucci","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"16","key":"10.1016\/j.scitotenv.2025.180414_bb0125","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180414_bb0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/13697137.2014.929106","article-title":"Impact of smoking on estrogenic efficacy","volume":"18","author":"Ruan","year":"2015","journal-title":"Climacteric"},{"key":"10.1016\/j.scitotenv.2025.180414_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152667","article-title":"Content of toxic components of cigarette, cigarette smoke vs cigarette butts: a comprehensive systematic review","volume":"813","author":"Soleimani","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114131","article-title":"Molecular mechanism of macrophage polarization regulating the cell senescence of nucleus pulposus during intervertebral disc degeneration","volume":"149","author":"Song","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180414_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12020427","article-title":"The impacts of intervertebral disc degeneration of the spine, alcohol consumption, smoking tobacco products, and glycemic disorders on the expression profiles of Neurotrophins-3 and -4","volume":"12","author":"Staszkiewicz","year":"2024","journal-title":"Biomedicines"},{"issue":"D1","key":"10.1016\/j.scitotenv.2025.180414_bb0150","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101793","article-title":"Facilitative role of circPVT1 in osteogenic differentiation potentials of bone marrow mesenchymal stem cells from patients with osteoporosis through the miR-30d-5p\/ITGB3 axis","volume":"76","author":"Tan","year":"2022","journal-title":"Tissue Cell"},{"issue":"15","key":"10.1016\/j.scitotenv.2025.180414_bb0160","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.lfs.2005.08.017","article-title":"Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts","volume":"78","author":"Tanaka","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0165","doi-asserted-by":"crossref","first-page":"2221112","DOI":"10.1155\/2021\/2221112","article-title":"The effect of smoking on salivary calcium levels, calcium intake, and bleeding on probing in female","volume":"2021","author":"Tjahajawati","year":"2021","journal-title":"Int. J. Dent."},{"issue":"D1","key":"10.1016\/j.scitotenv.2025.180414_bb0170","doi-asserted-by":"crossref","first-page":"D1032","DOI":"10.1093\/nar\/gkab1018","article-title":"Hymenoptera genome database: new genomes and annotation datasets for improved go enrichment and orthologue analyses","volume":"50","author":"Walsh","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0175","article-title":"Identification of ferroptosis-related molecular clusters and genes for diabetic osteoporosis based on the machine learning","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180414_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/genes13050806","article-title":"An overlooked bone metabolic disorder: cigarette smoking-induced osteoporosis","volume":"13","author":"Weng","year":"2022","journal-title":"Genes (Basel)"},{"issue":"D1","key":"10.1016\/j.scitotenv.2025.180414_bb0185","doi-asserted-by":"crossref","first-page":"D700","DOI":"10.1093\/nar\/gkae1067","article-title":"The natural products magnetic resonance database (NP-MRD) for 2025","volume":"53","author":"Wishart","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.180414_bb0190","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3892\/ijmm.2013.1259","article-title":"Nicotine favors osteoclastogenesis in human periodontal ligament cells co-cultured with CD4(+) T cells by upregulating IL-1\u03b2","volume":"31","author":"Wu","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.scitotenv.2025.180414_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004065","article-title":"Smoking control in China: a need for comprehensive national legislation","volume":"19","author":"Xi","year":"2022","journal-title":"PLoS Med."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116392","article-title":"Tobacco toxins trigger bone marrow mesenchymal stem cells aging by inhibiting mitophagy","volume":"277","author":"Xiang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells11010132","article-title":"Regulation of TNF-Induced Osteoclast Differentiation","volume":"11","author":"Yao","year":"2021","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.scitotenv.2025.180414_bb0210","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1007\/s00198-012-1940-y","article-title":"The effects of smoking on bone metabolism","volume":"23","author":"Yoon","year":"2012","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.scitotenv.2025.180414_bb0215","doi-asserted-by":"crossref","first-page":"123830","DOI":"10.1016\/j.jenvman.2024.123830","article-title":"Assessing the toxicological impact of PET-MPs exposure on IVDD: insights from network toxicology and molecular docking","volume":"373","author":"Zhang","year":"2024","journal-title":"J. Environ. Manag."},{"issue":"10","key":"10.1016\/j.scitotenv.2025.180414_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20885","article-title":"Smoking index and COPD duration as potential risk factors for development of osteoporosis in patients with non-small cell lung cancer - a retrospective case control study evaluated by CT Hounsfield unit","volume":"9","author":"Zhou","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.scitotenv.2025.180414_bb0225","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.2147\/COPD.S276913","article-title":"Osteoporosis in a rat model co-exposed to cigarette smoke and intermittent hypoxia","volume":"15","author":"Zhuang","year":"2020","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180414_bb0230","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/abbs\/gmaa174","article-title":"IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis","volume":"53","author":"Zou","year":"2021","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725020546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725020546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:07:52Z","timestamp":1792440472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969725020546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":46,"alternative-id":["S0048969725020546"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.180414","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the toxicity and mechanisms of osteoporosis caused by cigarette toxicants using network toxicology and molecular docking techniques","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.180414","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"180414"}}