{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:16:36Z","timestamp":1790104596229,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001704","name":"European Society of Clinical Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["2024"],"award-info":[{"award-number":["2024"]}],"id":[{"id":"10.13039\/501100001704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Science of The Total Environment"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.scitotenv.2026.181478","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:16:11Z","timestamp":1770182171000},"page":"181478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cefiderocol-resistant Aeromonas with expanded Resistomes in German hospital wastewater: Phenotypic and genomic evidence from the environment\u2013clinical Interface"],"prefix":"10.1016","volume":"1017","author":[{"given":"Mykhailo","family":"Savin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Erler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Dengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Andre","family":"Hammerl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes K.","family":"Knobloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"L\u00fcbbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijo","family":"Parcina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schwanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Zweigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico T.","family":"Mutters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0005","doi-asserted-by":"crossref","first-page":"7712","DOI":"10.1038\/s41598-023-34887-1","article-title":"Whole spectrum of Aeromonas hydrophila virulence determinants and the identification of novel SNPs using comparative pathogenomics","volume":"13","author":"Abdella","year":"2023","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.scitotenv.2026.181478_bb0010","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-017-1008-y","article-title":"Modified microplate method for rapid and efficient estimation of siderophore produced by bacteria","volume":"7","author":"Arora","year":"2017","journal-title":"3 Biotech"},{"issue":"9","key":"10.1016\/j.scitotenv.2026.181478_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7090363","article-title":"Horizontal gene transfer and its association with antibiotic resistance in the genus Aeromonas spp","volume":"7","author":"Bello-L\u00f3pez","year":"2019","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s42003-023-04676-7","article-title":"Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge","volume":"6","author":"Berglund","year":"2023","journal-title":"Communications biology"},{"issue":"4","key":"10.1016\/j.scitotenv.2026.181478_bb0025","first-page":"217","article-title":"Plasmids and Aeromonas virulence","volume":"17","author":"Brown","year":"1997","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0030","series-title":"Assembly-Based QUality Assessment for Microbial Isolate Sequencing: Gitlab","author":"Deneke","year":"2019"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0035","series-title":"BakCharak: Bakterial Characterization of Food-Borne Pathogens: Gitlab","author":"Deneke","year":"2018"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0040","series-title":"MiLongA: Microbial Long read assembly pipeline: Gitlab","author":"Deneke","year":"2020"},{"issue":"3","key":"10.1016\/j.scitotenv.2026.181478_bb0045","article-title":"Characterization of third generation cephalosporin- and carbapenem-resistant Aeromonas isolates from municipal and hospital wastewater","volume":"12","author":"Drk","year":"2023","journal-title":"Antibiotics (Basel, Switzerland)"},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-17379-2","article-title":"Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance","volume":"15","author":"Erler","year":"2025","journal-title":"Sci. Rep"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175344","article-title":"Analysing carbapenemases in hospital wastewater: insights from intracellular and extracellular DNA using qPCR and digital PCR","volume":"950","author":"Erler","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8010129","article-title":"An update on the genus Aeromonas: taxonomy, epidemiology, and pathogenicity","volume":"8","author":"Fern\u00e1ndez-Bravo","year":"2020","journal-title":"Microorganisms"},{"issue":"23","key":"10.1016\/j.scitotenv.2026.181478_bb0065","doi-asserted-by":"crossref","first-page":"10175","DOI":"10.1002\/ece3.3544","article-title":"Receptor uptake arrays for vitamin B12, siderophores, and glycans shape bacterial communities","volume":"7","author":"Frank","year":"2017","journal-title":"Ecol. Evol."},{"issue":"7","key":"10.1016\/j.scitotenv.2026.181478_bb0070","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s10482-016-0693-6","article-title":"Pan-genome analysis of Aeromonas hydrophila, Aeromonas veronii and Aeromonas caviae indicates phylogenomic diversity and greater pathogenic potential for Aeromonas hydrophila","volume":"109","author":"Ghatak","year":"2016","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"10","key":"10.1016\/j.scitotenv.2026.181478_bb0075","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/jac\/dkae263","article-title":"Impact of chromosomally encoded resistance mechanisms and transferable \u03b2-lactamases on the activity of cefiderocol and innovative \u03b2-lactam\/\u03b2-lactamase inhibitor combinations against Pseudomonas aeruginosa","volume":"79","author":"Gonz\u00e1lez-Pinto","year":"2024","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.scitotenv.2026.181478_bb0080","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.diagmicrobio.2019.03.003","article-title":"Reproducibility of broth microdilution MICs for the novel siderophore cephalosporin, cefiderocol, determined using iron-depleted cation-adjusted Mueller-Hinton broth","volume":"94","author":"Hackel","year":"2019","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"7","key":"10.1016\/j.scitotenv.2026.181478_bb0085","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.01883-22","article-title":"A selective culture medium for screening Cefiderocol resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii","volume":"61","author":"Ibrahim","year":"2023","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.00039-09","article-title":"The genus Aeromonas: taxonomy, pathogenicity, and infection","volume":"23","author":"Janda","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.scitotenv.2026.181478_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.106848","article-title":"One health and Global Health view of antimicrobial susceptibility through the \u201ceye\u201d of Aeromonas: systematic review and Meta-analysis","volume":"62","author":"Jones","year":"2023","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"16","key":"10.1016\/j.scitotenv.2026.181478_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167005","article-title":"Structural insights into transporter-mediated drug resistance in infectious diseases","volume":"433","author":"Kim","year":"2021","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.179035","article-title":"Similar antimicrobial resistance and virulence profiles among Aeromonas isolates from recreational beaches, post-chlorinated wastewater and clinical samples in Milwaukee, Wisconsin USA","volume":"970","author":"Bojar","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.825389","article-title":"Emergence of blaNDM- 1-carrying Aeromonas caviae K433 isolated from patient with community-acquired pneumonia","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-45638-9","article-title":"Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria","volume":"15","author":"Maddamsetti","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s44259-024-00026-7","article-title":"Co-selection for antibiotic resistance by environmental contaminants","volume":"2","author":"Murray","year":"2024","journal-title":"NPJ Antimicrob. Resist."},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0125","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00253-024-13055-z","article-title":"Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing","volume":"108","author":"Neil","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/163040","article-title":"Aeromonas hydrophila Sepsis associated with consumption of raw oysters","volume":"2014","author":"Nikiforov","year":"2014","journal-title":"Case reports in infectious diseases"},{"issue":"5","key":"10.1016\/j.scitotenv.2026.181478_bb0135","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1469-0691.2012.03815.x","article-title":"Identification and screening of carbapenemase-producing enterobacteriaceae","volume":"18","author":"Nordmann","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.hazadv.2022.100189","article-title":"Removal of antimicrobial resistance from secondary treated wastewater \u2013 a review","volume":"8","author":"Pant","year":"2022","journal-title":"Journal of Hazardous Materials Advances"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0145","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fmicb.2015.00494","article-title":"Insight into the mobilome of Aeromonas strains","volume":"6","author":"Piotrowska","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.00863","article-title":"Occurrence and variety of \u03b2-lactamase genes among Aeromonas spp. isolated from urban wastewater treatment plant","volume":"8","author":"Piotrowska","year":"2017","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.scitotenv.2026.181478_bb0155","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10096-021-04397-x","article-title":"Co-resistance to ceftazidime-avibactam and cefiderocol in clinical isolates producing KPC variants","volume":"41","author":"Poirel","year":"2022","journal-title":"European journal of clinical microbiology & infectious diseases official publication of the European Society of Clinical Microbiology"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0160","series-title":"A Language and Environment for Statistical Computing","author":"R core Team","year":"2025"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0165","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3389\/fmicb.2016.01337","article-title":"Virulence Factors of Aeromonas hydrophila: In the Wake of Reclassification","volume":"7","author":"Rasmussen-Ivey","year":"2016","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.scitotenv.2026.181478_bb0170","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00418-20","article-title":"The Association between Insertion Sequences and Antibiotic Resistance Genes","volume":"5","author":"Razavi","year":"2020","journal-title":"mSphere"},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0175","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41467-024-44827-w","article-title":"Host- plasmid network structure in wastewater is linked to antimicrobial resistance genes","volume":"15","author":"Risely","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.scitotenv.2026.181478_bb0180","doi-asserted-by":"crossref","DOI":"10.1099\/mgen.0.000206","article-title":"MOB-suite: software tools for clustering, reconstruction and typing of plasmids from draft assemblies","volume":"4","author":"Robertson","year":"2018","journal-title":"Microbial genomics"},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0185","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10096-022-04526-0","article-title":"Progressive in vivo development of resistance to cefiderocol in Pseudomonas aeruginosa","volume":"42","author":"Sadek","year":"2023","journal-title":"European journal of clinical microbiology & infectious diseases official publication of the European Society of Clinical Microbiology"},{"issue":"4","key":"10.1016\/j.scitotenv.2026.181478_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.diagmicrobio.2024.116549","article-title":"Epidemiology and clinical characteristics of Aeromonas-associated gastroenteritis in Northern Israel: Insights and implications for public health","volume":"110","author":"Sagas","year":"2024","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"9","key":"10.1016\/j.scitotenv.2026.181478_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiph.2025.102871","article-title":"Addressing antimicrobial resistance: Structural insights into cefiderocol\u2019s mode of action and emerging resistance mechanisms","volume":"18","author":"Salleh","year":"2025","journal-title":"Journal of infection and public health"},{"issue":"4","key":"10.1016\/j.scitotenv.2026.181478_bb0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.eimce.2018.02.012","article-title":"From CLSI to EUCAST guidelines in the interpretation of antimicrobial susceptibility: What is the effect in our setting?","volume":"36","author":"S\u00e1nchez-Bautista","year":"2018","journal-title":"Enfermedades infecciosas y microbiologia clinica (English ed.)"},{"key":"10.1016\/j.scitotenv.2026.181478_bb0205","doi-asserted-by":"crossref","first-page":"1498180","DOI":"10.3389\/fmicb.2024.1498180","article-title":"Emerging Aeromonas spp. infections in Europe: characterization of human clinical isolates from German patients","volume":"15","author":"Schwartz","year":"2024","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.scitotenv.2026.181478_bb0210","doi-asserted-by":"crossref","DOI":"10.1099\/mgen.0.000685","article-title":"Bakta: rapid and standardized annotation of bacterial genomes via alignment-free sequence identification","volume":"7","author":"Schwengers","year":"2021","journal-title":"Microbial genomics"},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0003-2697(87)90612-9","article-title":"Universal chemical assay for the detection and determination of siderophores","volume":"160","author":"Schwyn","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.scitotenv.2026.181478_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2025.178403","article-title":"Metagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens","volume":"961","author":"Silvester","year":"2025","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0225","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/mlf2.12114","article-title":"Understanding the rapid spread of antimicrobial resistance genes mediated by IS26","volume":"3","author":"Tang","year":"2024","journal-title":"mLife"},{"issue":"1","key":"10.1016\/j.scitotenv.2026.181478_bb0230","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13059-020-02090-4","article-title":"Producing polished prokaryotic pangenomes with the Panaroo pipeline","volume":"21","author":"Tonkin-Hill","year":"2020","journal-title":"Genome Biol."},{"issue":"21","key":"10.1016\/j.scitotenv.2026.181478_bb0235","first-page":"3340","article-title":"ISEScan: automated identification of insertion sequence elements in prokaryotic genomes","volume":"33","author":"Xie","year":"2017","journal-title":"Bioinf. (Oxf.)"},{"issue":"12","key":"10.1016\/j.scitotenv.2026.181478_bb0240","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01019-24","article-title":"Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in Klebsiella pneumoniae","volume":"68","author":"Yang","year":"2024","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.scitotenv.2026.181478_bb0245","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40265-019-1055-2","article-title":"Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli","volume":"79","author":"Zhanel","year":"2019","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.scitotenv.2026.181478_bb0250","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00252-19","article-title":"Comprehensive Analysis Reveals the Evolution and Pathogenicity of Aeromonas, Viewed from Both Single Isolated Species and Microbial Communities","volume":"4","author":"Zhong","year":"2019","journal-title":"mSystems"}],"container-title":["Science of The Total Environment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969726001385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0048969726001385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:07:09Z","timestamp":1771621629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0048969726001385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"alternative-id":["S0048969726001385"],"URL":"https:\/\/doi.org\/10.1016\/j.scitotenv.2026.181478","relation":{},"ISSN":["0048-9697"],"issn-type":[{"value":"0048-9697","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cefiderocol-resistant Aeromonas with expanded Resistomes in German hospital wastewater: Phenotypic and genomic evidence from the environment\u2013clinical Interface","name":"articletitle","label":"Article Title"},{"value":"Science of The Total Environment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scitotenv.2026.181478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"181478"}}