{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:47:26Z","timestamp":1764510446198},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T00:00:00Z","timestamp":1432944000000},"content-version":"vor","delay-in-days":879,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Colorectal Surgery"},{"name":"Cleveland Clinic Innovations of the Cleveland Clinic Cleveland, Ohio"},{"DOI":"10.13039\/100006380","name":"Rehabilitation Research and Development Service","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006380","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Research"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.scr.2012.10.002","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T22:48:31Z","timestamp":1350341311000},"page":"95-102","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mesenchymal stem cells can improve anal pressures after anal sphincter injury"],"prefix":"10.1016","volume":"10","author":[{"given":"Levilester","family":"Salcedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritza","family":"Mayorga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Damaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Balog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Penn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massarat","family":"Zutshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.scr.2012.10.002_bb0005","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1161\/01.CIR.0000147780.30124.CF","article-title":"Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury","volume":"110","author":"Abbott","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.scr.2012.10.002_bb0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/DCR.0b013e3181974444","article-title":"Long-term outcome of sacral nerve stimulation for fecal incontinence","volume":"52","author":"Altomare","year":"2009","journal-title":"Dis. Colon Rectum"},{"issue":"2","key":"10.1016\/j.scr.2012.10.002_bb0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.20070906","article-title":"Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases","volume":"205","author":"Armaka","year":"2008","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.scr.2012.10.002_bb0020","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.clinph.2008.03.018","article-title":"Evaluation and management of peripheral nerve injury","volume":"119","author":"Campbell","year":"2008","journal-title":"Clin. Neurophysiol."},{"issue":"5","key":"10.1016\/j.scr.2012.10.002_bb0025","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.scr.2012.10.002_bb0030","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10350-005-0307-2","article-title":"Injectable silicone biomaterial (PTQ) to treat fecal incontinence after hemorrhoidectomy","volume":"49","author":"Chan","year":"2006","journal-title":"Dis. Colon Rectum"},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0040","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1089\/ars.2010.3582","article-title":"Homing of progenitor cells to ischemic tissues","volume":"15","author":"Chavakis","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0045","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.yjmcc.2008.01.004","article-title":"Homing and engraftment of progenitor cells: a prerequisite for cell therapy","volume":"45","author":"Chavakis","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"10","key":"10.1016\/j.scr.2012.10.002_bb0050","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1517\/14712598.7.10.1483","article-title":"The potential of muscle-derived stem cells for stress urinary incontinence","volume":"7","author":"Furuta","year":"2007","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"1","key":"10.1016\/j.scr.2012.10.002_bb0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pharmthera.2010.09.011","article-title":"SDF-1alpha as a therapeutic stem cell homing factor in myocardial infarction","volume":"129","author":"Ghadge","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.scr.2012.10.002_bb0060","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10350-003-0114-6","article-title":"Long term results of anterior sphincteroplasty","volume":"47","author":"Gutirrez","year":"2003","journal-title":"Dis. Colon Rectum"},{"issue":"3","key":"10.1016\/j.scr.2012.10.002_bb0065","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10350-004-6180-6","article-title":"Long-term outcome of overlapping anal sphincter repair","volume":"45","author":"Halverson","year":"2002","journal-title":"Dis. Colon Rectum"},{"issue":"11","key":"10.1016\/j.scr.2012.10.002_bb0070","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s10350-008-9283-7","article-title":"Experimental models of neuropathic fecal incontinence: an animal model of childbirth injury to the pudendal nerve and external anal sphincter","volume":"51","author":"Healy","year":"2008","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.scr.2012.10.002_bb0075","first-page":"CD001310","article-title":"Electrical stimulation for faecal incontinence in adults","volume":"3","author":"Hosker","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"issue":"10","key":"10.1016\/j.scr.2012.10.002_bb0080","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/DCR.0b013e3181e53088","article-title":"Functional external anal sphincter reconstruction for treatment of anal incontinence using muscle progenitor cell auto grafting","volume":"53","author":"Kajbafzadeh","year":"2010","journal-title":"Dis. Colon Rectum"},{"issue":"9","key":"10.1016\/j.scr.2012.10.002_bb0085","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s10350-008-9360-y","article-title":"Sphincter contractility after muscle-derived stem cells autograft into the cryoinjured anal sphincters of rats","volume":"51","author":"Kang","year":"2008","journal-title":"Dis. Colon Rectum"},{"issue":"3","key":"10.1016\/j.scr.2012.10.002_bb0090","first-page":"345","article-title":"Results of sphincteroplasty in 86 patients with anal incontinence","volume":"45","author":"Karoui","year":"2000","journal-title":"Dis. Colon Rectum"},{"issue":"10","key":"10.1016\/j.scr.2012.10.002_bb0095","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archneurol.2010.248","article-title":"Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis","volume":"67","author":"Karussis","year":"2010","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.scr.2012.10.002_bb0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.51.2.225","article-title":"Injectable silicone biomaterial for faecal incontinence due to internal sphincter dysfunction","volume":"51","author":"Kenefick","year":"2007","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.scr.2012.10.002_bb0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/00015458.2003.11978401","article-title":"Anorectal incontinence: aetiology, pathophysiology and evaluation","volume":"104","author":"Kouraklis","year":"2004","journal-title":"Acta Chir. Belg."},{"issue":"5","key":"10.1016\/j.scr.2012.10.002_bb0110","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/mt.2011.18","article-title":"Vascular gene transfer of SDF-1 promotes endothelial progenitor cell engraftment and enhances angiogenesis in ischemic muscle","volume":"19","author":"Kuliszewski","year":"2011","journal-title":"Mol. Ther."},{"issue":"6","key":"10.1016\/j.scr.2012.10.002_bb0115","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1182\/blood-2005-04-1417","article-title":"How do stem cells find their way home?","volume":"106","author":"Lapidot","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0120","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1155\/2009\/905359","article-title":"Investigating and treating fecal incontinence: when and how","volume":"23","author":"Lazarescu","year":"2009","journal-title":"Can. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.scr.2012.10.002_bb0125","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1385\/SCR:1:3:233","article-title":"Gastrointestinal stem cells and cancer: bridging the molecular gap","volume":"1","author":"Leedham","year":"2005","journal-title":"Stem Cell Rev."},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0130","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10350-007-9153-8","article-title":"Treatment of experimental injury of anal sphincters with primary surgical repair and injection of bone marrow-derived mesenchymal stem cells","volume":"51","author":"Lorenzi","year":"2008","journal-title":"Dis. Colon Rectum"},{"issue":"3","key":"10.1016\/j.scr.2012.10.002_bb0135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00395-005-0521-z","article-title":"Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction","volume":"100","author":"Ma","year":"2005","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.scr.2012.10.002_bb0140","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(99)05218-6","article-title":"Longterm results of overlapping anterior anal-sphincter repair for obstetric trauma","volume":"355","author":"Malouf","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.scr.2012.10.002_bb0145","first-page":"56","article-title":"Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study","volume":"1","author":"Mazzini","year":"2011","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.scr.2012.10.002_bb0150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/AOG.0b013e3182397009","article-title":"Recovery of the injured external anal sphincter after injection of local or intravenous mesenchymal stem cells","volume":"119","author":"Pathi","year":"2012","journal-title":"Obstet. Gynecol."},{"issue":"Suppl. 1","key":"10.1016\/j.scr.2012.10.002_bb0155","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1038\/ncpcardio0733","article-title":"Cell-based gene therapy for the prevention and treatment of cardiac dysfunction","volume":"4","author":"Penn","year":"2007","journal-title":"Natl. Clin. Pract. Cardiovasc. Med."},{"issue":"6","key":"10.1016\/j.scr.2012.10.002_bb0160","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ahj.2011.01.028","article-title":"A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF). [Randomized Controlled Trial]","volume":"161","author":"Perin","year":"2011","journal-title":"Am. Heart J."},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00192-005-0014-5","article-title":"Prevalence of anal incontinence according to age and gender: a systematic review and meta-regression analysis","volume":"17","author":"Pretlove","year":"2006","journal-title":"Int. Urogynecol. J. Pelvic Floor Dysfunct."},{"issue":"85","key":"10.1016\/j.scr.2012.10.002_bb0175","first-page":"1320","article-title":"Anorectal incontinence: therapeutic strategy of a complex surgical problem","volume":"55","author":"Safioleas","year":"2008","journal-title":"Hepatogastroenterology"},{"issue":"8","key":"10.1016\/j.scr.2012.10.002_bb0180","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/DCR.0b013e3181de7fe0","article-title":"Long-term effects on pressure and electromyography in a rat model of anal sphincter injury","volume":"53","author":"Salcedo","year":"2010","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.scr.2012.10.002_bb0185","first-page":"577","article-title":"Chemokine upregulation in response to anal sphincter and pudendal nerve injury: potential signals for stem cell homing","author":"Salcedo","year":"2011","journal-title":"Int. J. Color. Dis."},{"issue":"1","key":"10.1016\/j.scr.2012.10.002_bb0190","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1634\/stemcells.2006-0293","article-title":"Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor","volume":"25","author":"Schenk","year":"2007","journal-title":"Stem Cells"},{"issue":"9","key":"10.1016\/j.scr.2012.10.002_bb0195","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1097\/TP.0b013e3181a1719b","article-title":"Muscular dystrophy therapy by nonautologous mesenchymal stem cells: muscle regeneration without immunosuppression and inflammation","volume":"87","author":"Shabbir","year":"2009","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.scr.2012.10.002_bb0200","doi-asserted-by":"crossref","first-page":"H1888","DOI":"10.1152\/ajpheart.00186.2009","article-title":"Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen","volume":"296","author":"Shabbir","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.scr.2012.10.002_bb0205","first-page":"378","article-title":"Adult stem cells therapy for urine incontinence in women","volume":"81","author":"Stangel-Wojcikiewicz","year":"2010","journal-title":"Ginekol. Pol."},{"issue":"3","key":"10.1016\/j.scr.2012.10.002_bb0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10350-007-9169-0","article-title":"SECCA procedure for the treatment of fecal incontinence: results of five-year follow-up","volume":"51","author":"Takahashi-Monroy","year":"2008","journal-title":"Dis. Colon Rectum"},{"issue":"1","key":"10.1016\/j.scr.2012.10.002_bb0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCINTERVENTIONS.110.958348","article-title":"Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA)","volume":"4","author":"Walter","year":"2011","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"4","key":"10.1016\/j.scr.2012.10.002_bb0220","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/AOG.0b013e3181d56cc5","article-title":"Effect of myogenic stem cells on contractile properties of the repaired and unrepaired transected external anal sphincter in an animal model","volume":"115","author":"White","year":"2010","journal-title":"Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.scr.2012.10.002_bb0225","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jtcvs.2007.07.019","article-title":"Injection of bone marrow mesenchymal stem cells in the borderline area of infarcted myocardium: heart status and cell distribution","volume":"134","author":"Zhang","year":"2007","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"12","key":"10.1016\/j.scr.2012.10.002_bb0230","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1096\/fj.06-6558com","article-title":"SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction","volume":"21","author":"Zhang","year":"2007","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.scr.2012.10.002_bb0235","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/DCR.0b013e31819f746d","article-title":"Effects of sphincterotomy and pudendal nerve transection on the anal sphincter in a rat model","volume":"52","author":"Zutshi","year":"2009","journal-title":"Dis. Colon Rectum"},{"issue":"6","key":"10.1016\/j.scr.2012.10.002_bb0240","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/DCR.0b013e3181a0a79c","article-title":"Ten-year outcome after anal sphincter repair for fecal incontinence","volume":"52","author":"Zutshi","year":"2009","journal-title":"Dis. Colon Rectum"}],"container-title":["Stem Cell Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506112000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1873506112000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T14:01:29Z","timestamp":1562248889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1873506112000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1873506112000992"],"URL":"https:\/\/doi.org\/10.1016\/j.scr.2012.10.002","relation":{},"ISSN":["1873-5061"],"issn-type":[{"value":"1873-5061","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cells can improve anal pressures after anal sphincter injury","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.scr.2012.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}