{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:10:12Z","timestamp":1792379412960,"version":"4.4.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010892","name":"Republic of the Philippines Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011096","name":"Philippine Council for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.scitotenv.2025.180618","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:04:35Z","timestamp":1759205075000},"page":"180618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Antibiotics in pig and chicken farm soils in Asia: Environmental impacts and perspectives"],"prefix":"10.1016","volume":"1002","author":[{"given":"Enrico Miguel","family":"Astrologo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pythias","family":"Espino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0005","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1038\/s41467-025-56825-7","article-title":"The future of antibiotic use in livestock","volume":"16","author":"Acosta","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.107008","article-title":"Biosynthesis of antimicrobial nanoparticle from Swertia spp. (Chirayita) against bacterial pathogens of poultry - a way forward to green nanotechnology and nano-medicines","volume":"197","author":"Ahmad","year":"2024","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180618_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2023.101060","article-title":"Global antimicrobial use in livestock farming: an estimate for cattle, chickens, and pigs","volume":"18","author":"Ardakani","year":"2024","journal-title":"Animal"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180618_bb0020","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/tmi.12854","article-title":"Prevalence and correlates of antibiotic sharing in the Philippines: antibiotic misconceptions and community-level access to non-medical sources of antibiotics","volume":"22","author":"Barber","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0025","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fvets.2020.00329","article-title":"Antimicrobials used in backyard and commercial poultry and swine farms in the Philippines: a qualitative pilot study","volume":"7","author":"Barroga","year":"2020","journal-title":"Front. Vet. Sci."},{"issue":"11","key":"10.1016\/j.scitotenv.2025.180618_bb0030","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01378-24","article-title":"Nanoemulsion is an effective antimicrobial for methicillin-resistant Staphylococcus aureus in infected swine skin burn wounds","volume":"12","author":"Cao","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0035","series-title":"Nano-enabled Sustainable and Precision Agriculture","first-page":"181","article-title":"Nanotechnology in livestock: Improving animal production and health","author":"Cerbu","year":"2023"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.608971","article-title":"Changing patient and public beliefs about antimicrobials and antimicrobial resistance (AMR) using a brief digital intervention","volume":"12","author":"Chan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.agee.2020.107123","article-title":"Fate, transport and ecological risk of antibiotics from pig farms along the bang pakong River, Thailand","volume":"304","author":"Chan","year":"2020","journal-title":"Agric. Ecosyst. Environ."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.emcon.2021.12.003","article-title":"Occurrence of antibiotics in typical pig farming and its wastewater treatment in Thailand","volume":"8","author":"Chan","year":"2022","journal-title":"Emerg. Contam."},{"issue":"23","key":"10.1016\/j.scitotenv.2025.180618_bb0055","doi-asserted-by":"crossref","first-page":"8719","DOI":"10.1021\/acs.est.2c07129","article-title":"Simultaneous dissemination of nanoplastics and antibiotic resistance by nematode couriers","volume":"57","author":"Chan","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0060","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.envpol.2016.11.047","article-title":"Polycyclic aromatic hydrocarbons (PAHs) enriching antibiotic resistance genes (ARGs) in the soils","volume":"220","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.scitotenv.2025.180618_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/pr8111479","article-title":"Tetracycline and sulfonamide antibiotics in soils: presence, fate and environmental risks","volume":"8","author":"Conde-Cid","year":"2020","journal-title":"Processes"},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/antibiotics8010033","article-title":"Characterizing antimicrobial use in the livestock sector in three South East Asian countries (Indonesia, Thailand, and Vietnam)","volume":"8","author":"Coyne","year":"2019","journal-title":"Antibiotics"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.00338","article-title":"Antibiotics in the soil environment\u2014degradation and their impact on microbial activity and diversity","volume":"10","author":"Cyco\u0144","year":"2019","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180618_bb0080","article-title":"Veterinary antibiotics in contaminated animal manure: fate, removal challenges, and future perspectives on conventional and emerging technologies","volume":"11","author":"Ding","year":"2025","journal-title":"Emerg. Contam."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0085","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.scitotenv.2018.04.020","article-title":"Tracking antibiotic resistance genes in soil irrigated with dairy wastewater","volume":"635","author":"Dungan","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.prevetmed.2019.104858","article-title":"Knowledge, attitudes and practices relating to antibiotic use and antibiotic resistance among backyard pig farmers in rural Shandong province, China","volume":"175","author":"Dyar","year":"2020","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0095","doi-asserted-by":"crossref","first-page":"707","DOI":"10.14202\/vetworld.2022.707-713","article-title":"An assessment of knowledge and attitude toward antibiotic misuse by small-scale broiler farmers in Bogor, West Java, Indonesia","author":"Efendi","year":"2022","journal-title":"Vet. World"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180618_bb0100","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1039\/D2VA00306F","article-title":"A framework to assess the terrestrial risk of antibiotic resistance from antibiotics in slurry or manure amended soils","volume":"2","author":"Elder","year":"2023","journal-title":"Environ. Sci. Adv."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2024.100856","article-title":"The contribution of animal antibiotic use to antibiotic resistance in human infections: panel evidence from Denmark","volume":"19","author":"Emes","year":"2024","journal-title":"One Health"},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180618_bb0110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/vms3.390","article-title":"Antibiotic use in pig farming and its associated factors in L County in Yunnan, China","volume":"7","author":"Fang","year":"2021","journal-title":"Vet. Med. Sci."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115175","article-title":"A comprehensive and global evaluation of residual antibiotics in agricultural soils: accumulation, potential ecological risks, and attenuation strategies","volume":"262","author":"Fang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0120","unstructured":"Food and Agriculture Organization. (2020). Livestock and environment statistics: Manure and greenhouse gas emissions Global, regional and country trends, 1990\u20132018 (1st ed.). Food and Agriculture Organization http:\/\/www.fao.org\/3\/cb1922en\/cb1922en.pdf."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.125069","article-title":"A review targeting veterinary antibiotics removal from livestock manure management systems and future outlook","volume":"333","author":"Gaballah","year":"2021","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136118","article-title":"A review of the occurrence of selected micropollutants and microorganisms in different raw and treated manure \u2013 environmental risk due to antibiotics after application to soil","volume":"707","author":"Ghirardini","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0135","article-title":"Tetracyclines in food and feeding stuffs: from regulation to analytical methods, bacterial resistance, and environmental and health implications","volume":"2017","author":"Granados-Chinchilla","year":"2017","journal-title":"J. Anal. Methods Chem."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.180618_bb0140","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s00128-019-02692-0","article-title":"Occurrence and risk assessment of antibiotics in manure, soil, wastewater, groundwater from livestock and poultry farms in Xuzhou, China","volume":"103","author":"Gu","year":"2019","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"7","key":"10.1016\/j.scitotenv.2025.180618_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10070784","article-title":"Knowledge, attitude, and practices on antimicrobial use and antimicrobial resistance among commercial poultry farmers in Bangladesh","volume":"10","author":"Hassan","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0150","unstructured":"HealthforAnimals. (2024). How Prevention Reduces the Need for Antibiotics. Retrieved from: https:\/\/healthforanimals.org\/animal-health-in-data\/antimicrobial-resistance\/how-prevention-reduces-the-need-for-antibiotics\/."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.prevetmed.2025.106534","article-title":"Formulating antibiotic policy: analysis of India\u2019s ban on colistin use in food producing animals","volume":"240","author":"Hennessey","year":"2025","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0160","series-title":"Emerging Issues in Climate Smart Livestock Production","first-page":"473","article-title":"Way forward for sustainable livestock sector","author":"Hoque","year":"2022"},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.47941\/ijcrs.1643","article-title":"Social dimensions of antimicrobial resistance and an anthropological approach: analytic review","volume":"5","author":"Jawad","year":"2024","journal-title":"Int. J. Cult. Relig. Stud."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0170","article-title":"Antibiotics in soil and water: occurrence, fate, and risk","volume":"32","author":"Jia","year":"2023","journal-title":"Curr. Opin. Environ. Sci. Health"},{"issue":"11","key":"10.1016\/j.scitotenv.2025.180618_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102994","article-title":"Comprehensive analysis of biosecurity practices and antimicrobial use in broiler chicken production by integrated operations in Korea","volume":"102","author":"Jung","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2024.100097","article-title":"Impact of antibiotic usage in food-producing animals on food safety and possible antibiotic alternatives","volume":"4","author":"Kaur","year":"2024","journal-title":"Microbe"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108830","article-title":"The significance of environmentally bioavailable antimicrobials in driving antimicrobial resistance in soils","volume":"190","author":"Kaw","year":"2024","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180618_bb0190","article-title":"Antibiotic use in broiler poultry farms in Kathmandu Valley of Nepal: which antibiotics and why?","volume":"6","author":"Koirala","year":"2021","journal-title":"Trop. Med. Infect. Dis."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13756-015-0050-y","article-title":"Antimicrobial use in Chinese swine and broiler poultry production","volume":"4","author":"Krishnasamy","year":"2015","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0200","doi-asserted-by":"crossref","first-page":"166","DOI":"10.14202\/IJOH.2023.166-171","article-title":"Generating evidence on antibiotic use across human and animal health sectors using the World Health Organization\u2019s Access, Watch, Reserve (AWaRe) classification: exploratory pilot study in rural Pune, India","author":"Kudale","year":"2023","journal-title":"Int. J. One Health"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.envadv.2024.100509","article-title":"Risks of veterinary antibiotics contamination in Indian organic farmlands: a reality unfolded","volume":"15","author":"Kuppusamy","year":"2024","journal-title":"Environ. Adv."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tvjl.2015.04.016","article-title":"The use of antimicrobial agents in broiler chickens","volume":"205","author":"Landoni","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.agee.2023.108725","article-title":"Exploring VA presence in groundwater of densely populated livestock farming watersheds: sources, seasonal dynamics and geospatial relationships","volume":"359","author":"Lee","year":"2024","journal-title":"Agric. Ecosyst. Environ."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0220","doi-asserted-by":"crossref","unstructured":"Li, C., Chen, J., Wang, J., Ma, Z., Han, P., Luan, Y., & Lu, A. (2015). Occurrence of antibiotics in soils and manures from greenhouse vegetable production bases of Beijing, China and an associated risk assessment. Sci. Total Environ., 521\u2013522, 101\u2013107. doi:https:\/\/doi.org\/10.1016\/j.scitotenv.2015.03.070.","DOI":"10.1016\/j.scitotenv.2015.03.070"},{"issue":"12","key":"10.1016\/j.scitotenv.2025.180618_bb0225","doi-asserted-by":"crossref","first-page":"11565","DOI":"10.1007\/s11356-018-1339-1","article-title":"Antibiotic residues in liquid manure from swine feedlot and their effects on nearby groundwater in regions of North China","volume":"25","author":"Li","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"6","key":"10.1016\/j.scitotenv.2025.180618_bb0230","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1093\/molbev\/msab029","article-title":"Herbicide selection promotes antibiotic resistance in soil microbiomes","volume":"38","author":"Liao","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2020.123794","article-title":"Effects of wastewater treatment and manure application on the dissemination of antimicrobial resistance around swine feedlots","volume":"280","author":"Liu","year":"2021","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143473","article-title":"Long-term biogas slurry application increased antibiotics accumulation and antibiotic resistance genes (ARGs) spread in agricultural soils with different properties","volume":"759","author":"Lu","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"11","key":"10.1016\/j.scitotenv.2025.180618_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11111461","article-title":"Occurrence and distribution of antibiotics in the water, sediment, and biota of freshwater and marine environments: a review","volume":"11","author":"Maghsodian","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0250","article-title":"Coccidiosis in poultry: disease mechanisms, control strategies, and future directions","author":"Mathis","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0255","unstructured":"Ministry of Health & Ministry of Agriculture and Food Security (2024, January 8). Malaysian Action Plan on Antimicrobial Resistance (MyAP-AMR) 2022-2026. Retrieved from https:\/\/www.who.int\/publications\/m\/item\/malaysia--malaysian-second-action-plan-on-antimicrobial-resistance-(myap-amr)."},{"issue":"6291","key":"10.1016\/j.scitotenv.2025.180618_bb0260","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1126\/science.aaf1160","article-title":"Bridging indigenous and scientific knowledge","volume":"352","author":"Mistry","year":"2016","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180618_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0001305","article-title":"Global trends in antimicrobial use in food-producing animals: 2020 to 2030","volume":"3","author":"Mulchandani","year":"2023","journal-title":"PLoS Glob Public Health"},{"issue":"7","key":"10.1016\/j.scitotenv.2025.180618_bb0270","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1080\/10942912.2016.1212874","article-title":"Antimicrobial drug residues in poultry products and implications on public health: a review","volume":"20","author":"Mund","year":"2017","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0275","unstructured":"National Action Plan for Containment of Antimicrobial Resistance: Myanmar 2017\u2013-2022. (2017, July). Retrieved from: https:\/\/www.who.int\/publications\/m\/item\/myanmar-national-action-plan-for-containment-of-antimicrobial-resistance."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0280","unstructured":"Nguyen, V. T., Padungtod, P., Nguyen, T. H., & Le, T. H. (2020). Handbook responsible use of antibiotics in livestock production for animal health workers in Viet Nam. United Nations Food and Agriculture Organization. Retrieved from: https:\/\/openknowledge.fao.org\/items\/dd1da3d3-0d89-42ae-a593-d40a44dedee2."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2024.120312","article-title":"Antibiotics soil-solution chemistry: a review of environmental behavior and uptake and transformation by plants","volume":"354","author":"Nkoh","year":"2024","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0290","series-title":"Reviews of Environmental Contamination and Toxicology","first-page":"121","article-title":"Sources of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the soil: a review of the spreading mechanism and human health risks","volume":"256","author":"Ondon","year":"2021"},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180618_bb0295","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/wer.1237","article-title":"Physicochemical properties of antibiotics: a review with an emphasis on detection in the aquatic environment","volume":"92","author":"Ozumchelouei","year":"2020","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0300","series-title":"Advances in Microbial Physiology","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/bs.ampbs.2017.02.001","article-title":"Metal resistance and its association with antibiotic resistance","volume":"Vol. 70","author":"Pal","year":"2017"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0305","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.envpol.2017.08.051","article-title":"Transfer of antibiotics from wastewater or animal manure to soil and edible crops","volume":"231","author":"Pan","year":"2017","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180618_bb0310","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3390\/antibiotics11050669","article-title":"Public health interventions to improve antimicrobial resistance awareness and behavioural change associated with antimicrobial use: a systematic review exploring the use of social media","volume":"11","author":"Parveen","year":"2022","journal-title":"Antibiotics"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180618_bb0315","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10661-022-10010-1","article-title":"Occurrence of veterinary antibiotics in animal manure, compost, and agricultural soil, originating from different feedlots in suburbs of Shanghai, East China","volume":"194","author":"Qian","year":"2022","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146502","article-title":"Distribution of the microbial community and antibiotic resistance genes in farmland surrounding gold tailings: a metagenomics approach","volume":"779","author":"Qiao","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.scitotenv.2025.180618_bb0325","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jksus.2019.11.015","article-title":"Veterinary antibiotics in animal manure and manure laden soil: scenario and challenges in Asian countries","volume":"32","author":"Quaik","year":"2020","journal-title":"J. King. Saud. Univ. Sci."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0330","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.micpath.2017.02.011","article-title":"Emergence of multi drug resistance among soil bacteria exposing to insecticides","volume":"105","author":"Rangasamy","year":"2017","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb9000","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e23718","article-title":"Prediction of the mobility and persistence of eight antibiotics based on soil characteristics","volume":"10","author":"Rietra","year":"2024","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180618_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096084","article-title":"Mapping the global distribution of livestock","volume":"9","author":"Robinson","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0340","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12960-018-0270-3","article-title":"Mapping educational opportunities for healthcare workers on antimicrobial resistance and stewardship around the world","volume":"16","author":"Rogers Van Katwyk","year":"2018","journal-title":"Hum. Resour. Health"},{"issue":"3","key":"10.1016\/j.scitotenv.2025.180618_bb0345","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3390\/microorganisms13030610","article-title":"Vertical distribution and drivers of antibiotic resistance genes in agricultural soil irrigated with livestock wastewater","volume":"13","author":"Shang","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116480","article-title":"Exploring the decentralized treatment of sulfamethoxazole-contained poultry wastewater through vertical-flow multi-soil-layering systems in rural communities","volume":"188","author":"Song","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.143263","article-title":"The contribution of swine wastewater on environmental pathogens and antibiotic resistance genes: antibiotic residues and beyond","volume":"364","author":"Sun","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148423","article-title":"Contamination of antibiotics and sul and tet(M) genes in veterinary wastewater, river, and coastal sea in Thailand","volume":"791","author":"Suzuki","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.scitotenv.2025.180618_bb0365","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2542-5196(17)30141-9","article-title":"Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis","volume":"1","author":"Tang","year":"2017","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0370","series-title":"Antibiotics and Antibiotics Resistance Genes in Soils","first-page":"55","article-title":"Entry routes of veterinary antibiotics in the environment","volume":"Vol. 51","author":"Tasho","year":"2017"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0375","series-title":"Manure Management in the (Sub-)Tropics Training Manual for Extension Workers","author":"Teenstra","year":"2015"},{"issue":"12","key":"10.1016\/j.scitotenv.2025.180618_bb0380","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/antibiotics9120918","article-title":"Global trends in antimicrobial use in food animals from 2017 to 2030","volume":"9","author":"Tiseo","year":"2020","journal-title":"Antibiotics"},{"issue":"02","key":"10.1016\/j.scitotenv.2025.180618_bb0385","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4236\/ojvm.2016.62006","article-title":"A review of enrofloxacin for veterinary use","volume":"06","author":"Trouchon","year":"2016","journal-title":"Open J. Vet. Med."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0390","unstructured":"United States Department of Agriculture. (2024). Livestock and Poultry: World Markets and Trade. Retrieved from: https:\/\/apps.fas.usda.gov\/psdonline\/circulars\/livestock_poultry.pdf."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.180618_bb0395","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/ieam.4560","article-title":"Default predicted no-effect target concentrations for antibiotics in the absence of data for the protection against antibiotic resistance and environmental toxicity","volume":"18","author":"Vestel","year":"2022","journal-title":"Integr. Environ. Assess. Manage."},{"issue":"4","key":"10.1016\/j.scitotenv.2025.180618_bb0400","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11783-015-0801-2","article-title":"Adsorption behavior of antibiotic in soil environment: A critical review","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Environ. Sci. Eng."},{"issue":"1","key":"10.1016\/j.scitotenv.2025.180618_bb0405","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s40168-022-01314-y","article-title":"Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133434","article-title":"Antibiotics and microplastics in manure and surrounding soil of farms in the Loess Plateau: occurrence and correlation","volume":"465","author":"Wang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.scitotenv.2025.180618_bb0415","article-title":"Knowledge, attitude, and practice on antibiotic use and antibiotic resistance among the veterinarians and para-veterinarians in Bhutan","volume":"16","author":"Wangmo","year":"2021","journal-title":"PLS ONE"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0420","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.chemosphere.2015.10.126","article-title":"Occurrence of 13 veterinary drugs in animal manure-amended soils in Eastern China","volume":"144","author":"Wei","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0425","author":"World Health Organization"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0430","unstructured":"World Health Organization. 2023, (November 21). Antimicrobial resistance. Retrieved from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0435","unstructured":"World Health Organization. 2024, (February 8). WHO list of medically important antimicrobials. Retrieved from: https:\/\/cdn.who.int\/media\/docs\/default-source\/gcp\/who-mia-list-2024-lv.pdf."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0440","author":"World Organization for Animal Health"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0445","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.soilbio.2018.04.009","article-title":"Long-term effects of manure and chemical fertilizers on soil antibiotic resistome","volume":"122","author":"Xie","year":"2018","journal-title":"Soil Biol. Biochem."},{"issue":"34","key":"10.1016\/j.scitotenv.2025.180618_bb0450","doi-asserted-by":"crossref","first-page":"43093","DOI":"10.1007\/s11356-020-10266-5","article-title":"The presence of tetracyclines and sulfonamides in swine feeds and feces: dependence on the antibiotic type and swine growth stages","volume":"27","author":"Xu","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"6","key":"10.1016\/j.scitotenv.2025.180618_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2021.106446","article-title":"Financial strategies targeting healthcare providers to promote the prudent use of antibiotics: a systematic review of the evidence","volume":"58","author":"Yoshikawa","year":"2021","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.scitotenv.2025.180618_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.115320","article-title":"Environmental risks caused by livestock and poultry farms to the soils: comparison of swine, chicken, and cattle farms","volume":"317","author":"Zhang","year":"2022","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172455","article-title":"When antibiotics encounter microplastics in aquatic environments: interaction, combined toxicity, and risk assessments","volume":"929","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2025.180618_bb0475","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.scitotenv.2018.11.372","article-title":"Evidence for co-selection of antibiotic resistance genes and mobile genetic elements in metal polluted urban soils","volume":"656","author":"Zhao","year":"2019","journal-title":"Sci. Total Environ."}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725022582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969725022582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T09:23:53Z","timestamp":1765445033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969725022582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":95,"alternative-id":["S0048969725022582"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.180618","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotics in pig and chicken farm soils in Asia: Environmental impacts and perspectives","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2025.180618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"180618"}}