{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:07:39Z","timestamp":1783163259698,"version":"3.54.6"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RD 83543301"],"award-info":[{"award-number":["RD 83543301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001589","name":"Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.scitotenv.2025.180501","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T21:08:13Z","timestamp":1758056893000},"page":"180501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Associations between brominated and organophosphate flame retardant levels and inflammatory biomarkers in maternal blood, cord blood, and placental tissue at mid-gestation"],"prefix":"10.1016","volume":"1001","author":[{"given":"Vince","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana E.","family":"Goin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Morello-Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey J.","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Varshavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June-Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Gaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.scitotenv.2025.180501_bb0005","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jri.2017.12.002","article-title":"Effect of polybrominated diphenyl ether congeners on placental cytokine production","volume":"125","author":"Arita","year":"2018","journal-title":"J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180501_bb0015","first-page":"165","article-title":"Tumor necrosis factor-\u03b1 and pregnancy complications: a prospective study","volume":"24","author":"Azizieh","year":"2015","journal-title":"Med. Princ. Pract. Int. J. Kuwait Univ. Health Sci. Cent."},{"issue":"4273","key":"10.1016\/j.scitotenv.2025.180501_bb0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1126\/science.831254","article-title":"Flame-retardant additives as possible cancer hazards","volume":"195","author":"Blum","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.scitotenv.2025.180501_bb0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.chemosphere.2017.02.149","article-title":"Immunotoxicity of organophosphate flame retardants TPHP and TDCIPP on murine dendritic cells in vitro","volume":"177","author":"Canbaz","year":"2017","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180501_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11030231","article-title":"Spleen toxicity of organophosphorus flame retardant TDCPP in mice and the related mechanisms","volume":"11","author":"Cao","year":"2023","journal-title":"Toxics"},{"issue":"8","key":"10.1016\/j.scitotenv.2025.180501_bb0030","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1021","article-title":"Urinary concentrations of organophosphate flame retardant metabolites and pregnancy outcomes among women undergoing in vitro fertilization","volume":"125","author":"Carignan","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fepid.2025.1452934","article-title":"Associations between brominated flame retardants, including polybrominated diphenyl ethers, and immune responses among women in the California teachers study","volume":"5","author":"Cauble","year":"2025","journal-title":"Front. Epidemiol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0040","article-title":"Urinary levels of organophosphate flame retardants metabolites in a young population from Southern Taiwan and potential health effects","volume":"14-2023","author":"Chen","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2024.114336","article-title":"Prenatal exposure to a mixture of organophosphate flame retardants and infant neurodevelopment: a prospective cohort study in Shandong, China","volume":"258","author":"Cheng","year":"2024","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"10","key":"10.1016\/j.scitotenv.2025.180501_bb0050","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1289\/ehp.1001905","article-title":"Polybrominated Diphenyl Ether (PBDE) flame retardants and thyroid hormone during pregnancy","volume":"118","author":"Chevrier","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.scitotenv.2016.02.171","article-title":"Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China","volume":"554-555","author":"Ding","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180501_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2022.100624","article-title":"Elevated midtrimester maternal plasma cytokines and preterm birth in patients with cerclage","volume":"4","author":"Donahue","year":"2022","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"issue":"22","key":"10.1016\/j.scitotenv.2025.180501_bb0065","doi-asserted-by":"crossref","first-page":"22126","DOI":"10.1007\/s11356-019-05669-y","article-title":"A review of organophosphorus flame retardants (OPFRs): occurrence, bioaccumulation, toxicity, and organism exposure","volume":"26","author":"Du","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137623","article-title":"Children\u2019s exposure to hazardous brominated flame retardants in plastic toys","volume":"720","author":"Fatunsin","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180501_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2023.101773","article-title":"Chemokines in thyroid autoimmunity","volume":"37","author":"Ferrari","year":"2023","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijheh.2015.08.004","article-title":"Brominated flame retardants \u2013 Exposure and risk assessment for the general population","volume":"219","author":"Fromme","year":"2016","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.scitotenv.2025.180501_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.140367","article-title":"Polybrominated diphenyl ether (PBDE) exposure and adverse maternal and infant health outcomes: Systematic review","volume":"347","author":"Gomes","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2025.180501_bb0095","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.scitotenv.2018.03.025","article-title":"Exposure to polybrominated diphenyl ethers (PBDEs) in American and Canadian workers: biomonitoring data from two national surveys","volume":"631-632","author":"Gravel","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cytogfr.2024.07.007","article-title":"Inflammatory mechanisms of preterm labor and emerging anti-inflammatory interventions","volume":"78","author":"Habelrih","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180501_bb0105","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1289\/ehp.0901340","article-title":"Prenatal exposure to PBDEs and neurodevelopment","volume":"118","author":"Herbstman","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0110","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1186\/s12884-023-06016-3","article-title":"Prediction of spontaneous preterm birth using CCL2 and CXCL10 in maternal serum of symptomatic high-risk pregnant women: a prospective cohort study","volume":"23","author":"Hoffmann","year":"2023","journal-title":"BMC Pregn. Childb."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00204-020-02903-2","article-title":"Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model","volume":"95","author":"Hogberg","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116640","article-title":"Effects of organophosphorus flame retardant EHDPP on mouse retinal photoreceptor cells: Oxidative stress, apoptosis, and proinflammatory response","volume":"281","author":"Hua","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.scitotenv.2025.180501_bb0125","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.35484","article-title":"Urinary concentrations of organophosphate flame-retardant metabolites in the US population","volume":"7","author":"Huang","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180501_bb0130","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1007\/s11356-015-4515-6","article-title":"Polybrominated diphenyl ethers in articles: a review of its applications and legislation","volume":"24","author":"Jinhui","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.180501_bb0135","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5838","article-title":"A quantile-based g-computation approach to addressing the effects of exposure mixtures","volume":"128","author":"Keil","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"14","key":"10.1016\/j.scitotenv.2025.180501_bb0140","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1021\/acs.est.0c01152","article-title":"In Vitro Immunotoxicity of Organophosphate Flame Retardants in Human THP-1-Derived Macrophages","volume":"54","author":"Li","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"18","key":"10.1016\/j.scitotenv.2025.180501_bb0145","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1021\/acs.est.2c06503","article-title":"Organophosphate flame retardants in pregnant women: sources, occurrence, and potential risks to pregnancy outcomes","volume":"57","author":"Li","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0150","article-title":"CCL2: An important cytokine in normal and pathological pregnancies: A review","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143319","article-title":"From e-waste to living space: Flame retardants contaminating household items add to concern about plastic recycling","volume":"365","author":"Liu","year":"2024","journal-title":"Chemosphere"},{"issue":"16","key":"10.1016\/j.scitotenv.2025.180501_bb0160","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1021\/acs.est.5b01793","article-title":"Prenatal Exposure to Polybrominated Flame Retardants and Fetal Growth in the INMA Cohort (Spain)","volume":"49","author":"Lopez-Espinosa","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.scitotenv.2025.180501_bb0165","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/imcb.12644","article-title":"CCL17\/TARC in autoimmunity and inflammation\u2014not just a T-cell chemokine","volume":"101","author":"Lupancu","year":"2023","journal-title":"Immunol. Cell Biol."},{"issue":"9","key":"10.1016\/j.scitotenv.2025.180501_bb0170","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1289\/ehp.6146","article-title":"Polybrominated diphenyl ethers in maternal and fetal blood samples","volume":"111","author":"Mazdai","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0010","doi-asserted-by":"crossref","first-page":"17004","DOI":"10.1289\/EHP13182","article-title":"Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program","volume":"132","author":"Oh","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0175","article-title":"Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort","volume":"202","author":"Oh","year":"2025","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180501_bb0180","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/ijmr.IJMR_1624_14","article-title":"Interplay of cytokines in preterm birth","volume":"146","author":"Pandey","year":"2017","journal-title":"Indian J. Med. Res."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.taap.2014.09.015","article-title":"Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8\/SVneo human first trimester extravillous trophoblast cell line","volume":"281","author":"Park","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180501_bb0190","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.taap.2013.11.015","article-title":"Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro","volume":"274","author":"Park","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0195","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.chemosphere.2017.12.065","article-title":"Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs): a six-year temporal trend in Northern California pregnant women","volume":"195","author":"Parry","year":"2018","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.scitotenv.2025.180501_bb0200","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.placenta.2012.06.005","article-title":"Polybrominated diphenyl ethers enhance the production of proinflammatory cytokines by the placenta","volume":"33","author":"Peltier","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.scitotenv.2025.180501_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115685","article-title":"Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice","volume":"268","author":"Peng","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124701","article-title":"Concentrations and loadings of organophosphate and replacement brominated flame retardants in house dust from the HOME Study during the PBDE phase-out","volume":"239","author":"Percy","year":"2020","journal-title":"Chemosphere"},{"issue":"17","key":"10.1016\/j.scitotenv.2025.180501_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15174237","article-title":"Polybrominated diphenyl ethers (PBDEs) and human health: effects on metabolism, diabetes and cancer","volume":"15","author":"Renzelli","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0220","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/toxsci\/kfy230","article-title":"Genomic profiling of BDE-47 effects on human placental cytotrophoblasts","volume":"167","author":"Robinson","year":"2019","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0225","article-title":"Mixture effects of prenatal exposure to polybrominated diphenyl ethers on urinary oxidative stress biomarkers in the Chemicals in Our Bodies Cohort","author":"Sehgal","year":"2024","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108922","article-title":"Psychosocial stress and associations with inflammation in mid-gestation maternal, fetal, and placental tissue","volume":"135","author":"Sehgal","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.180501_bb0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1515\/REVEH.2010.25.4.261","article-title":"Halogenated flame retardants: do the fire safety benefits justify the risks?","volume":"25","author":"Shaw","year":"2010","journal-title":"Rev. Environ. Health"},{"issue":"10","key":"10.1016\/j.scitotenv.2025.180501_bb0240","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1021\/acs.est.9b00471","article-title":"Polybrominated diphenyl ethers and biphenyl in serum: time trend study from the national health and nutrition examination survey for years 2005\/06 through 2013\/14","volume":"53","author":"Sj\u00f6din","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2024.104278","article-title":"Chemokine and cytokine profiles in preterm and term labor, in preterm prelabor rupture of the membranes, and in normal pregnancy","volume":"164","author":"Svenvik","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.140874","article-title":"Legacy and emerging flame retardants (FRs) in the urban atmosphere of Pakistan: Diurnal variations, gas-particle partitioning and human health exposure","volume":"743","author":"Syed","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180501_bb0255","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1023\/A:1021740108284","article-title":"TNF-alpha in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit?","volume":"20","author":"Toder","year":"2003","journal-title":"J. Assist. Reprod. Genet."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180501_bb0260","doi-asserted-by":"crossref","first-page":"12247","DOI":"10.1038\/s41598-020-69067-y","article-title":"Racial\/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation","volume":"10","author":"Varshavsky","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180501_bb0265","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/toxsci\/kfab028","article-title":"Organophosphate flame retardants, highly fluorinated chemicals, and biomarkers of placental development and disease during mid-gestation","volume":"181","author":"Varshavsky","year":"2021","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180501_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020379","article-title":"Human placenta buffers the fetus from adverse effects of perceived maternal stress","volume":"10","author":"Vuppaladhadiam","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.scitotenv.2025.180501_bb0275","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1289\/ehp.1002727","article-title":"Environmental chemicals in pregnant women in the United States: NHANES 2003\u20132004","volume":"119","author":"Woodruff","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106215","article-title":"Exposure to organophosphate ester flame retardants and plasticizers during pregnancy: thyroid endocrine disruption and mediation role of oxidative stress","volume":"146","author":"Yao","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0285","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.scitotenv.2016.10.028","article-title":"Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: The National Health and Nutrition Examination Survey 2003\u20132004","volume":"575","author":"Yuan","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115605","article-title":"Activation of LXR\u03b1 attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction","volume":"266","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"24","key":"10.1016\/j.scitotenv.2025.180501_bb0295","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1021\/acs.est.2c05357","article-title":"Chlorinated Organophosphate Flame Retardants Impair the Lung Function via the IL-6\/JAK\/STAT Signaling Pathway","volume":"56","author":"Zhu","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"18","key":"10.1016\/j.scitotenv.2025.180501_bb0300","doi-asserted-by":"crossref","first-page":"7896","DOI":"10.1021\/es200422b","article-title":"Polybrominated diphenyl ethers, hydroxylated polybrominated diphenyl ethers, and measures of thyroid function in second trimester pregnant women in California","volume":"45","author":"Zota","year":"2011","journal-title":"Environ. Sci. Technol."},{"issue":"20","key":"10.1016\/j.scitotenv.2025.180501_bb0305","doi-asserted-by":"crossref","first-page":"11776","DOI":"10.1021\/es402204y","article-title":"Temporal comparison of PBDEs, OH-PBDEs, PCBs, and OH-PCBs in the serum of second trimester pregnant women recruited from San Francisco General Hospital, California","volume":"47","author":"Zota","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0310","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.envint.2018.02.044","article-title":"Association between persistent endocrine-disrupting chemicals (PBDEs, OH-PBDEs, PCBs, and PFASs) and biomarkers of inflammation and cellular aging during pregnancy and postpartum","volume":"115","author":"Zota","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.scitotenv.2025.180501_bb0315","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.envint.2017.12.030","article-title":"Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression","volume":"112","author":"Zota","year":"2018","journal-title":"Environ. Int."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725021412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725021412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:55:16Z","timestamp":1772837716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969725021412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":63,"alternative-id":["S0048969725021412"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.180501","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between brominated and organophosphate flame retardant levels and inflammatory biomarkers in maternal blood, cord blood, and placental tissue at mid-gestation","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.180501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"180501"}}